Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction
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Social behavior impairments as a consequence of early life stress seem to stem from aberrations of the DA system, including long-lasting transcriptional changes in VTA DA neurons and impaired DA signaling in the lateral septum.
“Social behavior impairments as a consequence of early life stress also seem to stem from aberrations of the DA system, including long-lasting transcriptional changes in VTA DA neurons [151] and impaired DA signaling in the lateral septum [152].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [152]
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- Authors
- Shin, S., Pribiag, H., Lilascharoen, V., Knowland, D., Wang, X.-Y., & Lim, B. K.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Lim, Byung Kook
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 97
- Issue
- 1
- Pages
- 195-208.e6
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5766830
- OpenAlex
- W2778371518
- Cited by
- 120
- References
- 79
- Citations by year
- 2026: 16 · 2025: 12 · 2024: 19 · 2023: 17 · 2022: 15 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 6
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Klingenstein foundation
- Searle scholar program (15-SSP-229)
- Whitehall foundation (2014-08-63)
- NARSAD young investigator award (24094)
- NIMH (R01MH107742)
- Tobacco-related disease research program (TRDRP (25FT-0007)
- Canadian Institutes of Health Research (CHIR) Fellowship
- Anandamahidol Foundation Fellowship
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- dopamine D3 receptor, lateral septum, early life stress, social dysfunction, social behavior
- MeSH terms
- Animals, Behavior, Animal, Septal Nuclei, Stress, Psychological, Signal Transduction, Receptors, Dopamine D3, Mice
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