The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Global metabolic profiling of animal and human tissues via UPLC-MS
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sumner, L. W., Amberg, A., Barrett, D., Beale, M. H., Beger, R., Daykin, C. A., Fan, T. W.-M., Fiehn, O., Goodacre, R., Griffin, J. L., et al. (2007) · Metabolomics · doi:10.1007/s11306-007-0082-2 · Cited by 5,368
Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., & Siuzdak, G. (2006) · Analytical Chemistry · doi:10.1021/ac051437y · Cited by 5,262
Self-citationNicholson, J. K., Lindon, J. C., & Holmes, E. (1999) · Xenobiotica · doi:10.1080/004982599238047 · Cited by 3,895
Self-citationMetabolomics—the link between genotypes and phenotypes
Fiehn, O. (2002) · Plant Molecular Biology · doi:10.1023/a:1013713905833 · Cited by 3,445
The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.335 · Cited by 3,294
Self-citationHMDB: the Human Metabolome Database
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl923 · Cited by 3,231
Metabolomics — the link between genotypes and phenotypes
Fiehn, O. (2002) · Functional Genomics · doi:10.1007/978-94-010-0448-0_11 · Cited by 3,167
METLIN—a metabolite mass spectral database
Smith, C. A., Maille, G. O., Want, E. J., Qin, C., Trauger, S. A., Brandon, T. R., Custodio, D. E., Abagyan, R., & Siuzdak, G. (2005) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000179845.53213.39 · Cited by 2,226
Self-citationBeckonert, O., Keun, H. C., Ebbels, T. M. D., Bundy, J., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.376 · Cited by 2,109
Self-citationMetabonomics: a platform for studying drug toxicity and gene function
Nicholson, J. K., Connelly, J., Lindon, J. C., & Holmes, E. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd728 · Cited by 1,914
Self-citationNicholson, J. K., & Lindon, J. C. (2008) · Nature · doi:10.1038/4551054a · Cited by 1,886
Self-citationHMDB: a knowledgebase for the human metabolome
Wishart, D. S., Knox, C., Guo, A. C., Eisner, R., Young, N., Gautam, B., Hau, D. D., Psychogios, N., Dong, E., Bouatra, S., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn810 · Cited by 1,873
Metabolomics--the link between genotypes and phenotypes.
Fiehn, O. (2002) · PubMed · Cited by 1,517
Global metabolic profiling procedures for urine using UPLC–MS
Want, E. J., Wilson, I. D., Gika, H., Theodoridis, G., Plumb, R. S., Shockcor, J., Holmes, E., & Nicholson, J. K. (2010) · Nature Protocols · doi:10.1038/nprot.2010.50 · Cited by 1,169
Self-citationMZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data
Katajamaa, M., Miettinen, J., & Orešič, M. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btk039 · Cited by 831
Metabolic Phenotyping in Health and Disease
Holmes, E., Wilson, I. D., & Nicholson, J. K. (2008) · Cell · doi:10.1016/j.cell.2008.08.026 · Cited by 822
Self-citationSystemic gut microbial modulation of bile acid metabolism in host tissue compartments
Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K., & Holmes, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006734107 · Cited by 726
Self-citationMetabolomics-based methods for early disease diagnostics
Gowda, G. N., Zhang, S., Gu, H., Asiago, V., Shanaiah, N., & Raftery, D. (2008) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.8.5.617 · Cited by 692
Gut microbiome-host interactions in health and disease
Kinross, J. M., Darzi, A. W., & Nicholson, J. K. (2011) · Genome Medicine · doi:10.1186/gm228 · Cited by 691
Self-citationChemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS
Halket, J. M., Waterman, D., Przyborowska, A. M., Patel, R. K. P., Fraser, P. D., & Bramley, P. M. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri069 · Cited by 662
High-throughput tissue extraction protocol for NMR- and MS-based metabolomics
Wu, H., Southam, A. D., Hines, A., & Viant, M. R. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2007.10.002 · Cited by 634
Data processing for mass spectrometry-based metabolomics
Katajamaa, M., & Orešič, M. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.04.021 · Cited by 616
Scalbert, A., Brennan, L., Fiehn, O., Hankemeier, T., Kristal, B. S., van Ommen, B., Pujos-Guillot, E., Verheij, E., Wishart, D., & Wopereis, S. (2009) · Metabolomics · doi:10.1007/s11306-009-0168-0 · Cited by 565
Sangster, T., Major, H., Plumb, R., Wilson, A. J., & Wilson, I. D. (2006) · The Analyst · doi:10.1039/b604498k · Cited by 564
Self-citationGika, H. G., Theodoridis, G. A., Wingate, J. E., & Wilson, I. D. (2007) · Journal of Proteome Research · doi:10.1021/pr070183p · Cited by 502
Self-citationTolstikov, V. V., & Fiehn, O. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5513 · Cited by 472
Wilson, I. D., Nicholson, J. K., Castro-Perez, J., Granger, J. H., Johnson, K. A., Smith, B. W., & Plumb, R. S. (2005) · Journal of Proteome Research · doi:10.1021/pr049769r · Cited by 420
Self-citationHigh-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
Beckonert, O., Coen, M., Keun, H. C., Wang, Y., Ebbels, T. M. D., Holmes, E., Lindon, J. C., & Nicholson, J. K. (2010) · Nature Protocols · doi:10.1038/nprot.2010.45 · Cited by 381
Self-citationAssignment of Endogenous Substrates to Enzymes by Global Metabolite Profiling
Saghatelian, A., Trauger, S. A., Want, E. J., Hawkins, E. G., Siuzdak, G., & Cravatt, B. F. (2004) · Biochemistry · doi:10.1021/bi0480335 · Cited by 316
Self-citationMET-IDEA: Data Extraction Tool for Mass Spectrometry-Based Metabolomics
Broeckling, C. D., Reddy, I. R., Duran, A. L., Zhao, X., & Sumner, L. W. (2006) · Analytical Chemistry · doi:10.1021/ac0521596 · Cited by 275
A metabolomic study of substantial equivalence of field‐grown genetically modified wheat
Baker, J. M., Hawkins, N. D., Ward, J. L., Lovegrove, A., Napier, J. A., Shewry, P. R., & Beale, M. H. (2006) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2006.00197.x · Cited by 269
Quantitative Metabolomics by 1H-NMR and LC-MS/MS Confirms Altered Metabolic Pathways in Diabetes
Lanza, I. R., Zhang, S., Ward, L. E., Karakelides, H., Raftery, D., & Nair, K. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010538 · Cited by 266
Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry
Chan, E. C. Y., Pasikanti, K. K., & Nicholson, J. K. (2011) · Nature Protocols · doi:10.1038/nprot.2011.375 · Cited by 261
Self-citationApplications of Metabolomics in Drug Discovery and Development
Wishart, D. S. (2008) · Drugs in R & D · doi:10.2165/00126839-200809050-00002 · Cited by 247
Gika, H. G., Macpherson, E., Theodoridis, G. A., & Wilson, I. D. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.05.048 · Cited by 231
Self-citationAnalytical and statistical approaches to metabolomics research
Issaq, H. J., Van, Q. N., Waybright, T. J., Muschik, G. M., & Veenstra, T. D. (2009) · Journal of Separation Science · doi:10.1002/jssc.200900152 · Cited by 227
Nemes, P., Barton, A. A., & Vertes, A. (2009) · Analytical Chemistry · doi:10.1021/ac900745e · Cited by 223
Metabolic Profiling as a Tool for Understanding Mechanisms of Toxicity
Clarke, C. J., & Haselden, J. N. (2008) · Toxicologic Pathology · doi:10.1177/0192623307310947 · Cited by 216
Multiple Ionization Mass Spectrometry Strategy Used To Reveal the Complexity of Metabolomics
Nordström, A., Want, E., Northen, T., Lehtiö, J., & Siuzdak, G. (2008) · Analytical Chemistry · doi:10.1021/ac701982e · Cited by 211
Self-citationGika, H. G., Theodoridis, G. A., & Wilson, I. D. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.10.066 · Cited by 195
Self-citationMetabolomics spectral formatting, alignment and conversion tools (MSFACTs)
Duran, A. L., Yang, J., Wang, L., & Sumner, L. W. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btg315 · Cited by 190
Masson, P., Alves, A. C., Ebbels, T. M. D., Nicholson, J. K., & Want, E. J. (2010) · Analytical Chemistry · doi:10.1021/ac101722e · Cited by 173
Self-citationDraper, J., Enot, D. P., Parker, D., Beckmann, M., Snowdon, S., Lin, W., & Zubair, H. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-227 · Cited by 169
Identification of “Known Unknowns” Utilizing Accurate Mass Data and ChemSpider
Little, J. L., Williams, A. J., Pshenichnov, A., & Tkachenko, V. (2012) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0265-y · Cited by 168
MathDAMP: a package for differential analysis of metabolite profiles
Baran, R., Kochi, H., Saito, N., Suematsu, M., Soga, T., Nishioka, T., Robert, M., & Tomita, M. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-530 · Cited by 162
HILIC-UPLC-MS for Exploratory Urinary Metabolic Profiling in Toxicological Studies
Spagou, K., Wilson, I. D., Masson, P., Theodoridis, G. A., Raikos, Ν., Coen, M., Holmes, E. C., Lindon, J. C., Plumb, R. S., Nicholson, J. K., et al. (2010) · Analytical Chemistry · doi:10.1021/ac102523q · Cited by 148
Self-citationIdborg, H., ZAMANI, L., Edlund, P., et al. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.07.031 · Cited by 145
Zhang, N. R., Yu, S., Tiller, P. R., Yeh, S., Mahan, E. A., & Emary, W. B. (2009) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3975 · Cited by 133
Gika, H., Theodoridis, G. A., & Wilson, I. D. (2008) · Journal of Separation Science · doi:10.1002/jssc.200700644 · Cited by 131
Self-citationLenz, E. M., Bright, J. D., Knight, R. D., et al. (2004) · The Analyst · doi:10.1039/b400159c · Cited by 130
NMR and MS Methods for Metabonomics
Dieterle, F., Riefke, B., Schlotterbeck, G., Ross, A., Senn, H., & Amberg, A. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-849-2_24 · Cited by 122
Hydrophilic Interaction Chromatography for Mass Spectrometric Metabonomic Studies of Urine
Cubbon, S., Bradbury, T., Wilson, J. C., & THOMAS‐OATES, J. E. (2007) · Analytical Chemistry · doi:10.1021/ac071008v · Cited by 122
Geier, F. M., Want, E. J., Leroi, A. M., & Bundy, J. G. (2011) · Analytical Chemistry · doi:10.1021/ac2001109 · Cited by 118
Self-citationProcessing and Analysis of GC/LC-MS-Based Metabolomics Data
Want, E. J., & Masson, P. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-985-7_17 · Cited by 106
Self-citationRuiz‐Aracama, A., Peijnenburg, A., Kleinjans, J. C. S., Jennen, D. G. J., van Delft, J. H. M., Hellfrisch, C., & Lommen, A. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-251 · Cited by 90
Pham‐Tuan, H., Kaskavelis, L., Daykin, C. A., & Janssen, H. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00077-1 · Cited by 84
Dunn, W. B., Goodacre, R., Neyses, L., & Mamas, M. A. (2011) · Bioanalysis · doi:10.4155/bio.11.223 · Cited by 73
Loftus, N. J., Barnes, A. J., Ashton, S., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100885w · Cited by 65
Self-citationPlumb, R. S., Rainville, P. D., Potts, W. B., Johnson, K. A., Gika, E., & Wilson, I. D. (2009) · Journal of Proteome Research · doi:10.1021/pr801078a · Cited by 62
Self-citationMasson, P., Spagou, K., Nicholson, J. K., & Want, E. J. (2011) · Analytical Chemistry · doi:10.1021/ac103011b · Cited by 59
Self-citationMetabolomics Data Analysis, Visualization, and Integration
Sumner, L. W., Urbańczyk-Wochniak, E., & Broeckling, C. D. (2005) · Humana Press eBooks · doi:10.1007/978-1-59745-535-0_20 · Cited by 59
Analytical metabolomics: nutritional opportunities for personalized health
McNiven, E. M. S., German, J. B., & Slupsky, C. M. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.05.016 · Cited by 58
Liang, X., Ubhayakar, S., Liederer, B. M., Dean, B., Qin, A., Shahidi-Latham, S. K., & Deng, Y. (2011) · Bioanalysis · doi:10.4155/bio.11.181 · Cited by 47
Metabolic profiling using Fourier-transform ion-cyclotron-resonance mass spectrometry
Ohta, D., Shibata, D., & Kanaya, S. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-007-1650-z · Cited by 42
Huang, Q., Yin, P., Wang, J., Chen, J., Kong, H., Lu, X., & Xu, G. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.03.009 · Cited by 40
A Statistically Rigorous Test for the Identification of Parent−Fragment Pairs in LC-MS Datasets
Ipsen, A. B., Want, E. J., Lindon, J. C., et al. (2010) · Analytical Chemistry · doi:10.1021/ac902361f · Cited by 33
Self-citationAaltonen, N., Laitinen, J. T., & Lehtonen, M. (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.03.030 · Cited by 30
Imaging Mass Spectrometry for the Assessment of Drugs and Metabolites in Tissue
Trim, P. J., Francese, S., & Clench, M. R. (2009) · Bioanalysis · doi:10.4155/bio.09.33 · Cited by 27
LC‐MS/MS profiling for detection of endogenous steroids and prostaglandins in tissue samples
Surowiec, I., Koc, M., Antti, H., Wikström, P., & Möritz, T. (2011) · Journal of Separation Science · doi:10.1002/jssc.201100436 · Cited by 23
Cross-platform analysis of longitudinal data in metabolomics
Nevedomskaya, E., Mayboroda, O. A., & Deelder, A. M. (2011) · Molecular BioSystems · doi:10.1039/c1mb05280b · Cited by 20
Ipsen, A. B., Want, E. J., & Ebbels, T. M. D. (2010) · Analytical Chemistry · doi:10.1021/ac101278x · Cited by 12
Self-citation
Cited by
Pang, Z., Zhou, G., Ewald, J., Chang, L., Hacariz, O., Basu, N., & Xia, J. (2022) · Nature Protocols · doi:10.1038/s41596-022-00710-w · Cited by 1,444
Metabolite Measurement: Pitfalls to Avoid and Practices to Follow
Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., & Rabinowitz, J. D. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044952 · Cited by 462
Method validation strategies involved in non-targeted metabolomics
Naz, S., Vallejo, M., García, A., & Barbas, C. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.04.071 · Cited by 332
Changes in volatile flavor of yak meat during oxidation based on multi-omics
Huang, Q., Dong, K., Wang, Q., Huang, X., Wang, G., An, F., Luo, Z., & Luo, P. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2021.131103 · Cited by 268
Promises and pitfalls of untargeted metabolomics
Gertsman, I., & Barshop, B. A. (2018) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-017-0130-7 · Cited by 271
Metadata
- Authors
- Want, E. J., Masson, P., Michopoulos, F., Wilson, I. D., Theodoridis, G., Plumb, R. S., Shockcor, J., Loftus, N., Holmes, E., & Nicholson, J. K.
- Venue
- Nature Protocols
- Published
- 2012-12-06
- Volume
- 8
- Issue
- 1
- Pages
- 17-32
- ISSN
- 1750-2799 (ISSN-L)
- 1754-2189
- OpenAlex
- W2086500586
- Cited by
- 1,611
- References
- 71
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
