The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses

Singewald, Georg M; Rjabokon, Alesja; Singewald, Nicolas; Ebner, Karl

doi:10.1038/npp.2010.213

Cited by 149Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses

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Singewald, Georg M, Rjabokon, Alesja, Singewald, Nicolas, Ebner, Karl·2011·Neuropsychopharmacology

DOI 10.1038/npp.2010.213PMC PMC3055728

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Abstract

The lateral septum (LS) has been shown to have a key role in emotional processes and stress responses. However, the exact role of the LS on stress modulation is not clear, as previous lesion studies mostly used electrolytic lesions, thereby destroying the whole septal area, including medial components and/or fibers of passage. The aim of the present study was therefore, to investigate the effects of selective excitotoxic ablation of the LS on neuroendocrine and behavioral stress responses in rats. Bilateral ibotenic acid lesions of the LS increased hypothalamo-pituitary-adrenocortical (HPA) axis responses to forced swim stress indicated by enhanced plasma ACTH and corticosterone responses and higher stress-induced c-Fos-like immunoreactivity in the paraventricular hypothalamic nucleus. Moreover, LS-lesioned animals showed a more passive coping style in the forced swim test indicated by increased floating and reduced struggling/swimming behavior compared with sham-lesioned controls. Interestingly, intraseptal corticosteroid receptor blockade modulated behavioral stress coping but failed to change HPA axis stress responses. Further experiments aimed at elucidating underlying neurochemical mechanisms revealed that intraseptal administration of the selective 5-HT(1A) receptor antagonist WAY-100635 increased and prolonged stress-induced ACTH and corticosterone levels mimicking lesion effects, while the agonist 8-OH-DPAT suppressed HPA axis activity facilitating the inhibitory role of the LS. In addition, 8-OH-DPAT-injected animals showed increased active and decreased passive coping strategies during forced swimming suggesting antidepressant efficacy. Taken together, our data suggest that the LS promotes active stress coping behavior and is involved in a HPA-inhibitory mechanism that is at least in part mediated by septal 5-HT(1A) receptors and does not involve a glucocorticoid mediated feedback mechanism.

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Excitotoxic LS lesions can enhance stress-induced activation of the HPA axis.
“The existence of anxiolytic neurons is supported by the observation that excitotoxic LS lesions can enhance stress-induced activation of the HPA axis (Singewald et al., 2011).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Singewald et al., 2011

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Serotonin and stress coping
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“The lateral septum inhibits HPA axis stress responses, and the anatomy of the septal region suggests interactions with hypothalamic and brainstem regions projecting to the PVN (Staiger and Nurnberger 1991; Singewald et al. 2011).”
Individual differences in stress susceptibility and stress inhibitory mechanisms
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Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
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The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice
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An insular view of the social decision-making network
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Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction
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Lateral septum as a nexus for mood, motivation, and movement
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The behavioral phenotype of pituitary adenylate-cyclase activating polypeptide-deficient mice in anxiety and depression tests is accompanied by blunted c-Fos expression in the bed nucleus of the stria terminalis, central projecting Edinger–Westphal nucleus, ventral lateral septum, and dorsal raphe nucleus
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Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects
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How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish
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A limbic circuitry involved in emotional stress-induced grooming
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Characterization of GABAergic Neurons in the Mouse Lateral Septum: A Double Fluorescence In Situ Hybridization and Immunohistochemical Study Using Tyramide Signal Amplification
Zhao, C., Eisinger, B., & Gammie, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073750 · Cited by 105 · see citing works
Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: Possible role in edema resolution?
Fukuda, A. M., Pop, V., Spagnoli, D., Ashwal, S., Obenaus, A., & Badaut, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.033 · Cited by 94 · see citing works
Empathy and stress related neural responses in maternal decision making
Ho, S.-H. S., Konrath, S., Brown, S., & Swain, J. E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00152 · Cited by 93 · see citing works
Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects
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A limbic circuit selectively links active escape to food suppression
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An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses Feeding
Sweeney, P. R., & Yang, Y. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2042-16.2016 · Cited by 90 · see citing works
Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior
Mirrione, M. M., Schulz, D., Lapidus, K. A. B., Zhang, S., Goodman, W. K., & Henn, F. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00029 · Cited by 86 · see citing works
Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal
Plaza‐Zabala, A., Flores, Á., Maldonado, R. J., & Berrendero, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.06.025 · Cited by 81 · see citing works
Current Understanding of the Neural Circuitry in the Comorbidity of Chronic Pain and Anxiety
Chen, T., Wang, J., Wang, Y.-Q., & Chu, Y. (2022) · Neural Plasticity · doi:10.1155/2022/4217593 · Cited by 80 · see citing works
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids l-Tryptophan and l-Phenylalanine
Liu, C., Bonaventure, P., Lee, G., Nepomuceno, D. H., Kuei, C., Wu, J., Li, Q. S., Joseph, V. T., Sutton, S. W., Eckert, W. A., et al. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.100412 · Cited by 76 · see citing works
Prefrontal/Amygdalar System Determines Stress Coping Behavior Through 5-HT/GABA Connection
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GABAergic implications in anxiety and related disorders
Arora, I., Mal, P., Arora, P., Paul, A., & Kumar, M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150218 · Cited by 68 · see citing works
Endogenous GLP-1 in lateral septum promotes satiety and suppresses motivation for food in mice
Terrill, S. J., Holt, M. K., Maske, C. B., Abrams, N., Reimann, F. M., Trapp, S., & Williams, D. L. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.04.008 · Cited by 59 · see citing works
Optogenetic Activation of CA1 Pyramidal Neurons at the Dorsal and Ventral Hippocampus Evokes Distinct Brain-Wide Responses Revealed by Mouse fMRI
Takata, N., Yoshida, K., Komaki, Y., Xu, M. Q., Sakai, Y., Hikishima, K., Mimura, M., Okano, H., & Tanaka, K. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121417 · Cited by 55 · see citing works
Animal models of endocrine disruption
Patisaul, H. B., Fenton, S. E., & Aylor, D. L. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.03.011 · Cited by 57 · see citing works
Endocrine Disruption of Vasopressin Systems and Related Behaviors
Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works
“This region is thought to play a key role in stress responses and emotional processing (84).”
Background
Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models
Scheich, B., Gaszner, B., Kormos, V., László, K., Ádori, C., Borbély, É., Hajna, Z., Tékus, V., Bölcskei, K., Ábrahám, I. M., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.021 · Cited by 52 · see citing works
Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping
Vindas, M. A., Fokos, S., Pavlidis, M. A., Höglund, E., Dionysopoulou, S., Ebbesson, L. O. E., Papandroulakis, N., & Dermon, C. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-23950-x · Cited by 50 · see citing works
Imaging, Behavior and Endocrine Analysis of “Jealousy” in a Monogamous Primate
Maninger, N., Mendoza, S. P., Williams, D. R., Mason, W. A., Cherry, S. R., Rowland, D. J., Schaefer, T., & Bales, K. L. (2017) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2017.00119 · Cited by 51 · see citing works
Identification of arginine vasotocin (AVT) neurons activated by acute and chronic restraint stress in the avian septum and anterior diencephalon
Nagarajan, G., Tessaro, B. A., Kang, S. W., & Kuenzel, W. J. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.04.012 · Cited by 50 · see citing works
Substance P: A neuropeptide involved in the psychopathology of anxiety disorders
Iftikhar, K., Siddiq, A., Baig, S. G., & Zehra, S. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101993 · Cited by 48 · see citing works
GABAergic Signaling within a Limbic-Hypothalamic Circuit Integrates Social and Anxiety-Like Behavior with Stress Reactivity
Myers, B., de Carvalho-Netto, E. F., Wick, D. M., Wu, C. S., Naser, S., Solomon, M. B., Ulrich‐Lai, Y. M., & Herman, J. P. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.311 · Cited by 47 · see citing works
Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons
Smith, J., Honig-Frand, A., Antila, H., Choi, A., Kim, H., Beier, K. T., Weber, F., & Chung, S. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.035 · Cited by 45 · see citing works
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain
Li, Y., Wang, Q., Li, M., Hu, S.-F., & Xu, G. (2022) · Pain · doi:10.1097/j.pain.0000000000002750 · Cited by 44 · see citing works
Oxytocin neurons mediate stress-induced social memory impairment
Zhan, S., Qi, Z., Cai, F., Gao, Z., Xie, J., & Hu, J. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.037 · Cited by 44 · see citing works
Molecular fMRI of Serotonin Transport
Hai, A., Cai, L. X., Lee, T., Lelyveld, V. S., & Jasanoff, A. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.048 · Cited by 39 · see citing works
Social dominance and the Affective Neuroscience Personality Scales
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Endogenous GLP-1 in lateral septum contributes to stress-induced hypophagia
Terrill, S. J., Maske, C. B., & Williams, D. L. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.03.001 · Cited by 40 · see citing works
Appetite suppressive role of medial septal glutamatergic neurons
Sweeney, P. R., Li, C., & Yang, Y. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707228114 · Cited by 38 · see citing works
Frustrative reward omission increases aggressive behaviour of inferior fighters
Vindas, M. A., Johansen, I. B., Vela-Avitúa, S., Nørstrud, K. S., Aalgaard, M., Braastad, B. O., Höglund, E., & Øverli, Ø. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0300 · Cited by 37 · see citing works
Selective attention to emotional cues and emotion recognition in healthy subjects: the role of mineralocorticoid receptor stimulation
Schultebraucks, K., Deuter, C. E., Duesenberg, M., Schulze, L., Hellmann‐Regen, J., Domke, A., Lockenvitz, L., Kuehl, L. K., Otte, C., & Wingenfeld, K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4380-0 · Cited by 36 · see citing works
Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation
Malta, M. B., Martins, J., Novaes, L. S., dos Santos, N. B., Sita, L. V., Camarini, R., Scavone, C., Bittencourt, J. C., & Munhoz, C. D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02470-2 · Cited by 35 · see citing works
Effects of chronic treatment with corticosterone and imipramine on fos immunoreactivity and adult hippocampal neurogenesis.
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Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat
Felice, V. D., Gibney, S. M., Gosselin, R., Dinan, T. G., O’Mahony, S. M., & Cryan, J. F. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.064 · Cited by 36 · see citing works
Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period
Zhao, C., & Gammie, S. C. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.023 · Cited by 35 · see citing works
Activation of ventral CA1 hippocampal neurons projecting to the lateral septum during feeding
Kosugi, K., Yoshida, K., Suzuki, T., Kobayashi, K., Yoshida, K., Mimura, M., & Tanaka, K. F. (2020) · Hippocampus · doi:10.1002/hipo.23289 · Cited by 32 · see citing works
Activity in a prefrontal-periaqueductal gray circuit overcomes behavioral and endocrine features of the passive coping stress response
Johnson, S. B., Lingg, R. T., Skog, T. D., Hinz, D. C., Romig‐Martin, S. A., Viau, V., Narayanan, N. S., & Radley, J. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210783119 · Cited by 32 · see citing works
Involvement of CRF2 receptor in the brain regions in restraint-induced anorexia
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Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors
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Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
Joseph, A., Thủy, T. T. T., Thanh, L. T., & Okada, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201092 · Cited by 29 · see citing works
Neuroligin-2 Determines Inhibitory Synaptic Transmission in the Lateral Septum to Optimize Stress-Induced Neuronal Activation and Avoidance Behavior
Troyano‐Rodriguez, E., Wirsig‐Wiechmann, C. R., & Ahmad, M. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.01.022 · Cited by 29 · see citing works
Activation of septal OXTr neurons induces anxiety- but not depressive-like behaviors
Huang, T., Guan, F., Licinio, J., Wong, M., & Yang, Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01283-y · Cited by 28 · see citing works
Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by Desipramine and Citalopram
Choi, S. H., Chung, S., Cho, J. H., Cho, Y. H., Kim, J. W., Kim, J., Kim, H. J., Kim, H. J., & Shin, K. H. (2013) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2013.17.4.321 · Cited by 27 · see citing works
Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections
Lu, Y., Wang, L., Luo, F., Savani, R. H., Rossi, M. A., & Pang, Z. P. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101960 · Cited by 26 · see citing works
The stress-inducible actin-interacting protein DRR1 shapes social behavior
Masana, M., Su, Y., Liebl, C., Wang, X., Jansen, L., Westerholz, S., Wagner, K. V., Labermaier, C., Scharf, S. H., Santarelli, S., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.06.009 · Cited by 26 · see citing works
Pattern of c-Fos expression induced by tail suspension test in the mouse brain
Hiraoka, K., Motomura, K., Yanagida, S., Ohashi, A., Ishisaka-Furuno, N., & Kanba, S. (2017) · Heliyon · doi:10.1016/j.heliyon.2017.e00316 · Cited by 26 · see citing works
A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h
Jing, W., Zhang, T., Liu, J., Huang, X., Yu, Q., Yu, H., Zhang, Q., Li, H., Deng, M., Zhu, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110177 · Cited by 25 · see citing works
Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration
Zanos, P., Georgiou, P., Metaxas, A., Kitchen, I., Winsky‐Sommerer, R., & Bailey, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.054 · Cited by 23 · see citing works
Inhibition in the lateral septum increases sucrose intake and decreases anorectic effects of stress
Mitra, A., Lenglos, C., & Timofeeva, E. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12798 · Cited by 23 · see citing works
The role of the lateral septum in neuropsychiatric disease
Patel, H. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25052 · Cited by 24 · see citing works
Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity
Li, Z., Lin, Z., Ji, S., Lai, K. P., Wan, H., Wong, C. K. C., & Li, L. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156881 · Cited by 23 · see citing works
Antidepressant-like effects of mineralocorticoid but not glucocorticoid antagonists in the lateral septum: Interactions with the serotonergic system
Mostalac-Preciado, C. R., de Gortari, P., & López‐Rubalcava, C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.008 · Cited by 23 · see citing works
Neurobiology of Wild and Hatchery-Reared Atlantic Salmon: How Nurture Drives Neuroplasticity
Mes, D., von Krogh, K., Gorissen, M., Mayer, I., & Vindas, M. A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00210 · Cited by 22 · see citing works
Enhanced Responsiveness to Selective Serotonin Reuptake Inhibitors during Lactation
Jury, N. J., McCormick, B. A., Horseman, N. D., Benoit, S. C., & Gregerson, K. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117339 · Cited by 21 · see citing works
Glutamic acid decarboxylase 65 and 67 expression in the lateral septum is up-regulated in association with the postpartum period in mice
Zhao, C., Driessen, T. M., & Gammie, S. C. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.002 · Cited by 22 · see citing works
Regional distribution of cholinergic, catecholaminergic, serotonergic and orexinergic neurons in the brain of two carnivore species: The feliform banded mongoose ( Mungos mungo ) and the caniform domestic ferret ( Mustela putorius furo )
Pillay, S., Bhagwandin, A., Bertelsen, M. F., Patzke, N., Engler, G., Engel, A. K., & Manger, P. R. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.04.001 · Cited by 21 · see citing works
Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice
Iemolo, A., Montilla‐Perez, P., Nguyen, J. D., Risbrough, V. B., Taffe, M. A., & Telese, F. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108495 · Cited by 18 · see citing works
PACAP regulates neuroendocrine and behavioral stress responses via CRF-containing neurons of the rat hypothalamic paraventricular nucleus
Ebner, K., Fontebasso, V., Ferro, F., Singewald, N., & Hannibal, J. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02016-9 · Cited by 20 · see citing works
Activation of Somatostatin-Expressing Neurons in the Lateral Septum Improves Stress-Induced Depressive-like Behaviors in Mice
Li, H., Sung, H. H., & Lau, C. G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102253 · Cited by 18 · see citing works
Effect of acute imipramine administration on the pattern of forced swim-induced c-Fos expression in the mouse brain
Yanagida, S., Motomura, K., Ohashi, A., Hiraoka, K., Miura, T., & Kanba, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.059 · Cited by 20 · see citing works
Inhibitory Function of the Dorsomedial Hypothalamic Nucleus on the Hypothalamic–Pituitary–Adrenal Axis Response to an Emotional Stressor but not Immune Challenge
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High fat diet blunts stress-induced hypophagia and activation of Glp1r dorsal lateral septum neurons in male but not in female mice
Bales, M. B., Centanni, S. W., Luchsinger, J. R., Fathi, P. A., Biddinger, J. E., Le, T. D. V., Nwaba, K. G., Paldrmic, I. M., Winder, D. G., & Ayala, J. E. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101571 · Cited by 18 · see citing works
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro
Nepomuceno, D. H., Kuei, C., Dvorak, C. A., Lovenberg, T. W., Liu, C., & Bonaventure, P. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00157 · Cited by 18 · see citing works
In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist
Shoblock, J. R., Welty, N., Fraser, I. C., Wyatt, R. M., Lord, B., Lovenberg, T. W., Liu, C., & Bonaventure, P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00273 · Cited by 18 · see citing works
Distinct patterns of brain Fos expression in Carioca High- and Low-conditioned Freezing Rats
León, L. A., Brandão, M. L., Cárdenas, F. P., Parra, D., Krahe, T. E., Cruz, A. P. D. M., & Landeira-Fernández, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0236039 · Cited by 18 · see citing works
Epigenetics of amphetamine-induced sensitization: HDAC5 expression and microRNA in neural remodeling
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Functional Neuroimaging of Human Hypothalamus in Socioemotional Behavior: A Systematic Review
Carìa, A., & Dall‘O’, G. M. (2022) · Brain Sciences · doi:10.3390/brainsci12060707 · Cited by 17 · see citing works
Elucidation of the neural circuits activated by a GABAB receptor positive modulator: Relevance to anxiety
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Authors: Singewald, G. M., Rjabokon, A., Singewald, N., & Ebner, K.
Affiliations: Universität Innsbruck (AT)
Corresponding author: Ebner, Karl
ORCID: Singewald, Nicolas
Ebner, Karl
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2010-12-15
Volume: 36
Issue: 4
Pages: 793-804
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2010.213
PMC: PMC3055728
OpenAlex: W1987515936
Cited by: 149
References: 84
Citations by year: 2026: 5 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 17 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 16 · 2013: 6 · 2012: 10
FWCI: 3.03
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.springer.com/tdm (unspecified)
Locations: Neuropsychopharmacology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: Austrian Science Fund
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: lateral septum, stress response, hypothalamic-pituitary-adrenal axis, forced swim test, passive coping, active coping, ACTH, corticosterone, paraventricular nucleus, c-fos, 5-HT1A receptor, 8-OH-DPAT, WAY-100635, excitotoxic lesions, antidepressant efficacy, glucocorticoid feedback
MeSH terms: Adaptation, Psychological, Adrenocorticotropic Hormone, Animals, Corticosterone, Male, Neurosecretory Systems, Stress, Psychological, Rats, Sprague-Dawley, Septum of Brain, Rats

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The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses

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