The DOI matches its Crossref record; 234 of the 236 references it cites were found in a registry or an index.
p21 in cancer: intricate networks and multiple activities
Open accessAbstract
One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“p21 is a potent cell-cycle inhibitor (39)”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [39]
In the citing paper
“CDKN1A (p21, WAF1, CIP1) was among the first p53 target genes11, 12 to be identified and is now recognized as an encoder for a major cell cycle checkpoint control protein.145”
From Census and evaluation of p53 target genes (2017) · cites this paper as [145]
In the citing paper
“As p21 is rarely genetically affected in cancers [1,124]”
From CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication (2020) · cites this paper as [1]
In the citing paper
“Members of the Krüppel-like factor (KLF) transcription factor (TF) family can activate the CDKN1A gene by cooperating with p300-CREBBP (Aliouat-Denis et al., 2005; Abbas and Dutta, 2009).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Abbas and Dutta, 2009
In the citing paper
“p21WAF1/CIP1 can also be activated by p53 independent mechanisms by other stimulators such as nuclear receptors including androgen, vitamin D and retinoid receptors.”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Abbas and Dutta, 2009
In the citing paper
“Although this is the first detectable event, it is more likely that main role of p21 lies in its capacity to trigger pRb-mediated repression of cell cycle regulators (Fig. 2, for more information on p21 functions (see ref. 98 ).”
From Senescence from G2 arrest, revisited (2015) · cites this paper as [98]
In the citing paper
“For example, cyclin-dependent kinase inhibitor 1A (CDKN1A), a tumor suppressor that is downregulated in multiple cancers (106), is targeted by at least 28 miRNAs and many of which are upregulated together in cancers where CDKN1A has been implicated (107).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Cell cycle, CDKs and cancer: a changing paradigm
Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · cited 1×
“CDK1, at least in some tissues, may be the crucial target of p21 in tumorigenesi”
BackgroundRequirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051
Xu, X., Yuan, G., Li, Q., Shan, S.-L., & Jiang, S. (2012) · Hepatogastroenterology · doi:10.5754/hge12404 · Cited by 1,825
Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · cited 1×
“Recent work suggests that tumour regression can be achieved through the reactivation of senescence, for example by restoring p53 functio”
BackgroundPCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
Cellular senescence in cancer and aging.
Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708
Flagged first, then by citations
2 of the 236 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Martin-Caballero, J., Flores, J. M., Garcia-Palencia, P. & Serrano, M. Tumor susceptibility of p21Waf1/Cip1-deficient mice. Cancer Res. 61, 6234–6238 (2001). This study demonstrates that deletion of Cdkn1a in mice results in spontaneous tumours but with late onset.
Cited by
Sorted by citations
Items 901–1,000 of 1,005
Sun, B., Chang, E., Gerhartl, A., & Szele, F. G. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx289 · Cited by 30
Wu, J., Jiang, Y., Cao, W., Li, X., Xie, C., Geng, S., Zhu, M., Liang, Z., Zhu, J., Zhu, W., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.05.040 · Cited by 33
Chatterjee, B., Ghosh, K. K., & Kanade, S. R. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27442 · Cited by 32
Escher, T. E., Lui, A. J., Geanes, E. S., Walter, K. R., Tawfik, O. W., Hagan, C. R., & Lewis-Wambi, J. S. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0916 · Cited by 32
Yuan, X., Huang, Y., Yu, T., Jiang, H., Xu, Y., & Zhao, X. (2019) · Oncology Letters · doi:10.3892/ol.2019.10301 · Cited by 32
Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21
Park, M. H., Lee, H., Lee, H. L., Son, D. J., Ju, J. H., Hyun, B. K., Jung, S. H., Song, J.-K., Lee, D., Hwang, C. J., et al. (2017) · Theranostics · doi:10.7150/thno.19824 · Cited by 33
CDKN1A upregulation and cisplatin‑pemetrexed resistance in non‑small cell lung cancer cells
Zamagni, A., Pasini, A., Pirini, F., Ravaioli, S., Giordano, E., Tesei, A., Calistri, D., Ulivi, P., Fabbri, F., Foca, F., et al. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5024 · Cited by 32
Walczak, K., Langner, E., Szalast, K., Makuch‐Kocka, A., Pożarowski, P., & Plech, T. (2020) · Molecules · doi:10.3390/molecules25071655 · Cited by 32
Fu, J., Jiang, C., Wu, M., Mei, R., Yang, A.-Q., Tao, H. P., Chen, X. J., Zhang, J., Huang, L., & Zhao, X. F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.664003 · Cited by 32
Franco, C. N., Seabrook, L. J., Nguyen, S. T., Leonard, J. T., & Albrecht, L. V. (2022) · Metabolites · doi:10.3390/metabo12100961 · Cited by 36
Kim, D., Mollah, M. L., & Kim, K. (2012) · PubMed · Cited by 32
Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group
Li, Y., & Woster, P. M. (2014) · MedChemComm · doi:10.1039/c4md00401a · Cited by 32
RSK2Ser227 at N-Terminal Kinase Domain Is a Potential Therapeutic Target for Multiple Myeloma
Shimura, Y., Kuroda, J., Ri, M., Nagoshi, H., Yamamoto‐Sugitani, M., Kobayashi, T., Kiyota, M., Nakayama, R., Mizutani, S., Chinen, Y., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0605 · Cited by 32
Kikuyama, M., Takeshima, H., Kinoshita, T., Okochi‐Takada, E., Wakabayashi, M., Akashi‐Tanaka, S., Ogawa, T., Seto, Y., & Ushijima, T. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.03.016 · Cited by 32
Yeo, S. Y., Itahana, Y., Guo, A. K., Han, R., Iwamoto, K., Nguyen, T., Bao, Y., Kleiber, K., Wu, Y., Bay, B., et al. (2016) · eLife · doi:10.7554/elife.07101 · Cited by 32
Therapeutic potential of melatonin for breast cancer radiation therapy patients
Griffin, F., & Marignol, L. H. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1446227 · Cited by 32
The Yin and Yang of cancer genes
Bashyam, M. D., Animireddy, S., Bala, P., Naz, A., & George, S. A. (2019) · Gene · doi:10.1016/j.gene.2019.04.025 · Cited by 31
Shin, D., Lee, J., & Roh, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216645 · Cited by 33
Zhou, S., Zhang, H., Li, J., Li, W., Su, M., Ren, Y., Ge, F., Zhang, H., & Shang, H. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108693 · Cited by 34
Wang, F.-Z., Fei, H., Lian, L., Wang, J., & Qiu, Y. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010179 · Cited by 31
Kotoku, N., Higashimoto, K., Kurioka, M., Arai, M., Fukuda, A., Sumii, Y., Sowa, Y., Sakai, T., & Kobayashi, M. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.05.083 · Cited by 31
Liu, B., Wen, J., Li, B. H., Fang, X. M., Wang, J. J., Zhang, Y. P., Shi, C., Zhang, D. Q., & Han, M. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.64 · Cited by 31
Dietary Non-nutritive Factors in Targeting of Regulatory Molecules in Colorectal Cancer: An Update
Pandurangan, A. K., & Esa, N. M. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.10.5543 · Cited by 31
Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma
Wang, Y., Chen, C.-L., Pan, Q., Wu, Y.-Y., Zhao, J.-J., Jiang, S.-S., Chao, J., Zhang, X.-F., Zhang, H.-X., Zhou, Z.-Q., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6319 · Cited by 31
Dietary 5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung tumorigenesis in mice
Song, M., Wu, X., Charoensinphon, N., Wang, M., Zheng, J., Gao, Z., Xu, F., Li, Z., Li, F., Zhou, J., et al. (2017) · Food & Function · doi:10.1039/c6fo01367h · Cited by 31
Fenelon, J. C., Shaw, G., Frankenberg, S., Murphy, B. D., & Renfree, M. B. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox019 · Cited by 30
Malyarenko, O. S., Dyshlovoy, S. A., Kicha, A. A., Ivanchina, N. V., Malyarenko, T. V., Bokemeyer, C., von Gunhild, Stonik, V. A., & Ermakova, S. P. (2017) · Marine Drugs · doi:10.3390/md15070227 · Cited by 31
Taromi, S., Lewens, F., Arsenić, R., Sedding, D., Sänger, J., Kunze, A., Möbs, M., Benecke, J., Freitag, H., Christen, F., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21221 · Cited by 31
Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma
Stafman, L. L., Mruthyunjayappa, S., Waters, A. M., Garner, E. F., Aye, J. M., Stewart, J. E., Yoon, K. J., Whelan, K. F., Mroczek‐Musulman, E., & Beierle, E. A. (2018) · Oncotarget · doi:10.18632/oncotarget.25205 · Cited by 31
Siddique, A. B., Ebrahim, H. Y., Akl, M. R., Ayoub, N. M., Goda, A. A., Mohyeldin, M. M., Nagumalli, S. K., Hananeh, W. M., Liu, Y., Meyer, S. A., et al. (2019) · Nutrients · doi:10.3390/nu11020412 · Cited by 31
Zhou, Z., Wang, X., Yu, X., Mei, X., Chen, X., Hu, Q., Yang, Z., & Guo, X. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2019.12.114 · Cited by 31
Epigenetics and cell cycle regulation in cystogenesis
Li, X. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109509 · Cited by 31
Wang, W., Zhang, R., Wang, X., Wang, N., Zhao, J., Wei, Z., Xiang, F., & Wang, C. (2020) · Cancer Science · doi:10.1111/cas.14324 · Cited by 31
Alaaeldin, R., Nazmy, M., Abdel‐Aziz, M., Abuo‐Rahma, G. E. A., & Fathy, M. (2020) · Anticancer Research · doi:10.21873/anticanres.14245 · Cited by 34
MicroRNA let-7b inhibits cell proliferation via upregulation of p21 in hepatocellular carcinoma
Li, H., Zheng, F., Yuan, B., Ma, S., Li, A., Zhou, W., Zhang, Y., & Yin, L. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00443-x · Cited by 31
Sha, B., Sun, Y., Zhao, S., Li, M., Huang, W., Li, Z., Shi, J., Han, X., Li, P., Hu, T., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09686-x · Cited by 31
Cyclin-dependent kinase inhibitors in malignant hematopoiesis
Schirripa, A., Sexl, V., & Kollmann, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.916682 · Cited by 39
PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63
Conforti, F., Yang, A. L., Piro, M. C., Mellone, M., Terrinoni, A., Candi, E., Tucci, P., Thomas, G. J., Knight, R. A., Melino, G., et al. (2012) · Oncogene · doi:10.1038/onc.2012.497 · Cited by 31
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Apraiz, A., Mitxelena, J., & Zubiaga, A. M. (2017) · Journal of Visualized Experiments · doi:10.3791/55745 · Cited by 31
Zhang, M., & Mu, T. (2017) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13625 · Cited by 31
A cellular, molecular, and pharmacological basis for appendage regeneration in micePreprint
Leung, T., Snyder, E. R., Liu, Y., Wang, J., & Kim, S. K. (2015) · Genes & Development · doi:10.1101/gad.267724.115 · Cited by 33
Viafara-García, S. M., Khan, M. S., Haidar, Z. S., & Acevedo, J. P. (2023) · Nanomaterials · doi:10.3390/nano13233060 · Cited by 30
Liu, X., Yu, H., Cai, H., & Wang, Y. (2014) · Journal of Surgical Oncology · doi:10.1002/jso.23599 · Cited by 30
Chang, Y., Lee, H., Liu, S.-T., Lin, Y., Chen, T., Hsieh, T., Huang, H., & Huang, S.-M. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.08.006 · Cited by 31
Ruan, J., Liao, Y., Lua, I., Li, M.-H., Hsu, C.-Y., & Chen, J. H. (2012) · Breast Cancer Research · doi:10.1186/bcr3226 · Cited by 30
HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway
Huang, H., Han, Y. K., Yang, X., Li, M., Zhu, R., Hu, J., Zhang, X., Wei, R., Li, K., & Gao, R. (2017) · Oncotarget · doi:10.18632/oncotarget.21873 · Cited by 30
let‑7 and miR‑17 promote self‑renewal and drive gefitinib resistance in non‑small cell lung cancer
Yin, J., Hu, W., Pan, L., Fu, W., Dai, L., Jiang, Z., Zhang, F., & Zhao, J. (2019) · Oncology Reports · doi:10.3892/or.2019.7197 · Cited by 30
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53
Kuffour, E. O., König, R., Häussinger, D., Schulz, W. A., & Münk, C. (2019) · mBio · doi:10.1128/mbio.01342-19 · Cited by 31
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer
Yu, Y., Chen, L., Zhao, G., Li, H., Guo, Q., Zhu, S., Li, P., Min, L., & Zhang, S. (2019) · Oncogene · doi:10.1038/s41388-019-1060-7 · Cited by 28
Zhao, W., Yan, W., Chen, D., Dai, L. X., Yang, Y., Kang, X., Fu, H., Chen, P., Deng, K., Wang, X., et al. (2019) · PubMed Central · Cited by 30
Zhang, D., Liu, S., Liu, Z., Ma, C., Jiang, Y., Sun, C., Li, K., Cao, G., Lin, Z., Wang, P., et al. (2019) · Medicine · doi:10.1097/md.0000000000017743 · Cited by 30
Long Non-Coding RNA in Drug Resistance of Non-Small Cell Lung Cancer: A Mini Review
Sun, R., Wang, R., Chang, S., Li, K., Sun, R., Wang, M., & Li, Z. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01457 · Cited by 30
Ohashi, R., Angori, S., Batavia, A. A., Rupp, N. J., Ajioka, Y., Schraml, P., & Moch, H. (2020) · Cancers · doi:10.3390/cancers12020465 · Cited by 30
Allegra, M., D’Anneo, A., Frazzitta, A., Restivo, I., Livrea, M. A., Attanzio, A., & Tesoriere, L. (2020) · Biomolecules · doi:10.3390/biom10070994 · Cited by 30
Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview
Lermyte, F. (2020) · Life · doi:10.3390/life10120320 · Cited by 32
Zhang, H., Gui, T., Liu, R., Tong, K., Wu, C., Li, Z., Huang, X., Xu, Q., Yang, J., Tang, W., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03416-1 · Cited by 36
Yuan, J., Li, X., Zhang, G., Cheng, W., Wang, W., Lei, Y., Ma, Q., & Song, G. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23290 · Cited by 29
Sanzo, S. D., Spengler, K., Leheis, A., Kirkpatrick, J. M., Rändler, T. L., Baldensperger, T., Dau, T., Henning, C., Parca, L., Marx, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26982-6 · Cited by 30
Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application
Megerian, M. F., Kim, J., Badreddine, J., Hong, S. H., Ponsky, L. E., Shin, J. I., & Ghayda, R. A. (2022) · Aging and Disease · doi:10.14336/ad.2022.1010 · Cited by 31
Liu, R., Miao, J., Jia, Y., Kong, G., Hong, F., Li, F., Zhai, M., Zhang, R., Liu, J., Xu, X., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02675-w · Cited by 30
Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma
Xiang, Y., Yang, Y., Liu, J., & Yang, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1219211 · Cited by 30
In vitro and in vivo anti-glioma activity of a chalcone-quinoxaline hybrid
Loch-Neckel, G., Bicca, M. A., Leal, P. C., Mascarello, A., Siqueira, J. M., & Calixto, J. Β. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.11.014 · Cited by 30
McCann, M. J., Rowland, I. R., & Roy, N. C. (2014) · Nutrients · doi:10.3390/nu6114839 · Cited by 30
Upregulation of p21 activates the intrinsic apoptotic pathway in β-cells
Hernandez, A. M., Colvin, E. S., Chen, Y., Geiss, S. L., Eller, L. E., & Fueger, P. T. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00663.2012 · Cited by 30
Induction of p53‐independent growth inhibition in lung carcinoma cell A549 by gypenosides
Liu, J., Chiang, T., Wang, J., Lin, L., Chao, W., Inbaraj, B. S., Lu, J., & Chen, B. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12546 · Cited by 30
Adeyemi, R. O., & Pintel, D. J. (2012) · Journal of Virology · doi:10.1128/jvi.00820-12 · Cited by 30
Noureini, S. K., & Wink, M. (2015) · Molecules · doi:10.3390/molecules20033730 · Cited by 30
AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21
Gongpan, P., Lu, Y., Wang, F., Xu, Y., & Xiong, W. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1183853 · Cited by 30
Antiangiogenic compounds: well-established drugs versus emerging natural molecules
Ribeiro, A., Abreu, R. M. V., Dias, M. M., Barreiro, M. F., & Ferreira, I. C. F. R. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.006 · Cited by 30
Rockfield, S., Flores, I., & Nanjundan, M. (2017) · Oncotarget · doi:10.18632/oncotarget.23747 · Cited by 31
Predicting Tumor Sensitivity to Chemotherapeutic Drugs in Oral Squamous Cell Carcinoma Patients
Robert, B. M., Muralidharan, D., Brindha, G. R., Dhandapani, M., Radhiga, T., Muthusamy, G., Nirmal, R. M., & Prasad, N. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-33998-4 · Cited by 30
Liu, D., Liu, J., Lin, B., Liu, S., Hou, R., Hao, Y., Liu, Q., Zhang, S., & Iwamori, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13010828 · Cited by 29
Wang, Z., Ma, B., Li, H., Xiao, X., Zhou, W., Liu, F., Zhang, B., Zhu, M. P., Yang, Q., Zeng, Y., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6312 · Cited by 30
Apuri, S., & Sokol, L. (2016) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1164140 · Cited by 30
Zhang, J., Yang, Y., Lei, L., & Tian, M. (2015) · Medical Science Monitor · doi:10.12659/msm.895084 · Cited by 29
The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair
Kulaberoglu, Y., Gündoğdu, R., & Hergovich, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00015-x · Cited by 30
Yang, D., Zhang, Q., Ma, Y., Che, Z., Zhang, W., Wu, M., Wu, L., Liu, F., Chu, Y., Xu, W. G., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.068 · Cited by 28
Lei, K., Li, W., Huang, C., Li, Y., Alfason, L., Zhao, H., Miyagishi, M., Wu, S., & Kasim, V. (2019) · Cancer Science · doi:10.1111/cas.14233 · Cited by 29
Liu, J., Feng, Y., Zeng, S., & Zhong, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117134 · Cited by 29
RetractedKolmus, K., Erdenebat, P., Stewig, B. E., Szymańska, E., Goryca, K., Derezińska‐Wołek, E., Szumera‐Ciećkiewicz, A., Brewińska‐Olchowik, M., Piwocka, K., Prochorec‐Sobieszek, M., et al. (2021) · Journal of Cell Science · doi:10.1242/jcs.250951 · Cited by 28
Li, W., Herkilini, A., Tang, Y. R., Huang, P. C., Song, G., Miyagishi, M., Kasim, V., & Wu, S. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00599-9 · Cited by 30
Cheng, Y., Hu, Y., Wang, H., Zhao, Z. Q., Jiang, X., Zhang, Y., Zhang, J., Tong, Y. A., & Qiu, X. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16674 · Cited by 29
Moghadam, S. K., Bakhshinejad, B., Khalafizadeh, A., Hussen, B. M., & Babashah, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17126 · Cited by 31
Sivakumar, S., Qi, S., Cheng, N., Sathe, A. A., Kanchwala, M., Kumar, A., Evers, B. M., Xing, C., & Yu, H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110395 · Cited by 28
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Kumar, V., Bauer, C., & Stewart, J. H. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151338 · Cited by 33
Endothelial FGF receptor signaling accelerates atherosclerosis
Che, J., Okigaki, M., Takahashi, T., Katsume, A., Adachi, Y., Yamaguchi, S., Matsunaga, S., Takeda, M., Matsui, A., Kishita, E., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00075.2010 · Cited by 29
Hsu, Y., Chang, C., Yang, N., Lee, Y., & Juan, S. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24583 · Cited by 29
Recio, L., Phillips, S. L., Maynor, T., Waters, M. D., Jackson, A. F., & Yauk, C. L. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft153 · Cited by 29
Radiloff, D. R., Wakeman, T. P., Feng, J., Schilling, S. H., Seto, E., & Wang, X. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017269108 · Cited by 32
Li, X., Kikuchi, K., Yang, Z., Noguchi, A., Takahashi, H., Nishida, T., Masuda, S., Yang, X., & Takano, Y. (2011) · Oral Oncology · doi:10.1016/j.oraloncology.2011.01.004 · Cited by 29
Guo, C., Liu, S., Dong, P., Zhao, D., Wang, C., Tao, Z., & Sun, M. (2015) · Scientific Reports · doi:10.1038/srep18215 · Cited by 29
The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation
Peters, D., Radine, C., Reese, A., Budach, W., Sohn, D., & Jänicke, R. U. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.772327 · Cited by 30
Geng, Y., Zhang, C., Lei, J.-L., Yu, P., Xia, Y., Zhang, H., Yang, L., & Kong, L. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.134 · Cited by 29
Dubey, N. K., Peng, B., Lin, C., Wang, P. D., Wang, J. R., Chan, C.-H., Wei, H.-J., & Deng, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061625 · Cited by 30
Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma
Kang, N., Wang, Y., Guo, S., Ou, Y., Wang, G., Chen, J., Li, D., & Zhan, Q. (2018) · BMC Cell Biology · doi:10.1186/s12860-018-0167-y · Cited by 30
CIP/KIP and INK4 families as hostages of oncogenic signaling
Csergeová, L., Krbušek, D., & Janoštiak, R. (2024) · Cell Division · doi:10.1186/s13008-024-00115-z · Cited by 31
Gupta, S., Silveira, D. A., Lorenzoni, P. R., Mombach, J. C. M., & Hashimoto, R. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158264 · Cited by 30
Ooi, K. K., Yeo, C. I., Ang, K. P., Akim, A. M., Cheah, Y. K., Halim, S. N. A., Seng, H., & Tiekink, E. R. T. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1271-5 · Cited by 29
Liu, J., Cui, Z., Wang, F., Yao, Y., Yu, G., Liu, J., Cao, D., Niu, S., You, M., Sun, Z., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802072r · Cited by 28
TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer
Zhang, T., Liu, C., Yu, Y., Geng, J., Meng, Q., Xu, S., Zhou, F., Chen, Y., Shi, J., Shen, J., et al. (2019) · Cancer Gene Therapy · doi:10.1038/s41417-019-0111-0 · Cited by 28
Metadata
- Authors
- Abbas, T., & Dutta, A.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Abbas, Tarek
- Dutta, Anindya
- Venue
- Nature Reviews Cancer
- Published
- 2009-05-14
- Volume
- 9
- Issue
- 6
- Pages
- 400-414
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC2722839
- OpenAlex
- W2162262059
- Cited by
- 2,712
- References
- 236
- Citations by year
- 2026: 99 · 2025: 156 · 2024: 161 · 2023: 206 · 2022: 182 · 2021: 205 · 2020: 204 · 2019: 180 · 2018: 191 · 2017: 196 · 2016: 148 · 2015: 160 · 2014: 142 · 2013: 151 · 2012: 122
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA089406, R01 CA 89406, T32CA009109)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- p21, cyclin-dependent kinase inhibitors, cell cycle arrest, therapeutic target, cell transformation
- MeSH terms
- Animals, Cell Cycle, Humans, Neoplasms, Tumor Suppressor Protein p53, Cyclin-Dependent Kinase Inhibitor p21
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
