Hypoxia signalling through mTOR and the unfolded protein response in cancer

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181

Autophagy: process and functionPreprint

Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833

The Unfolded Protein Response Regulates an Angiogenic Response by the Kidney Epithelium during Ischemic Stress

Bouvier, N., Fougeray, S., Beaune, P. H., Thervet, É., & Pallet, N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340570 · Cited by 30

ROS-Inducing Agents for Cancer Chemotherapy

Kasiappan, R., & Safe, S. H. (2016) · Reactive Oxygen Species · doi:10.20455/ros.2016.805 · Cited by 27

Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer

Pra, A. D., Locke, J. A., Borst, G. R., Supiot, S., & Bristow, R. G. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00024 · Cited by 24

The Importance of Histology and Pathology in Mass Spectrometry Imaging

Schwamborn, K. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.11.001 · Cited by 24

Linking unfolded protein response to ovarian cancer cell fusion

Yart, L., Bastida-Ruiz, D., Allard, M., Dietrich, P., Petignat, P., & Cohen, M. (2022) · BMC Cancer · doi:10.1186/s12885-022-09648-4 · Cited by 24

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Ceranski, A. K., Carreño-Gonzalez, M. J., Ehlers, A. C., Colombo, M. V., Cidre‐Aranaz, F., & Grünewald, T. G. P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01750-w · Cited by 25

Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences

Çam, H., & Houghton, P. J. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0173-x · Cited by 25

Effects of Lipoxin A4 on CoCl2-Induced Angiogenesis and Its Possible Mechanisms in Human Umbilical Vein Endothelial Cells

Liu, S.-J., Wu, P., Ye, D., Huang, Y., Zhou, X., Li, Y., & Cai, L. (2009) · Pharmacology · doi:10.1159/000221379 · Cited by 24

DEPTOR ubiquitination and destruction by SCFβ-TrCP

Wang, Z. P., Zhong, J., Gao, D., Inuzuka, H., Liu, P., & Wei, W. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00105.2012 · Cited by 24

Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours

Seront, E., Boidot, R., Bouzin, C., Karroum, O., Jordan, B. F., Gallez, B., Machiels, J.-P., & Féron, O. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.644 · Cited by 26

Concise synthesis and structure–activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge

Kotoku, N., Fujioka, S., Nakata, C., Yamada, M., Sumii, Y., Kawachi, T., Arai, M., & Kobayashi, M. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.05.009 · Cited by 24

Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment

Nagasawa, H., Narise, K., Okuda, K., Hirayama, T., & Enomoto, Y. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s59679 · Cited by 24

Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures

Levin, V. A., Panchabhai, S. C., Shen, L., & Baggerly, K. (2012) · Proteome Science · doi:10.1186/1477-5956-10-5 · Cited by 27

Impaired liver regeneration after hepatectomy and bleeding is associated with a shift from hepatocyte proliferation to hypertrophy

Matot, I., Nachmansson, N., Duev, O., Schulz, S., Schroeder‐Stein, K., Frede, S., & Abramovitch, R. (2017) · The FASEB Journal · doi:10.1096/fj.201700153r · Cited by 24

Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics

Börlin, C. S., Lang, V., Hamacher‐Brady, A., & Brady, N. R. (2014) · Cell Communication and Signaling · doi:10.1186/s12964-014-0056-8 · Cited by 23

Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles

Koizume, S., Takahashi, T., Yoshihara, M., Nakamura, Y., Ruf, W., Takenaka, K., Miyagi, E., & Miyagi, Y. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1687876 · Cited by 23

STAT3 governs the HIF-1α response in IL-15 primed human NK cells

Coulibaly, A., Velásquez, S. Y., Kassner, N., Schulte, J., Barbarossa, M. V., & Lindner, H. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84916-0 · Cited by 24

HIF-1α in the Crosstalk Between Reactive Oxygen Species and Autophagy Process: A Review in Multiple Sclerosis

Asgari, R., Yarani, R., Mohammadi, P., & Aleagha, M. S. E. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01111-5 · Cited by 25

The Interrelating Dynamics of Hypoxic Tumor Microenvironments and Cancer Cell Phenotypes in Cancer Metastasis

Bartkowiak, K., Riethdorf, S., & Pantel, K. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0067-6 · Cited by 23

Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma

Lobo, M. R., Green, S. C., Schabel, M. C., Gillespie, G. Y., Woltjer, R. L., & Pike, M. M. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not119 · Cited by 23

Hypoxia‐induced alterations of G2 checkpoint regulators

Hasvold, G., Lund‐Andersen, C., Lando, M., Patzke, S., Hauge, S., Suo, Z., Lyng, H., & Syljuåsen, R. G. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2015.12.015 · Cited by 24

Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments

Kawachi, T., Tanaka, S., Fukuda, A., Sumii, Y., Setiawan, A., Kotoku, N., Kobayashi, M., & Arai, M. (2019) · Marine Drugs · doi:10.3390/md17030163 · Cited by 23

Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression

Park, J. E., Tse, S. W., Guo, X., Assisi, C., Serra, A., Ramon, G. P. X., Low, J. K., Kon, O. L., Tay, C. Y., Tam, J. P., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.26669 · Cited by 24

PCAT-1 facilitates breast cancer progression via binding to RACK1 and enhancing oxygen-independent stability of HIF-1α

Wang, J., Chen, X., Hu, H., Yao, M., Song, Y., Yang, A., Xu, X., Zhang, N., Gao, J., & Liu, B. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.02.034 · Cited by 23

Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer

Shih, H.-J., Chang, H., Chen, C., & Torng, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-02400-1 · Cited by 23

Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways

Tchevkina, E. M., & Komelkov, A. V. (2012) · InTech eBooks · doi:10.5772/48274 · Cited by 26

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

Rouschop, K. M. A., Dubois, L. J., Schaaf, M. B. E., van den Beucken, T., Lieuwes, N. G., Keulers, T. G., Savelkouls, K. G. M., Bussink, J., van der Kogel, A. J., Koritzinsky, M., et al. (2011) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2011.05.047 · Cited by 23

Metabolic labeling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels

Tiana, M., Acosta-Iborra, B., Hernández, R., Galiana, C., Fernández-Moreno, M. Á., Jimenez, B., & del Peso, L. (2020) · RNA · doi:10.1261/rna.072611.119 · Cited by 23

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Batie, M., Fasanya, T., Kenneth, N. S., & Rocha, S. (2023) · EMBO Reports · doi:10.15252/embr.202357849 · Cited by 18

Endoplasmic reticulum oxidoreductin 1‐alpha deficiency and activation of protein translation synergistically impair breast tumour resilience

Varone, E., Decio, A., Barbera, M. C., Bolis, M., Rito, L. D., Pisati, F., Giavazzi, R., & Zito, E. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15927 · Cited by 22

Specific HIF-2α (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP)

Colson, A., Depoix, C. L., Lambert, I., Leducq, C., Bedin, M., Beukelaer, M. D., Gatto, L., Loriot, A. E., de Nieuwburgh, M. P., Bouhna, K., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.20739 · Cited by 22

β-Catenin and Peroxisome Proliferator-activated Receptor-δ Coordinate Dynamic Chromatin Loops for the Transcription of Vascular Endothelial Growth Factor A Gene in Colon Cancer Cells

Hwang, I., Kim, J., & Jeong-Yu, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377739 · Cited by 25

A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors

Piccione, E. C., Lieu, T. J., Gentile, C., Williams, T. R., Connolly, A. J., Godwin, A. K., Koong, A. C., & Wong, A. J. (2011) · Oncogene · doi:10.1038/onc.2011.465 · Cited by 22

Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy

Wang, B., Atherton, P. J., Patel, R. S., Manning, G., & Donnelly, R. (2010) · Microvascular Research · doi:10.1016/j.mvr.2010.02.012 · Cited by 22

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo

Zhang, Y., Xu, S., Lin, J., Yao, G., Han, Z., Liang, B., Zou, Z., Chen, Z., Song, Q., Dai, Y., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2270-7 · Cited by 22

Hypoxia‐inducible factors – regulation, role and comparative aspects in tumourigenesis

Hansen, A. E., Kristensen, A. T., Law, I. G., Jørgensen, J. T., & Engelholm, S. A. (2010) · Veterinary and Comparative Oncology · doi:10.1111/j.1476-5829.2010.00233.x · Cited by 23

The Plasminogen Activation System Promotes Dendritic Spine Recovery and Improvement in Neurological Function After an Ischemic Stroke

Jeanneret, V., & Yepes, M. (2016) · Translational Stroke Research · doi:10.1007/s12975-016-0454-x · Cited by 22

Protein synthesis is lowered by 4EBP1 and eIF2-α signaling while protein degradation may be maintained in fasting, hypoxic Amazonian cichlid, Astronotus ocellatus

Cassidy, A. A., Driedzic, W. R., Campos, D. F., Heinrichs-Caldas, W., de Almeida‐Val, V. M. F., Val, A. L., & Lamarre, S. G. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.167601 · Cited by 22

Cancer-free aging: Insights from Spalax ehrenbergi superspecies

Lagunas‐Rangel, F. A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.004 · Cited by 23

Glucuronidation of Anticancer Prodrug PR-104A: Species Differences, Identification of Human UDP-Glucuronosyltransferases, and Implications for Therapy

Gu, Y., Tingle, M. D., & Wilson, W. R. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.180703 · Cited by 22

Past approaches and future directions for targeting tumor hypoxia in squamous cell carcinomas of the head and neck

Curtis, K. K., Wong, W. W., & Ross, H. J. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.05.005 · Cited by 22

Correction to: Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Peng, K., Zhuo, M., Li, M., Chen, Q., Mo, P., & Yu, C. (2021) · Oncogene · doi:10.1038/s41388-021-01678-9 · Cited by 22

Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma

Uva, P., Bosco, M. C., Eva, A., Conte, M., Garaventa, A., Amoroso, L., & Cangelosi, D. (2021) · Cancers · doi:10.3390/cancers13112809 · Cited by 21

Innate Lymphoid Cell Plasticity in Mucosal Infections

Korchagina, A. A., Koroleva, E. P., & Tumanov, A. V. (2023) · Microorganisms · doi:10.3390/microorganisms11020461 · Cited by 23

Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions

Ushijima, H., Suzuki, Y., Oike, T., Komachi, M., Yoshimoto, Y., Ando, K., Okonogi, N., Sato, H., Noda, S., Saito, J.-I., et al. (2015) · Journal of Radiation Research · doi:10.1093/jrr/rrv021 · Cited by 21

Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells

Chen, J.-T., Liu, C.-C., Yu, J., Li, H., & Lai, M. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.02.031 · Cited by 21

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury

Vozdek, R., Long, Y., & Ma, D. K. (2018) · Science Signaling · doi:10.1126/scisignal.aat0138 · Cited by 21

Nitidine Chloride Inhibits SIN1 Expression in Osteosarcoma Cells

Xu, H., Cao, T., Zhang, X., Shi, Y., Zhang, Q., Chai, S., Li, Y., Jin, G., Ma, J., Wang, Z. P., et al. (2019) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2019.01.005 · Cited by 21

Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models

Harms, J. K., Lee, T. W., Wang, T., Lai, A., Kee, D., Chaplin, J. M., McIvor, N., Hunter, F. W., Macann, A., Wilson, W. R., et al. (2019) · Cells · doi:10.3390/cells8070717 · Cited by 21

Normoxically Overexpressed Hypoxia Inducible Factor 1-Alpha is Involved in Arsenic Trioxide Resistance Acquisition in Hepatocellular Carcinoma

Tung, J.-N., Cheng, Y., Hsu, C.-H., Liu, T., Hsieh, P.-Y., Ting, L., Ko, H.-L., Chang, Y., Chiou, J.-F., & Wu, A. T. H. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-1444-y · Cited by 21

Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions

Jones, D. T., & Harris, A. L. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.674516 · Cited by 21

The Protective Effects of Botulinum Toxin A Against Flap Necrosis After Perforator Twisting and Its Underlying Molecular Mechanism in a Rat Model

Kim, S. Y., Lee, S. H., Lee, B., Park, Y. J., Park, J. H., Lee, Y., Rah, D. K., & Park, T. H. (2015) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000000563 · Cited by 21

Endoplasmic reticulum stress in acute lung injury and pulmonary fibrosis

Sun, Z., He, W., Meng, H., Li, P., & Qu, J. (2024) · The FASEB Journal · doi:10.1096/fj.202401849rr · Cited by 21

Mitochondrial Respiration Inhibitors Suppress Protein Translation and Hypoxic Signaling via the Hyperphosphorylation and Inactivation of Translation Initiation Factor eIF2α and Elongation Factor eEF2

Li, J., Mahdi, F., Du, L., Datta, S., Nagle, D. G., & Zhou, Y. (2011) · Journal of Natural Products · doi:10.1021/np200370z · Cited by 20

Models and discovery strategies for new therapies of retinoblastoma

Houston, S. K. S., Lampidis, T. J., & Murray, T. G. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.772975 · Cited by 20

Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX

Takáčová, M., Kajanová, I., Kolarcikova, M., Lapinova, J., Zaťovičová, M., & Pastoreková, S. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10011-5 · Cited by 20

Hypoxia activates the unfolded protein response signaling network: An adaptive mechanism for endometriosis

Zhou, Y., Jin, Y., Wang, Y., & Wu, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.945578 · Cited by 20

Andes Virus Infection of Lymphatic Endothelial Cells Causes Giant Cell and Enhanced Permeability Responses That Are Rapamycin and Vascular Endothelial Growth Factor C Sensitive

Gavrilovskaya, I. N., Gorbunova, E. E., & Mackow, E. R. (2012) · Journal of Virology · doi:10.1128/jvi.00817-12 · Cited by 20

Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism

Bonnet‐Magnaval, F., Philippe, C., Berghe, L. V. D., Prats, H., Touriol, C., & Lacazette, É. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.082 · Cited by 25

eIF3a mediates HIF1α-dependent glycolytic metabolism in hepatocellular carcinoma cells through translational regulation.

Miao, B., Wei, C., Qiao, Z., Han, W., Chai, X., Lu, J., Gao, C., Dong, R., Gao, D., Huang, C., et al. (2019) · PubMed Central · Cited by 20

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Drug Discovery for Targeting the Tumor Microenvironment

Nagasawa, H. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.10r25fm · Cited by 20

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1α

Genetos, D. C., Rao, R. R., & Vidal, M. A. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-0929-0 · Cited by 20

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia

Watt, K., Dauber, B., Szkop, K. J., Lee, L. J., Jovanovic, P., Chen, S., Palia, R., Vassalakis, J. A., Cooper, T. T., Papadopoli, D. J., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01786-8 · Cited by 21

The protective effect of Zn2+ on As3+ toxicity in common carp: Resistance to oxidative stress, inhibition of endoplasmic reticulum stress, apoptosis and autophagy

Liu, Y., Zhao, H., Yin, K., Guo, M., Wang, Y., Wang, D., Zong, H., & Xing, M. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737375 · Cited by 19

Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition

Osuru, H. P., Lavallee, M., & Thiele, R. H. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.711421 · Cited by 19

Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination

Sælen, M. G., Flatmark, K., Folkvord, S., de Wijn, R., Rasmussen, H., Fodstad, Ø., & Ree, A. H. (2011) · Angiogenesis · doi:10.1007/s10456-011-9231-3 · Cited by 19

NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK)

Sommer, L. A. M., Schaad, M., & Dames, S. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467233 · Cited by 22

Role of oxygen consumption in hypoxia protection by translation factor depletion

Scott, B. A., Sun, C., Mao, X. R., Yu, C., Vohra, B. P. S., Milbrandt, J., & Crowder, C. M. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.082263 · Cited by 19

Spatial control of oxygen delivery to three‐dimensional cultures alters cancer cell growth and gene expression

Wulftange, W. J., Rose, M. A., Garmendia‐Cedillos, M., da Silva, D., Poprawski, J. E., Srinivasachar, D., Sullivan, T., Lim, L., Bliskovsky, V. V., Hall, M. D., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28665 · Cited by 21

A novel method to establish glucocorticoid resistant acute lymphoblastic leukemia cell lines

Gu, L., Zhang, G., & Zhang, Y. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1280-2 · Cited by 21

Dimeric Diarylheptanoids with Neuroprotective Activities from Rhizomes of Alpinia officinarum

Liu, H., Wang, X., Shi, Q., Li, L., Zhang, Q., Wu, Z., Huang, X., Zhang, Q., Ye, W., Wang, Y., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01019 · Cited by 19

Hypoxia Stimulates SUMOylation-Dependent Stabilization of KDM5B

Zhou, B., Zhu, Y., Xu, W., Zhou, Q., Tan, L., Zhu, L., Chen, H., Feng, L., Hou, T., Wang, X., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.741736 · Cited by 19

Enhancing co-translational folding of heterologous protein by deleting non-essential ribosomal proteins in Pichia pastoris

Liao, X., Zhao, J., Liang, S., Jin, J., Cheng, L., Xiao, R., Li, L., Guo, M., Zhang, G., & Lin, Y. C. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1377-z · Cited by 18

Angiogenic response following renal ischemia reperfusion injury: new players

Pallet, N., Thervet, É., & Timsit, M. (2014) · The French Journal of Urology · doi:10.1016/s1166-7087(14)70059-4 · Cited by 18

Role of Noxa in proliferation, apoptosis, and autophagy in human adenoid cystic carcinoma

Liang, L., Weng, J., You, Y., He, Q., Fan, Y., & Liao, G. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12787 · Cited by 18

Immunosurveillance of cancer cell stress

Lorenzo‐Herrero, S., Sordo‐Bahamonde, C., Gonzalez, S. R., & López‐Soto, A. (2019) · Cell Stress · doi:10.15698/cst2019.09.198 · Cited by 18

Discriminating different grades of cervical intraepithelial neoplasia based on label-free phasor fluorescence lifetime imaging microscopy

Wang, X., Wang, Y., Zhang, Z., Huang, M., Fei, Y., Ma, J., & Mi, L. (2020) · Biomedical Optics Express · doi:10.1364/boe.386999 · Cited by 18

ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles

Gorban, I. E., Soldatov, M. A., Butova, V. V., Medvedev, P. V., Burachevskaia, O. A., Belanova, A. A., Zolotukhin, P. V., & Soldatov, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249758 · Cited by 18

High protein intake promotes the adaptation to chronic hypoxia in zebrafish (Danio rerio)

Ma, Q., Wang, X., Li, L., Qiao, F., Zhang, M., & Du, Z. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736356 · Cited by 18

Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma

Brinkhuizen, T., Weijzen, C. A. H., Eben, J., Thissen, M. R. T. M., Marion, A. M. W. V., Lohman, B. G. P. M., Winnepenninckx, V. J. L., Nelemans, P. J., & Steensel, M. A. M. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106427 · Cited by 18

Support for the hypoxia theory in the pathogenesis of infantile haemangioma

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Furospinosulin‐1, Marine Spongean Furanosesterterpene, Suppresses the Growth of Hypoxia‐Adapted Cancer Cells by Binding to Transcriptional Regulators p54nrb and LEDGF/p75

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