Individual Differences in Anterior Cingulate Activation Associated with Attentional Bias Predict Cocaine Use After Treatment
Open accessAbstract
Drug-dependent patients often relapse into drug use after treatment. Behavioral studies show that enhanced attentional bias to drug cues is a precursor of relapse. The present functional magnetic resonance imaging (fMRI) study examined whether brain regions involved in attentional bias are predictive of cocaine use after treatment. Attentional bias-related brain activity was measured-with a cocaine Stroop task-in cocaine-dependent patients during their first week in detoxification treatment and was used to predict cocaine use at 3-month follow-up. The predictive value of attentional bias-related brain activity in a priori defined regions of interest, in addition to other measures such as self-reports of substance severity, craving, and behavioral attentional bias were examined. The results show that craving in the week before treatment and individual variability in attentional bias-related activity in the dorsal anterior cingulate cortex (dACC) were significant predictors of days of cocaine use at 3-month follow-up and accounted for 45% in explained variance. Brain activity in the dACC uniquely contributed 22% of explained variance to the prediction model. These findings suggest that hyperactive attentional bias-related brain activity in the dACC might be a biomarker of relapse vulnerability as early as in the first week of detoxification treatment. Ultimately, this may help to develop individually tailored treatment interventions to reduce relapse risk.
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Behavioral indices of greater attentional bias and incentive salience attributed to drug cues have neural correlates that also predict relapse.
“More recently, these behavioral indices of greater attentional bias and incentive salience attributed to drug cues have also been shown to possess several neural correlates that also predict relapse (Janes et al., 2010; Marhe, Luijten, van de Wetering, Smits, & Franken, 2013).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Marhe, Luijten, van de Wetering, Smits, & Franken, 2013
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Cites
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500 · see citing works
Discovering Statistics Using SPSS
Field, A. P., & Miles, J. N. V. (2000) · Medical Entomology and Zoology · Cited by 28,268 · see citing works
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1993) · doi:10.1007/978-1-4899-4541-9 · Cited by 21,230 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Conflict monitoring and anterior cingulate cortex: an update
Botvinick, M. M., Cohen, J. D., & Carter, C. S. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.10.003 · Cited by 3,623 · see citing works
An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients
McLellan, A. T., Luborsky, L. B., WOODY, G. E., & Brien, C. P. O. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198001000-00006 · Cited by 3,163 · see citing works
Anterior Cingulate Conflict Monitoring and Adjustments in Control
Kerns, J. G., Cohen, J. D., MacDonald, A. W., Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004) · Science · doi:10.1126/science.1089910 · Cited by 2,891 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Addiction Is a Brain Disease, and It Matters
Leshner, A. I. (1997) · Science · doi:10.1126/science.278.5335.45 · Cited by 1,615 · see citing works
New Data from the Addiction Severity Index Reliability and Validity in Three Centers
McLELLAN, A. T., LUBORSKY, L., CACCIOLA, J., GRIFFITH, J., EVANS, F., BARR, H. L., & OʼBRIEN, C. P. (1985) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198507000-00005 · Cited by 1,503 · see citing works
Attentional bias in addictive behaviors: A review of its development, causes, and consequences
FIELD, M., & COX, W. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.03.030 · Cited by 1,376 · see citing works
Bootstrapping: A Nonparametric Approach to Statistical Inference.
Aa, Mooney, C. Z., & Duval, R. D. (1994) · Journal of the American Statistical Association · doi:10.2307/2290969 · Cited by 1,368 · see citing works
Detecting activations in PET and fMRI: levels of inference and power
Friston, K. J., Holmes, A., Poline, J.-B., Price, C. J., & Frith, C. D. (1996) · NeuroImage · doi:10.1006/nimg.1996.0074 · Cited by 1,148 · see citing works
Mooney, C., & Duval, R. (1993) · doi:10.4135/9781412983532 · Cited by 893 · see citing works
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
Franken, I. H. A. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00081-2 · Cited by 765 · see citing works
Self-citationField, M., Munafò, M. R., & Franken, I. H. A. (2009) · Psychological Bulletin · doi:10.1037/a0015843 · Cited by 602 · see citing works
Self-citationThe Addiction-Stroop test: Theoretical considerations and procedural recommendations.
Cox, W. M., Fadardi, J. S., & Pothos, E. M. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.443 · Cited by 517 · see citing works
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner, T., Etkin, A., Gale, S. A., & Joy Hirsch, C. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm179 · Cited by 499 · see citing works
Janes, A. C., Pizzagalli, D. A., Richardt, S., Frederick, B. D., Chuzi, S., Pachas, G., Culhane, M. A., Holmes, A. J., Fava, M., Evins, A. E., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.034 · Cited by 416 · see citing works
Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients
Schoenmakers, T. M., de Bruin, M., Lux, I. F. M., Goertz, A. G., Van Kerkhof, D. H. A. T., & Wiers, R. W. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.022 · Cited by 373 · see citing works
Paulus, M. P., Tapert, S. F., & Schuckit, M. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.761 · Cited by 369 · see citing works
Alcohol attentional bias as a predictor of alcohol abusers’ treatment outcome
Cox, W. M., Hogan, L. M., Kristian, M. R., & Race, J. H. (2002) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(02)00219-3 · Cited by 340 · see citing works
What predicts relapse? Prospective testing of antecedent models
Miller, W. R., Westerberg, V. S., Harris, R. J., & Tonigan, J. S. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.7.x · Cited by 336 · see citing works
Attentional bias predicts outcome in smoking cessation.
Waters, A. J., Shiffman, S., Sayette, M. A., Paty, J. A., Gwaltney, C. J., & Balabanis, M. H. (2003) · Health Psychology · doi:10.1037/0278-6133.22.4.378 · Cited by 332 · see citing works
The Role of Cognitive Control in Cocaine Dependence
Garavan, H., & Hester, R. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9034-x · Cited by 327 · see citing works
Initial validation of two opiate craving questionnaires
Franken, I. H. A., Hendriks, V. M., & van den Brink, W. (2002) · Addictive Behaviors · doi:10.1016/s0306-4603(01)00201-5 · Cited by 308 · see citing works
Self-citationCue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
Kosten, T. R., Scanley, B. E., Tucker, K. A., Oliveto, A. H., Prince, C. N., Sinha, R., Potenza, M. N., Skudlarski, P., & Wexler, B. E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300851 · Cited by 306 · see citing works
Attentional bias predicts heroin relapse following treatment
Marissen, M. A. E., Franken, I. H. A., Waters, A. J., Blanken, P., van den Brink, W., & Hendriks, V. M. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01498.x · Cited by 277 · see citing works
Self-citationGoldstein, R. Z., Tomasi, D. G., Rajaram, S., Cottone, L. A., Zhang, L., Maloney, T., Telang, F., Alia‐Klein, N., & Volkow, N. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.024 · Cited by 276 · see citing works
The Addiction Severity Index: reliability and validity in a Dutch addict population.
Hendriks, V., Kaplan, C. D., van Limbeek, J., & Geerlings, P. (1989) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(89)90041-x · Cited by 255 · see citing works
Brewer, J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M. N. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.024 · Cited by 226 · see citing works
Paliwal, P., Hyman, S. M., & Sinha, R. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.10.002 · Cited by 197 · see citing works
Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
Goldstein, R. Z., Nelly Alia-klein, A., Tomasi, D. G., Honorio, J., Maloney, T., Woicik, P. A., Wang, R., Telang, F., & Volkow, N. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900491106 · Cited by 191 · see citing works
Carpenter, K. M., Schreiber, E., Church, S. H., & McDowell, D. M. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.04.012 · Cited by 189 · see citing works
Relapse to smoking during unaided cessation: clinical, cognitive and motivational predictors
Powell, J. E., Dawkins, L., West, R., Powell, J. F., & Pickering, A. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1975-8 · Cited by 174 · see citing works
Nestor, L. J., McCabe, E., Jones, J. L., Clancy, L., & Garavan, H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.054 · Cited by 172 · see citing works
The relationship between cocaine craving, psychosocial treatment, and subsequent cocaine use
Weiss, R. D., Griffin, M. L., Mazurick, C., Berkman, B., Gastfriend, D. R., Frank, A., Barber, J. P., Blaine, J., Salloum, I., & Moras, K. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1320 · Cited by 171 · see citing works
Neural Antecedents of the Endowment Effect
Knutson, B. D., Wimmer, G. E., Rick, S. I., Hollon, N. G., Prelec, D., & Loewenstein, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.018 · Cited by 162 · see citing works
McLellan, A. T., Luborsky, L. B., WOODY, G. E., & O'Brien, C. P. (1980) · PsycTESTS Dataset · doi:10.1037/t00025-000 · Cited by 153 · see citing works
Marhe, R., Waters, A. J., van de Wetering, B. J. M., & Franken, I. H. A. (2012) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0030754 · Cited by 151 · see citing works
Self-citationVollstädt‐Klein, S., Loeber, S., Richter, A., Kirsch, M., Bach, P., von der Goltz, C., Hermann, D., Mann, K. F., & Kiefer, F. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00352.x · Cited by 149 · see citing works
What is a relapse? Fifty ways to leave the wagon
Miller, W. R. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.6.x · Cited by 149 · see citing works
Neural dynamics of error processing in medial frontal cortex
Mars, R. B., COLES, M. G. H., Grol, M. J., Holroyd, C. B., Nieuwenhuis, S., Hulstijn, W., & Toni, I. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.041 · Cited by 148 · see citing works
Jia, Z., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.008 · Cited by 147 · see citing works
Neural Substrates of Attentional Bias for Smoking-Related Cues: An fMRI Study
Janes, A. C., Pizzagalli, D. A., Richardt, S., Frederick, B. B., Holmes, A. J., Sousa, J., D, M. F. M., Evins, A. E., & Kaufman, M. J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.103 · Cited by 136 · see citing works
McKay, J. R. (1999) · Journal of Studies on Alcohol · doi:10.15288/jsa.1999.60.566 · Cited by 135 · see citing works
Treatment Outcome Predictors for Cocaine Dependence
Poling, J. C., Kosten, T. R., & Sofuoglu, M. (2007) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990701199416 · Cited by 131 · see citing works
Neural mechanisms underlying drug-related cue distraction in active cocaine users
Hester, R., & Garavan, H. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.12.009 · Cited by 127 · see citing works
Cocaine craving and use during daily life
Preston, K. L., Vahabzadeh, M., Schmittner, J., Lin, J.-L., Gorelick, D. A., & Epstein, D. H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1655-8 · Cited by 123 · see citing works
Goldstein, R. Z., Woicik, P. A., Maloney, T., Tomasi, D. G., Alia‐Klein, N., Shan, J., Honorio, J., Samaras, D., Wang, R., Telang, F., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011455107 · Cited by 120 · see citing works
Attentional bias to drug cues is elevated before and during temptations to use heroin and cocaine
Waters, A. J., Marhe, R., & Franken, I. H. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2424-z · Cited by 115 · see citing works
Self-citationNeurobiological substrate of smoking-related attentional bias
Luijten, M., Veltman, D. J., van den Brink, W., Hester, R., Field, M., Smits, M., & Franken, I. H. A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.064 · Cited by 110 · see citing works
Self-citationInterference produced by emotional conflict associated with anterior cingulate activation
Haas, B. W., OMURA, K., Constable, R. T., & Canli, T. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.2.152 · Cited by 108 · see citing works
Ersche, K. D., Bullmore, E. T., Craig, K. J., Shabbir, S. S., Abbott, S., Müller, U., Ooi, C., Suckling, J., Barnes, A., Sahakian, B. J., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.60 · Cited by 108 · see citing works
Cognitive-motivational predictors of excessive drinkers’ success in changing
Cox, W. M., Pothos, E. M., & Hosier, S. G. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0736-9 · Cited by 103 · see citing works
What predicts relapse? Prospective testing of antecedent models
Miller, W. R., Westerberg, V. S., Harris, R. J., & Tonigan, J. S. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02336.x · Cited by 101 · see citing works
Predicting Outcome of Inpatient Detoxification of Substance Abusers
Franken, I. H. A., & Hendriks, V. M. (1999) · Psychiatric Services · doi:10.1176/ps.50.6.813 · Cited by 91 · see citing works
Self-citationWhat is a relapse? Fifty ways to leave the wagon
Miller, W. R. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02324.x · Cited by 81 · see citing works
Assessment issues and domains in the prediction of relapse
Donovan, D. M. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.14.x · Cited by 66 · see citing works
Moeller, S. J., Tomasi, D. G., Woicik, P. A., Maloney, T., Nelly Alia-klein, A., Honorio, J., Telang, F., Wang, G., Wang, R., Sinha, R., et al. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00440.x · Cited by 49 · see citing works
Assessment issues and domains in the prediction of relapse
Donovan, D. M. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02325.x · Cited by 41 · see citing works
Brain Activation Associated with Attentional Bias in Smokers is Modulated by a Dopamine Antagonist
Luijten, M., Veltman, D. J., Hester, R., Smits, M., Pepplinkhuizen, L., & Franken, I. H. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.143 · Cited by 40 · see citing works
Self-citationMcKay, J. R., Alterman, A., Koppenhaver, J., Mulvaney, F., Bovasso, G. B., & Ward, K. M. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00156-3 · Cited by 27 · see citing works
Effectiveness of Inpatient Drug Detoxification: Links between Process and Outcome Variables
Hättenschwiler, J. A., Rüesch, P., & Hell, D. (2000) · European Addiction Research · doi:10.1159/000019024 · Cited by 13 · see citing works
Worsley (1996) · doi:10.1002/(sici)1097-0193(1996)4:1
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Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513 · see citing works
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- Authors
- Marhe, R., Luijten, M., van de Wetering, B. J. M., Smits, M., & Franken, I. H. A.
- Affiliations
- Erasmus University Rotterdam (NL)
- Erasmus MC (NL)
- Corresponding author
- Franken, Ingmar H A
- Venue
- Neuropsychopharmacology
- Published
- 2013-01-07
- Volume
- 38
- Issue
- 6
- Pages
- 1085-1093
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3629408
- OpenAlex
- W2058966436
- Cited by
- 108
- References
- 67
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 18 · 2016: 12 · 2015: 10 · 2014: 13 · 2013: 10
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- ZonMw (31160203)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- cocaine dependence, recurrence prediction, attentional bias, dorsal anterior cingulate cortex, craving, drug cue reactivity, detoxification treatment, individual differences
- MeSH terms
- Adult, Attention, Female, Follow-Up Studies, Gyrus Cinguli, Humans, Individuality, Male, Middle Aged, Photic Stimulation, Predictive Value of Tests, Psychomotor Performance, Reaction Time, Recurrence, Treatment Outcome, Cocaine-Related Disorders, Stroop Test
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