The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
In vivo integrity of polymer-coated gold nanoparticles
Open accessAbstract
Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their physicochemical properties, and it is well known that their colloidal properties may change upon internalization by cells. While the stability of such nanoparticles is typically assayed in simple in vitro tests, their stability in a mammalian organism remains unknown. Here, we show that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats. We synthesized monodisperse radioactively labelled gold nanoparticles ((198)Au) and engineered an (111)In-labelled polymer shell around them. Upon intravenous injection into rats, quantitative biodistribution analyses performed independently for (198)Au and (111)In showed partial removal of the polymer shell in vivo. While (198)Au accumulates mostly in the liver, part of the (111)In shows a non-particulate biodistribution similar to intravenous injection of chelated (111)In. Further in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver. Our results show that even nanoparticles with high colloidal stability can change their physicochemical properties in vivo.
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Cites
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Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
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Self-citationLipka, J., Semmler-Behnke, M., Sperling, R. A., Wenk, A., Takenaka, S., Schleh, C., Kissel, T., Parak, W. J., & Kreyling, W. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.009 · Cited by 529
Self-citationBiodistribution of 1.4‐ and 18‐nm Gold Particles in Rats
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Self-citationLong term in vivo biotransformation of iron oxide nanoparticles
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Self-citationBertrand, N., Grenier, P., Mahmoudi, M., Lima, E. M., Appel, E. A., Dormont, F., Lim, J.-M., Karnik, R., Langer, R., & Farokhzad, O. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00600-w · Cited by 708
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
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In vivo degeneration and the fate of inorganic nanoparticles
Feliu, N., Docter, D., Heine, M., del Pino, P., Ashraf, S., Kolosnjaj-Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00699f · Cited by 423
Self-citationParticle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 237
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Metadata
- Authors
- Kreyling, W. G., Abdelmonem, A. M., Ali, Z., Alves, F., Geiser, M., Haberl, N., Hartmann, R., Hirn, S., de Aberasturi, D. J., Kantner, K., Khadem-Saba, G., Montenegro, J.-M., Rejman, J., Rojo, T., de Larramendi, I. R., Ufartes, R., Wenk, A., & Parak, W. J.
- Venue
- Nature Nanotechnology
- Published
- 2015-06-15
- Volume
- 10
- Issue
- 7
- Pages
- 619-623
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W1592617873
- Cited by
- 349
- References
- 23
- FWCI
- 18.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Kreyling, W. G., Abdelmonem, A. M., Ali, Z., Alves, F., Geiser, M., Haberl, N., Hartmann, R., Hirn, S., de Aberasturi, D. J., Kantner, K., Khadem-Saba, G., Montenegro, J.-M., Rejman, J., Rojo, T., de Larramendi, I. R., Ufartes, R., Wenk, A., & Parak, W. J. (2015). In vivo integrity of polymer-coated gold nanoparticles. Nature Nanotechnology. https://doi.org/10.1038/nnano.2015.111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
