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Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Open accessAbstract
Patients with generalized social anxiety disorder (GSAD) exhibit heightened activation of the amygdala in response to social cues conveying threat (eg, fearful/angry faces). The neuropeptide oxytocin (OXT) decreases anxiety and stress, facilitates social encounters, and attenuates amygdala reactivity to threatening faces in healthy subjects. The goal of this study was to examine the effects of OXT on fear-related amygdala reactivity in GSAD and matched healthy control (CON) subjects. In a functional magnetic resonance imaging study utilizing a double-blind placebo-controlled within-subjects design, we measured amygdala activation to an emotional face matching task of fearful, angry, and happy faces following acute intranasal administration of OXT (24 IU or 40.32 μg) and placebo in 18 GSAD and 18 CON subjects. Both the CON and GSAD groups activated bilateral amygdala to all emotional faces during placebo, with the GSAD group exhibiting hyperactivity specifically to fearful faces in bilateral amygdala compared with the CON group. OXT had no effect on amygdala activity to emotional faces in the CON group, but attenuated the heightened amygdala reactivity to fearful faces in the GSAD group, such that the hyperactivity observed during the placebo session was no longer evident following OXT (ie, normalization). These findings suggest that OXT has a specific effect on fear-related amygdala activity, particularly when the amygdala is hyperactive, such as in GSAD, thereby providing a brain-based mechanism of the impact of OXT in modulating the exaggerated processing of social signals of threat in patients with pathological anxiety.
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In the citing paper
“Heightened amygdala reactivity has been strongly linked to these social threat-related impairments and many have posited that the amygdala is an important therapeutic target for the management of GSAD (Labuschagne et al, 2010;Phan et al, 2006).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“Heightened amygdala reactivity has been strongly linked to these social threat-related impairments and many have posited that the amygdala is an important therapeutic target for the management of GSAD (Labuschagne et al, 2010;Phan et al, 2006).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We have extended these studies to examine the effects of OXT on amygdala reactivity to social threat in GSAD (Labuschagne et al, 2010) and found that OXT attenuated (or normalized) the hyperactive amygdala reactivity to fearful faces in GSAD patients.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“These effects were not observed in response to angry or happy faces.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We first confirmed using a whole-brain, 2 (session: PBO, OXT)  2 (group: HC, GSAD) analysis of variance (ANOVA) that consistent with Labuschagne et al (2010), there was a significant group  drug interaction on left amygdala reactivity to fearful faces (peak MNI coordinates: ( À 24, À 2, À 22), Z ¼ 2.77, k ¼ 81, po0.05, small volume corrected), such that OXT attenuated (or normalized) the hypera”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“The EFMT task has previously been described in detail elsewhere (Labuschagne et al, 2010), and has been used in previous pharmaco-fMRI studies to probe drug effects on amygdala activation (Kirsch et al, 2005;Paulus et al, 2005;Phan et al, 2008;Labuschagne et al, 2010) and amygdala functional connectivity (Gorka et al, 2013).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This finding of divergent effects is consistent with the two other OXT administration studies from our group (Dodhia et al, 2014;Labuschagne et al, 2010)”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We had previously shown that acute OXT exerted effects on the amygdala and mPFC/ACC during the processing of threat and other negative emotions (Labuschagne et al, 2010(Labuschagne et al, , 2011)).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Labuschagne et al, 2010
In the citing paper
“In two recent task-based studies, we showed that OXT attenuates heightened activity in the amygdala of GSAD patients after viewing fearful faces (Labuschagne et al, 2010)”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This is also agreement with decreasing amygdala activation to fearful faces in healthy (45), as well as anxious (46), humans with OT administration.”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [46]
In the citing paper
“Importantly, IN-OT attenuates heightened amygdala reactivity to fearful faces in patients with generalized social anxiety disorder (GSAD) (Labuschagne et al. 2010).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“there are increasing evidence for the role of OT in reducing anxiety, fear, and stress, in part by dampening amygdala activity”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“IN-OT restores functional connectivity between subcortical regions such as amygdala and frontal areas, including the ACC and mPFC”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“reduces the heightened amygdala reactivity to fearful faces in patients with generalized anxiety disorders”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“Results indicate that the tested type of intranasal OT delivery -but not peripherally delivered OT that produces similar blood levels -replicates prior findings of reduced right amygdala activation in response to emotional stimuli after OT treatment (Domes et al., 2007;Labuschagne et al., 2010;Petrovic et al., 2008).”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Labuschagne et al., 2010
In the citing paper
“Of note, other studies have reported similar results after administration of 24 IU (Domes et al., 2007;Kanat et al., 2015;Labuschagne et al., 2010), however, the dosages are difficult to compare between experiments as these studies used traditional nasal spray devices to administer OT.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Labuschagne et al., 2010
In the citing paper
“normalized the abnormal neural responses to negative social stimuli in patients with social anxiety disorder (32, 33).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [32]
In the citing paper
“Some research indicates that OXT could be influential in the treatment of established SAD (Labuschagne et al, 2010) and PTSD (Olff et al, 2014).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This fits with the hypothesis that OT administration effects may be especially beneficial in those who lack proficiency in fear regulation (Labuschagne et al, 2010) or social functioning (Olff et al, 2013;Weisman and Feldman, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Labuschagne et al, 2010
In the citing paper
“In addition, functional MRI (fMRI) studies have shown that OT administration dampened amygdala reactivity toward emotional stimuli in healthy males (Kirsch et al, 2005), males with generalized social anxiety disorder (GSAD; Labuschagne et al, 2010) and females with borderline personality disorder (BPD; Bertsch et al, 2013), although findings for females have been mixed (Domes et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Labuschagne et al, 2010
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“…has been demonstrated by numerous animal (Amico et al., 2004; Engelmann et al., 1999; Ring et al., 2006; Waldherr and Neumann, 2007; Yoshida et al., 2009) and some human (Guastella et al., 2009; Labuschagne et al., 2010) studies, and is likely to be amygdala-mediated (Viviani et al., 2011, 2010).”
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“, 2011), in patients with social anxiety (Labuschagne et al., 2010), and in male goldfish with low sociability (Thompson and Walton, 2004), but has no effect in normal individuals.”
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“2A) that produces robust amygdala activity (26–28), is sensitive to the effects of OXT (10, 11) and LZP (6) on amygdala activity, and elicits increased amygdala activation in patients with anxiety disorders (10, 29).”
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Self-citationIntranasal oxytocin does not reduce age-related difficulties in social cognition
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“However, when social anxiety disorder subjects were given oxytocin, the presentation of fearful faces did not evoke the same amygdala reactivity that was present at baseline [74].”
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“It is possible that oxytocin acts upon visuocognitive mechanisms within the core face-processing system (Haxby et al. , 2000), and some neuroimaging evidence supports this possibility (e.g. Domes et al. , 2010; Labuschagne et al. , 2010).”
Genetic and psychological underpinnings of motivation and satisfaction of industrial salespeople
Bagozzi, R. P., & Verbeke, W. J. M. I. (2019) · Industrial Marketing Management · doi:10.1016/j.indmarman.2019.08.011 · Cited by 29
Oxytocin affects spontaneous neural oscillations in trauma-exposed war veterans
Eidelman-Rothman, M., Goldstein, A., Lévy, J., Weisman, O., Schneiderman, I., Mankuta, D., Zagoory‐Sharon, O., & Feldman, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00165 · Cited by 29
“, 2011b), including the presence of psychiatric symptoms, as demonstrated in a number of studies showing differential effects of OT administration on brain activity among patients and controls (Labuschagne et al., 2010; Pincus et al., 2010; Dodhia et al., 2014).”
BackgroundDNA Methylation and Hydroxymethylation and Behavior
Rustad, S. R., Papale, L. A., & Alisch, R. S. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_104 · Cited by 26
Cognitive enhancers for the treatment of anxiety disorders
Hofmann, S. G., Fang, A., & Gutner, C. A. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139002 · Cited by 29
“…of action regard to fear-related circuitry, as well as its dose-response effects, needs to be conducted to better inform Another study demonstrated that OXT attenuated amygdalar reactivity to fearful faces in patients face matching paradigm with fearful, angry, and faces (Labuschagne et al., 2010).”
The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms
Oh, K., Kim, E., Ha, J., Woo, H., Kwon, M., Shin, D., Shin, Y.-C., & Lim, S.-W. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.08.31 · Cited by 26
Oxytocin reverses ethanol consumption and neuroinflammation induced by social defeat in male mice
Reguilón, M. D., Perez, C. F., Miñarro, J., & Rodríguez‐Arias, M. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104875 · Cited by 28
Jeung-Maarse, H., Schmitgen, M. M., Schmitt, R., Bertsch, K., & Herpertz, S. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01549-9 · Cited by 28
Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic‐Pituitary‐Adrenal Axis
Borrow, A. P., Stranahan, A. M., Suchecki, D., & Yunes, R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12403 · Cited by 27
Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
Schmidt, A., Müller, F., Dolder, P. C., Schmid, Y., Zanchi, D., Egloff, L., Liechti, M. E., & Borgwardt, S. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx112 · Cited by 24
“Supportive for such an interpretation, it has been demonstrated that the neuropeptide oxytocin, which decreases anxiety and stress and facilitates social behavior (Bartz and Hollander, 2006), reduces amygdala responses to fearful faces in patients with generalized social anxiety disorder (Labuschagne et al., 2010) pro…”
BackgroundFulford, D., Treadway, M. T., & Woolley, J. D. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000320 · Cited by 26
“The role of the oxytocin system in the etiology and course of SZ and other disorders characterized by social impairment (e.g., autism, anxiety) has seen a surge in research in recent years (Chevallier, Kohls, Troiani, Brodkin, & Schultz, 2012; Feifel et al., 2010; Labuschagne et al., 2010).”
Potential for oxytocin use in children and adolescents with mental illness
Netherton, E., & Schatte, D. J. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1212 · Cited by 24
Amygdala Regulation of Fear and Emotionality in Fragile X Syndrome
Olmos-Serrano, J. L., & Corbin, J. G. (2011) · Developmental Neuroscience · doi:10.1159/000329424 · Cited by 25
Finger, E. C. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9550-2 · Cited by 30
“It has been proposed that oxytocin may reduce behavioral and neural responses to threat cues (Domes et al. 2007a; Kirsch et al. 2005; Labuschagne et al. 2010).”
BackgroundRío, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 26
Flanagan, J. C., Sippel, L. M., Maria, M. M. M., Hartwell, K. J., Brady, K. T., & Joseph, J. E. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1606626 · Cited by 29
“Oxytocin has also been shown to ameliorate fear responses in humans (Labuschagne et al., 2010; Petrovic, Kalisch, Singer, & Dolan, 2008).”
BackgroundAre We There Yet? The Clinical Potential of Intranasal Oxytocin in Psychiatry
Liu, J. C., McErlean, R. A., & Dadds, M. R. (2012) · Current Psychiatry Reviews · doi:10.2174/157340012798994902 · Cited by 25
“found in individuals with social phobia that oxytocin administration reduced the exaggerated amygdala activation to fearful faces [63].”
Backgroundvan der Merwe, C., Jahanshad, N., Cheung, J. W., Mufford, M. S., Groenewold, N. A., Koen, N., Ramesar, R., Dalvie, S., Knowles, J. A., Hibar, D. P., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.082 · Cited by 26
Lapp, H. E., Bartlett, A. A., Zup, S. L., Hunter, R. G., & Moore, C. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104822 · Cited by 25
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 23
OXTRpolymorphism predicts social relationships through its effects on social temperament
Creswell, K. G., Wright, A. G. C., Troxel, W., Ferrell, R. E., Flory, J. D., & Manuck, S. B. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu132 · Cited by 25
Effects of intranasal oxytocin prior to encoding and retrieval on recognition memory
Weigand, A., Feeser, M., Gärtner, M., Brandt, E. S. L., Fan, Y., Fuge, P., Böker, H., Bajbouj, M., & Grimm, S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2962-z · Cited by 23
“Consistent with previous studies (e.g., Gamer and Buchel 2012; Hurlemann et al. 2010; Labuschagne et al. 2010; Marsh et al. 2010), participants self-administered three puffs per nostril with a dose of 24 international units (IU).”
ResultLiu, C., Lan, C., Li, K., Zhou, F., Yao, S., Xu, L., Yang, N., Zhou, X., Yang, J., Yong, X., et al. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.04.009 · Cited by 24
The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates
Lancaster, K., Goldbeck, L., Pournajafi‐Nazarloo, H., Connelly, J. J., Carter, C. S., & Morris, J. P. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.10.003 · Cited by 24
Lancaster, K., Goldbeck, L., Puglia, M. H., Morris, J. P., & Connelly, J. J. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy086 · Cited by 25
Oxytocin increases eye gaze in schizophrenia
Bradley, E. R., Seitz, A., Niles, A. N., Rankin, K. P., Mathalon, D. H., O'Donovan, A., & Woolley, J. D. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.07.039 · Cited by 22
“There is also evidence that oxytocin modulates functional connectivity of the amygdala to frontal regions (Dodhia et al., 2014; Koch et al., 2016; Labuschagne et al., 2010), as well as to the insula and middle/dorsal anterior cingulate cortex—regions implicated in processing emotional stimuli (Gorka et al.”
BackgroundAnterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior
Laing, B. T., Anderson, M. S., Bonaventura, J., Jayan, A., Sarsfield, S., Gajendiran, A., Michaelides, M., & Aponte, Y. (2023) · Current Biology · doi:10.1016/j.cub.2023.06.070 · Cited by 22
Clinical trials of intranasal delivery for treating neurological disorders – a critical review
Liu, X. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.633508 · Cited by 24
“Another study explored the brain-based mechanism of the impact of intranasally delivered oxytocin on social anxiety disorder and found that oxytocin reduces amygdala activity in response to fearful faces in participants with social anxiety disorder [52].”
BackgroundEllenbogen, M. A., Linnen, A., Cardoso, C., & Joober, R. (2014) · Psychophysiology · doi:10.1111/psyp.12263 · Cited by 24
The oxytocin receptor gene and social perception
Melchers, M., Montag, C., Felten, A., & Reuter, M. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1008646 · Cited by 23
“…disorders like schizophrenia (e.g., Fischer-Shofty, Brüne, et al., 2013) and autism (e.g., Anagnostou et al., 2012) and has been shown to attenuate amygdala reactivity to threatening faces in patients suffering from generalized social anxiety disorder (GSAD; e.g., Labuschagne et al., 2010).”
BackgroundTracy, L. M., Gibson, S. J., Labuschagne, I., Georgiou‐Karistianis, N., & Giummarra, M. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.016 · Cited by 21
“Moreover, neuroimaging studies have shown that intranasal oxytocin restores normal amygdala and prefrontal activity (Labuschagne et al., 2010, 2012), including amygdala connectivity with prefrontal regions (Dodhia et al., 2014; Gorka et al., 2015) in persons with social anxiety.”
Self-citationFeng, C., DeMarco, A. C., Haroon, E., & Rilling, J. K. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.05.004 · Cited by 22
“In addition, intranasal administration of OT normalizes hyperactivity of amygdala and mPFC to negative stimuli in individuals with generalized social anxiety disorder, whereas there were no effects of OT on the activity of amygdala and mPFC in the control group (Labuschagne et al., 2010, 2012).”
Li, J., Li, H.-X., Shou, X., Xu, X., Song, T.-J., Han, S., Zhang, R., & Han, J. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.08.011 · Cited by 21
“It has been well accepted that the abnormal social behavior and excessive anxious reactions are the core symptoms of mental disorders like ASD and SAD.”
InfluentialBertelsen, F., Folloni, D., Møller, A., Landau, A. M., Scheel‐Krüger, J., & Winterdahl, M. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000316 · Cited by 19
“Indeed, studies in humans have shown that systemic administration of OXT attenuates the amygdala response in paradigms of context-dependent fear and anxiety, which may indirectly influence the social behaviour (Labuschagne et al., 2010; Knobloch et al., 2012; Neumann and Landgraf, 2012; Gorka et al., 2015).”
BackgroundSutherland, M. T., Carroll, A. J., Salmeron, B. J., Ross, T. J., Hong, L. E., & Stein, E. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.043 · Cited by 20
“, 2008) and previously utilized to assess the impact of pharmacological manipulations (Bigos et al., 2008; Labuschagne et al., 2010; Paulus et al., 2005).”
BackgroundKent, P., Awadia, A., Zhao, L. L., Ensan, D., Silva, D., Cayer, C., James, J. S., Anisman, H., & Merali, Z. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.019 · Cited by 20
Motoki, K., Sugiura, M., Takeuchi, H., Kotozaki, Y., Nakagawa, S., Yokoyama, R., & Kawashima, R. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00480 · Cited by 24
Oxytocin effects on the resting-state mentalizing brain network
Wu, H., Feng, C., Lu, X., Liu, X., & Liu, Q. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00205-5 · Cited by 21
Neuroendocrine models of social anxiety disorder
van Honk, J., Bos, P. A., Terburg, D., Heany, S. J., & Stein, D. J. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/jhonk · Cited by 20
“61,62 Taken together these preliminary data are promising and provide a foundation for”
Chronic intranasal oxytocin reverses stress-induced social avoidance in female prairie voles
Hale, L. H., Tickerhoof, M. C., & Smith, A. S. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108770 · Cited by 19
Effects of oxycodone on brain responses to emotional images
Wardle, M. C., Fitzgerald, D. A., Angstadt, M., Rabinak, C. A., de Wit, H., & Phan, K. L. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3592-4 · Cited by 19
“…to probe emotional brain functioning, the Emotional Pictures Task (EPT) and the Emotional Faces Matching Task (EFMT), both of which have been used extensively in pharmaco-fMRI studies (e.g., Bedi et al. 2009; Labuschagne et al. 2010; Phan et al. 2008; Rabinak et al. 2012; Sripada et al. 2011) ).”
InfluentialSelf-citationSherman, B. J., Baker, N. L., Brady, K. T., Joseph, J. E., Nunn, L. M., & McRae‐Clark, A. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05516-w · Cited by 19
Festante, F., Ferrari, P. F., Thorpe, S., Buchanan, R. W., & Fox, N. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104467 · Cited by 19
“Following the administration of acute OT, several functional neuroimaging (fMRI) investigations have reported attenuated amygdala activation for fearful and stressful stimuli and, in contrast, enhanced activation of this region in response to the presentation of stimuli with positive valence (Gamer et al., 2010; Labus…”
BackgroundOxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish
Chuang, H.-J., Chang, C.-Y., Ho, H.-P., & Chou, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147459 · Cited by 20
DiGangi, J. A., Burkhouse, K. L., Aase, D. M., Babione, J. M., Schroth, C., Kennedy, A. E., Greenstein, J. E., Proescher, E., & Phan, K. L. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.013 · Cited by 18
Self-citationOxytocin conditions trait-based rule adherence
Gross, J., & Dreu, C. K. W. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw138 · Cited by 19
“More specifically, and because oxytocin has been implicated in fear modulation (Kirsch et al., 2005; Labuschagne et al., 2010), subjects reported their current anxiety level (STAI; Spielberger and Sydeman, 1994).”
BackgroundPrajapati, S. K., Bhaseen, S., Krishnamurthy, S., & Sahu, A. N. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02944-9 · Cited by 17
“NK-1 receptor regulate oxytocin secretion [59].”
BackgroundSpecialization of amygdala subregions in emotion processing
Labuschagne, I., Domínguez, J. F., Grace, S., Mizzi, S., Henry, J. D., Peters, C. A., Rabinak, C. A., Sinclair, E., Lorenzetti, V., Terrett, G., et al. (2024) · Human Brain Mapping · doi:10.1002/hbm.26673 · Cited by 21
“This task elicited activation in areas, including the amygdala (see Figure S2), consistent with previous studies involving both clinical and healthy populations (Hariri et al., 2002; Labuschagne et al., 2010; Tessitore et al., 2002).”
ResultSelf-citationDiGangi, J. A., Kujawa, A., Aase, D. M., Babione, J. M., Schroth, C., Levy, D. M., Kennedy, A. E., Greenstein, J. E., Proescher, E., Walters, R. P., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.01.004 · Cited by 17
“, 2002), which has proven useful in characterizing threat-processing in anxious and non-anxious participants (Labuschagne et al., 2010) and facilitates comparison with prior ERP work in PTSD (Felmingham et al.”
Self-citationGorka, S. M., Lieberman, L., Shankman, S. A., & Phan, K. L. (2017) · Psychophysiology · doi:10.1111/psyp.12829 · Cited by 18
“This threshold has been used by others (Banks et al., 2007; Labuschagne et al., 2010) but is considered lenient and we intentionally chosen to focus on replication rather than adopt conservative statistical threshold cutoffs.”
Self-citationFroemke, R. C., & Carcea, I. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00037-1 · Cited by 20
Fang, A., Jacoby, R. J., Beatty, C. C., Germine, L. T., Plessow, F., Wilhelm, S., & Lawson, E. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104541 · Cited by 18
“As a neuromodulator, oxytocin plays a role in the regulation of socio-emotional functioning (Leppanen et al., 2017) and has antidepressant and anxiolytic e ff ects in animal models and human studies (Labuschagne et al., 2010; Neumann and Slattery, 2016; Scantamburlo et al., 2007).”
BackgroundRomero‐Martínez, Á., Sarrate‐Costa, C., & Moya‐Albiol, L. (2021) · Biology · doi:10.3390/biology10121334 · Cited by 19
“[89] 18 GSAD From 18 to 55; 100% ♂ Right-handed 24 IU OX Single administration Nasal 45 min Emotional face matching task Double-blind, randomized, placebo-controlled”
Background
Metadata
- Authors
- Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J.
- Affiliations
- Monash University (AU)
- University of Michigan (US)
- Royal Children's Hospital (AU)
- University of Freiburg (DE)
- University of Cambridge (GB)
- Corresponding author
- Nathan, Pradeep J
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2010-08-18
- Volume
- 35
- Issue
- 12
- Pages
- 2403-2413
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055328
- OpenAlex
- W2116280488
- Cited by
- 549
- References
- 91
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 20 · 2023: 62 · 2022: 22 · 2021: 22 · 2020: 47 · 2019: 27 · 2018: 35 · 2017: 48 · 2016: 37 · 2015: 54 · 2014: 44 · 2013: 43 · 2012: 28
- FWCI
- 45.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (114788)
- National Institute of Mental Health (MH076198, K23MH076198)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, generalized social anxiety disorder, amygdala reactivity, fear, emotional face processing, amygdala hyperactivity, intranasal administration, social danger
- MeSH terms
- Administration, Intranasal, Adult, Amygdala, Anxiety Disorders, Brain Mapping, Double-Blind Method, Facial Expression, Fear, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oxytocin, Placebos, Psychomotor Performance
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