Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women
Abstract
Objective This study aims to identify the lifestyle determinants of insulin-like growth factor-I (IGF-I) and its main binding proteins (IGFBPs), C-peptide, and sex hormone-binding globulin (SHBG) to help elucidate the mechanism through which lifestyle factors may affect cancer risk. Methods This study is based on a sample of 292 British women, aged 20-70 years, whose lifestyle characteristics were assessed using a self-administered questionnaire and whose serum hormone concentrations were measured using immunoassays. Results Age was a strong determinant of both IGF-I and IGFBP levels; women aged 65-70 years had significantly lower IGF-I and IGFBP-3 concentrations and significantly higher IGFBP-1 and IGFBP-2 concentrations than women aged 20-24 years. Body mass index (BMI) was not strongly associated with IGF-I, although women with a BMI of 26-27.9 kg/m2 had a higher IGF-I concentration compared with both lean (BMI Conclusions Our data show that age is a major determinant of both IGF-I and its main binding proteins in women. BMI has strong effects on IGFBPs, C-peptide, and SHBG, but its effects on IGF-I remain unclear. The possible effect of physical activity on IGFBP-1 requires further investigation.
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IGFBP-2 is a member of the insulin and IGF signaling pathway, and IGFBP-2 levels in humans are inversely associated with BMI, fat mass, insulin levels, and fatty liver index.
“IGFBP-2 is a member of the insulin and IGF signaling pathway, and IGFBP-2 levels in humans are inversely associated with BMI, fat mass, insulin levels, and fatty liver index [26‐30].”
From Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1). (2023) · cites this paper as [28]
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- Authors
- Allen, N. E., Appleby, P. N., Kaaks, R., Rinaldi, S., Davey, G. K., & Key, T. J.
- Affiliations
- Cancer Research UK (GB)
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Allen, Naomi E.
- Venue
- Cancer Causes & Control
- Published
- 2003-02
- Volume
- 14
- Issue
- 1
- Pages
- 65-74
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- OpenAlex
- W332185995
- Cited by
- 104
- References
- 60
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin-like growth factor I, IGF binding proteins, C-peptide, sex hormone-binding globulin, lifestyle factors, obesity, body mass index, physical activity, age, women, cancer risk, IGFBP-1, IGFBP-3
- MeSH terms
- Adult, Age Factors, C-Peptide, Female, United Kingdom, Humans, Insulin-Like Growth Factor I, Life Style, Middle Aged, Motor Activity, Neoplasms, Risk, Sex Hormone-Binding Globulin, Body Mass Index, Insulin-Like Growth Factor Binding Protein 1
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