Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders

Quintana, Daniel S.; Dieset, Ingrid; Elvsåshagen, Torbjørn; Westlye, Lars T.; Andreassen, Ole A.

doi:10.1016/j.yfrne.2016.12.004

Cited by 39Neuroendocrine regulation and behaviorSchizophrenia research and treatmentRegulation of Appetite and Obesity

Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders

Open access

Quintana, Daniel S., Dieset, Ingrid, Elvsåshagen, Torbjørn, Westlye, Lars T., Andreassen, Ole A.·2017·Frontiers in Neuroendocrinology

DOI 10.1016/j.yfrne.2016.12.004

Open this paper in CoChat — free account

Abstract

There is growing interest in using intranasal oxytocin (OT) to treat social dysfunction in schizophrenia and bipolar disorders (i.e., psychotic disorders). While OT treatment results have been mixed, emerging evidence suggests that OT system dysfunction may also play a role in the etiology of metabolic syndrome (MetS), which appears in one-third of individuals with psychotic disorders and associated with increased mortality. Here we examine the evidence for a potential role of the OT system in the shared risk for MetS and psychotic disorders, and its prospects for ameliorating MetS. Using several studies to demonstrate the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, we show that OT system dysfunction may be one common mechanism underlying MetS and psychotic disorders. Given the critical need to better understand metabolic dysregulation in these disorders, future OT trials assessing behavioural and cognitive outcomes should additionally include metabolic risk factor parameters.

Integrity signals

Registry

Crossref · 10.1016/j.yfrne.2016.12.004

Cites

201 of 201 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Emerging evidence points to the oxytocin system's role in energy metabolism, with relevance for metabolic functions.
“Emerging evidence also points to the oxytocin system’s role in energy metabolism, with relevance for metabolic functions5.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [5]
These results are consistent with emerging evidence that the oxytocin system plays a role in the metabolic and feeding dysregulation, which are overrepresented in severe mental illnesses.
“Altogether, these results are consistent with emerging evidence that the oxytocin system plays a role in the metabolic and feeding dysregulation, which are overrepresented in severe mental illnesses5.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [5]

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Antipsychotic-induced weight gain: a comprehensive research synthesis
Allison, D. B., Mentore, J. L., Heo, M., Chandler, L. P., Cappelleri, J. C., Infante, M. C., & Weiden, P. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1686 · Cited by 2,382 · see citing works
The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994
Park, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074 · see citing works
A Systematic Review of Mortality in Schizophrenia: Is the Differential Mortality Gap Worsening Over Time?
Saha, S., Chant, D., & McGrath, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.10.1123 · Cited by 2,065 · see citing works
Metabolic Syndrome and Risk of Incident Cardiovascular Events and Death
Gami, A. S., Witt, B. J., Howard, D. E., Erwin, P. J., Gami, L. A., Somers, V. K., & Montori, V. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.09.032 · Cited by 1,888 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · cited 2× · see citing works
“Leading theories suggest that OT exerts its effects by either increasing social salience (Bartz et al., 2011) or facilitating approach related behaviors (Kemp and Guastella, 2011), although both processes likely occur in tandem (Quintana et al., 2015a).”
Background
Metabolic Syndrome and Risk of Cancer
Esposito, K., Chiodini, P., Colao, A. A. L., Lenzi, A., & Giugliano, D. (2012) · Diabetes Care · doi:10.2337/dc12-0336 · Cited by 1,212 · see citing works
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
for the ENIGMA Schizophrenia Working Group, van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.63 · Cited by 1,140 · see citing works
Self-citation
Prevalence of Metabolic Syndrome and Metabolic Abnormalities in Schizophrenia and Related Disorders—A Systematic Review and Meta-Analysis
Mitchell, A. J., Vancampfort, D., Sweers, K., van Winkel, R., Yu, W., & Binder, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr148 · Cited by 1,087 · see citing works
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
Greenway, F. L., Fujioka, K., Plodkowski, R. A., Mudaliar, S., Guttadauria, M., Erickson, J., Kim, D. D., & Dunayevich, E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60888-4 · Cited by 1,036 · see citing works
Lifetime risks of cardiovascular disease
Berry, J. D., Dyer, A., Cai, X., Garside, D. B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R. P., & Lloyd-Jones, D. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1012848 · Cited by 945 · see citing works
Oxytocin promotes human ethnocentrism
De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015316108 · Cited by 838 · cited 1× · see citing works
“For instance, a single dose of OT has been shown to increase ethnocentrism (De Dreu et al., 2011), envy, and gloating (Shamay-Tsoory et al., 2009) in neurotypical individuals.”
Background
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 2× · see citing works
“For instance, while neuroimaging studies suggest that intranasal OT decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle pha…”
Background
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734 · see citing works
Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): A randomized, placebo-controlled, phase 3 extension study
Garvey, W. T., Ryan, D. H., Look, M., Gadde, K. M., Allison, D. B., Peterson, C. A., Schwiers, M., Day, W. W., & Bowden, C. H. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.024927 · Cited by 716 · see citing works
CD38 is critical for social behaviour by regulating oxytocin secretion
Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Shnayder, N. A., Yamada, K., Noda, M., Seike, T., et al. (2007) · Nature · doi:10.1038/nature05526 · Cited by 665 · see citing works
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study
Crump, C., Winkleby, M. A., Sundquist, K., & Sundquist, J. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050599 · Cited by 619 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · cited 7× · see citing works
“Although only very little peripherally administered OT appears to cross the BBB (Leng and Ludwig, 2016; Mens et al., 1983), others argue that these small amounts can still be physiologically relevant (Neumann et al., 2013).”
BackgroundResultInfluential
A common allele in the oxytocin receptor gene ( <i>OXTR</i> ) impacts prosocial temperament and human hypothalamic-limbic structure and function
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · cited 2× · see citing works
“For instance, while neuroimaging studies suggest that intranasal OT decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle pha…”
Background
Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)
Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.009 · Cited by 542 · cited 2× · see citing works
“For instance, a single dose of OT has been shown to increase ethnocentrism (De Dreu et al., 2011), envy, and gloating (Shamay-Tsoory et al., 2009) in neurotypical individuals.”
Background
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · cited 1× · see citing works
“…decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle phase (Domes et al., 2010; Lischke et al., 2012).”
Background
Diabetes, impaired fasting glucose, and development of cognitive impairment in older women
Yaffe, K., Blackwell, T., Kanaya, A. M., Davidowitz, N., Barrett-Connor, E., & Krueger, K. (2004) · Neurology · doi:10.1212/01.wnl.0000134666.64593.ba · Cited by 520 · see citing works
Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients
Keene, D., Price, C., Shun-Shin, M. J., & Francis, D. P. (2014) · BMJ · doi:10.1136/bmj.g4379 · Cited by 519 · cited 1× · see citing works
“Even if OT treatment increased HDL cholesterol, pharmacologically increasing HDL cholesterol may not even improve CVD outcomes (Keene et al., 2014).”
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis
Alvares, G. A., Quintana, D. S., Hickie, I. B., & Guastella, A. J. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140217 · Cited by 503 · see citing works
Self-citation
Diet, smoking and cardiovascular risk in people with schizophrenia
McCreadie, R. G., & Scottish Schizophrenia Lifestyle Group (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.183.6.534 · Cited by 494 · see citing works
The association between exaggeration in health related science news and academic press releases: retrospective observational study
Sumner, P., Vivian-Griffiths, S., Boivin, J., Williams, A., Venetis, C. A., Davies, A., Ogden, J., Whelan, L., Hughes, B., Dalton, B., et al. (2014) · BMJ · doi:10.1136/bmj.g7015 · Cited by 489 · see citing works
Oxytocin — A neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475 · see citing works
Cortical Thickness and Subcortical Volumes in Schizophrenia and Bipolar Disorder
Rimol, L. M., Hartberg, C. B., Nesvåg, R., Fennema‐Notestine, C., Hagler, D. J., Pung, C. J., Jennings, R. G., Haukvik, U. K., Lange, E., Nakstad, P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.036 · Cited by 453 · see citing works
Self-citation
Oxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452 · see citing works
CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior
Bale, T. L., Davis, A. M., Auger, A. P., Dorsa, D. M., & McCarthy, M. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02546.2001 · Cited by 446 · see citing works
Impact of Metabolic Syndrome on Cognition and Brain: A Selected Review of the Literature
Yates, K. F., Sweat, V., Yau, P. L., Turchiano, M. M., & Convit, A. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.252759 · Cited by 444 · see citing works
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4572-07.2008 · Cited by 424 · cited 1× · see citing works
“…studies suggest that intranasal OT decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle phase…”
Background
Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases
Swaab, D. F., Purba, J. S., & Hofman, M. A. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7852523 · Cited by 421 · see citing works
Oxytocin and sexual behavior
Carter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417 · see citing works
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416 · see citing works
Diet, smoking and cardiovascular risk in people with schizophrenia
McCreadie, R. G., & Scottish Schizophrenia Lifestyle Group (2003) · The British Journal of Psychiatry · doi:10.1192/03-162 · Cited by 392 · see citing works
A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379 · see citing works
Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): Half-times of disappearance of these neuropeptides from CSF
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
fMRI during affect discrimination in bipolar affective disorder
Yurgelun‐Todd, D. A., Gruber, S. A., Kanayama, G., Killgore, W. D., Baird, A. A., & Young, A. D. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20304.x · Cited by 359 · see citing works
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research
Guastella, A. J., Hickie, I. B., McGuinness, M. M., Otis, M., Woods, E. A., Disinger, H. M., Chan, H.-K., Chen, T. F., & Banati, R. B. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.019 · Cited by 357 · see citing works
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 352 · cited 1× · see citing works
“A 2011 review of 38 randomized placebocontrolled OT trials including 1529 participants revealed several commonly reported somatic adverse effects, such as light headedness, drowsiness, nasal irritation, dry mouth, and abdominal pain (MacDonald et al., 2011).”
Background
Intranasal oxytocin versus placebo in the treatment of adults with Autism Spectrum Disorders: A randomized controlled trial
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350 · see citing works
Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies
Walum, H., Waldman, I. D., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.016 · Cited by 345 · cited 2× · see citing works
“…the mechanisms underlying the role of OT in the development and maintenance of individual MetS risk factors before undertaking a raft of underpowered OT trials (Walum et al., 2016) can accelerate the period of enlightenment for OT and MetS, and if efficacious, a period of research productivity.”
BackgroundResult
The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: a randomized clinical crossover trial
Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.162 · Cited by 344 · see citing works
Cardiac Autonomic Function and Incident Coronary Heart Disease: A Population-based Case-Cohort Study: The ARIC Study
Liao, D., Cai, J., Rosamond, W. D., Barnes, R. W., Hutchinson, R. G., Whitsel, E. A., Rautaharju, P. M., & HEISS, G. M. (1997) · American Journal of Epidemiology · doi:10.1093/aje/145.8.696 · Cited by 337 · see citing works
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
Influence of oxytocin on feeding behavior in the rat
Arletti, R., Benelli, A., & Bertolini, A. (1989) · Peptides · doi:10.1016/0196-9781(89)90082-x · Cited by 328 · see citing works
Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients
Feifel, D., Macdonald, K., Nguyen, A., Cobb, P., Warlan, H., Galangue, B., Minassian, A., Becker, O., Cooper, J., Perry, W., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.039 · Cited by 308 · see citing works
The social deficits of the oxytocin knockout mouse
Winslow, J. T., & Insel, T. R. (2002) · Neuropeptides · doi:10.1054/npep.2002.0909 · Cited by 307 · see citing works
Physical Activity Patterns in Adults With Severe Mental Illness
Daumit, G. L., Goldberg, R. W., Anthony, C. B., Dickerson, F., Brown, C. H., Kreyenbuhl, J. A., Wohlheiter, K. A., & Dixon, L. B. (2005) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000180737.85895.60 · Cited by 306 · see citing works
Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group
Simonsen, C., Sundet, K. S., Vaskinn, A., Birkenaes, A. B., Engh, J. A., Færden, A., Jónsdóttir, H., Ringen, P. A., Opjordsmoen, S., Melle, I., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp034 · Cited by 306 · see citing works
Self-citation
Elevated Levels of Insulin, Leptin, and Blood Lipids in Olanzapine-Treated Patients With Schizophrenia or Related Psychoses
Melkersson, K. I., Hulting, A., & Brismar, K. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n1006 · Cited by 300 · see citing works
The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial
Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
The obese brain: Association of body mass index and insulin sensitivity with resting state network functional connectivity
Kullmann, S., Heni, M., Veit, R., Ketterer, C., Schick, F., Häring, H., Fritsche, A., & Preissl, H. T. (2011) · Human Brain Mapping · doi:10.1002/hbm.21268 · Cited by 273 · see citing works
Obesity and Metabolic Syndrome and Functional and Structural Brain Impairments in Adolescence
Yau, P. L., Castro, M. G., Tagani, A., Tsui, W. H., & Convit, A. J. (2012) · PEDIATRICS · doi:10.1542/peds.2012-0324 · Cited by 272 · see citing works
Prospective Investigation of Autonomic Nervous System Function and the Development of Type 2 Diabetes
Carnethon, M. R., Golden, S. H., Folsom, A. R., Haskell, W. L., & Liao, D. (2003) · Circulation · doi:10.1161/01.cir.0000066324.74807.95 · Cited by 270 · see citing works
Release of oxytocin and vasopressin by magnocellular nuclei in vitro : specific facilitatory effect of oxytocin on its own release
Moos, F., Freund‐Mercier, M. J., Guerné, Y., Jm, G., Stoeckel, M. E., & Richard, P. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1020063 · Cited by 269 · see citing works
Prediction of Type 2 Diabetes Mellitus With Alternative Definitions of the Metabolic Syndrome
Hanley, A. J., Karter, A. J., Williams, K., Festa, A., Agostino, R. B. D., Wagenknecht, L. E., & Haffner, S. M. (2005) · Circulation · doi:10.1161/circulationaha.105.559633 · Cited by 267 · see citing works
Oxytocin is an anabolic bone hormone
Tamma, R., Colaianni, G., Zhu, L.-L., DiBenedetto, A., Greco, G., Montemurro, G., Patano, N., Strippoli, M., Vergari, R., Mancini, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901890106 · Cited by 267 · see citing works
Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
Scott, N., Prigge, M., Yizhar, O., & Kimchi, T. (2015) · Nature · doi:10.1038/nature15378 · Cited by 261 · see citing works
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254 · see citing works
Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial
Dadds, M. R., MacDonald, E., Cauchi, A., Williams, K., Levy, F., & Brennan, J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1899-3 · Cited by 250 · see citing works
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes
Musen, G., Jacobson, A. M., Bolo, N. R., Simonson, D. C., Shenton, M. E., McCartney, R. L., Flores, V. L., & Hoogenboom, W. S. (2012) · Diabetes · doi:10.2337/db11-1669 · Cited by 242 · see citing works
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235 · see citing works
A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors
Li, K., Nakajima, M., Ibañez-Tallon, I., & Heintz, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.067 · Cited by 234 · see citing works
Chronic Somatic Comorbidity and Excess Mortality Due to Natural Causes in Persons with Schizophrenia or Bipolar Affective Disorder
Laursen, T. M., Munk‐Olsen, T., & Gasse, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024597 · Cited by 232 · see citing works
Oxytocin causes a long-term decrease of blood pressure in female and male rats
PETERSSON, M., ALSTER, P., LUNDEBERG, T., & UVNÄS-MOBERG, K. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00261-2 · Cited by 229 · see citing works
Estimating the consequences of anti-psychotic induced weight gain on health and mortality rate
Fontaine, K. R., Heo, M., Harrigan, E. P., Shear, C. L., Lakshminarayanan, M. Y., Casey, D. E., & Allison, D. B. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00234-7 · Cited by 228 · see citing works
Peripheral oxytocin is associated with reduced symptom severity in schizophrenia
Rubin, L. H., Carter, C. S., Drogos, L. L., Pournajafi‐Nazarloo, H., Sweeney, J. A., & Maki, P. M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.09.014 · Cited by 228 · see citing works
The Role of Oxytocin in Human Affect: A Novel Hypothesis
Kemp, A. H., & Guastella, A. J. (2011) · Current Directions in Psychological Science · doi:10.1177/0963721411417547 · Cited by 228 · see citing works
Oxytocin Reduces Reward-Driven Food Intake in Humans
Ott, V., Finlayson, G., Lehnert, H., Heitmann, B., Heinrichs, M., Born, J., & Hallschmid, M. (2013) · Diabetes · doi:10.2337/db13-0663 · Cited by 226 · see citing works
Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models
Zhang, H., Wu, C., Chen, Q., Chen, X., Xu, Z., Wu, J., & Cai, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061477 · Cited by 224 · see citing works
The association among autonomic nervous system function, incident diabetes, and intervention arm in the diabetes prevention program
Carnethon, M. R., Prineas, R. J., Temprosa, M., Zhang, Z.-M., Uwaifo, G., Molitch, M. E., & for the Diabetes Prevention Program Research Group (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1729 · Cited by 220 · see citing works
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220 · see citing works
Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder
Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020263 · Cited by 214 · see citing works
Oxytocin Levels in Social Anxiety Disorder
Hoge, E. A., Pollack, M. H., Kaufman, R. E., Zak, P. J., & Simon, N. M. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00051.x · Cited by 213 · see citing works
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
Alterations of the salience network in obesity: A resting‐state fMRI study
García‐García, I., Jurado, M. Á., Garolera, M., Segura, B., Sala‐Llonch, R., Marqués‐Iturria, I., Pueyo, R., Sender‐Palacios, M. J., Vernet‐Vernet, M., Narberhaus, A., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22104 · Cited by 200 · see citing works
Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats
Melis, M. R., Melis, T., Cocco, C., Succu, S., Sanna, F., Pillolla, G., Boi, A., Ferri, G., & Argiolas, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05721.x · Cited by 198 · see citing works
Leptin: in search of role(s) in human physiology and pathophysiology
Mantzoros, C. S., & Moschos, S. J. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00571.x · Cited by 196 · see citing works
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · cited 1× · see citing works
“…decreases amygdala activity in males (Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010; Petrovic et al., 2008; Quintana et al., 2016b), it appears to increase amygdala activity in females, even when controlling for menstrual cycle phase (Domes et al., 2010; Lischke et al., 2012).”
Background
Statistical considerations for reporting and planning heart rate variability case‐control studies
Quintana, D. S. (2017) · Psychophysiology · doi:10.1111/psyp.12798 · Cited by 192 · see citing works
Self-citation
Insulin and Insulin-Like Growth Factor-1 Abnormalities in Antipsychotic-Naive Schizophrenia
Venkatasubramanian, G., Chittiprol, S., Neelakantachar, N., Naveen, M. N., Thirthall, J., Gangadhar, B. N., & Shetty, K. T. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020233 · Cited by 191 · see citing works
Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 187 · see citing works
Prevalence of cardiovascular risk factors and disease in people with schizophrenia: a population-based study.
Bresee, L. C., Majumdar, S., Patten, S., & Johnson, J. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.016 · Cited by 187 · see citing works
The effects of atypical antipsychotics on visceral fat distribution in first episode, drug-naive patients with schizophrenia
Ryan, M. C. M., Flanagan, S., Kinsella, U., Keeling, F., & Thakore, J. H. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.08.044 · Cited by 186 · see citing works
The Level of Cardiovascular Risk Factors in Bipolar Disorder Equals That of Schizophrenia: A Comparative Study
Birkenaes, A. B., Opjordsmoen, S., Brunborg, C., Engh, J. A., Jonsdottir, H., Ringen, P. A., Simonsen, C., Vaskinn, A., Birkeland, K. I., Friis, S., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0614 · Cited by 185 · see citing works
Self-citation
Disintegration of Sensorimotor Brain Networks in Schizophrenia
Kaufmann, T., Skåtun, K. C., Alnæs, D., Doan, N. T., Duff, E. P., Tønnesen, S., Roussos, E., Ueland, T., Aminoff, S. R., Lagerberg, T. V., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv060 · Cited by 181 · see citing works
Self-citation
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
Consequences of Early Experiences and Exposure to Oxytocin and Vasopressin Are Sexually Dimorphic
Carter, C. S., Boone, E. M., Pournajafi-Nazarloo, H., & Bales, K. L. (2009) · Developmental Neuroscience · doi:10.1159/000216544 · Cited by 176 · see citing works
Association Between Early and Rapid Weight Gain and Change in Weight Over One Year of Olanzapine Therapy in Patients with Schizophrenia and Related Disorders
Kinon, B. J., Kaiser, C. J., Ahmed, S., Rotelli, M. D., & Kollack‐Walker, S. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000161501.65890.22 · Cited by 164 · see citing works
Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement
Kemp, A. H., Quintana, D. S., Kuhnert, R.-L., Griffiths, K., Hickie, I. B., & Guastella, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044014 · Cited by 158 · see citing works
Self-citation
Intranasal oxytocin in the treatment of autism spectrum disorders: A review of literature and early safety and efficacy data in youth
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155 · see citing works
Long-Term Administration of Intranasal Oxytocin Is a Safe and Promising Therapy for Early Adolescent Boys with Autism Spectrum Disorders
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., Oishi, M., Kimura, T., Onaka, T., Ozono, K., et al. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0048 · Cited by 151 · see citing works
Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Qian, W., Zhu, T., Tang, B., Yu, S., Hu, H., Sun, W., Pan, R., Wang, J., Wang, D., Yang, L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2206 · Cited by 149 · see citing works
Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model
Quintana, D. S., Alvares, G. A., Hickie, I. B., & Guastella, A. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.011 · Cited by 149 · see citing works
Self-citation
Oxytocin-Augmented Social Cognitive Skills Training in Schizophrenia
Davis, M. C., Green, M. F., Lee, J., Horan, W. P., Senturk, D., Clarke, A. D., & Marder, S. R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.68 · Cited by 149 · see citing works
Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: A route for ameliorating hyperphagia and obesity
Iwasaki, Y., Maejima, Y., Suyama, S., Yoshida, M., Arai, T., Katsurada, K., Kumari, P., Nakabayashi, H., Kakei, M., & Yada, T. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00344.2014 · Cited by 148 · see citing works
An oxytocin receptor antagonist infused into the supraoptic nucleus attenuates intranuclear and peripheral release of oxytocin during suckling in conscious rats
Neumann, I. D., Koehler, E., Landgraf, R., & Summy‐Long, J. Y. (1994) · Endocrinology · doi:10.1210/endo.134.1.8275928 · Cited by 146 · see citing works
Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse
Gould, B. R., & Zingg, H. H. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00283-5 · Cited by 138 · cited 1× · see citing works
“Brain regions known to be involved in appetite regulation, such as the dorsomedial and ventromedial hypothalamic nuclei, are also rich in OT receptors (Gould and Zingg, 2003).”
Background
Action of Oxytocin and Related Peptides on Epididymal Adipose Tissue of the Rat
Mirsky, I. A., Perisutti, G., Jinks, R., et al. (1962) · Endocrinology · doi:10.1210/endo-71-1-158 · Cited by 137 · see citing works
Visualisation of Kiss1 Neurone Distribution Using a Kiss1‐ CRE Transgenic Mouse
Yeo, S. ‐., Kyle, V., Morris, P. G., Jackman, S., Sinnett‐Smith, L. C., Schacker, M., Chen, C., & Colledge, W. H. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12435 · Cited by 137 · see citing works
Is there a Publication Bias in Behavioural Intranasal Oxytocin Research on Humans? Opening the File Drawer of One Laboratory
Lane, A., Luminet, O., Nave, G., & Mikolajczak, M. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12384 · Cited by 134 · cited 1× · see citing works
“Moreover, recent efforts to ‘open the file draw’ of OT laboratories (Lane et al., 2016) and a steadily increasing rate of preregistered OT trials (Alvares et al., 2016b) will contribute towards the reduction of publication bias in this field, thus increasing the overall quality of research.”
Background
Physical comorbidity and its relevance on mortality in schizophrenia: a naturalistic 12-year follow-up in general hospital admissions
Schoepf, D., Uppal, H., Potluri, R., & Heun, R. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0436-x · Cited by 132 · see citing works
Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome
Einfeld, S. L., Smith, E., McGregor, I. S., Steinbeck, K., Taffe, J., Rice, L. J., Horstead, S. K., Rogers, N., Hodge, M. A., & Guastella, A. J. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36653 · Cited by 131 · see citing works
Insulin-like activity of vasopressin and oxytocin
Pittman, J. A., Boshell, B. R., Williams, B., et al. (1961) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(61)90179-6 · Cited by 131 · see citing works
Long-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131 · see citing works
Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions
Sclafani, A. J., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00826.2006 · Cited by 131 · see citing works
Aberrant Brain Functional Connectivity Related to Insulin Resistance in Type 2 Diabetes: A Resting-State fMRI Study
Chen, Y., Jiao, Y., Cui, Y., Shang, S., Ding, J., Feng, Y., Wen, S., Ju, S., & Teng, G. (2014) · Diabetes Care · doi:10.2337/dc13-2127 · Cited by 130 · see citing works
Oxytocin: an extremely potent inducer of penile erection and yawning in male rats
Argiolas, A., Melis, M. R., & Gessa, G. L. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90277-3 · Cited by 124 · see citing works
The Fat-Induced Satiety Factor Oleoylethanolamide Suppresses Feeding through Central Release of Oxytocin
Gaetani, S., Fu, J., Cassano, T., Dipasquale, P., Romano, A., Righetti, L., Cianci, S., Laconca, L., Giannini, E., Scaccianoce, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0036-10.2010 · Cited by 124 · see citing works
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120 · see citing works
A double-blind randomized controlled trial of oxytocin nasal spray and social cognition training for young people with early psychosis
Cacciotti-Saija, C., Langdon, R., Ward, P. B., Hickie, I. B., Scott, E. M., Naismith, S. L., Moore, L., Alvares, G. A., Redoblado Hodge, M. A., & Guastella, A. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu094 · Cited by 119 · see citing works
Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face
Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv157 · Cited by 116 · cited 2× · see citing works
“The use of hormonal contraceptives is also an important consideration in light of their dampening effect on neural responses to OT (Scheele et al., 2016).”
Background
Regulatory Role of CD38 (ADP-ribosyl Cyclase/Cyclic ADP-ribose Hydrolase) in Insulin Secretion by Glucose in Pancreatic βCells
Kato, I., Takasawa, S., Akabane, A., Tanaka, O., Abe, H., Takamura, T., Suzuki, Y., Nata, K., Yonekura, H., Yoshimoto, T., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.30045 · Cited by 116 · see citing works
Oxytocin in schizophrenia: a review of evidence for its therapeutic effects
MacDonald, K. S., & Feifel, D. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00634.x · Cited by 111 · see citing works
Divergent Effects of Oxytocin Treatment of Obese Diabetic Mice on Adiposity and Diabetes
Altirriba, J., Poher, A.-L., Caillon, A., Arsenijevic, D., Veyrat‐Durebex, C., Lyautey, J., Dulloo, A. G., & Rohner‐Jeanrenaud, F. (2014) · Endocrinology · doi:10.1210/en.2014-1466 · Cited by 111 · see citing works
Heart rate variability and the metabolic syndrome: a systematic review of the literature
Stuckey, M. I., Tulppo, M. P., Kiviniemi, A. M., & Petrella, R. J. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2555 · Cited by 110 · see citing works
The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders
Quintana, D. S., Guastella, A. J., Westlye, L. T., & Andreassen, O. A. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.166 · Cited by 107 · see citing works
Self-citation
Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization
Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden‐Hanson, T., Nelson, J. T., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00220.2015 · Cited by 107 · see citing works
Relationship between metabolic syndrome and cognition in patients with schizophrenia
Lindenmayer, J. P., Khan, A., Kaushik, S., Thanju, A., Praveen, R., Hoffman, L., Cherath, L., Valdez, G., & Wance, D. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.09.019 · Cited by 104 · see citing works
Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
Montag, C., Brockmann, E.-M., Bayerl, M., Rujescu, D., Müller, D. J., & Gallinat, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.677547 · Cited by 104 · see citing works
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
Self-citation
Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102 · see citing works
Self-citation
Glucose abnormalities in the siblings of people with schizophrenia
Fernández-Egea, E., Bernardo, M., Parellada, E., Justicia, A., García‐Rizo, C., Esmatjes, E., Conget, I., & Kirkpatrick, B. W. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.017 · Cited by 98 · see citing works
Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Repeated intranasal oxytocin administration in early life dysregulates the HPA axis and alters social behavior
Rault, J.-L., Carter, C. S., Garner, J. P., Marchant, J. N., Richert, B. T., & Lay, D. C. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.007 · Cited by 94 · see citing works
Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
Cavalieri, M., Ropele, S., Petrovic, K., Pluta-Fuerst, A., Homayoon, N., Enzinger, C., Grazer, A., Katschnig, P., Schwingenschuh, P., Berghold, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0851 · Cited by 92 · see citing works
Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91 · see citing works
Self-citation
Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes
Andreassen, O. A., McEvoy, L. K., Thompson, W. K., Wang, Y., Reppe, S., Schork, A. J., Zuber, V., Barrett-Connor, E. L., Gautvik, K. M., Aukrust, P., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02077 · Cited by 88 · see citing works
Self-citation
Cumulative risk on the oxytocin receptor gene (OXTR) underpins empathic communication difficulties at the first stages of romantic love
Schneiderman, I., Kanat‐Maymon, Y., Ebstein, R. P., & Feldman, R. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst142 · Cited by 87 · see citing works
Thyroid Hormones and Estrogen Affect Oxytocin Gene Expression in Hypothalamic Neurons
Dellovade, T., Zhu, Y., & Pfaff, D. W. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00250.x · Cited by 86 · see citing works
Oxytocin receptor expressed on the smooth muscle mediates the excitatory effect of oxytocin on gastric motility in rats
Qin, J., Feng, M., Wang, C., Ye, Y., Wang, P. S., & Liu, C. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01282.x · Cited by 86 · see citing works
Schizophrenia patients at higher risk of diabetes, hypertension and hyperlipidemia: A population-based study
Liao, C.-H., Chang, C.-S., Wei, W.-C., Chang, S., Liao, C., Lane, H., & Sung, F.-C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.007 · Cited by 82 · see citing works
Effects of adjunctive intranasal oxytocin on olfactory identification and clinical symptoms in schizophrenia: Results from a randomized double blind placebo controlled pilot study
Lee, M. R., Wehring, H. J., McMahon, R. P., Linthicum, J., Cascella, N., Liu, F., Bellack, A., Buchanan, R. W., Strauss, G. P., Contoreggi, C., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.001 · Cited by 80 · see citing works
Normal CSF oxytocin and NPY levels in OCD
Altemus, M. M., Jacobson, K. R., DeBellis, M. D., Kling, M. A., Pigott, T. A., Murphy, D. L., & Gold, P. W. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00263-7 · Cited by 78 · see citing works
Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings
May, P., Bowen, A. C., Tong, S. Y. C., Steer, A. C., Prince, S., Andrews, R. M., Currie, B. J., & Carapetis, J. R. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0335-0 · Cited by 76 · see citing works
A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro
Yagui, K., Shimada, F., Mimura, M., Hashimoto, N., Suzuki, Y., Tokuyama, Y., Nata, K., Tohgo, A., Ikehata, F., Takasawa, S., et al. (1998) · Diabetologia · doi:10.1007/s001250051026 · Cited by 74 · see citing works
BLOOD SUGAR STUDIES IN DEMENTIA PRAECOX AND MANIC-DEPRESSIVE INSANITY
Raphael, T. (1921) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1921.02180300052005 · Cited by 74 · see citing works
Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls
Quintana, D. S., Westlye, L. T., Kaufmann, T., Rustan, Ø. G., Brandt, C. L., Haatveit, B., Steen, N. E., & Andreassen, O. A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12498 · Cited by 73 · cited 9× · see citing works
“These results have led to randomized controlled trials (RCTs) investigating its potential application in the treatment of various psychiatric disorders (for a review of published registered trials, see Quintana et al., 2016a).”
BackgroundInfluentialSelf-citation
Oxytocin neuron activation prevents hypertension that occurs with chronic intermittent hypoxia/hypercapnia in rats
Jameson, H. S., Bateman, R., Byrne, P., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00808.2015 · Cited by 73 · see citing works
Elevated plasma levels of oxytocin in obese subjects before and after gastric banding.
Stock, S., Granström, L., Bäckman, L., et al. (1989) · PubMed · Cited by 72 · see citing works
Metabolic Syndrome Is Associated with Learning and Recall Impairment in Middle Age
Hassenstab, J. J., Sweat, V., Bruehl, H., & Convit, A. J. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000296071 · Cited by 71 · see citing works
Lack of association between human plasma oxytocin and interpersonal trust in a prisoner’s dilemma paradigm
Christensen, J. C., Shiyanov, P. A., Estepp, J. R., & Schlager, J. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116172 · Cited by 69 · see citing works
Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis
Eckertova, M., Ondrejcakova, M., Krskova, K., Zorad, S., & Jezova, D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01037.x · Cited by 68 · see citing works
Variation in the oxytocin receptor gene influences neurocardiac reactivity to social stress and HPA function: A population based study
Norman, G. J., Hawkley, L. C., Luhmann, M., Ball, A. B., Cole, S. W., Berntson, G. G., & Cacioppo, J. T. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.006 · Cited by 67 · see citing works
Metabolic Syndrome, Prediabetes, and Brain Abnormalities on MRI in Patients With Manifest Arterial Disease: The SMART-MR Study
Tiehuis, A. M., van der Graaf, Y., Mali, W. P. T. M., Vincken, K. L., Muller, M., & Geerlings, M. I. (2014) · Diabetes Care · doi:10.2337/dc14-0154 · Cited by 63 · see citing works
Altered Cardiac Autonomic Function May Precede Insulin Resistance in Metabolic Syndrome
Chang, C., Yang, Y., Lu, F., Lin, T., Chen, J., Yeh, T. L., Wu, C., & Wu, J. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.07.031 · Cited by 62 · see citing works
A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness
Quintana, D. S., Kemp, A. H., Alvares, G. A., & Guastella, A. J. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00048 · Cited by 61 · see citing works
Self-citation
Chronic sugar intake dampens feeding-related activity of neurons synthesizing a satiety mediator, oxytocin
Mitra, A., Gosnell, B. A., Schiöth, H. B., Grace, M. K., Klockars, A., Olszewski, P. K., & Levine, A. S. (2010) · Peptides · doi:10.1016/j.peptides.2010.04.005 · Cited by 61 · see citing works
Effects of Central Oxytocin Administration on Intraoral Intake of Glucose in Deprived and Nondeprived Rats
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57 · see citing works
Vagal afferent fibres determine the oxytocin‐induced modulation of gastric tone
Holmes, G. M., Browning, K. N., Babic, T., Fortna, S. R., Coleman, F. H., & Travagli, R. A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.253732 · Cited by 56 · see citing works
Oxytocin: A Conditional Anorexigen whose Effects on Appetite Depend on the Physiological, Behavioural and Social Contexts
Olszewski, P. K., Klockars, A., & Levine, A. S. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12376 · Cited by 56 · see citing works
Involvement of Prolactin‐Releasing Peptide in the Activation of Oxytocin Neurones in Response to Food Intake
Yamashita, M., Takayanagi, Y., Yoshida, M., Nishimori, K., Kusama, M., & Onaka, T. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12019 · Cited by 52 · see citing works
Longitudinal course of behavioural and emotional problems of young persons with Prader-Willi, Fragile X, Williams and Down syndromes
Einfeld, S., Tonge, B. J., TURNER, G. M., Parmenter, T. R., & Smith, A. (1999) · Journal of Intellectual & Developmental Disability · doi:10.1080/13668259900034111 · Cited by 51 · see citing works
Oxytocin stimulates colonic motor activity in healthy women
Ohlsson, B., Ringström, G., Abrahamsson, H., et al. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00507.x · Cited by 51 · see citing works
Central Oxytocin and Food Intake: Focus on Macronutrient-Driven Reward
Klockars, A., Levine, A. S., & Olszewski, P. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00065 · Cited by 46 · see citing works
Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large U.S. cohorts
Chang, S.-C., Glymour, M. M., Rewak, M., Cornelis, M. C., Walter, S., Koenen, K. C., Kawachi, I. I., Liang, L., Tchetgen, E. J. T., & Kubzansky, L. D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.024 · Cited by 44 · see citing works
The effect of oxytocin on basal and pethidine‐induced delayed gastric emptying.
Petring, O. (1989) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1989.tb05434.x · Cited by 42 · see citing works
Oxytocin response to insulin-induced hypoglycemia in obese subjects before and after weight loss
Coiro, V., Passeri, M., Davoli, C., d'Amato, L., Gelmini, G., Fagnoni, F. F., Schianchi, L., Bentivoglio, M., Volpi, R., & Chiodera, P. (1988) · Journal of Endocrinological Investigation · doi:10.1007/bf03350119 · Cited by 41 · see citing works
The effects of a single dose of oxytocin on working memory in schizophrenia
Michalopoulou, P. G., Averbeck, B. B., Kalpakidou, A. K., Evans, S., Bobin, T., Kapur, S., & Shergill, S. S. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.029 · Cited by 41 · see citing works
Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia
Davis, M. C., Horan, W. P., Nurmi, E. L., Rizzo, S., Li, W. W., Sugar, C. A., & Green, M. F. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.006 · Cited by 40 · see citing works
Oxytocin decreases blood pressure in male but not in female spontaneously hypertensive rats
Petersson, M., Lundeberg, T., & Uvnäs‐Moberg, K. (1997) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(97)00040-4 · Cited by 40 · see citing works
A new horizon: oxytocin as a novel therapeutic option for obesity and diabetes
Cai, D., & Purkayastha, S. (2013) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2013.05.006 · Cited by 38 · see citing works
Prolonged post-vagotomy gastric atony treated by oxytocin
Hashmonai, M., Torem, S., Argov, S., Barzilai, A., & SCHRAMEK, A. (1979) · British journal of surgery · doi:10.1002/bjs.1800660809 · Cited by 37 · see citing works
Pituitary Portal Plasma Levels of Oxytocin during the Estrous Cycle, Lactation, and Hyperprolactinemia
Sarkar, D. K., Frautschy, S. A., & Mitsugi, N. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34370.x · Cited by 35 · see citing works
Acute Effects of Oxytocin and Vasopressin on Plasma Levels of Glucagon, Insulin and Glucose in Rabbits
Knudtzon, J. (1983) · Hormone and Metabolic Research · doi:10.1055/s-2007-1018641 · Cited by 34 · see citing works
Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome
Yuan, G., Qian, W., Pan, R., Jia, J., Jiang, D., Yang, Q., Wang, S., Liu, Y., Yu, S., Hu, H., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0078 · Cited by 33 · see citing works
Behavioral effects of intracerebroventricular injection of oxytocin in birds
Jonaidi, H., Oloumi, M. M., & Denbow, D. M. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00145-8 · Cited by 32 · see citing works
The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol
Valstad, M., Alvares, G. A., Andreassen, O. A., Westlye, L. T., & Quintana, D. S. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0225-5 · Cited by 31 · see citing works
Self-citation
Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome
Hoth, K. F., Gonzales, M. M., Tarumi, T., Miles, S. C., Tanaka, H., & Haley, A. P. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2315 · Cited by 30 · see citing works
Effects of annetocin, an oxytocin‐related peptide isolated from the earthworm Eisenia foetida, and some putative neurotransmitters on gut motility of the earthworm
Ukena, K., Oumi, T., Matsushima, O., Ikeda, T., Fujita, T., Minakata, H., & Nomoto, K. (1995) · Journal of Experimental Zoology · doi:10.1002/jez.1402720303 · Cited by 28 · see citing works
Induced Pluripotent Stem Cells: An Emerging Technology Platform and the Gartner Hype Cycle
Mason, C., & Manzotti, E. (2009) · Regenerative Medicine · doi:10.2217/rme.09.20 · Cited by 28 · see citing works
Regional cortical thickness and subcortical volume changes in patients with metabolic syndrome
Song, S.-W., Chung, J., Rho, J. S., Lee, Y.-A., Lim, H. K., Kang, S. G., Kim, H.-N., Kim, J. E., & Kim, S. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9311-2 · Cited by 26 · see citing works
Binding and structural properties of oxytocin receptors in isolated rat epididymal adipocytes
Boland, D., & Goren, H. J. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90045-0 · Cited by 23 · see citing works
When too much of a good thing is bad: chronic oxytocin, development, and social impairments
Young, L. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.015 · Cited by 22 · see citing works
Oxytocin - An Emerging Treatment for Obesity and Dysglycemia: Review of Randomized Controlled Trials and Cohort Studies
Barengolts, E. I. (2016) · Endocrine Practice · doi:10.4158/ep151192.ra · Cited by 21 · see citing works
The micro-module learning tests: work-sample assessments of responsiveness to skills training.
Silverstein, S., Wallace, C., & Schenkel, L. S. (2005) · Schizophrenia bulletin · doi:10.1093/schbul/sbi008 · Cited by 20 · see citing works
Unaltered Oxytocin and Vasopressin Plasma Levels in Patients with Schizophrenia After 4 Months of Daily Treatment with Intranasal Oxytocin
Busnelli, M., Dagani, J., de Girolamo, G., Balestrieri, M., Pini, S., Saviotti, F. M., Scocco, P., Sisti, D., Rocchi, M., & Chini, B. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12359 · Cited by 18 · see citing works
Effects of Oxytocin Delivery on Counter-Regulatory Hormone Response in Insulin-Dependent (Type 1) Diabetic Subjects
Paolisso, G., Sgambato, S., Giugliano, D., et al. (2008) · Hormone Research · doi:10.1159/000181126 · Cited by 17 · see citing works
Effect of the interaction between food state and the action of estrogen on oxytocinergic system activity
Lucio-Oliveira, F., & Franci, C. R. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0272 · Cited by 17 · see citing works
Clock Gene Modulates Roles of OXTR and AVPR1b Genes in Prosociality
Ci, H., Wu, N., & Su, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109086 · Cited by 14 · see citing works
Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders
Haram, M., Bettella, F., Brandt, C. L., Quintana, D. S., Nerhus, M., Bjella, T., Djurovic, S., Westlye, L. T., Andreassen, O. A., Melle, I., et al. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.116.003376 · Cited by 13 · see citing works
Oxytocin Receptors and Human Parturition
Fuchs, A., Fuchs, F., Husslein, P. W., et al. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198209000-00002 · Cited by 5 · see citing works
P.1.g.055 Intranasal oxytocin dampens amygdala reactivity and normalises amygdala connectivity in PTSD patients
Koch, S. B. J., van Zuiden, M., Nawijn, L., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(15)30308-4 · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Is oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Self-citation
Salivary oxytocin concentration changes during a group drumming intervention for maltreated school children
Yuhi, T., Kyuta, H., Mori, H.-A., Murakami, C., Furuhara, K., Okuno, M., Takahashi, M., Fuji, D., & Higashida, H. (2017) · Brain Sciences · doi:10.3390/brainsci7110152 · Cited by 32 · see citing works

Psychotic Controls in Schizophrenia Research
Ritzler, B. A., & Rinehart, K. (1981) · Schizophrenia Bulletin · doi:10.1093/schbul/7.4.729 · Cited by 4 · see citing works
Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder
Gotra, M. Y., Hill, S. K., Gershon, E. S., Tamminga, C. A., Ivleva, E. I., Pearlson, G. D., Keshavan, M. S., Clementz, B. A., McDowell, J. E., Buckley, P. F., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.06.033 · Cited by 32 · see citing works
Common variant at 16p11.2 conferring risk of psychosis
Steinberg, S., de Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietiläinen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.157 · Cited by 104 · see citing works
Self-citation
Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
Keck, P. E., McElroy, S. L., Havens, J. R., Altshuler, L. L., Nolen, W. A., Frye, M. A., Suppes, T. M., Denicoff, K. D., Kupka, R., Leverich, G. S., et al. (2003) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(03)00089-0 · Cited by 201 · see citing works
Cognitive functions in late-onset psychosis
Гаяровна, А. Е., Ma, S., Rupchev, G., Sheshenin, V., & Витальевна, П. В. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212206163 · Cited by 5 · see citing works

Authors: Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A.
Affiliations: Oslo University Hospital (NO)
Corresponding author: Quintana, Daniel S.
ORCID: Quintana, Daniel S.
Dieset, Ingrid
Elvsåshagen, Torbjørn
Westlye, Lars T.
Andreassen, Ole A.
Venue: Frontiers in Neuroendocrinology
Publisher: Elsevier BV
Published: 2017-04
Volume: 45
Pages: 1-10
ISSN: 0091-3022 (ISSN-L)
DOI: 10.1016/j.yfrne.2016.12.004
OpenAlex: W2566824518
Semantic Scholar: f27c0d8fb94f98744d1c0490788db11a11b95b11
Cited by: 39
References: 201
Citations by year: 2026: 3 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 8 · 2017: 5
FWCI: 1.01
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Frontiers in Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders: Novo Nordisk Foundation (NNF16OC0019856)
Research Council of Norway and OptiNose AS (BIA 219483)
Research Council of Norway CoE grant (223273)
South-Eastern Norway Regional Health Authority grants (2014-097, 2016-064)
KG Jebsen Foundation (SKGJ‐MED‐008)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: metabolic syndrome, schizophrenia, bipolar disorder, psychosis, intranasal oxytocin, social dysfunction, metabolic dysfunction, metabolic risk factors
MeSH terms: Animals, Bipolar Disorder, Humans, Oxytocin, Psychotic Disorders, Schizophrenia, Treatment Outcome, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks