Cited by 514Immunotherapy and Immune ResponsesDendrimers and Hyperbranched PolymersNanoparticle-Based Drug Delivery

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

Open access
Cho, Nam-Hyuk, Cheong, Taek-Chin, Min, Ji Hyun, Wu, Jun Hua, Lee, Sang Jin, Kim, Daehong, Yang, Jae-Seong, Kim, Sanguk +2 more·2011·Nature Nanotechnology

Abstract

Dendritic cell-based cancer immunotherapy requires tumour antigens to be delivered efficiently into dendritic cells and their migration to be monitored in vivo. Nanoparticles have been explored as carriers for antigen delivery, but applications have been limited by the toxicity of the solvents used to make nanoparticles, and by the need to use transfection agents to deliver nanoparticles into cells. Here we show that an iron oxide-zinc oxide core-shell nanoparticle can deliver carcinoembryonic antigen into dendritic cells while simultaneously acting as an imaging agent. The nanoparticle-antigen complex is efficiently taken up by dendritic cells within one hour and can be detected in vitro by confocal microscopy and in vivo by magnetic resonance imaging. Mice immunized with dendritic cells containing the nanoparticle-antigen complex showed enhanced tumour antigen specific T-cell responses, delayed tumour growth and better survival than controls.

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Authors
Cho, N.-H., Cheong, T.-C., Min, J. H., Wu, J. H., Lee, S. J., Kim, D., Yang, J.-S., Kim, S., Kim, Y. K., & Seong, S.-Y.
Affiliations
  • Seoul National University (KR)
  • Korea University (KR)
  • National Cancer Center (KR)
  • Pohang University of Science and Technology (KR)
Corresponding author
  • Kim, Young Keun
  • Seong, Seung-Yong
Venue
Nature Nanotechnology
Published
2011-09-11
Volume
6
Issue
10
Pages
675-682
ISSN
  • 1748-3387 (ISSN-L)
  • 1748-3395
OpenAlex
W2107525560
Cited by
514
References
49
Citations by year
2026: 5 · 2025: 14 · 2024: 28 · 2023: 29 · 2022: 34 · 2021: 47 · 2020: 45 · 2019: 45 · 2018: 43 · 2017: 48 · 2016: 34 · 2015: 37 · 2014: 35 · 2013: 37 · 2012: 28
FWCI
14.47
Type
journal article
Language
en
Open access
Locations
  • Nature Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
  • Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
Funders
  • National Research Foundation
  • National Research Foundation of Korea (A062260)
  • Ministry of Education, Science and Technology
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
dendritic cell-based cancer immunotherapy, core-shell nanoparticles, carcinoembryonic antigen, dendritic cell uptake, magnetic resonance imaging, T cell response, tumor growth inhibition, nanoparticle toxicity
MeSH terms
Animals, Carcinoembryonic Antigen, Dendritic Cells, Drug Carriers, Humans, Immunity, Cellular, Neoplasms, T-Lymphocytes, Immunotherapy, Adoptive, Mice, Nanoparticles

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