Tricine–SDS-PAGE

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

Wilhelm, B. G., Mandad, S., Truckenbrodt, S., Kröhnert, K., Schäfer, C., Rammner, B., Koo, S. J., Claßen, G. A., Krauss, M., Haucke, V., et al. (2014) · Science · doi:10.1126/science.1252884 · Cited by 770

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Yang, H., Jiang, X., Li, B., Yang, H. J., Miller, M., Yang, A., Dhar, A., & Pavletich, N. P. (2017) · Nature · doi:10.1038/nature25023 · Cited by 548

A repository of assays to quantify 10,000 human proteins by SWATH-MS

Rosenberger, G., Koh, C. C., Guo, T., Röst, H. L., Kouvonen, P., Collins, B. C., Heusel, M., Liu, Y., Caron, E., Vichalkovski, A., et al. (2014) · Scientific Data · doi:10.1038/sdata.2014.31 · Cited by 413

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W. T., et al. (2012) · Nature · doi:10.1038/nature11468 · Cited by 388

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

Friedman, J. R., Mourier, A., Yamada, J., McCaffery, J. M., & Nunnari, J. (2015) · eLife · doi:10.7554/elife.07739 · Cited by 291

Extraction of Proteins from Two Marine Macroalgae, Ulva Sp. and Gracilaria Sp., for Food Application, and Evaluating Digestibility, Amino Acid Composition and Antioxidant Properties of the Protein Concentrates

Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., & Livney, Y. D. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.047 · Cited by 269

Na(+) controls hypoxic signalling by the mitochondrial respiratory chain

Hernansanz-Agustín, P., Choya-Foces, C., Carregal-Romero, S., Ramos, E., Oliva, T., Villa-Piña, T., Moreno, L., Izquierdo-Álvarez, A., Cabrera-García, J. D., Cortés, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2551-y · Cited by 238

CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice

Kiyota, T., Okuyama, S., Swan, R. J., Jacobsen, M. T., Gendelman, H. E., & Ikezu, T. (2010) · The FASEB Journal · doi:10.1096/fj.10-155317 · Cited by 212

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons.

Laulagnier, K., Javalet, C., Hemming, F. J., Chivet, M., Lachenal, G., Blot, B., Chatellard, C., & Sadoul, R. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2664-0 · Cited by 164

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer’s disease

Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., et al. (2016) · Scientific Reports · doi:10.1038/srep31895 · Cited by 160

Adding value to the chia (Salvia hispanica L.) expeller: Production of bioactive peptides with antioxidant properties by enzymatic hydrolysis with Papain

Cotabarren, J., Rosso, A. M., Tellechea, M., García-Pardo, J., Rivera, J. L., Obregón, W. D., & Parisi, M. G. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2018.09.061 · Cited by 155

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

Pigoni, M., Wanngren, J., Kuhn, P.-H., Munro, K. M., Gunnersen, J. M., Takeshima, H., Feederle, R., Voytyuk, I., De Strooper, B., Levasseur, M. D., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0134-z · Cited by 125

CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

Kiyota, T., Yamamoto, M., Xiong, H., Lambert, M. P., Klein, W. L., Gendelman, H. E., Ransohoff, R. M., & Ikezu, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006197 · Cited by 114

Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance

Shibuya, Y., Chang, C. C. Y., Huang, L.-H., Bryleva, E. Y., & Chang, T.-Y. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2567-14.2014 · Cited by 108

Conformational Change of Mitochondrial Complex I Increases ROS Sensitivity During Ischemia

Gorenkova, N., Robinson, E., Grieve, D. J., & Galkin, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4698 · Cited by 82

Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3

Upmanyu, N., Jin, J., Emde, H. V. D., Ganzella, M., Bösche, L., Malviya, V. N., Zhuleku, E., Politi, A. Z., Ninov, M., Silbern, I., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.008 · Cited by 69

Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

Wang, F., Chan, C. H., Suciu, V., Mustafa, K., Ammend, M., Si, D., Hochbaum, A. I., Egelman, E. H., & Bond, D. R. (2022) · eLife · doi:10.7554/elife.81551 · Cited by 69

Chia expeller: A promising source of antioxidant, antihypertensive and antithrombotic peptides produced by enzymatic hydrolysis with Alcalase and Flavourzyme

Ozón, B., Cotabarren, J., Valicenti, T., Graciela Parisi, M., & David Obregón, W. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132185 · Cited by 66

Characterisation of potential milk coagulants from Calotropis gigantea plant parts and their hydrolytic pattern of bovine casein

Anusha, R., Singh, M. K., & Bindhu, O. S. (2014) · European Food Research and Technology · doi:10.1007/s00217-014-2177-0 · Cited by 63

Empirical evaluation of bone extraction protocols

Cleland, T. P., Voegele, K., & Schweitzer, M. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031443 · Cited by 60

Unexpected complexity of the ammonia monooxygenase in archaea

(2023) · doi:10.1038/s41396-023-01367-3 · Cited by 58

Unique, Diverged, and Conserved Mitochondrial Functions Influencing Candida albicans Respiration

Sun, N., Parrish, R. S., Calderone, R. A., & Fonzi, W. A. (2019) · mBio · doi:10.1128/mbio.00300-19 · Cited by 51

Inhibition of Alzheimer's amyloid-beta aggregation in-vitro by carbenoxolone: Insight into mechanism of action

Sharma, S., Nehru, B., & Saini, A. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.06.011 · Cited by 48

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

Ito, F., Yanatori, I., Maeda, Y., Nimura, K., Ito, S., Hirayama, T., Nagasawa, H., Kohyama, N., Okazaki, Y., Akatsuka, S., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101616 · Cited by 45

Enrichment and identification of small proteins in a simplified human gut microbiome

Petruschke, H., Anders, J., Stadler, P. F., Jehmlich, N., & von Bergen, M. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103604 · Cited by 43

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer’s disease

van Tijn, P., Dennissen, F. J. A., Gentier, R. J. G., Hobo, B., Hermes, D., Steinbusch, H. W. M., Van Leeuwen, F. W., & Fischer, D. F. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.007 · Cited by 39

Dual Targeting Factors Are Required for LXG Toxin Export by the Bacterial Type VIIb Secretion System

(2022) · doi:10.1128/mbio.02137-22 · Cited by 36

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.

Steinberg, R., Origi, A., Natriashvili, A., Sarmah, P., Licheva, M., Walker, P. M., Kraft, C., High, S., Luirink, J., Shi, W. Q., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000874 · Cited by 34

Modulating in vitro digestion of whey protein cold-set emulsion gels via gel properties modification with gallic acid and EGCG

Cao, Y., Wang, Q., Lin, J., Ding, Y.-Y., & Han, J. (2024) · Food Research International · doi:10.1016/j.foodres.2023.113686 · Cited by 33

Bacteriocin-like inhibitory substances (BLIS) produced by Bacillus cereus: Preliminary characterization and application of partially purified extract containing BLIS for inhibiting Listeria monocytogenes in pineapple pulp

Leite, J. A., Tulini, F. L., Reis-Teixeira, F. B. D., Rabinovitch, L., Chaves, J. Q., Rosa, N. G., Cabral, H., & De Martinis, E. C. P. (2016) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2016.04.058 · Cited by 33

Conformation‐specific crosslinking of mitochondrial complex I

Ciano, M., Fuszard, M., Heide, H., Botting, C. H., & Galkin, A. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.02.039 · Cited by 29

Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Klein, T. A., Shah, P. Y., Gkragkopoulou, P., Grebenc, D. W., Kim, Y., & Whitney, J. C. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312455121 · Cited by 28

HSV-1 cellular model reveals links between aggresome formation and early step of Alzheimer’s disease

Albaret, M. A., Textoris, J., Dalzon, B., Lambert, J., Linard, M., Helmer, C., Hacot, S., Ghayad, S. E., Ferréol, M., Mertani, H. C., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02376-8 · Cited by 25

Ultrasound pretreatment combined with emulsion coagulant: Synergistic effects on soybean protein gel properties and salt-coagulated tofu quality

Xin, Y., Lv, D., Du, F., Shi, X., Yang, J., & Li, T. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107437 · Cited by 16

An alphaherpesvirus exploits antimicrobial β-Defensins to initiate respiratory tract infection.

Van Cleemput, J., Poelaert, K. C. K., Laval, K., Vanderheijden, N., Dhaenens, M., Daled, S., Boyen, F., Pasmans, F., & Nauwynck, H. J. (2020) · Journal of Virology · doi:10.1128/jvi.01676-19 · Cited by 13

Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis

(2022) · doi:10.1371/journal.pone.0267370 · Cited by 9

Roles of multiple TEF30-associated intermediate complexes in the repair and reassembly of photosystem II in Chlamydomonas reinhardtii

Wang, Y., Wang, C., Li, A., & Liu, Z. (2025) · Nature Plants · doi:10.1038/s41477-025-02036-3 · Cited by 5

Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor

Nabarro, J., Leaman, R. M., Lenton, S., Mantion, L., Spears, R. J., Coles, M. C., Pushkin, D. O., Fascione, M. A., & Baumann, C. G. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00711-5 · Cited by 3

The Paulinella chromatophore transit peptide part2 adopts a structural fold similar to the γ-glutamyl-cyclotransferase fold

Klimenko, V., Reiners, J., Applegate, V., Reimann, K., Hoeppner, A., Smits, S. H. J., & Nowack, E. C. M. (2025) · doi:10.1101/2025.01.15.633182