A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy
Open accessAbstract
Dendritic cell-based cancer immunotherapy requires tumour antigens to be delivered efficiently into dendritic cells and their migration to be monitored in vivo. Nanoparticles have been explored as carriers for antigen delivery, but applications have been limited by the toxicity of the solvents used to make nanoparticles, and by the need to use transfection agents to deliver nanoparticles into cells. Here we show that an iron oxide-zinc oxide core-shell nanoparticle can deliver carcinoembryonic antigen into dendritic cells while simultaneously acting as an imaging agent. The nanoparticle-antigen complex is efficiently taken up by dendritic cells within one hour and can be detected in vitro by confocal microscopy and in vivo by magnetic resonance imaging. Mice immunized with dendritic cells containing the nanoparticle-antigen complex showed enhanced tumour antigen specific T-cell responses, delayed tumour growth and better survival than controls.
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- Authors
- Cho, N.-H., Cheong, T.-C., Min, J. H., Wu, J. H., Lee, S. J., Kim, D., Yang, J.-S., Kim, S., Kim, Y. K., & Seong, S.-Y.
- Affiliations
- Seoul National University (KR)
- Korea University (KR)
- National Cancer Center (KR)
- Pohang University of Science and Technology (KR)
- Corresponding author
- Kim, Young Keun
- Seong, Seung-Yong
- ORCID
- Venue
- Nature Nanotechnology
- Published
- 2011-09-11
- Volume
- 6
- Issue
- 10
- Pages
- 675-682
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2107525560
- Cited by
- 514
- References
- 49
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 28 · 2023: 29 · 2022: 34 · 2021: 47 · 2020: 45 · 2019: 45 · 2018: 43 · 2017: 48 · 2016: 34 · 2015: 37 · 2014: 35 · 2013: 37 · 2012: 28
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (A062260)
- Ministry of Education, Science and Technology
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- dendritic cell-based cancer immunotherapy, core-shell nanoparticles, carcinoembryonic antigen, dendritic cell uptake, magnetic resonance imaging, T cell response, tumor growth inhibition, nanoparticle toxicity
- MeSH terms
- Animals, Carcinoembryonic Antigen, Dendritic Cells, Drug Carriers, Humans, Immunity, Cellular, Neoplasms, T-Lymphocytes, Immunotherapy, Adoptive, Mice, Nanoparticles
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