The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
DOI 10.1038/nn913
Cited by (557)
Items 101–200 of 557
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- Mechanisms of general anesthesia: from molecules to mindGeorge A. Mashour, Stuart A. Forman, Jason A. Campagna · 2005 · Best practice & research. Clinical anaesthesiology
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- Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal StabilityAkie Fujita, Patricia Bonnavion, Miryam H. Wilson, Laura E. Mickelsen, Julien Bloit, Luı́s de Lecea, Alexander C. Jackson · 2017 · Journal of Neuroscience
- Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in ratsMin Chu, Zhi‐Li Huang, Wei‐Min Qu, Naomi Eguchi, Minghui Yao, Yoshihiro Urade · 2004 · Neuroscience Research
- General anesthesia alters time perception by phase shifting the circadian clockJames Frederick Cheeseman, Eva C. Winnebeck, Craig D. Millar, Lisa S. Kirkland, James Wallace Sleigh, Mark Goodwin, Matthew D. M. Pawley, Guy Bloch, Konstantin Lehmann, Randolf Menzel et al. · 2012 · Proceedings of the National Academy of Sciences
- Sedative choice in drug‐induced sleep endoscopy: A neuropharmacology‐based reviewJack W. Shteamer, Raj C. Dedhia · 2016 · The Laryngoscope
- Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABA A ‐active anestheticsInna Sukhotinsky, V. I. Zalkind, Jun Lu, David A. Hopkins, Clifford B. Saper, Marshall G. Devor · 2007 · European Journal of Neuroscience
- Rapid eye movement sleep debt accrues in mice exposed to volatile anestheticsPick, Jeremy, Chen, Yihan, Moore, Jason T., Sun, Yi, Wyner, Abraham J., Friedman, Eliot B., Kelz, Max B. · 2011 · Anesthesiology
- Closed Loop AnesthesiaAnthony Ray Absalom, Robin DE KEYSER, Michel M. R. F. Struys · 2011 · Anesthesia & Analgesia
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- Sleep Circuitry and the Hypnotic Mechanism of GABAA DrugsJun Lu, Mary Ann Greco · 2006 · Journal of Clinical Sleep Medicine
- Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology StudyKirill V. Nourski, Mitchell Steinschneider, Ariane E. Rhone, Hiroto Kawasaki, Matthew A. Howard, Matthew I. Banks · 2018 · Journal of Neuroscience
- Different effects of propofol and dexmedetomidine sedation on electroencephalogram patterns: Wakefulness, moderate sedation, deep sedation and recoveryChunhua Xi, Shiyue Sun, Chuxiong Pan, Fang Ji, Xu Cui, Tianzuo Li · 2018 · PLoS ONE
- Suppressing consciousness: Mechanisms of general anesthesiaAnthony G. Hudetz · 2006 · Seminars in Anesthesia Perioperative Medicine and Pain
- Orexins Increase Cortical Acetylcholine Release and Electroencephalographic Activation through Orexin-1 Receptor in the Rat Basal Forebrain during Isoflurane AnesthesiaHailong Dong, Satoru Fukuda, Eri Murata, Zhenghua Zhu, Takashi Higuchi · 2006 · Anesthesiology
- Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disordersRonald W. Irwin, Christine M. Solinsky, Roberta Dı́az Brinton · 2014 · Frontiers in Cellular Neuroscience
- State-specific Effects of Sevoflurane Anesthesia on Sleep Homeostasis: Selective Recovery of Slow Wave but Not Rapid Eye Movement SleepPal, Dinesh, Lipinski, William J., Walker, Amanda J., Turner, Ashley M., Mashour, George A. · 2011 · Anesthesiology
- The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesiaDelia Belelli · 2003 · Neuropharmacology
- Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousnessYonatan Sanz Perl, Carla Pallavicini, Ignacio Pérez Ipiña, Athena Demertzi A, Vincent Luce Bonhomme, Charlotte Martial, Rajanikant Panda, Jitka Annen, Agustín M. Ibáñez, Morten L. Kringelbach et al. · 2021 · PLoS Computational Biology
- Inhibition of thalamic excitability by 4,5,6,7‐tetrahydroisoxazolo[4,5‐c]pyridine‐3‐ol: a selective role for δ‐GABAAreceptorsMurray B. Herd, Nicola Foister, Dev Chandra, Dianne R. Peden, Gregg E. Homanics, Verity Joy Brown, David J.K. Balfour, Jeremy J. Lambert, Delia Belelli · 2009 · European Journal of Neuroscience
- Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of DiscoveryWeiwei Bao, Shan Jiang, Wei‐Min Qu, Wenxian Li, Changhong Miao, Zhi‐Li Huang · 2023 · Pharmacological Reviews
- Nitrous oxide (N 2 O) requires the N -methyl- d -aspartate receptor for its action in Caenorhabditis elegansPeter Nägele, Laura B. Metz, C. Michael Crowder · 2004 · Proceedings of the National Academy of Sciences
- The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years?Elda Arrigoni, Patrick Michael Fuller · 2022 · International Journal of Molecular Sciences
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- Involvement of Tuberomamillary Histaminergic Neurons in Isoflurane AnesthesiaTao Luo, Lai-Wo Stan Leung · 2011 · Anesthesiology
- Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in ratsTomoko Ishizuka, Masahiro Murakami, Atsushi Yamatodani · 2007 · European Journal of Pharmacology
- A sleep/wake circuit controls isoflurane sensitivity in DrosophilaKottler, Benjamin, Bao, Hong, Zalucki, Oressia, Imlach, Wendy, Troup, Michael, van Alphen, Bart, Paulk, Angelique, Zhang, Bing, van Swinderen, Bruno · 2013 · Current Biology
- General Anesthetics and Molecular Mechanisms of UnconsciousnessStuart A. Forman, Victor A. Chin · 2008 · International Anesthesiology Clinics
- Prostaglandin E2Activates the Histaminergic System via the EP4Receptor to Induce Wakefulness in RatsZhi‐Li Huang, Yo Sato, Takatoshi Mochizuki, Tetsuya Okada, Wei‐Min Qu, Atsushi Yamatodani, Yoshihiro Urade, Osamu Hayaishi · 2003 · Journal of Neuroscience
- Hormonal basis of sex differences in anesthetic sensitivityAndrzej Z. Wasilczuk, Cole Rinehart, Adeeti Aggarwal, Martha E. Stone, George A. Mashour, Michael Simon Avidan, Max B. Kelz, Alex Proekt, ReCCognition Study Group, Mathias Basner et al. · 2024 · Proceedings of the National Academy of Sciences
- Effects of orexin-A on propofol anesthesia in ratsTetsuro Shirasaka, Tetsu Yonaha, Shin Onizuka, Isao Tsuneyoshi · 2010 · Journal of Anesthesia
- Cerebral mechanisms of general anesthesiaLynn Uhrig, Stanislas Dehaene, Béchir Jarraya · 2013 · Annales Françaises d Anesthésie et de Réanimation
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- Opioid-induced Decreases in Rat Brain Adenosine Levels Are Reversed by Inhibiting Adenosine DeaminaseAriana Marie Nelson, Alanna S. Battersby, Helen A. Baghdoyan, Ralph Lydic · 2009 · Anesthesiology
- Nitrous oxide-induced slow and delta oscillationsKara J. Pavone, Oluwaseun Akeju, Aaron L. Sampson, Kelly Ling, Patrick L. Purdon, Emery N. Brown · 2015 · Clinical Neurophysiology
- Transformations of Electrosensory Encoding Associated with an Adaptive FilterSawtell, Nathaniel B., Williams, Alan · 2008 · The Journal of Neuroscience
- Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in RatsÉtienne Challet, Sylviane Gourmelen, Paul Pévet, Philippe Oberling, L. Pain · 2006 · Neuropsychopharmacology
- Does the Amygdala Mediate Anesthetic-induced Amnesia?Michael T. Alkire, Sheila V. Nathan · 2005 · Anesthesiology
- Orexin-A Facilitates Emergence from Propofol Anesthesia in the RatLi-Na Zhang, Zhao-Ju Li, Tong Li, Chao Guo, Jiyuan Niu, Wugang Hou, Hailong Dong · 2012 · Anesthesia & Analgesia
- Hypnotic Hypersensitivity to Volatile Anesthetics and Dexmedetomidine in Dopamine β-Hydroxylase Knockout MiceHu, Frances Y., Hanna, George M., Han, Wei, Mardini, Feras, Thomas, Steven A., Wyner, Abraham J., Kelz, Max B. · 2012 · Anesthesiology
- Amnestic Concentrations of Sevoflurane Inhibit Synaptic Plasticity of Hippocampal CA1 Neurons through γ-Aminobutyric Acid–mediated MechanismsJunko Ishizeki, Koichi Nishikawa, Kazuhiro Kubo, Shigeru Saito, Fumio Goto · 2008 · Anesthesiology
- Brain histamine modulates recognition memory: possible implications in major cognitive disordersGustavo Provensi, Alessia Costa, Iván Izquierdo, Patrizio Blandina, Maria Beatrice Passani · 2018 · British Journal of Pharmacology
- Dexmedetomidine sedation in ICUSoo-Bong Yu · 2012 · Korean Journal of Anesthesiology
- Slow Wave Sleep Enhancement with Gaboxadol Reduces Daytime Sleepiness During Sleep RestrictionJames K. Walsh, Ellen Snyder, Janine Hall, Angela C. Randazzo, Kara S. Griffin, John A. Groeger, Rhody D. Eisenstein, Stephen D. Feren, Pam Dickey, Paula Klingenberg Schweitzer · 2008 · SLEEP
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- Safe Sedation and Hypnosis using Dexmedetomidine for Minimally Invasive Spine Surgery in a Prone PositionKyung-Hoon Kim · 2014 · The Korean journal of pain
- Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in ratHailong Dong, Jiyuan Niu, Binxiao Su, Zhenghua Zhu, Yan Lv, Yizhi Li, Lize Xiong · 2009 · Neuropeptides
- Histamine and SchizophreniaJean‐Michel Arrang · 2007 · International review of neurobiology
- The Role of Dendritic Signaling in the Anesthetic Suppression of ConsciousnessKaspar Meyer · 2015 · Anesthesiology
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- Behavior and Cellular Evidence for Propofol-induced Hypnosis Involving Brain Glycine ReceptorsHai T. Nguyen, Ke-Yong Li, Ralph L. daGraca, Ellise S. Delphin, Ming Xiong, Jiang H. Ye · 2009 · Anesthesiology
- Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in MiceHuan Gui, Chengxi Liu, Haifeng He, Jie Zhang, Hong Chen, Yi Zhang · 2021 · Frontiers in Cellular Neuroscience
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- Limbic System Participates in Mediating the Effects of General AnestheticsJingyi Ma, Lai-Wo Stan Leung · 2005 · Neuropsychopharmacology
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- Propofol-Block of SK Channels in Reticular Thalamic Neurons Enhances GABAergic Inhibition in Relay NeuronsShui‐Wang Ying, Peter A. Goldstein · 2004 · Journal of Neurophysiology
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- Fragrant Dioxane Derivatives Identify β1-Subunit-containing GABAA ReceptorsOlga A. Sergeeva, Olaf Kletke, Andrea Kragler, Anja Poppek, Wiebke Fleischer, Stephan R. Schubring, Boris Görg, Helmut L. Haas, Xin‐Ran Zhu, Hermann Lübbert et al. · 2010 · Journal of Biological Chemistry
- Interaction of Propofol and Sevoflurane on Loss of Consciousness and Movement to Skin Incision during General AnesthesiaRobert S. Harris, Olga Lazar, Jay W. Johansen, Peter S. Sebel · 2006 · Anesthesiology
- GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assembliesYevgenij Yanovsky, Stephan R. Schubring, Wiebke Fleischer, Günter Gisselmann, Xin‐Ran Zhu, Hermann Lübbert, Hanns H. Hatt, Uwe Rudolph, Helmut L. Haas, Olga A. Sergeeva · 2011 · Pflügers Archiv - European Journal of Physiology
- Visual P2–N2 Complex and Arousal at the Time of Encoding Predict the Time Domain Characteristics of Amnesia for Multiple Intravenous Anesthetic Drugs in HumansKane O. Pryor, Ruth A. Reinsel, Meghana Mehta, Yuelin Li, John Timothy Wixted, Robert A. Veselis · 2010 · Anesthesiology
- Propofol-induced Dyskinesias Controlled with Dexmedetomidine during Deep Brain Stimulation SurgeryAnupa Deogaonkar, Milind S. Deogaonkar, John Y. K. Lee, Zeyd Ebrahim, Armin Schubert · 2006 · Anesthesiology
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