The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Nanoparticle-detained toxins for safe and effective vaccination
Open accessAbstract
Toxoid vaccines—vaccines based on inactivated bacterial toxins— are routinely used to promote antitoxin immunity for the treatment and prevention of bacterial infections1–4. Following chemical or heat denaturation, inactivated toxins can be administered to mount toxin-specific immune responses. However, retaining faithful antigenic presentation while removing toxin virulence remains a major challenge and presents a trade-off between efficacy and safety in toxoid development. Here we show a nanoparticle-based toxin-detainment strategy that safely delivers non-disrupted pore-forming toxins for immune processing. Using erythrocyte membrane-coated nanoparticles and staphylococcal α-haemolysin, we demonstrate effective virulence neutralization via spontaneous particle entrapment. As compared to vaccination with heat-denatured toxin, mice vaccinated with the nanoparticle-detained toxin showed superior protective immunity against toxin adverse effects. We find that the non-disruptive detoxification approach benefited the immunogenicity and efficacy of toxoid vaccines. We anticipate the reported study to open new possibilities in the preparation of antitoxin vaccines against the many virulence factors that threaten public health.
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Cites
Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
Hu, C.-M. J., Zhang, L., Aryal, S., Cheung, C., Fang, R. H., & Zhang, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106634108 · Cited by 2,433
Self-citationImmunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O'Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,350
Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., Brown, B. S., Khaled, S. Z., Yazdi, I. K., Enzo, M. V., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.212 · Cited by 1,168
A biomimetic nanosponge that absorbs pore-forming toxins
Hu, C.-M. J., Fang, R. H., Copp, J., Luk, B. T., & Zhang, L. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.54 · Cited by 751
Self-citationIdentification of Formaldehyde-induced Modifications in Proteins
Metz, B., Kersten, G. F. A., Hoogerhout, P., Brugghe, H. F., Timmermans, H. A. M., de Jong, A., Meiring, H., ten Hove, J., Hennink, W. E., Crommelin, D. J. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310752200 · Cited by 610
Helicobacter pylori VacA, a paradigm for toxin multifunctionality
Cover, T. L., & Blanke, S. R. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1095 · Cited by 565
Moon, J. J., Suh, H., Bershteyn, A., Stephan, M. T., Liu, H., Huang, B., Sohail, M., Luo, S., Ho Um, S., Khant, H., et al. (2011) · Nature Materials · doi:10.1038/nmat2960 · Cited by 564
Materials engineering for immunomodulation
Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009) · Nature · doi:10.1038/nature08604 · Cited by 561
Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity
Roberts, D. M., Nanda, A., Havenga, M. J. E., Abbink, P., Lynch, D. M., Ewald, B. A., Liu, J., Thorner, A. R., Swanson, P. E., Gorgone, D. A., et al. (2006) · Nature · doi:10.1038/nature04721 · Cited by 491
Cited by
Cell Membrane Coating Nanotechnology
Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Self-citationChen, Z., Zhao, P., Luo, Z., Zheng, M., Tian, H., Gong, P., Gao, G., Pan, H., Liu, L., Ma, A., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b04695 · Cited by 895
Pore-forming toxins: ancient, but never really out of fashion
Peraro, M. D., & van der Goot, F. G. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.3 · Cited by 788
Erythrocyte–Platelet Hybrid Membrane Coating for Enhanced Nanoparticle Functionalization
Dehaini, D., Wei, X., Fang, R. H., Masson, S., Angsantikul, P., Luk, B. T., Zhang, Y., Ying, M., Jiang, Y., Kroll, A. V., et al. (2017) · Advanced Materials · doi:10.1002/adma.201606209 · Cited by 769
Self-citationAnticancer Platelet‐Mimicking Nanovehicles
Hu, Q., Sun, W., Qian, C., Wang, C., Bomba, H. N., & Gu, Z. (2015) · Advanced Materials · doi:10.1002/adma.201503323 · Cited by 630
Metadata
- Authors
- Hu, C.-M. J., Fang, R. H., Luk, B. T., & Zhang, L.
- Venue
- Nature Nanotechnology
- Published
- 2013-12
- Volume
- 8
- Issue
- 12
- Pages
- 933-938
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2021163996
- Cited by
- 342
- References
- 22
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
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