The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
Open accessAbstract
Administration of oxytocin has been proposed as a treatment for the core symptoms of autism spectrum disorder (ASD), including social-communicative deficit. Previous clinical trials have investigated the efficacy and safety of oxytocin intranasal single-dose and long-term administration for individuals with ASD. All studies suggest that singledose and long-term administration are well tolerated, and no severe adverse events have been reported. However, the efficacy of long-term oxytocin administration is controversial. Some studies have reported significant improvement of the core symptoms of ASD by long-term oxytocin administration, while other studies showed no such improvement. To elucidate the factors influencing the efficacy of oxytocin administration, it is necessary to examine the effects of administration schedules (e.g., dosage amount, frequency per day) and participant characteristics (e.g., age, sex, intellectual ability). In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal oxytocin administration, which could be essential for establishing optimal oxytocin treatments for individuals with ASD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intranasal oxytocin administration may be effective for autism spectrum disorder.
“recent studies have proposed that intranasal oxytocin administration may be effective.2, 3”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555 · see citing works
Baron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 3× · see citing works
“Oxytocin administration changes not only social behaviors but also neural responses [11, 21, 22].”
BackgroundResultAdult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773 · see citing works
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689 · see citing works
Gastrointestinal microbiota in children with autism in Slovakia
Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632 · see citing works
Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · cited 1× · see citing works
“Second, it is debatable whether the incremental amount of CSF oxytocin increase due to intranasal oxytocin administration is sufficient to modulate brain function and behaviors [67].”
BackgroundOxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder
Labuschagne, I., Phan, K. L., Wood, A., Angstadt, M., Chua, P., Heinrichs, M., Stout, J. C., & Nathan, P. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.123 · Cited by 549 · see citing works
Striepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013) · Scientific Reports · doi:10.1038/srep03440 · Cited by 452 · see citing works
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416 · see citing works
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
Oxytocin Makes a Face in Memory Familiar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4260-08.2009 · Cited by 402 · see citing works
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383 · cited 1× · see citing works
“In TD individuals, they suggested that the oxytocininduced effect was modulated by personal history; for instance, positive oxytocin effects on behavior and neurobiology is attenuated in individuals with negative childhood experiences [61].”
BackgroundAnagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350 · see citing works
Yatawara, C. J., Einfeld, S. L., Hickie, I. B., Davenport, T. A., & Guastella, A. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.162 · Cited by 344 · see citing works
The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis
LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343 · see citing works
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., Schneiderman, N., & Mendez, A. J. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821df0c2 · Cited by 330 · see citing works
Guastella, A. J., Gray, K. M., Rinehart, N. J., Alvares, G. A., Tonge, B. J., Hickie, I. B., Keating, C. M., Cacciotti‐Saija, C., & Einfeld, S. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12305 · Cited by 299 · see citing works
Bales, K. L., Perkeybile, A. M., Conley, O. G., Lee, M. H., Guoynes, C. D., Downing, G. M., Yun, C. R., Solomon, M., Jacob, S., & Mendoza, S. P. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.025 · Cited by 265 · see citing works
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255 · see citing works
Chang, S. W. C., Barter, J. W., Ebitz, R. B., Watson, K. K., & Platt, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114621109 · Cited by 252 · cited 3× · see citing works
“Elevated levels following intranasally injected oxytocin were also confirmed in non-human primates [62-64].”
BackgroundNasal oxytocin for social deficits in childhood autism: A randomized controlled trial
Dadds, M. R., MacDonald, E., Cauchi, A., Williams, K., Levy, F., & Brennan, J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1899-3 · Cited by 250 · see citing works
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 250 · see citing works
Auyeung, B., Lombardo, M. V., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J. B., Bethlehem, R. A. I., Dickens, L., Mooney, N., Sipple, J. A. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.146 · Cited by 234 · see citing works
The prevalence puzzle: Autism counts
Weintraub, K. (2011) · Nature · doi:10.1038/479022a · Cited by 234 · see citing works
Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism
Watanabe, T., Kuroda, M., Kuwabara, H., Aoki, Y., Iwashiro, N., Tatsunobu, N., Takao, H., Nippashi, Y., Kawakubo, Y., Kunimatsu, A., et al. (2015) · Brain · doi:10.1093/brain/awv249 · Cited by 222 · see citing works
The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy
Wu, N., Li, Z., & Su, Y. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.009 · Cited by 221 · see citing works
Parker, K. J., Garner, J. P., Libove, R. A., Hyde, S. A., Hornbeak, K. B., Carson, D. S., Liao, C.-P., Phillips, J. M., Hallmayer, J. F., & Hardan, A. Y. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402236111 · Cited by 215 · see citing works
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212 · see citing works
Chronic and acute intranasal oxytocin produce divergent social effects in mice
Huang, H., Michetti, C., Busnelli, M., Managò, F., Sannino, S., Scheggia, D., Giancardo, L., Sona, D., Murino, V., Chini, B., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.310 · Cited by 199 · see citing works
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187 · see citing works
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3181 · Cited by 183 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
CSF and blood oxytocin concentration changes following intranasal delivery in macaque
Dal Monte, O., Noble, P. L., Turchi, J., Cummins, A., & Averbeck, B. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103677 · Cited by 177 · see citing works
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
Munesue, T., Yokoyama, S., Nakamura, K., Anitha, A., Yamada, K., Hayashi, K., Asaka, T., Liu, H.-X., Jin, D., Koizumi, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.004 · Cited by 177 · see citing works
Scheele, D., Kendrick, K. M., Khouri, C., Kretzer, E., Schläpfer, T. E., Stoffel-Wagner, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.78 · Cited by 171 · see citing works
Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160 · see citing works
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155 · see citing works
Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., Oishi, M., Kimura, T., Onaka, T., Ozono, K., et al. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0048 · Cited by 151 · see citing works
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143 · see citing works
Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques
Modi, M. E., Connor-Stroud, F., Landgraf, R., Young, L. J., & Parr, L. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.011 · Cited by 129 · see citing works
Association of social and cognitive impairment and biomarkers in autism spectrum disorders
Alabdali, A., Al-Ayadhi, L., & El-Ansary, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-4 · Cited by 117 · see citing works
Oxytocin and Autism: A Systematic Review of Randomized Controlled Trials
Preti, A., Melis, M., Siddi, S., Vellante, M., Doneddu, G., & Fadda, R. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0040 · Cited by 114 · see citing works
Goldman, M. B., Gomes, A. M., Carter, C. S., & Lee, R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2193-8 · Cited by 112 · see citing works
Maternal oxytocin response predicts mother-to-infant gaze
Kim, S., Fonagy, P., Koos, O., Dorsett, K., & Strathearn, L. (2014) · Brain Research · doi:10.1016/j.brainres.2013.10.050 · Cited by 102 · see citing works
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95 · see citing works
Parent–child interaction and oxytocin production in pre-schoolers with autism spectrum disorder
Feldman, R., Golan, O., Hirschler‐Guttenberg, Y., Ostfeld‐Etzion, S., & Zagoory‐Sharon, O. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.137513 · Cited by 86 · see citing works
Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia
AL-Ayadhi, L. Y. (2005) · Neurosciences · doi:10.17712/1658-3183.1311 · Cited by 71 · see citing works
Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
Kosaka, H., Munesue, T., Ishitobi, M., Asano, M., Omori, M., Sato, M., Tomoda, A., & Wada, Y. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-110 · Cited by 65 · see citing works
Self-citationDeveloping Drugs for Core Social and Communication Impairment in Autism
Posey, D. J., Erickson, C. A., & McDougle, C. J. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2008.06.010 · Cited by 62 · see citing works
Taurines, R., Schwenck, C., Lyttwin, B., Schecklmann, M., Jans, T., Reefschläger, L., Geissler, J. M., Gerlach, M., & Romanos, M. (2014) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0145-y · Cited by 61 · see citing works
Yamasue, H. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12364 · Cited by 58 · see citing works
Quintana, D. S., & Woolley, J. D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.021 · Cited by 46 · see citing works
Evidence for alterations in stimulatory G proteins and oxytocin levels in children with autism
Jacobson, J. D., Ellerbeck, K. A., Kelly, K., Fleming, K., Jamison, T. R., Coffey, C. W., Smith, C. M., Reese, R. M., & Sands, S. A. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.014 · Cited by 41 · see citing works
Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Kawakubo, Y., et al. (2014) · UCL Discovery (University College London) · Cited by 10 · see citing works
Leng, G., & Ludwig, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.022 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., Loth, E., McAlonan, G. M., McCracken, J. T., Parr, J. R., et al. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117741766 · Cited by 342 · see citing works
Lai, M.-C., Anagnostou, E., Wiznitzer, M., Allison, C., & Baron-Cohen, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30034-x · Cited by 250 · see citing works
The effects of oxytocin on eating behaviour and metabolism in humans
Lawson, E. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.115 · Cited by 196 · see citing works
Miller, J. L., Tamura, R., Butler, M. G., Kimonis, V. E., Sulsona, C. R., Gold, J., & Driscoll, D. J. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38160 · Cited by 149 · see citing works
Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis
Huang, Y., Huang, X., Ebstein, R. P., & Yu, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.028 · Cited by 119 · see citing works
Kosaka, H., Okamoto, Y., Munesue, T., Yamasue, H., Inohara, K., Fujioka, T., Anme, T., Orisaka, M., Ishitobi, M., Jung, M., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.152 · Cited by 117 · see citing works
Self-citationSmith, A. S., Korgan, A. C., & Young, W. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104324 · Cited by 107 · see citing works
Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans
Hansson, A. C., Koopmann, A., Uhrig, S., Bühler, S., Domi, E., Kiessling, E., Ciccocioppo, R., Froemke, R. C., Grinevich, V., Kiefer, F., et al. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.257 · Cited by 109 · see citing works
Cai, Q., Feng, L., & Yap, K. Z. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12627 · Cited by 77 · see citing works
Zhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
Clinical trials in autism spectrum disorder: evidence, challenges and future directions
Anagnostou, E. A. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000542 · Cited by 72 · see citing works
Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator
Meguro, Y., Miyano, K., Hirayama, S., Yoshida, Y., Ishibashi, N., Ogino, T., Fujii, Y., Manabe, S., Eto, M., Nonaka, M., et al. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.04.002 · Cited by 68 · see citing works
Higashida, H., Munesue, T., Kosaka, H., Yamasue, H., Yokoyama, S., & Kikuchi, M. (2019) · Diseases · doi:10.3390/diseases7010024 · Cited by 64 · see citing works
Self-citationTorres, N., Martins, D., dos Santos, A. J., Prata, D. P., & Veríssimo, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.004 · Cited by 46 · see citing works
Effects of Intranasal Oxytocin on Long‐Term Memory in Healthy Humans: A Systematic Review
Brambilla, M., Manenti, R., de Girolamo, G., Adenzato, M., Bocchio‐Chiavetto, L., & Cotelli, M. (2016) · Drug Development Research · doi:10.1002/ddr.21343 · Cited by 31 · see citing works
Yang, J., Liu, Y., Xu, Y., Li, X., Fu, J., Jiang, X., Chou, Y., Ma, J., Hao, R., Zhang, R., et al. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s203464 · Cited by 25 · see citing works
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 23 · see citing works
Oxytocin and vasopressin in the hippocampus
Zăgrean, A., Georgescu, I.-A., Ieșanu, M. I., Ionescu, R.-B., Haret, R. M., Panaitescu, A. M., & Zăgrean, L. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.11.002 · Cited by 20 · see citing works
Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex
Duchemin, A., Seelke, A. M. H., Simmons, T. C., Freeman, S. M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.017 · Cited by 19 · see citing works
Higashida, H., Furuhara, K., Lopatina, O. L., Gerasimenko, M., Hori, O., Hattori, T., Hayashi, Y., Михайлович, Ч. С., Shabalova, A. A., Salmina, A. B., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.858070 · Cited by 13 · see citing works
Trieu, M., Foster, A. E., Yaseen, Z. S., Beaubian, C., & Calati, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-29876-0_2 · Cited by 12 · see citing works
Mahmuda, N. A., Yokoyama, S., Munesue, T., Hayashi, K., Yagi, K., Tsuji, C., & Higashida, H. (2020) · Diseases · doi:10.3390/diseases8010004 · Cited by 8 · see citing works
Nasal Delivery of High Molecular Weight Drugs: Recent Trends and Clinical Evidence
Kahraman, E., Güngör, S., & Özsoy, Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-23112-4_13 · Cited by 7 · see citing works
A Placebo-Controlled Crossover Trial of Gastrin-Releasing Peptide in Childhood Autism
Marchezan, J., Becker, M. M., Schwartsmann, G., Ohlweiler, L., Roesler, R., Renck, L. B., Gonçalves, M. M. M., Ranzan, J., & Riesgo, R. D. S. (2017) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000213 · Cited by 6 · see citing works
Lai, M., Anagnostou, E. A., Wiznitzer, M., Allison, C. L., & Baron‐Cohen, S. (2018) · doi:10.31219/osf.io/8z5rv · Cited by 5 · see citing works
From bedside to bench and back: Translating ASD models
Drozd, H. P., Karathanasis, S. F., Molosh, A. I., Lukkes, J. L., Clapp, D. W., & Shekhar, A. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.10.003 · Cited by 3 · see citing works
Social dysfunction in autism spectrum disorder: Tactility and oxytocin
Yujie, H., Rong, Z., Libinuer·aierken, K., Jingjing, L., Junqi, W., Haiping, P., & Jun, G. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.00800 · Cited by 2 · see citing works
The multifarious oxytocin: a review
Kapur, A., & Kapur, V. (2019) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20191717 · Cited by 2 · see citing works
Measuring Affinity of Ligands to the Oxytocin Receptor Using Radioligand Binding
Werry, E. L., & Kassiou, M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1759-5_14 · Cited by 2 · see citing works
Kumkum, M., Marzan, L. W., Akter, S., Biswas, S. C., Chowdhury, M. A., & Hossain, M. A. (2020) · Asian Journal of Medical and Biological Research · doi:10.3329/ajmbr.v6i2.48048 · Cited by 1 · see citing works
Kishikawa, N., Ajiki, H., El‐Maghrabey, M., & Kuroda, N. (2025) · Chromatography · doi:10.15583/jpchrom.2025.009
Fang, G., Pan, W., Li, G., Ma, L., & Wei, J. (2026) · ALPHA PSYCHIATRY · doi:10.31083/ap45322
- Authors
- Okamoto, Y., Ishitobi, M., Wada, Y., & Kosaka, H.
- Affiliations
- Kanazawa University (JP)
- University of Fukui (JP)
- Corresponding author
- Kosaka, Hirotaka
- Venue
- CNS & Neurological Disorders - Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2016-05-05
- Volume
- 15
- Issue
- 5
- Pages
- 564-577
- ISSN
- 1568-007X (ISSN-L)
- 1871-5273
- PMC
- PMC5080861
- OpenAlex
- W2340485469
- Cited by
- 33
- References
- 72
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CNS & Neurological Disorders - Drug Targets (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (15K08093)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- intranasal oxytocin, autism spectrum disorder, administration schedule, pharmacokinetics, mechanism of action, treatment efficacy, adverse events
- MeSH terms
- Autism Spectrum Disorder, Administration, Intranasal, Animals, Humans, Oxytocin, Psychotropic Drugs, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
