The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585

Molecular and cellular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

Anis, N. A., Berry, S. C., Burton, N. R., & Lodge, D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11031.x · Cited by 1,399

Activation of ventrolateral preoptic neurons during sleep

Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

Sherin, J. E., Elmquist, J. K., Torrealba, F., & Saper, C. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04705.1998 · Cited by 746

c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems

Hoffman, G. E., Smith, M. S., & Verbalis, J. G. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1006 · Cited by 715

Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

Jevtović‐Todorović, V., Todorovć, S. M., Mennerick, S. J., Powell, S., Dikranian, K. T., Benshoff, N. D., Zorumski, C. F., & Olney, J. W. (1998) · Nature Medicine · doi:10.1038/nm0498-460 · Cited by 675

How does xenon produce anaesthesia?

Franks, N. P., Dickinson, R., de Sousa, S. L. M., Hall, A. C., & Lieb, W. R. (1998) · Nature · doi:10.1038/24525 · Cited by 514

Identification of sleep-promoting neurons in vitro

Gallopin, T., Fort, P., Eggermann, E., Cauli, B., Luppi, P.-H., Rossier, J., Audinat, E., Mühlethaler, M., & Serafin, M. (2000) · Nature · doi:10.1038/35010109 · Cited by 504

Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

McKinstry-Wu, A. R., Wasilczuk, A. Z., Harrison, B. A., Bedell, V. M., Sridharan, M. J., Breig, J. J., Pack, M. A., Kelz, M. B., & Proekt, A. (2019) · eLife · doi:10.7554/elife.50143 · Cited by 39

Sleep and Anesthesia Interactions: A Pharmacological Appraisal

Scharf, M. T., & Kelz, M. B. (2012) · Current anesthesiology reports · doi:10.1007/s40140-012-0007-0 · Cited by 41

Modulation of the Acoustic Startle Response by the Level of Arousal: Comparison of Clonidine and Modafinil in Healthy Volunteers

Samuels, E. R., Hou, R. H., Langley, R. W., Szabadi, E., & Bradshaw, C. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301363 · Cited by 41

Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics

Leung, L.-W. S., Sophie Petropoulos, A., Bixia Shen, A., Luo, T., Herrick, I. A., Rajakumar, N., & Ma, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.019 · Cited by 39

Propofol and Etomidate Depress Cortical, Thalamic, and Reticular Formation Neurons During Anesthetic-Induced Unconsciousness

Andrada, J., Livingston, P., Lee, B.-J., & Antognini, J. F. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182405228 · Cited by 39

Episodic Waveforms in the Electroencephalogram during General Anaesthesia: A Study of Patterns of Response to Noxious Stimuli

Mackay, E. C., SLEIGH, J. W., Voss, L. J., & Barnard, J. P. M. (2010) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1003800118 · Cited by 39

Survival benefits of dexmedetomidine used for sedating septic patients in intensive care setting: A systematic review

Zamani, M. M., Keshavarz‐Fathi, M., B, M. S. F., Hirbod‐Mobarakeh, A., Rezaei, N., Bahrami, A., & Nader, N. D. (2015) · Journal of Critical Care · doi:10.1016/j.jcrc.2015.11.013 · Cited by 38

Relationship between sedation and pupillary function: comparison of diazepam and diphenhydramine

Hou, R. H., Scaife, J. C., Freeman, C., Langley, R. W., Szabadi, E., & Bradshaw, C. M. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02632.x · Cited by 38

The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers

Bonhomme, V. L., Maquet, P., Phillips, C. L. M., Plenevaux, A., Hans, P., Luxen, A., Lamy, M., & Laureys, S. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181619685 · Cited by 38

Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations

Voss, L. J., García, P. S., Hentschke, H., & Banks, M. I. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002554 · Cited by 38

Generative Embeddings of Brain Collective Dynamics Using Variational Autoencoders

Perl, Y. S., Bocaccio, H., Ipiña, I. P., Zamberlán, F., Piccinini, J., Laufs, H., Kringelbach, M. L., Deco, G., & Tagliazucchi, E. (2020) · Physical Review Letters · doi:10.1103/physrevlett.125.238101 · Cited by 37

Halothane-induced Hypnosis Is Not Accompanied by Inactivation of Orexinergic Output in Rodents

Gompf, H. S., Chen, J., Sun, Y., Yanagisawa, M., Aston‐Jones, G., & Kelz, M. B. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b764b3 · Cited by 37

Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study

Panhelainen, A. E., & Korpi, E. R. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.12.011 · Cited by 38

Pretreatment with volatile anesthetics, but not with the nonimmobilizer 1,2-dichlorohexafluorocyclobutane, reduced cell injury in rat cerebellar slices after an in vitro simulated ischemia

Wang, C., Lee, J. J., Jung, H. H., & Zuo, Z. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.030 · Cited by 36

Safranal Enhances Non‐Rapid Eye Movement Sleep in Pentobarbital‐Treated Mice

Liu, Z., Xu, X., Liu, T., Hong, Z., Urade, Y., Huang, Z., & Qu, W. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00334.x · Cited by 35

The Mouse as a Model Organism for Assessing Anesthetic Sensitivity

Wasilczuk, A. Z., Maier, K. L., & Kelz, M. B. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.008 · Cited by 35

Frontal electroencephalogram activity during emergence from general anaesthesia in children with and without emergence delirium

Kim, J., Lee, H., Byun, S. H., Lim, H., Lee, M., Choung, Y., & Kim, E. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.07.060 · Cited by 35

The Effects of Neuropeptide S on General Anesthesia in Rats

Kushikata, T., Yoshida, H., Kudo, M., Salvadori, S., Calò, G., & Hirota, K. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31820b990d · Cited by 35

Anesthetic Treatment Blocks Synaptogenesis But Not Neuronal Regeneration of CulturedLymnaeaNeurons

Woodall, A. J., Naruo, H., Prince, D. J., Feng, Z. P., Winlow, W., Takasaki, M., & Syed, N. I. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00347.2003 · Cited by 36

Waking action of ursodeoxycholic acid (UDCA) involves histamine and GABAA receptor block

Yanovsky, Y., Schubring, S. R., Yao, Q., Zhao, Y., Li, S., May, A., Haas, H. L., Lin, J.-S., & Sergeeva, O. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042512 · Cited by 34

Sleep and Anesthesia

Vacas, S., Kurien, P. A., & Maze, M. (2013) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2012.11.009 · Cited by 36

Divergent Neural Activity in the VLPO During Anesthesia and Sleep

Luo, M., Fei, X., Liu, X., Jin, Z., Wang, Y., & Xu, M. (2022) · Advanced Science · doi:10.1002/advs.202203395 · Cited by 37

Are We Unconscious During General Anesthesia?

Hudetz, A. G. (2008) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e3181755db5 · Cited by 34

Sleep and its disorders in translational medicine

Paterson, L. M., Nutt, D., & Wilson, S. J. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400643 · Cited by 35

α2-Adrenergic receptor-mediated presynaptic inhibition of GABAergic IPSPs in rat histaminergic neurons

Stevens, D. R., Kuramasu, A., Eriksson, K. S., Selbach, O., & Haas, H. L. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.01.004 · Cited by 34

A succession of anesthetic endpoints in the Drosophila brain

van Swinderen, B. (2006) · Journal of Neurobiology · doi:10.1002/neu.20300 · Cited by 33

Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner

He, Y., Liu, T., He, Q., Ke, W., Li, X., Du, J., Deng, S., Shu, Z., Wu, J. S., Yang, B., et al. (2023) · eLife · doi:10.7554/elife.92252 · Cited by 33

A Sleep‐Specific Midbrain Target for Sevoflurane Anesthesia

Yi, T., Wang, N., Huang, J., Wang, Y., Ren, S., Hu, Y., Xia, J., Liao, Y., Li, X., Luo, F., et al. (2023) · Advanced Science · doi:10.1002/advs.202300189 · Cited by 34

Neurochemical Modulators of Sleep and Anesthetic States

Dort, C. J. V., Baghdoyan, H. A., & Lydic, R. (2008) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e318181a8ca · Cited by 34

Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms

Huang, Y., Cui, S., Cui, X., Cao, Q., Ding, H., Song, J., Hu, X., Ye, H., Yu, B., Sheng, Z., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.021 · Cited by 32

Pharmacology I: Effects on Sleep of Commonly Used ICU Medications

Weinhouse, G. L. (2008) · Critical Care Clinics · doi:10.1016/j.ccc.2008.02.008 · Cited by 32

Ketamine and propofol have opposite effects on postanesthetic sleep architecture in rats: relevance to the endogenous sleep–wakefulness substances orexin and melanin-concentrating hormone

Kushikata, T., Sawada, M., Niwa, H., Kudo, T., Kudo, M., Tonosaki, M., & Hirota, K. (2016) · Journal of Anesthesia · doi:10.1007/s00540-016-2161-x · Cited by 34

What is unconsciousness in a fly or a worm? A review of general anesthesia in different animal models

Zalucki, O. H., & van Swinderen, B. (2016) · Consciousness and Cognition · doi:10.1016/j.concog.2016.06.017 · Cited by 33

Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation

Orth, M., Barter, L. S., Dominguez, C. L., Atherley, R. J., Carstens, E. E., & Antognini, J. F. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei208 · Cited by 32

Neurobiological basis of emergence from anesthesia

Song, X., & Hu, J.-J. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.02.006 · Cited by 32

Delir auf der Intensivstation

von Haken, R., Gruß, M., Plaschke, K., Scholz, M., Engelhardt, R., Brobeil, A., Martin, E., & Weigand, M. A. (2010) · Der Anaesthesist · doi:10.1007/s00101-009-1664-3 · Cited by 32

Reticular thalamic responses to nociceptive inputs in anesthetized rats

Yen, C., & Shaw, F.-Z. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02235-2 · Cited by 31

Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions

Zeller, A., Jurd, R., Lambert, S., Arras, M., Drexler, B., Grashoff, C., Antkowiak, B., & Rudolph, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-74806-9_2 · Cited by 31

Riluzole, a Glutamate Release Inhibitor, Induces Loss of Righting Reflex, Antinociception, and Immobility in Response to Noxious Stimulation in Mice

Irifune, M., Kikuchi, N., Saida, T., Takarada, T., Shimizu, Y., Endo, C., Morita, K., Dohi, T., Sato, T., & Kawahara, M. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000263267.04198.36 · Cited by 31

Comparative brain-wide mapping of ketamine- and isoflurane-activated nuclei and functional networks in the mouse brain

Hu, Y., Du, W., Qi, J., Luo, H., Zhang, Z., Luo, M., & Wang, Y. (2023) · eLife · doi:10.7554/elife.88420 · Cited by 33

Medial septal lesion enhances general anesthesia response

Leung, L.-W. S., Ma, J., Bixia Shen, A., Nachim, I., & Luo, T. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.010 · Cited by 30

Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster

Zalucki, O. H., Menon, H., Kottler, B., Faville, R., Day, R., Bademosi, A. T., Lavidis, N. A., Karunanithi, S., & van Swinderen, B. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000629 · Cited by 30

CSF Levels of the Histamine Metabolite tele-Methylhistamine are only Slightly Decreased in Alzheimer's Disease

Motawaj, M., Peoc’h, K., Callebert, J., & Arrang, J. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100381 · Cited by 30

GABA B receptor‐mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram‐treated rats

Wang, H., Kuo, Z., Fu, Y.-S., Chen, R., Min, M., & Yang, H. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.281378 · Cited by 29

Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis

Hou, R. H., Samuels, E. R., Langley, R. W., Szabadi, E., & Bradshaw, C. M. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0884-y · Cited by 29

Waking with the hypothalamus

Haas, H. L., & Lin, J. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0996-4 · Cited by 32

Increased γ-Aminobutyric Acid Levels in Mouse Brain Induce Loss of Righting Reflex, but Not Immobility, in Response to Noxious Stimulation

Katayama, S., Irifune, M., Kikuchi, N., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Dohi, T., Sato, T., & Kawahara, M. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000261519.04083.3e · Cited by 29

Presence of 14 Hz spindle oscillations in the human EEG during deep anesthesia

Wolter, S., FRIEDEL, C., Böhler, K., Hartmann, U. H., Kox, W., & Hensel, M. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.08.031 · Cited by 29

Patterns of neural activity in the mouse brain: Wakefulness vs. General anesthesia

Yatziv, S.-L., Yudco, O., Dickmann, S., & Devor, M. G. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135212 · Cited by 30

The Interaction Between the Ventrolateral Preoptic Nucleus and the Tuberomammillary Nucleus in Regulating the Sleep-Wakefulness Cycle

Cheng, J., Wu, F., Zhang, M., Ding, D., Fan, S., Chen, G., Zhang, J., & Wang, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.615854 · Cited by 28

Distinctive Recruitment of Endogenous Sleep-promoting Neurons by Volatile Anesthetics and a Nonimmobilizer

Han, B., McCarren, H. S., O’Neill, D., & Kelz, M. B. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000383 · Cited by 29

Projections from the mesopontine tegmental anesthesia area to regions involved in pain modulation

Sukhotinsky, I., Reiner, K., Govrin-Lippmann, R., Belenky, M. A., Lu, J., Hopkins, D. A., Saper, C. B., & Devor, M. G. (2006) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2006.08.003 · Cited by 28

Differential Anaesthetic Effects following Microinjection of Thiopentone and Propofol into the Pons of Adult Rats: A Pilot Study

Voss, L. J., Young, B. J., Barnard, J. P. M., & Sleigh, J. W. (2005) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0503300313 · Cited by 28

Fast-spiking Cell to Pyramidal Cell Connections Are the Most Sensitive to Propofol-induced Facilitation of GABAergic Currents in Rat Insular Cortex

Koyanagi, Y., Oi, Y., Yamamoto, K., Koshikawa, N., & Kobayashi, M. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000183 · Cited by 27

Rested and Refreshed after Anesthesia? Overlapping Neurobiologic Mechanisms of Sleep and Anesthesia

Nelson, L. E., Franks, N. P., & Maze, M. (2004) · Anesthesiology · doi:10.1097/00000542-200406000-00003 · Cited by 27

Inhaled Anesthetics: Mechanisms of Action

Perouansky, M. A., Pearce, R. A., & Hemmings, H. C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06959-8.00020-0 · Cited by 27

An emerging link between general anesthesia and sleep

Allada, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711532105 · Cited by 28

Pharmacokinetics Profiler (PhaKinPro): Model Development, Validation, and Implementation as a Web Tool for Triaging Compounds with Undesired Pharmacokinetics Profiles

Rath, M. K., Wellnitz, J., Martin, H., Melo-Filho, C. C., Hochuli, J. E., Silva, G. M., Beasley, J.-M. T., Maxfield, T., Sessions, Z. L., Popov, K. I., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02446 · Cited by 27

The Differential Effects of Halothane and Isoflurane on Electroencephalographic Responses to Electrical Microstimulation of the Reticular Formation

Orth, M., Bravo, E., Barter, L. S., Carstens, E. E., & Antognini, J. F. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000205752.00303.94 · Cited by 26

Long-term Exposure to Local but Not Inhalation Anesthetics Affects Neurite Regeneration and Synapse Formation between Identified Lymnaea Neurons

Onizuka, S., Takasaki, M., & Syed, N. I. (2005) · Anesthesiology · doi:10.1097/00000542-200502000-00018 · Cited by 26

Explaining general anesthesia: A two‐step hypothesis linking sleep circuits and the synaptic release machinery

van Swinderen, B., & Kottler, B. (2014) · BioEssays · doi:10.1002/bies.201300154 · Cited by 28

Interfaces of Sleep and Anesthesia

Mashour, G. A., & Pal, D. (2012) · Anesthesiology Clinics · doi:10.1016/j.anclin.2012.05.003 · Cited by 28

Identification and characterization of anesthetic targets by mouse molecular genetics approaches

Drexler, B., Antkowiak, B., Engin, E., & Rudolph, U. (2010) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9414-1 · Cited by 25

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

McCarren, H. S., Moore, J. T., & Kelz, M. B. (2013) · Journal of Visualized Experiments · doi:10.3791/51079 · Cited by 28

Amanita muscaria: Ecology, Chemistry, Myths

Carboué, Q., & Lopez, M. (2021) · Encyclopedia · doi:10.3390/encyclopedia1030069 · Cited by 27

MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility

Irifune, M., Katayama, S., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Morita, K., Dohi, T., Sato, T., & Kawahara, M. (2007) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03016634 · Cited by 24

Mesopontine Switch for the Induction of General Anesthesia by Dedicated Neural Pathways

Sukhotinsky, I., Minert, A., Soja, P. J., & Devor, M. G. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001489 · Cited by 24

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats

Mansouri, M. T., Fidler, J. A., Meng, Q. C., Eckenhoff, R. G., & García, P. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.029 · Cited by 24

Modulation of α2-Adrenoceptor Functions by Heterotrimeric Gαi Protein Isoforms

Albarrán-Juárez, J., Gilsbach, R., Piekorz, R. P., Pexa, K., Beetz, N., Schneider, J., Nürnberg, B., Birnbaumer, L., & Hein, L. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.157230 · Cited by 24

Modulation of GABA A receptor function and sleep

Brickley, S. G., Franks, N. P., & Wisden, W. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2017.12.011 · Cited by 25

Assessing circadian rhythms in propofol PK and PD during prolonged infusion in ICU patients

Bienert, A., Kusza, K., Wawrzyniak, K., Grześkowiak, E., Kokot, Z. J., Matysiak, J., Grabowski, T., Wolc, A., Wiczling, P., & Regulski, M. (2010) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-010-9161-5 · Cited by 23

Propofol decreases the excitability of cholinergic neurons in mouse basal forebrain via GABAA receptors

Chen, L., Yang, Z., Cheng, J., Zhang, P.-P., Zhang, L., Liu, X., & Wang, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0168-6 · Cited by 23

Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization

Vyazovskiy, V. V., Tobler, I., & Winsky‐Sommerer, R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.003 · Cited by 23

Propofol Stimulates Noradrenalin-Inhibited Neurons in the Ventrolateral Preoptic Nucleus by Reducing GABAergic Inhibition

Liu, Y., Zuo, W., & Ye, J.-H. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318297366e · Cited by 22

Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers

Berglund, K., Wen, L., Dunbar, R. L., Feng, G., & Augustine, G. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4366-15.2016 · Cited by 22

Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat

Kumar, S., Szymusiak, R. S., Bashir, T., Suntsova, N., Rai, S., McGinty, D., & Alam, M. N. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.115 · Cited by 22

General Anesthesia and Ascending Arousal Pathways

Zecharia, A. Y., & Franks, N. P. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b061bc · Cited by 22

General Anaesthesia and Consciousness

Alkire, M. T. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374168-4.00010-1 · Cited by 22

Progress in modelling of brain dynamics during anaesthesia and the role of sleep-wake circuitry

Nguyen, G., & Postnova, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114388 · Cited by 21

Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents

Cylinder, D. M., van Zundert, A. A. J., Solt, K., & van Swinderen, B. (2024) · Anesthesiology · doi:10.1097/aln.0000000000004846 · Cited by 21

Dreams recall and auditory evoked potentials during propofol anaesthesia

Aceto, P., Congedo, E., Lai, C., Valente, A., Gualtieri, E., & COSMO, G. D. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280e129f5 · Cited by 21

Glycine Receptors Contribute to Hypnosis Induced by Ethanol

Ye, J. H., Sokol, K. A., & Bhavsar, U. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00928.x · Cited by 21

Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats

Sanders, R. D., Patel, N. A., Hossain, M. S., Ma, D., & Maze, M. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei182 · Cited by 21

Mechanisms of Anesthetic Emergence: Evidence for Active Reanimation

Kushikata, T., & Hirota, K. (2013) · Current anesthesiology reports · doi:10.1007/s40140-013-0045-2 · Cited by 20

Actions of Propofol on Neurons in the Cerebral Cortex

Kobayashi, M., & Oi, Y. (2017) · Journal of Nippon Medical School · doi:10.1272/jnms.84.165 · Cited by 20

Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy

Chai, D., Cheng, Y., & Jiang, H. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.001 · Cited by 21

Noradrenergic Trespass in Anesthetic and Sedative States

Sanders, R. D., & Maze, M. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182700c93 · Cited by 20

Inactivation of the Tuberomammillary Nucleus by GABAA Receptor Agonist Promotes Slow Wave Sleep in Freely Moving Rats and Histamine-Treated Rats

Xie, J.-F., Fan, K., Wang, C., Xie, P., Hou, M., Xin, L., Cui, G.-F., Wang, L., Shao, Y.-F., & Hou, Y.-P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2247-3 · Cited by 20

Microwave-assisted green synthesis of silver nanoparticles using Mitragyna parvifolia bark extract and their biological activities: an economical and environment-friendly approach

Dwivedi, A., Das, S., Tiwari, V., Yadav, V., Jain, S. K., Mandal, V., Mukherjee, S., Satpathy, S., Mohapatra, D., Sahu, A. N., et al. (2024) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2024.2395919 · Cited by 19

Pre- versus Postsynaptic Signaling by α2-Adrenoceptors

Gilsbach, R., Albarrán-Juárez, J., & Hein, L. (2011) · Current topics in membranes · doi:10.1016/b978-0-12-384921-2.00007-0 · Cited by 19

Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia

Jeleazcov, C., Lavielle, M., Schüttler, J., & Ihmsen, H. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aeu553 · Cited by 19

Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System

Zhang, D., Liu, J., Zhu, T., & Zhou, C. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210909150200 · Cited by 19

The ventrolateral preoptic nucleus is required for propofol-induced inhibition of locus coeruleus neuronal activity

Zhang, Y., Yu, T., Yuan, J., & Yu, B. (2015) · Neurological Sciences · doi:10.1007/s10072-015-2292-0 · Cited by 19

Microinjection of Propofol into the Perifornical Area Induces Sedation with Decreasing Cortical Acetylcholine Release in Rats

Gamou, S., Fukuda, S., Ogura, M., Sakamoto, H., & Morita, S. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181e24776 · Cited by 19

Emerging therapeutics in sleep

Saper, C. B., & Scammell, T. E. (2013) · Annals of Neurology · doi:10.1002/ana.24000 · Cited by 18

A possible mechanism for pressure reversal of general anaesthetics from molecular simulations

Chau, P. ‐., Hoang, P. N. M., Picaud, S., & Jedlovszky, P. (2007) · Chemical Physics Letters · doi:10.1016/j.cplett.2007.02.071 · Cited by 18

Processed EEG in natural sleep

Nieuwenhuijs, D. J. F. (2006) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2005.08.006 · Cited by 18

Attenuation of high-frequency (30–200 Hz) thalamocortical EEG rhythms as correlate of anaesthetic action: evidence from dexmedetomidine

Plourde, G., & Arseneau, F. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex329 · Cited by 20

Sleep and Anesthesia: The Shared Circuit Hypothesis Has Been Put to Bed

Eikermann, M., Akeju, O., & Chamberlin, N. L. (2020) · Current Biology · doi:10.1016/j.cub.2020.01.057 · Cited by 18

Preoptic Area Modulation of Arousal in Natural and Drug Induced Unconscious States

Reitz, S. L., & Kelz, M. B. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.644330 · Cited by 19

GABAergic anaesthetic site of action identified

Butcher, J. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00183-7

Activation of GABAergic Neurons in the Rostromedial Tegmental Nucleus and Other Brainstem Regions Promotes Sedation and Facilitates Sevoflurane Anesthesia in Mice

Vlasov, K. Y., Pei, J., Nehs, C. J., Guidera, J. A., Zhang, E. R., Kenny, J. D., Houle, T. T., Brenner, G. J., Taylor, N. E., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005387 · Cited by 23

GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies

Yanovsky, Y., Schubring, S. R., Fleischer, W., Gisselmann, G., Zhu, X., Lübbert, H., Hatt, H. H., Rudolph, U., Haas, H. L., & Sergeeva, O. A. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0988-4 · Cited by 48

Benzodiazepine‐site pharmacology on GABAA receptors in histaminergic neurons

May, A., Fleischer, W., Kletke, O., Haas, H. L., & Sergeeva, O. A. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12280 · Cited by 15

0124 BIDIRECTIONAL CHEMOGENETIC CONTROL OF GABA NEURONS IN THE VENTRAL TEGMENTAL AREA MODULATES AROUSAL IN MICE

Vlasov, K. Y., Pei, J., Taylor, N. D., Dort, C. J. V., Guidera, J. A., Brown, E. N., & Solt, K. (2017) · SLEEP · doi:10.1093/sleepj/zsx050.123