GABAA receptor subtypes underlying general anesthesia

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works

Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study

Møller, J. T., Cluitmans, P. P., Rasmussen, L., Houx, P. J., Rasmussen, H., Canet, J., Rabbitt, P., Jolles, J., Larsen, K., Hanning, C. D., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07382-0 · Cited by 2,407 · see citing works

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081 · see citing works

GABA_A Receptor Channels

Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975 · see citing works

Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons

Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works

Which GABAA-receptor subtypes really occur in the brain?

McKernan, R. M., & Whiting, P. J. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80023-3 · Cited by 1,222 · see citing works

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219 · see citing works

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204 · see citing works

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., & Möhler, H. (1999) · Nature · doi:10.1038/44579 · Cited by 1,172 · see citing works

Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition

Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097 · see citing works

Mechanisms of Actions of Inhaled Anesthetics

Campagna, J. A., Miller, K. W., & Forman, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021261 · Cited by 805 · see citing works

Molecular and neuronal substrates for general anaesthetics

Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771 · see citing works

The Incidence of Awareness During Anesthesia: A Multicenter United States Study

Sebel, P. S., Bowdle, A. T., Ghoneim, M. M., Rampil, I. J., Padilla, R. E., Gan, T. J., & Domino, K. B. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000130261.90896.6c · Cited by 722 · see citing works

Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.

Brickley, S. G., Cull-Candy, S. G., & Farrant, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021806 · Cited by 717 · see citing works

International Union of Pharmacology. XV. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01363-2 · Cited by 711 · see citing works

Integration of quanta in cerebellar granule cells during sensory processing

Chadderton, P. T., Margrie, T. W., & Häusser, M. (2004) · Nature · doi:10.1038/nature02442 · Cited by 653 · see citing works

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA _A Receptor

Collinson, N., Kuenzi, F. M., Jarolimek, W., Maubach, K. A., Cothliff, R., Sur, C., Smith, A., Otu, F. M., Howell, O., Atack, J. R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05572.2002 · Cited by 628 · see citing works

Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors

Brown, N. A., Kerby, J., Bonnert, T. P., Whiting, P. J., & Wafford, K. A. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704795 · Cited by 603 · see citing works

Shunting Inhibition Modulates Neuronal Gain during Synaptic Excitation

Mitchell, S. J., & Silver, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00200-9 · Cited by 602 · see citing works

Neurodegenerative and Neuroprotective Effects of Tumor Necrosis Factor (TNF) in Retinal Ischemia: Opposite Roles of TNF Receptor 1 and TNF Receptor 2

Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 587 · see citing works

Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance

Brickley, S. G., Revilla, V., Cull-Candy, S. G., Wisden, W., & Farrant, M. (2001) · Nature · doi:10.1038/35051086 · Cited by 572 · see citing works

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

Caraiscos, V. B., Elliott, E. M., You-Ten, K. E., Cheng, V., Belelli, D., Newell, J. G., Jackson, M. F., Lambert, J. J., Rosahl, T. W., Wafford, K. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307231101 · Cited by 571 · see citing works

The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568 · see citing works

General anesthetic actions <i>in vivo</i> strongly attenuated by a point mutation in the GABA _A receptor β3 subunit

Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558 · see citing works

Emerging molecular mechanisms of general anesthetic action

Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 542 · see citing works

Trace fear conditioning involves hippocampal α ₅ GABA _A receptors

Crestani, F., Keist, R., Fritschy, J.-M., Benke, D., Vogt, K., Prut, L., Blüthmann, H., Möhler, H., & Rudolph, U. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142288699 · Cited by 528 · see citing works

Identification of Differentiation-Associated Brain-Specific Phosphate Transporter as a Second Vesicular Glutamate Transporter (VGLUT2)

Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-j0002.2001 · Cited by 492 · see citing works

Selective Modulation of Tonic and Phasic Inhibitions in Dentate Gyrus Granule Cells

Nusser, Z., & Módy, I. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.5.2624 · Cited by 487 · see citing works

Sleep, epilepsy and thalamic reticular inhibitory neurons

Steriade, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.007 · Cited by 443 · see citing works

GABA uptake regulates cortical excitability via cell type–specific tonic inhibition

Semyanov, A. V., Walker, M. C., & Kullmann, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn1043 · Cited by 427 · see citing works

Distinct Functional and Pharmacological Properties of Tonic and Quantal Inhibitory Postsynaptic Currents Mediated by γ-Aminobutyric AcidAReceptors in Hippocampal Neurons

Bai, D., Zhu, G., Pennefather, P., Jackson, M. F., MacDonald, J. F., & Orser, B. A. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.814 · Cited by 358 · see citing works

Receptors with Different Affinities Mediate Phasic and Tonic GABA A Conductances in Hippocampal Neurons

Stell, B. M., & Módy, I. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0003.2002 · Cited by 328 · see citing works

Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration

Sonner, J. M., Antognini, J. F., Dutton, R. C., Flood, P. D., Gray, A. T., Harris, R. A., Homanics, G. E., Kendig, J. J., Orser, B. A., Raines, D. E., et al. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000081063.76651.33 · Cited by 328 · see citing works

Sedation and Anesthesia Mediated by Distinct GABA _A Receptor Isoforms

Reynolds, D. S., Rosahl, T. W., Cirone, J., O'Meara, G. F., Haythornthwaite, A., Newman, R. J., Myers, J., Sur, C., Howell, O., Rutter, A. R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08608.2003 · Cited by 318 · see citing works

GABA A receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D. F., Spigelman, I., Houser, C. R., Olsen, R. W., Harrison, N. L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604304103 · Cited by 315 · see citing works

GABA A Receptor-Mediated Tonic Inhibition in Thalamic Neurons

Cope, D. W., Hughes, S. W., & Crunelli, V. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3362-05.2005 · Cited by 312 · see citing works

Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic Autoradiography

Bloom, F. E., & Iversen, L. L. (1971) · Nature · doi:10.1038/229628a0 · Cited by 307 · see citing works

Identification of a GABA A Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Li, G., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., & Cohen, J. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-06.2006 · Cited by 289 · see citing works

Development of Action Potential‐dependent and Independent Spontaneous GABAA Receptor‐mediated Currents in Granule Cells of Postnatal Rat Cerebellum

Wall, M. J., & Usowicz, M. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01630.x · Cited by 270 · see citing works

GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts

Haas, K. F., & Macdonald, R. L. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.027af.x · Cited by 268 · see citing works

The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus

Glykys, J. C., & Módy, I. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134460 · Cited by 253 · see citing works

Extrasynaptic GABA A Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics

Belelli, D., Peden, D. R., Rosahl, T. W., Wafford, K. A., & Lambert, J. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2679-05.2005 · Cited by 252 · see citing works

How quickly can GABAA receptors open?

Maconochie, D. J., Zempel, J. M., & Steinbach, J. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90152-x · Cited by 251 · see citing works

α5GABA A Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Cheng, V., Martin, L. J., Elliott, E. M., Kim, J. H., Mount, H. T. J., Taverna, F. A., Roder, J., MacDonald, J. F., Bhambri, A., Collinson, N., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5024-05.2006 · Cited by 246 · see citing works

Evidence for a Common Binding Cavity for Three General Anesthetics within the GABAAReceptor

Jenkins, A., Greenblatt, E. P., Faulkner, H. J., Bertaccini, E. J., Light, A., Lin, A., Andreasen, A., Viner, A., Trudell, J. R., & Harrison, N. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-j0002.2001 · Cited by 244 · see citing works

An Extrasynaptic GABAA Receptor Mediates Tonic Inhibition in Thalamic VB Neurons

Jia, F., Pignataro, L., Schofield, C. M., Yue, M. E., Harrison, N. L., & Goldstein, P. A. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00421.2005 · Cited by 242 · see citing works

Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor

Hill‐Venning, C., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700927 · Cited by 239 · see citing works

Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?

Kullmann, D. M., Ruiz, A. J., Rusakov, D. A., Scott, R. S., Semyanov, A. V., & Walker, M. C. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.06.003 · Cited by 222 · see citing works

THIP, a Hypnotic and Antinociceptive Drug, Enhances an Extrasynaptic GABAA Receptor-mediated Conductance in Mouse Neocortex

Drasbek, K. R., & Jensen, K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj055 · Cited by 178 · see citing works

Tonically Activated GABAA Receptors in Hippocampal Neurons Are High-Affinity, Low-Conductance Sensors for Extracellular GABA

Yeung, J. Y. T., Canning, K. J., Zhu, G., Pennefather, P., MacDonald, J. F., & Orser, B. A. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.2 · Cited by 171 · see citing works

Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor‐mediated inhibition

Hentschke, H., Schwarz, C., & Antkowiak, B. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03843.x · Cited by 163 · see citing works

Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences

Cavelier, P., Hamann, M., Rossi, D. J., Mobbs, P. G., & Attwell, D. (2004) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2004.06.001 · Cited by 156 · see citing works

Autoradiographic localization of α5 subunit-containing GABAA receptors in rat brain

Sur, C., Fresu, L. G., Howell, O. W., McKernan, R. M., & Atack, J. R. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01152-x · Cited by 155 · see citing works

Selective Enhancement of Tonic GABAergic Inhibition in Murine Hippocampal Neurons by Low Concentrations of the Volatile Anesthetic Isoflurane

Caraiscos, V. B., Newell, J. G., You-Ten, K. E., Elliott, E. M., Rosahl, T. W., Wafford, K. A., MacDonald, J. F., & Orser, B. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2063-04.2004 · Cited by 150 · see citing works

Identification of a Novel, Selective GABAAα5 Receptor Inverse Agonist Which Enhances Cognition

Chambers, M. S., Atack, J. R., Broughton, H. B., Collinson, N., Cook, S. M., Dawson, G. R., Hobbs, S. C., Marshall, G. R., Maubach, K. A., Pillai, G. V., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020582q · Cited by 140 · see citing works

Molecular determinants for the action of general anesthetics at recombinant α2β3γ2γ‐aminobutyric acidA receptors

Siegwart, R., Jurd, R., & Rudolph, U. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00682.x · Cited by 138 · see citing works

Major Role For Tonic GABAA Conductances in Anesthetic Suppression of Intrinsic Neuronal Excitability

Bieda, M. C., & MacIver, M. B. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00223.2004 · Cited by 127 · see citing works

GABAA agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic

Krogsgaard‐Larsen, P., Frølund, B., Liljefors, T., & Ebert, B. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.06.040 · Cited by 121 · see citing works

α5GABAA Receptors Regulate the Intrinsic Excitability of Mouse Hippocampal Pyramidal Neurons

Bonin, R. P., Martin, L. J., MacDonald, J. F., & Orser, B. A. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00482.2007 · Cited by 118 · see citing works

Intact Synaptic GABAergic Inhibition and Altered Neurosteroid Modulation of Thalamic Relay Neurons in Mice Lacking δ Subunit

Porcello, D. M., Huntsman, M. M., Mihalek, R., Homanics, G. E., & Huguenard, J. R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00899.2002 · Cited by 110 · see citing works

An Orally Bioavailable, Functionally Selective Inverse Agonist at the Benzodiazepine Site of GABAA α5 Receptors with Cognition Enhancing Properties

Chambers, M. S., Atack, J. R., Carling, R. W., Collinson, N., Cook, S. M., Dawson, G. R., Ferris, P., Hobbs, S. C., O'Connor, D. V., Marshall, G. R., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm040863t · Cited by 109 · see citing works

Blockade of alcohol's amnestic activity in humans by an α5 subtype benzodiazepine receptor inverse agonist

Nutt, D., Besson, M. J., Wilson, S. J., Dawson, G. R., & Lingford-Hughes, A. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.08.008 · Cited by 109 · see citing works

α1 and α6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABAA receptors containing the δ subunit

Bianchi, M. T., Haas, K. F., & Macdonald, R. L. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00163-6 · Cited by 101 · see citing works

Electrophysiological mapping of GABAA receptor-mediated inhibition in adult rat somatosensory cortex

Salin, P. A., & Prince, D. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1589 · Cited by 101 · see citing works

Postoperative Cognitive Dysfunction in Older Patients with a History of Alcohol Abuse

Hudetz, J. A., Iqbal, Z., Gandhi, S. D., Patterson, K. M., Hyde, T., Reddy, D. M., Hudetz, A. G., & Warltier, D. C. (2007) · Anesthesiology · doi:10.1097/00000542-200703000-00005 · Cited by 86 · see citing works

Effect of Isoflurane and Other Potent Inhaled Anesthetics on Minimum Alveolar Concentration, Learning, and the Righting Reflex in Mice Engineered to Express α1γ-Aminobutyric Acid Type A Receptors Unresponsive to Isoflurane

Sonner, J. M., Werner, D. F., Elsen, F. P., Xing, Y., Liao, M., Harris, R. A., Harrison, N. L., Fanselow, M. S., Eger, E. I., & Homanics, G. E. (2007) · Anesthesiology · doi:10.1097/00000542-200701000-00019 · Cited by 82 · see citing works

Agonist Gating and Isoflurane Potentiation in the Human γ-Aminobutyric Acid Type A Receptor Determined by the Volume of a Second Transmembrane Domain Residue

Koltchine, V. V., Finn, S. E., Jenkins, A., Nikolaeva, N., Lin, A., & Harrison, N. L. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.5.1087 · Cited by 80 · see citing works

Volatile anesthetic actions on the GABAA receptors: contrasting effects of α1(S270) and β2(N265) point mutations

Nishikawa, K., Jenkins, A., Paraskevakis, I., & Harrison, N. L. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00189-7 · Cited by 79 · see citing works

An Isoflurane- and Alcohol-Insensitive Mutant GABAA Receptor α1 Subunit with Near-Normal Apparent Affinity for GABA: Characterization in Heterologous Systems and Production of Knockin Mice

Borghese, C. M., Werner, D. F., Topf, N., Baron, N. V., Henderson, L. A., Boehm, S. L., Blednov, Y. A., Saad, A., Dai, S., Pearce, R. A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104406 · Cited by 63 · see citing works

α1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear

Sonner, J. M., Cascio, M., Xing, Y., Fanselow, M. S., Kralic, J. E., Morrow, A. L., Korpi, E. R., Hardy, S. L., Sloat, B. R., Eger, E. I., et al. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.009936 · Cited by 56 · see citing works

In the developing rat hippocampus a tonic GABAA‐mediated conductance selectively enhances the glutamatergic drive of principal cells

Marchionni, I., Omrani, A., & Cherubini, E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.125609 · Cited by 53 · see citing works

β3-Containing Gamma-Aminobutyric AcidA Receptors Are Not Major Targets for the Amnesic and Immobilizing Actions of Isoflurane

Liao, M. Y., Sonner, J. M., Jurd, R., Rudolph, U., Borghese, C. M., Harris, R. A., Laster, M. J., & Eger, E. I. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000154196.86587.35 · Cited by 49 · see citing works

General anaesthetics and their effects on GABAA receptor desensitization

Orser, B. A., McAdam, L. C., Röder, S., & MacDonald, J. F. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00188-x · Cited by 46 · see citing works

Mapping the contribution of β3-containing GABAA receptors to volatile and intravenous general anesthetic actions

Zeller, A., Arras, M., Jurd, R., & Rudolph, U. (2007) · BMC Pharmacology · doi:10.1186/1471-2210-7-2 · Cited by 44 · see citing works

Isoflurane-induced surgical tolerance mediated only in part by β3-containing GABAA receptors

Lambert, S., Arras, M., Vogt, K. E., & Rudolph, U. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.030 · Cited by 35 · see citing works

The Effects of Isoflurane on Desensitized Wild-Type and ??1(S270H) ??-Aminobutyric Acid Type A Receptors

Hall, A. C., Rowan, K. C., Stevens, R. J. N., Kelley, J. C., & Harrison, N. L. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000111108.78745.ad · Cited by 23 · see citing works

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

Kell, D. B., Dobson, P. D., & Oliver, S. G. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.05.010 · Cited by 184 · see citing works

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Kell, D. B., & Oliver, S. G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00231 · Cited by 155 · see citing works

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Saari, T. I., Uusi‐Oukari, M., Ahonen, J., & Olkkola, K. T. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002717 · Cited by 154 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

Role of GABAAreceptors in the physiology and pharmacology of sleep

Winsky‐Sommerer, R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06716.x · Cited by 144 · see citing works

Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study

Akeju, O., Hobbs, L. E., Gao, L., Burns, S. M., Pavone, K. J., Plummer, G. S., Walsh, E. C., Houle, T. T., Kim, S., Bianchi, M. T., et al. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.10.005 · Cited by 145 · see citing works

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

Kell, D. B., Dobson, P. D., Bilsland, E., & Oliver, S. G. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.11.008 · Cited by 141 · see citing works

The Concise Guide to PHARMACOLOGY 2013/14: Ligand‐Gated Ion Channels

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12446 · Cited by 120 · see citing works

Electroencephalographic Variation during End Maintenance and Emergence from Surgical Anesthesia

Chander, D., García, P. S., MacColl, J. N., Illing, S., & SLEIGH, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106291 · Cited by 105 · see citing works

GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of Consciousness

Zecharia, A. Y., Yu, X., Götz, T., Ye, Z., Carr, D. R., Wulff, P., Bettler, B., Vyssotski, A. L., Brickley, S. G., Franks, N. P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2931-12.2012 · Cited by 106 · see citing works

Intraoperative Awareness

Mashour, G. A., Orser, B. A., Avidan, M. S., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e31820fc9b6 · Cited by 108 · see citing works

Thein vivoneurochemistry of the brain during general anesthesia

Müller, C. P., Pum, M. E., Amato, D., Schüttler, J., Huston, J. P., & Silva, M. A. D. S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07445.x · Cited by 90 · see citing works

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

Li, G., Chiara, D. C., Cohen, J. B., & Olsen, R. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074708 · Cited by 82 · see citing works

Activation of orexin system facilitates anesthesia emergence and pain control

Zhou, W., Cheung, K., Kyu, S., Wang, L., Guan, Z., Kurien, P. A., Bickler, P. E., & Jan, L. Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808622115 · Cited by 81 · see citing works

Awareness during anesthesia

Orser, B. A., Mazer, C. D., & BAKER, A. J. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.071761 · Cited by 65 · see citing works

A New Hypothesis for Alzheimer’s Disease: The Lipid Invasion Model

Rudge, J. D. (2022) · Journal of Alzheimer's Disease Reports · doi:10.3233/adr-210299 · Cited by 58 · see citing works

Inhibition of learning and memory by general anesthetics

Wang, D.-S., & Orser, B. A. (2010) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9428-8 · Cited by 54 · see citing works

Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation

Yang, W., Chini, M., Pöpplau, J. A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu‐Opatz, I. L., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001146 · Cited by 56 · see citing works

Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3β in the hippocampus

Liu, X., Xue, Q., Zeng, Q., Li, Q., Liu, J., Feng, X., & Yu, B. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.011 · Cited by 54 · see citing works

Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant α4β3δ and α4β3 GABAA receptors expressed in HEK cells

Meera, P., Olsen, R. W., Otis, T. S., & Wallner, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.011 · Cited by 54 · see citing works

The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction

Bimonte, S., & Cascella, M. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.219032 · Cited by 54 · see citing works

Behavior and Cellular Evidence for Propofol-induced Hypnosis Involving Brain Glycine Receptors

Nguyen, H. T., Li, K.-Y., daGraca, R. L., Delphin, E. S., Xiong, M., & Ye, J. H. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181942b5b · Cited by 51 · see citing works

Fragrant Dioxane Derivatives Identify β1-Subunit-containing GABAA Receptors

Sergeeva, O. A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S. R., Görg, B., Haas, H. L., Zhu, X., Lübbert, H., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103309 · Cited by 47 · see citing works

GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies

Yanovsky, Y., Schubring, S. R., Fleischer, W., Gisselmann, G., Zhu, X., Lübbert, H., Hatt, H. H., Rudolph, U., Haas, H. L., & Sergeeva, O. A. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0988-4 · Cited by 46 · see citing works

MmTX1 and MmTX2 from coral snake venom potently modulate GABA A receptor activity

Rosso, J.-P., Schwarz, J. R., Diaz-Bustamante, M., Céard, B., Gutiérrez, J. M., Kneussel, M., Pongs, O., Bosmans, F., & Bougis, P. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415488112 · Cited by 45 · see citing works

Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Ngo, E. O., Taïwé, G. S., Moto, F. C. O., Ngoupaye, G. T., Vougat, R. R. N., Sakoue, V. D., Gwa, C., Ayissi, E. R., Dong, C., Rakotonirina, A., et al. (2011) · InTech eBooks · doi:10.5772/18469 · Cited by 41 · see citing works

Gamma-Aminobutyric Acid Type A Receptor Alpha 4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane

Rau, V., Iyer, S. V., Oh, I., Chandra, D., Harrison, N. L., Eger, E. I., Fanselow, M. S., Homanics, G. E., & Sonner, J. M. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181bf6ae6 · Cited by 41 · see citing works

The influence of depth of anesthesia on motor evoked potential response during awake craniotomy

Ohtaki, S., Akiyama, Y., Kanno, A., Noshiro, S., Hayase, T., Yamakage, M., & Mikuni, N. (2016) · Journal of neurosurgery · doi:10.3171/2015.11.jns151291 · Cited by 38 · see citing works

The α5-Containing GABAA Receptors—a Brief Summary

Mohamad, F. H., & Has, A. T. C. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1246-4 · Cited by 38 · see citing works

Volatile anesthetic effects on isolated GABA synapses and extrasynaptic receptors

Ogawa, S. K., Tanaka, E., Shin, M. C., Kotani, N., & Akaike, N. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.016 · Cited by 36 · see citing works

GABAergic transmission in hepatic encephalopathy

Sergeeva, O. A. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.04.005 · Cited by 34 · see citing works

New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors

Antkowiak, B., & Rudolph, U. (2016) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000358 · Cited by 34 · see citing works

Tonic GABAA Receptor–Mediated Signaling in Epilepsy

Walker, M. C., & Kullmann, D. M. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0009 · Cited by 33 · see citing works

The cellular uptake of pharmaceutical drugs is mainly carrier-mediated and is thus an issue not so much of biophysics but of systems biology

Kell, D. B., & Dobson, P. D. (2009) · Cited by 30 · see citing works

Restoring ionotropic inhibition as an analgesic strategy

Bonin, R. P., & Koninck, Y. D. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.047 · Cited by 29 · see citing works

RNA editing of the GABAA receptor α3 subunit alters the functional properties of recombinant receptors

Nimmich, M. L., Heidelberg, L. S., & Fisher, J. L. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.01.003 · Cited by 28 · see citing works

Insights into the Structure and Pharmacology of GABAAReceptors

Carter, C. R. J., Kozuska, J. L., & Dunn, S. M. J. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.10.178 · Cited by 27 · see citing works

The Influence of Regional Distribution and Pharmacologic Specificity of GABAAR Subtype Expression on Anesthesia and Emergence

Speigel, I. A., Bichler, E. K., & García, P. S. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00058 · Cited by 27 · see citing works

The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors

Minami, K., & Uezono, Y. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1507-2 · Cited by 24 · see citing works

The plasticity of nerve fibers: the prolonged effects of polarization of afferent fibers

Jankowska, E., & Hammar, I. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00718.2020 · Cited by 24 · see citing works

GABA system as the cause and effect in early development

Topchiy, I., Mohbat, J., Folorunso, O. O., Wang, Z., Lazcano-Etchebarne, C., & Engin, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105651 · Cited by 23 · see citing works

Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C-Flumazenil in Awake and Anesthetized Animals

Sandiego, C. M., Jin, X., Mulnix, T., Fowles, K., Labaree, D. C., Ropchan, J. R., Huang, Y. H., Cosgrove, K., Castner, S. A., Williams, G. V., et al. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.122077 · Cited by 22 · see citing works

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain

Jayakar, S. S., Zhou, X., Chiara, D. C., Jarava‐Barrera, C., Savechenkov, P. Y., Bruzik, K. S., Tortosa, M., Miller, K. W., & Cohen, J. B. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.114975 · Cited by 21 · see citing works

Glycine Receptors Contribute to Hypnosis Induced by Ethanol

Ye, J. H., Sokol, K. A., & Bhavsar, U. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00928.x · Cited by 21 · see citing works

Recent Developments in Potential Anxiolytic Agents Targeting GABAA/BzR Complex or the Translocator Protein (18kDa) (TSPO)

Nothdurfter, C., Rupprecht, R., & Rammes, G. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612799078748 · Cited by 19 · see citing works

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA A receptor‐mediated inhibition

Herd, M. B., Lambert, J. J., & Belelli, D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12601 · Cited by 18 · see citing works

Structural Studies of the Actions of Anesthetic Drugs on the γ-Aminobutyric Acid Type A Receptor

Akk, G., & Steinbach, J. H. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3182315d93 · Cited by 16 · see citing works

A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation

Kell, D. B. (2021) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2021.01.001 · Cited by 16 · see citing works

Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review

Speigel, I. A., & Hemmings, H. C. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.812905 · Cited by 15 · see citing works

Neurosteroids and their potential as a safer class of general anesthetics

Tateiwa, H., & Evers, A. S. (2024) · Journal of Anesthesia · doi:10.1007/s00540-023-03291-4 · Cited by 13 · see citing works

The Lipid Invasion Model: Growing Evidence for This New Explanation of Alzheimer’s Disease

Rudge, J. D. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221175 · Cited by 13 · see citing works

GABAA receptors in GtoPdb v.2021.3

Belelli, D., Hales, T. G., Lambert, J. J., Lüscher, B., Olsen, R. W., Peters, J. A., Rudolph, U., & Sieghart, W. (2021) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f72/2021.3 · Cited by 13 · see citing works

Distinct α subunit variations of the hypothalamic GABAA receptor triplets (αβγ) are linked to hibernating state in hamsters

Alò, R., Avolio, E., Vito, A. D., Carelli, A., Facciolo, R. M., & Canonaco, M. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-111 · Cited by 12 · see citing works

Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R–mTFD-MPAB

Amlong, C. A., Perkins, M. G., Houle, T. T., Miller, K. W., & Pearce, R. A. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001358 · Cited by 12 · see citing works

The discovery of new anesthetics by targeting GABAAreceptors

Krasowski, M. D., & Hopfinger, A. J. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.627324 · Cited by 11 · see citing works

Cambios en la perfusión cerebral inducidos por etomidato en pacientes con epilepsia del lóbulo temporal

Herrera‐Peco, I., Wix, R., Gadea, L. D., Paz, M. L. M., Chacón, J. L. M., Tomás, E., de Sola, R. G., & Gómez, J. P. (2009) · Revista de Neurología · doi:10.33588/rn.4911.2009406 · Cited by 11 · see citing works

Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats

Zhang, F., Feng, X., Zeng, Q., Wang, B., Wilhelmsen, K., Li, Q., Cao, X., & Yu, B. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.066 · Cited by 10 · see citing works

General Anesthesia for Monitoring

Sloan, T. B. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0308-1_15 · Cited by 10 · see citing works

Multimodal Anesthesia and Systems Neuroscience

Orser, B. A., & Saper, C. B. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31818e47fb · Cited by 10 · see citing works

Muscle power during intravenous sedation

Matsuura, N. (2017) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2017.02.001 · Cited by 9 · see citing works

Lungfish aestivating activities are locked in distinct encephalic γ-aminobutyric acid type A receptor α subunits

Giusi, G., Crudo, M., Vito, A. D., Facciolo, R. M., Garofalo, F., Chew, S. F., Ip, Y. K., & Canonaco, M. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22553 · Cited by 8 · see citing works

Bidirectional Regulation of Intravenous General Anesthetic Actions by α3-containing γ-aminobutyric AcidAReceptors

Straub, C. J., Lau, H. M., Parlato, R., Schuetz, G., Fritschy, J., & Rudolph, U. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182800d76 · Cited by 8 · see citing works

Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidationPreprint

Yang, W., Chini, M., Pöpplau, J. A., Formozov, A., Dieter, A., Piechocinski, P., Rais, C., Morellini, F., Sporns, O., Hanganu-Opatz, I. L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.05.135905 · Cited by 9 · see citing works

Anesthesia Management and Intraoperative Electrophysiological Monitoring

Sloan, T. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-46542-5_19 · Cited by 7 · see citing works

Advances in Structural Biology for Anesthetic Drug Mechanisms: Insights into General and Local Anesthesia

Liu, H., Liu, Z., Zhou, H., Yan, R., Li, Y., Zhang, X., Bao, L., Yang, Y., Zhang, J., & Song, S. (2025) · BioChem · doi:10.3390/biochem5020018 · Cited by 6 · see citing works

Can Anesthesia Trigger Delayed-Onset Posttraumatic Stress Disorder in Veterans?

Berger, K. C., & Schärer, K. (2011) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2011.00321.x · Cited by 6 · see citing works

L-655,708 does not prevent isoflurane-induced memory deficits in old mice

Gao, T., Liu, Y., Zhao, Z., Luo, Y. M., Wang, L., Wang, Y., & Yin, Y. (2019) · Translational Neuroscience · doi:10.1515/tnsci-2019-0032 · Cited by 5 · see citing works

Etiology and risk factors of intraoperative awareness

Ghoneim, M. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511676291.006 · Cited by 4 · see citing works

Anti-convulsivant and sedative like-effect of Abyssinone V-4′ methyl ether Isolated from Erythrina droogmansiana (Leguminosae)

Emmanuel, T., Sidoine, N., Njapdounké, J. S. K., Gisèle, N. N. C., Yaya, A. J. G., Elisabeth, N. B., Joseph, M. T., & Njintang, N. Y. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.501001 · Cited by 4 · see citing works

Microtubule-stabilizer epothilone B counteracts anesthetic-induced slowed swimming in Tetrahymena pyriformis

Yu, X., Qiu, Z., Nashrah, F., Garg, A., Chang, A., Schieber, A., Wu, S., Magavi, V., & Wiest, M. C. (2026) · Experimental Cell Research · doi:10.1016/j.yexcr.2026.114938 · Cited by 3 · see citing works

GABA-A Receptor Complex in the Anxiolytic Properties of Parkia biglobosa in Mice

Omam, J. P. O., Mbomo, R. E. A., Kandeda, A. K., Minkoulou, M. D. Z., Njapdounke, S. J. K., Moto, F. C. O., & Bum, E. N. (2017) · International Journal of Brain and Cognitive Sciences · Cited by 3 · see citing works

Principles of anesthesia

Sloan, T. B., & Koht, A. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815000-9.00040-x · Cited by 2 · see citing works

Rôle de la génétique dans la variabilité interindividuelle en anesthésie

Textoris, J., Davidson, J., Martin, C., & Léone, M. (2009) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2009.04.014 · Cited by 2 · see citing works

NEUROCIENCIA Y ANESTESIA

Antonello Penna, S., & Rodrigo Gutiérrez, R. (2017) · Revista Médica Clínica Las Condes · doi:10.1016/j.rmclc.2017.08.002 · Cited by 1 · see citing works

Xenon anesthesia: safe, protective and neurotoxic?

Hare, G. M. T. (2008) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03016305 · Cited by 1 · see citing works

Patch Clamp Study of Neurotransmission at Single Mammalian CNS Synapses

Akaike, N. (2012) · InTech eBooks · doi:10.5772/38076

Neurochemical regulation of auditory information processing studied with EEG/MEG: application to schizophrenia

Korostenskaja, M. (2008) · Työväentutkimus Vuosikirja

Neurotoxic Effects of Anesthetics and Potential Protective Agents

Zhang, X., Patterson, T. A., Paule, M. G., Slikker, W., & Wang, C. (2010) · Wiley eBooks · doi:10.1002/9780470917060.ch5

Differential effects of propofol on gamma-band activity across cortical and thalamic sites in the rat, «in vivo»

Reed, S. J. (2012) · eScholarship@McGill (McGill) · doi:10.82308/33426

The Regulatory Properties of α5 Subunit-Containing γ-Aminobutyric Acid Subtype A Receptors in Learning and Synaptic Plasticity

Martin, L. J. (2010) · TSpace (University of Toronto)

The Regulation of Neuronal Excitability and Nociception by Tonic GABAergic Inhibition

Bonin, R. P. (2012) · TSpace (University of Toronto)

Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats

Xiong, B., Karim, F., Eloy, J. D., & Ye, J.-H. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136142

Optimization of Intraoperative Neurophysiological Monitoring Through Anesthetic Management

Rabai, F., Sloan, T. B., & Seubert, C. N. (2022) · Springer eBooks · doi:10.1007/978-3-031-09719-5_17

Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

Nettesheim, P., Vadodaria, K. C., Vanover, K. E., Borghans, L. G. J. M., Cirauqui, E. A., Brubaker, W., Cunningham, S., Parks, S., Serrats, J., Sudarsan, V., et al. (2025) · Cells · doi:10.3390/cells14201575

Preventing and managing awareness during general anesthesia

Berger, J., Mušič, P., Zakrajšek, B. L., & Mekiš, D. (2014) · DOAJ (DOAJ: Directory of Open Access Journals)

γ-aminobutyric acid subtype a receptor underlying intravenous general anesthesia

Liu, X., Xue, Q., & Yu, B. (2011) · Guoji mazuixue yu fusu zazhi · doi:10.3760/cma.j.issn.1673-4378.2011.02.017

Mechanisms of general anesthesia

Orser, B. A., Canning, K. J., & MacDonald, J. F. (2002) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-200208000-00004 · Cited by 32 · see citing works

Closing the Gap Between the Molecular and Systemic Actions of Anesthetic Agents

Antkowiak, B. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.10.009 · Cited by 7 · see citing works

The role of γ-aminobutyric acid type-A receptor subtypes in the pharmacology of general anesthesia

Firestone, L. L., Quinlan, J. J., & Homanics, G. E. (1995) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-199508000-00006 · Cited by 3 · see citing works

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J., & Lambert, J. J. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex369 · Cited by 78 · see citing works