The DOI matches its Crossref record; 88 of the 91 references it cites were found in a registry or an index.
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Open accessAbstract
Patients with generalized social anxiety disorder (GSAD) exhibit heightened activation of the amygdala in response to social cues conveying threat (eg, fearful/angry faces). The neuropeptide oxytocin (OXT) decreases anxiety and stress, facilitates social encounters, and attenuates amygdala reactivity to threatening faces in healthy subjects. The goal of this study was to examine the effects of OXT on fear-related amygdala reactivity in GSAD and matched healthy control (CON) subjects. In a functional magnetic resonance imaging study utilizing a double-blind placebo-controlled within-subjects design, we measured amygdala activation to an emotional face matching task of fearful, angry, and happy faces following acute intranasal administration of OXT (24 IU or 40.32 μg) and placebo in 18 GSAD and 18 CON subjects. Both the CON and GSAD groups activated bilateral amygdala to all emotional faces during placebo, with the GSAD group exhibiting hyperactivity specifically to fearful faces in bilateral amygdala compared with the CON group. OXT had no effect on amygdala activity to emotional faces in the CON group, but attenuated the heightened amygdala reactivity to fearful faces in the GSAD group, such that the hyperactivity observed during the placebo session was no longer evident following OXT (ie, normalization). These findings suggest that OXT has a specific effect on fear-related amygdala activity, particularly when the amygdala is hyperactive, such as in GSAD, thereby providing a brain-based mechanism of the impact of OXT in modulating the exaggerated processing of social signals of threat in patients with pathological anxiety.
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“Heightened amygdala reactivity has been strongly linked to these social threat-related impairments and many have posited that the amygdala is an important therapeutic target for the management of GSAD (Labuschagne et al, 2010;Phan et al, 2006).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“Heightened amygdala reactivity has been strongly linked to these social threat-related impairments and many have posited that the amygdala is an important therapeutic target for the management of GSAD (Labuschagne et al, 2010;Phan et al, 2006).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We have extended these studies to examine the effects of OXT on amygdala reactivity to social threat in GSAD (Labuschagne et al, 2010) and found that OXT attenuated (or normalized) the hyperactive amygdala reactivity to fearful faces in GSAD patients.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“These effects were not observed in response to angry or happy faces.”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We first confirmed using a whole-brain, 2 (session: PBO, OXT)  2 (group: HC, GSAD) analysis of variance (ANOVA) that consistent with Labuschagne et al (2010), there was a significant group  drug interaction on left amygdala reactivity to fearful faces (peak MNI coordinates: ( À 24, À 2, À 22), Z ¼ 2.77, k ¼ 81, po0.05, small volume corrected), such that OXT attenuated (or normalized) the hypera”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“The EFMT task has previously been described in detail elsewhere (Labuschagne et al, 2010), and has been used in previous pharmaco-fMRI studies to probe drug effects on amygdala activation (Kirsch et al, 2005;Paulus et al, 2005;Phan et al, 2008;Labuschagne et al, 2010) and amygdala functional connectivity (Gorka et al, 2013).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This finding of divergent effects is consistent with the two other OXT administration studies from our group (Dodhia et al, 2014;Labuschagne et al, 2010)”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Labuschagne et al, 2010
In the citing paper
“We had previously shown that acute OXT exerted effects on the amygdala and mPFC/ACC during the processing of threat and other negative emotions (Labuschagne et al, 2010(Labuschagne et al, , 2011)).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Labuschagne et al, 2010
In the citing paper
“In two recent task-based studies, we showed that OXT attenuates heightened activity in the amygdala of GSAD patients after viewing fearful faces (Labuschagne et al, 2010)”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This is also agreement with decreasing amygdala activation to fearful faces in healthy (45), as well as anxious (46), humans with OT administration.”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [46]
In the citing paper
“Importantly, IN-OT attenuates heightened amygdala reactivity to fearful faces in patients with generalized social anxiety disorder (GSAD) (Labuschagne et al. 2010).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“there are increasing evidence for the role of OT in reducing anxiety, fear, and stress, in part by dampening amygdala activity”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“IN-OT restores functional connectivity between subcortical regions such as amygdala and frontal areas, including the ACC and mPFC”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“reduces the heightened amygdala reactivity to fearful faces in patients with generalized anxiety disorders”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Labuschagne et al. 2010
In the citing paper
“Results indicate that the tested type of intranasal OT delivery -but not peripherally delivered OT that produces similar blood levels -replicates prior findings of reduced right amygdala activation in response to emotional stimuli after OT treatment (Domes et al., 2007;Labuschagne et al., 2010;Petrovic et al., 2008).”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Labuschagne et al., 2010
In the citing paper
“Of note, other studies have reported similar results after administration of 24 IU (Domes et al., 2007;Kanat et al., 2015;Labuschagne et al., 2010), however, the dosages are difficult to compare between experiments as these studies used traditional nasal spray devices to administer OT.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Labuschagne et al., 2010
In the citing paper
“normalized the abnormal neural responses to negative social stimuli in patients with social anxiety disorder (32, 33).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [32]
In the citing paper
“Some research indicates that OXT could be influential in the treatment of established SAD (Labuschagne et al, 2010) and PTSD (Olff et al, 2014).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Labuschagne et al, 2010
In the citing paper
“This fits with the hypothesis that OT administration effects may be especially beneficial in those who lack proficiency in fear regulation (Labuschagne et al, 2010) or social functioning (Olff et al, 2013;Weisman and Feldman, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Labuschagne et al, 2010
In the citing paper
“In addition, functional MRI (fMRI) studies have shown that OT administration dampened amygdala reactivity toward emotional stimuli in healthy males (Kirsch et al, 2005), males with generalized social anxiety disorder (GSAD; Labuschagne et al, 2010) and females with borderline personality disorder (BPD; Bertsch et al, 2013), although findings for females have been mixed (Domes et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Labuschagne et al, 2010
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“Similarly, in human studies intranasal OT application reduced hyperresponsivity of the amygdala to facial cues in socially anxious patients, while not affecting the response observed in normal patients (Labuschagne et al, 2010).”
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“Finally, oxytocin blunts attention to negative social cues such as angry faces and displays of dominance (38–41), and in patients with anxiety disorders, intranasal oxytocin attenuates hyperactivity in the amygdala when social cues conveying threat are displayed (42).”
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“On the other hand, some acute neural responses (attenuation of amygdala activity) are seen in both patient groups (Labuschagne et al., 2010) and normals (Zink and MeyerLindenberg, 2012) (Figure 1).”
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“Paralleling these findings, intranasal oxytocin administration to humans attenuated amygdala activation elicited by anxiety-provoking social stimuli (Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008).”
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“Labuschagne et al. (2010) observed a bilateral amygdala activation after showing fearful faces and extended their observations in 2011 (Labuschagne et al., 2011) by showing that in generalizedsocial-anxiety-disorder (GSAD) patients the medial prefrontal cortex and the anterior cingulate cortex…”
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“In an fMRI study, oxytocin attenuated the heightened amygdala reactivity to fearful faces in individuals with SAD (Labuschagne et al. 2010).”
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“In patients with generalized social anxiety disorder, hyper-reactivity to fearful faces in the left amygdala has been reported to be attenuated by intranasal oxytocin [80].”
BackgroundOptogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150
“Ormel, J, Von Korff, M., Van den Brink, W., Katon, W., Brilman, E., and Oldehinkel, T. (1993). Depression, anxiety, and social disability show synchrony of change”
BackgroundMethodInfluentialQuintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
“Intranasal OT has also been shown to normalize heightened amygdala and medial prefrontal cortex activity associated with social anxiety disorder (Labuschagne et al., 2010, 2011).”
BackgroundEstrogen Receptors Modulation of Anxiety-Like Behavior
Borrow, A. P., & Handa, R. J. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.08.004 · Cited by 146
“Plasma OT levels are negatively correlated with anxiety symptoms in depressed patients (Scantamburlo et al., 2007), and intranasal OT administration attenuates emotional fear reactivity in patients with social anxiety disorder (Labuschagne et al., 2010).”
BackgroundNeuroimaging in anxiety disorders
Holzschneider, K., & Mulert, C. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.4/kholzschneider · Cited by 146
“In patients with social anxiety disorder, oxytocin attenuated the heightened amygdala activation in response to fearful faces.(73) Hence, it appears to modulate the exaggerated amygdala activity during confrontation with social stimuli in pathological social anxiety.”
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139
Bowen, M. T., Carson, D. S., Spiro, A., Arnold, J. C., & McGregor, I. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027237 · Cited by 143
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.1 · Cited by 132
Acheson, D., Feifel, D., de Wilde, S., Mckinney, R., Lohr, J., & Risbrough, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3099-4 · Cited by 141
“This dose has been shown to produce anxiolytic effects in healthy humans (de Oliveira et al. 2012; Labuschagne et al. 2010).”
BackgroundLabuschagne, I., Phan, K. L., WOOD, A. G., Angstadt, M., Chua, P. M.-L., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001489 · Cited by 144
“…have shown that patients with GSAD exhibit heightened activation of the amygdala in response to social cues conveying threat and/or negative feedback such as fearful, angry, contemptuous and/or disgusted faces (Evans et al. 2008; Labuschagne et al. 2010; Phan et al. 2006; Stein et al. 2002).”
BackgroundMethodInfluentialSelf-citationHarari-Dahan, O., & Bernstein, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.007 · Cited by 143
Herpertz, S. C., & Bertsch, K. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020216 · Cited by 147
“While, for instance, oxytocin dampens amygdala response in individuals with social anxiety (90), it enhances amygdala activity in individuals with autism spectrum disorder (91) who experience low interest in their conspecifics.”
BackgroundFan, Y., Herrera-Meléndez, A. L., Pestke, K., Feeser, M., Aust, S., Otte, C., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22553 · Cited by 142
Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion
Mah, B. L., van IJzendoorn, M. H., Smith, R., & Bakermans‐Kranenburg, M. J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.005 · Cited by 143
“OT administration has been found to produce no effect on mood in both community samples (Kirsch et al., 2005; Rockliff et al., 2011) and a clinical sample of participants with anxiety disorders (Labuschagne et al., 2010).”
Oxytocin facilitates accurate perception of competition in men and kinship in women
Fischer-Shofty, M., Levkovitz, Y., & Shamay-Tsoory, S. G. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr100 · Cited by 132
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 141
Gorka, S. M., Fitzgerald, D. A., Labuschagne, I., Hosanagar, A., Wood, A. G., Nathan, P. J., & Phan, K. L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.168 · Cited by 131
“The current study is a novel analysis of existing fMRI data from our previous study on the neural effects of OXT in a sample of HC and GSAD subjects (Labuschagne et al, 2010).”
BackgroundMethodResultInfluentialSelf-citationSex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin
Steinman, M. Q., Duque-Wilckens, N., Greenberg, G. D., Hao, R., Campi, K. L., Laredo, S. A., Laman-Maharg, A., Manning, C. E., Doig, I. E., Lopez, E. M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.007 · Cited by 131
“Deficits in social processes and exaggerated responses to threat are common in stress-induced psychiatric disorders (10,11), so there has been strong interest in investigating OT as a potential therapeutic agent (12,13).”
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131
“Thus, one line of research has investigated how OT modulates affective neural responses in such patients [12,45,56,60].”
BackgroundInfluentialLong-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131
Wong, R. Y., Oxendine, S. E., & Godwin, J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-348 · Cited by 132
“Oxytocin is thought to affect many social behaviors in humans [73] including having anxiolytic effects [74,75].”
Effect of oxytocin on craving and stress response in marijuana-dependent individuals: A pilot study
McRae-Clark, A. L., Baker, N. L., Maria, M. M.-S., & Brady, K. T. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3062-4 · Cited by 124
“In agreement, neuroimaging studies demonstrate that intranasal administration of oxytocin attenuates amygdala activation following stressful and fearful stimuli (Baumgartner et al. 2008; Domes et al. 2007; Kirsch et al. 2005; Labuschagne et al. 2010).”
BackgroundInfluentialThe effects of oxytocin on social cognition and behaviour in frontotemporal dementia
Jesso, S., Morlog, D., Ross, S., Pell, M. D., Pasternak, S., Mitchell, D. G. V., Kertesz, A., & Finger, E. C. (2011) · Brain · doi:10.1093/brain/awr171 · Cited by 136
“that the effects of oxytocin on facial expression processing in healthy adults may be mediated via oxytocin-induced reductions in amygdala activation during threatening and fearful stimuli (Kirsch et al., 2005; Domes et al., 2007a; Labuschagne et al., 2010); however, in females, oxytocin may increase amygdala activity…”
BackgroundRoles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123
Positive maternal mental health, parenting, and child development
Phua, D. Y., Kee, M. Z. L., & Meaney, M. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.028 · Cited by 124
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123
“Notably, in this study no effect of OT on amygdala reactivity was found in healthy controls, suggesting that OT might be most effective in dampening amygdala responsiveness in pathological states, for example when the amygdala is hyperresponsive (Labuschagne et al., 2010), as in PTSD.”
BackgroundGrace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120
“Of greatest community interest, IN-OXT provides a unique therapeutic tool for conditions characterised by anxiety and social dysfunction such as social anxiety (Labuschagne et al., 2010) and autism (Domes et al., 2013).”
InfluentialSelf-citationOxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122
“Administration of OT reduced this neural hyperreactivity in social anxiety, supporting the assumption that OT may reduce stress reactivity and exert anxiolytic effects by modulating activation in neural correlates of threat processing (Labuschagne et al., 2011, 2010).”
BackgroundInfluentialSelf-citationLawson, E. A., Holsen, L. M., Santin, M., Meenaghan, E. M., Eddy, K. T., Becker, A. E., Herzog, D. B., Goldstein, J. M., & Klibanski, A. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1702 · Cited by 121
Bethlehem, R. A. I., Baron-Cohen, S., van Honk, J., Auyeung, B., & Bos, P. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00048 · Cited by 120
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 123
Oxytocin and postpartum depression: Delivering on what's known and what's not
Kim, S., Soeken, T. A., CROMER, S. J., Martinez, S. R., Hardy, L. R., & Strathearn, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.11.009 · Cited by 121
Cagna, F. D., Fusar‐Poli, L., Damiani, S., Rocchetti, M., Giovanna, G., Mori, A., Politi, P., & Brondino, N. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.1.1 · Cited by 121
“Of note, Fang et al. (2014),31) Fang et al. (2017),32) Dodhia et al. (2014),34) Gorka et al. (2015),35) Labuschagne et al. (2010)36) and Labuschagne et al. (2012)37) reported results of trials with overlapping samples, but focusing on different outcomes and outcome measures.”
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132
Phan, K. L., Coccaro, E. F., Angstadt, M., Kreger, K. J., Mayberg, H. S., Liberzon, I., & Stein, M. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.003 · Cited by 114
“fMRI Task Brain activation was assessed using a modified version of the Emotional Face Matching Task [EFMT] (30), which has been previously validated and described in our pharmacological fMRI studies in healthy (31) and gSP (32) subjects.”
MethodSelf-citationOxytocin and Autism: A Systematic Review of Randomized Controlled Trials
Preti, A., Melis, M., Siddi, S., Vellante, M., Doneddu, G., & Fadda, R. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0040 · Cited by 118
“…with generalized social anxiety disorder, acute intra-nasal oxytocin (24IU) reduced amygdala hyperactivity caused by the presentation of threatening stimuli (fearful face), and also decreased medial prefrontal hyperactivity caused by negative stimuli (sad faces) (Labuschagne et al. 2010, 2011).”
Kujawa, A., MacNamara, A., Fitzgerald, K. D., Monk, C. S., & Phan, K. L. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-0029-4 · Cited by 117
“Emotional Face-Matching Task Participants completed an emotional face-matching task (Hariri et al. 2002), which has been used to assess ERPs to threat in adult anxiety (Labuschagne et al. 2010; MacNamara et al. 2013).”
Self-citationBrüne, M. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-38 · Cited by 116
“In anxiety disorders, OXT attenuated conditioned fear responses and amygdala activity [44] to become similar to the effects observed in psychologically healthy individuals [45].”
BackgroundNinan, I. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07430.x · Cited by 110
Kelly, A. M., Kingsbury, M. A., Hoffbuhr, K., Schrock, S. E., Waxman, B., Kabelik, D., Thompson, R. R., & Goodson, J. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.012 · Cited by 106
“Notably, nonapeptides influence social cognition and affiliation behaviors by acting within numerous neural loci where nonapeptides also modulate anxiety (Choleris et al., 2008; Goodson and Thompson, 2010; Labuschagne et al., 2010).”
Neuroendocrinology of Parental Response to Baby‐Cry
Swain, J. E., Kim, P., & Ho, S. S. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02212.x · Cited by 106
Toth, I., Neumann, I. D., & Slattery, D. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2702-4 · Cited by 107
“…also found in humans (Heinrichs et al. 2003), as OXT was shown to reduce the activation of the amygdala to threatening faces, thereby reducing the autonomic and behavioral manifestation of fear in healthy volunteers and social anxiety disorder patients (Kirsch et al. 2005; Labuschagne et al. 2010).”
Oxytocin in learning and addiction: From early discoveries to the present
Sarnyai, Z., & Kovács, G. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.019 · Cited by 110
“OXT administration has been shown to attenuate HPA axis activation via the amygdala, a key brain area involved in fear and anxiety behaviors (Labuschagne et al., 2010).”
BackgroundRDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 107
A brief history of oxytocin and its role in modulating psychostimulant effects
Carson, D. S., Guastella, A. J., Taylor, E. R., & McGregor, I. S. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473788 · Cited by 105
“For example, Labuschagne et al. (2010) showed that an acute intranasal dose of OT (24 IU) attenuated amygdala hyperactivity resulting from the presentation of threatening stimuli (fearful faces) in patients with generalized social anxiety disorder.”
BackgroundAn affective neuroscience model of boosting resilience in adults
Tabibnia, G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.005 · Cited by 115
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102
Early life stress modulates oxytocin effects on limbic system during acute psychosocial stress
Grimm, S., Pestke, K., Feeser, M., Aust, S., Weigand, A., Wang, J., Wingenfeld, K., Pruessner, J. C., Marca, R. L., Böker, H., et al. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu020 · Cited by 106
Metadata
- Authors
- Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J.
- Affiliations
- Monash University (AU)
- University of Michigan (US)
- Royal Children's Hospital (AU)
- University of Freiburg (DE)
- University of Cambridge (GB)
- Corresponding author
- Nathan, Pradeep J
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2010-08-18
- Volume
- 35
- Issue
- 12
- Pages
- 2403-2413
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055328
- OpenAlex
- W2116280488
- Cited by
- 549
- References
- 91
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 20 · 2023: 62 · 2022: 22 · 2021: 22 · 2020: 47 · 2019: 27 · 2018: 35 · 2017: 48 · 2016: 37 · 2015: 54 · 2014: 44 · 2013: 43 · 2012: 28
- FWCI
- 45.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Aston Publications Explorer (Aston University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (114788)
- National Institute of Mental Health (MH076198, K23MH076198)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, generalized social anxiety disorder, amygdala reactivity, fear, emotional face processing, amygdala hyperactivity, intranasal administration, social danger
- MeSH terms
- Administration, Intranasal, Adult, Amygdala, Anxiety Disorders, Brain Mapping, Double-Blind Method, Facial Expression, Fear, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Oxytocin, Placebos, Psychomotor Performance
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