p21 in cancer: intricate networks and multiple activities

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · cited 1×

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051

Hepatogastroenterology

Xu, X., Yuan, G., Li, Q., Shan, S.-L., & Jiang, S. (2012) · Hepatogastroenterology · doi:10.5754/hge12404 · Cited by 1,825

Restoration of p53 function leads to tumour regression in vivo

Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · cited 1×

PCNA, the Maestro of the Replication Fork

Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796

Cellular senescence in cancer and aging.

Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585

Regulation of the G2/M transition by p53

Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,584

New functional activities for the p21 family of CDK inhibitors.

LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., & Harlow, E. (1997) · Genes & Development · doi:10.1101/gad.11.7.847 · Cited by 1,402

Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature · doi:10.1038/377552a0 · Cited by 1,242 · cited 1×

CDK inhibitors: Cell cycle regulators and beyond

Besson, A., Dowdy, S. F., & Roberts, J. M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.013 · Cited by 1,152

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,148

Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer

Black, A. R., Black, J. D., & Azizkhan‐Clifford, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1111 · Cited by 1,048

Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

Frescas, D., & Pagano, M. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2396 · Cited by 903

Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

Liang, J., & Slingerland, J. M. (2003) · Cell Cycle · doi:10.4161/cc.2.4.433 · Cited by 885

E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer

Petrocca, F., Visone, R., Onelli, M. R., Shah, M. H., Nicoloso, M. S., Martino, I. D., Iliopoulos, D., Pilozzi, E., Liu, C. G., Negrini, M., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.013 · Cited by 832

DNA damage checkpoints: from initiation to recovery or adaptation

Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784

Transcriptional regulation of the p21((WAF1/CIP1)) gene.

Gartel, A., & Tyner, A. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4319 · Cited by 735

Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.629 · Cited by 725

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S., & Der, C. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6443 · Cited by 683

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

Woods, D. B., Parry, D., Cherwinski, H. M., Bosch, E., Lees, E. M., & McMahon, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5598 · Cited by 639

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

Rowland, B. D., Bernards, R., & Peeper, D. S. (2005) · Nature Cell Biology · doi:10.1038/ncb1314 · Cited by 593

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A., Liskay, R. M., & Kunkel, T. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81323-9 · Cited by 577

KLF4, p21 and context-dependent opposing forces in cancer

Rowland, B. D., & Peeper, D. S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1780 · Cited by 566

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

Luo, Y., Hurwitz, J., & Massagué, J. (1995) · Nature · doi:10.1038/375159a0 · Cited by 549

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548 · cited 1×

A role for Rho in Ras transformation

Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11781 · Cited by 533

Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase

Bornstein, G., Bloom, J., Sitry-Shevah, D., Nakayama, K., Pagano, M., & Hershko, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301774200 · Cited by 508

A new mouse model to explore the initiation, progression, and therapy of BRAF V600E -induced lung tumorsPreprint

Dankort, D. L., Filenova, E., Collado, M., Serrano, M., Jones, K. D., & McMahon, M. (2007) · Genes & Development · doi:10.1101/gad.1516407 · Cited by 492

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis

Sarkisian, C. J., Keister, B. A., Stairs, D. B., Boxer, R. B., Moody, S. E., & Chodosh, L. A. (2007) · Nature Cell Biology · doi:10.1038/ncb1567 · Cited by 490

An Intestine-Specific Homeobox Gene Regulates Proliferation and Differentiation

Suh, E. R., & Traber, P. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.619 · Cited by 487

Proliferation of cancer cells despite CDK2 inhibition

Tetsu, O., & McCormick, F. P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00053-9 · Cited by 472

p21WAF1/Cip1: more than a break to the cell cycle?

Dotto, G. P. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00019-6 · Cited by 470

Myc represses transcription through recruitment of DNA methyltransferase corepressor

Brenner, C., Deplus, R., Mirjolet, C., Loriot, A. E., Viré, E. A., Smet, C. D., Gutiérrez, A., Danovi, D., Bernard, D., Boon, T., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600509 · Cited by 468

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

Olson, M. F., Paterson, H. F., & Marshall, C. J. (1998) · Nature · doi:10.1038/28425 · Cited by 461

Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts

Roninson, I. B. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00847-3 · Cited by 443

AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

Li, Y., Dowbenko, D. J., & Lasky, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109062200 · Cited by 442

KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

Narla, G., Heath, K. E., Reeves, H. L., Li, D., Giono, L. E., Kimmelman, A. C., Glucksman, M., Narla, J., Eng, F. J., Chan, A. M.-L., et al. (2001) · Science · doi:10.1126/science.1066326 · Cited by 442

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

Kippin, T. E., Martens, D. J., & van der Kooy, D. (2005) · Genes & Development · doi:10.1101/gad.1272305 · Cited by 442

Effects of p21 Waf1/Cip1/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

Chang, B.-D., Watanabe, K., Broude, E. V., Fang, J., Poole, J. C., Kalinichenko, T. V., & Roninson, I. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4291 · Cited by 432

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

Wu, C.-H., van Riggelen, J., Yetil, A., Fan, A. C., Bachireddy, P., & Felsher, D. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701953104 · Cited by 417

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 CIP1/WAF1 and cyclin D proteins

Yu, Z.-K., Gervais, J., & Zhang, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11324 · Cited by 410

Proteasomal Turnover of p21Cip1 Does Not Require p21Cip1 Ubiquitination

Sheaff, R. J., Singer, J. D., Swanger, J., Smitherman, M., Roberts, J. M., & Clurman, B. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80435-9 · Cited by 382

Recruitment of DNA methyltransferase I to DNA repair sites

Mortusewicz, O., Schermelleh, L., Walter, J., Cardoso, M. C., & Leonhardt, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501034102 · Cited by 380

Akt-Dependent Phosphorylation of p21Cip1 Regulates PCNA Binding and Proliferation of Endothelial Cells

Rössig, L., Jadidi, A., Urbich, C., Badorff, C., Zeiher, A. M., & Dimmeler, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5644-5657.2001 · Cited by 378

Absence of WAF1 mutations in a variety of human malignancies

Shiohara, M., El‐Deiry, W. S., Wada, M., Nakamaki, T., Takeuchi, S., Yang, R., Chen, D., Vogelstein, B., & Koeffler, H. (1994) · Blood · doi:10.1182/blood.v84.11.3781.bloodjournal84113781 · Cited by 366

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4 Cdt2 ubiquitin ligase complexPreprint

Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano, M., & Dutta, A. (2008) · Genes & Development · doi:10.1101/gad.1676108 · Cited by 363

Nuclear Accumulation of p21 Cip1 at the Onset of Mitosis: a Role at the G 2 /M-Phase Transition

Dulić, V., Stein, G. H., Far, D. F., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.546 · Cited by 352

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

Martín‐Caballero, J., Flores, J. M., Garcı́a, P., & Serrano, M. (2001) · PubMed · Cited by 352

Untitled work

(1999) · PubMed · Cited by 338

The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter

Zhang, W., Geiman, D. E., Shields, J. M., Dang, D. T., Mahatan, C. S., Kaestner, K. H., Biggs, J. R., Kraft, A. S., & Yang, V. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000062200 · Cited by 333

Cyclin-Binding Motifs Are Essential for the Function of p21 CIP1

Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4673 · Cited by 320

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Viale, A., Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Ronchini, C., Ronzoni, S., Muradore, I., Monestiroli, S., et al. (2008) · Nature · doi:10.1038/nature07618 · Cited by 314

The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.Preprint

Missero, C., Cunto, F. D., Kiyokawa, H., Koff, A., & Dotto, G. P. (1996) · Genes & Development · doi:10.1101/gad.10.23.3065 · Cited by 311

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

Zhao, W., Hisamuddin, I. M., Nandan, M. O., Babbin, B. A., Lamb, N. E., & Yang, V. W. (2004) · Oncogene · doi:10.1038/sj.onc.1207067 · Cited by 307

Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

Franklin, D. S., Godfrey, V., O’Brien, D. A., Deng, C., & Xiong, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6147-6158.2000 · Cited by 303

Ubiquitin-Independent Degradation of Cell-Cycle Inhibitors by the REGγ Proteasome

Chen, X., Barton, L. F., Chi, Y., Clurman, B. E., & Roberts, J. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.022 · Cited by 276

Ubiquitin- and ATP-Independent Proteolytic Turnover of p21 by the REGγ-Proteasome Pathway

Li, X., Amazit, L., Long, W., Lonard, D. M., Monaco, J. J., & O’Malley, B. W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.028 · Cited by 267

Krüppel-like Factor 4 Mediates p53-dependent G1/S Cell Cycle Arrest in Response to DNA Damage

Yoon, H. S., Chen, X., & Yang, V. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211027200 · Cited by 265

Cooperative effects of genes controlling the G2/M checkpointPreprint

Chan, T. A.-T., Hwang, P. M., Hermeking, H., Kinzler, K. W., & Vogelstein, B. (2000) · Genes & Development · doi:10.1101/gad.14.13.1584 · Cited by 261

p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.Preprint

Zhu, L., Harlow, E. E., & Dynlacht, B. D. (1995) · Genes & Development · doi:10.1101/gad.9.14.1740 · Cited by 252

Histone deacetylase inhibitors: Signalling towards p21cip1/waf1

Ocker, M., & Schneider‐Stock, R. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.001 · Cited by 252

Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1

Kim, Y.-S., Ratziu, V., Choi, S.-G., Lalazar, A., Theiss, G., Dang, Q., Kim, S., & Friedman, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33750 · Cited by 249

ID genes mediate tumor reinitiation during breast cancer lung metastasis

Gupta, G. P., Perk, J., Acharyya, S., de Candia, P., Mittal, V., Manova-Todorova, K., Gerald, W. L., Brogi, E., Benezra, R., & Massagué, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709185104 · Cited by 245

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation

Nishitani, H., Shiomi, Y., Iida, H., Michishita, M., Takami, T., & Tsurimoto, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806045200 · Cited by 241

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

Kim, Y., Starostina, N. G., & Kipreos, E. T. (2008) · Genes & Development · doi:10.1101/gad.1703708 · Cited by 240

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

Zhang, Y., Fujita, N., & Tsuruo, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202426 · Cited by 238

Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes

Gartel, A. L., & Shchors, K. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00020-4 · Cited by 238

A degradation signal located in the C‐terminus of p21WAF1/CIP1 is a binding site for the C8 α‐subunit of the 20S proteasome

Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J., & Allday, M. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2367 · Cited by 235

p21/CDKN1A Mediates Negative Regulation of Transcription by p53

Löhr, K., Möritz, C., Contente, A., & Dobbelstein, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212517200 · Cited by 227

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1

Martín, A., Odajima, J., Hunt, S. L., Dubus, P. R., Ortega, S., Malumbres, M., & Barbacid, M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.006 · Cited by 223

p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint

Smits, V. A. J., Klompmaker, R., Vallenius, T., Rijksen, G., Mäkelä, T. P., & Medema, R. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005437200 · Cited by 221

Glycogen Synthase Kinase-3 Couples AKT-dependent Signaling to the Regulation of p21Cip1 Degradation

Rössig, L., Badorff, C., Holzmann, Y., Zeiher, A. M., & Dimmeler, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106157200 · Cited by 218

p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

Devgan, V., Mammucari, C., Millar, S. E., Brisken, C., & Dotto, G. P. (2005) · Genes & Development · doi:10.1101/gad.341405 · Cited by 209

APC/CCdc20 Controls the Ubiquitin-Mediated Degradation of p21 in Prometaphase

Amador, V., Ge, S., Santamarı́a, P. G., Guardavaccaro, D., & Pagano, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.013 · Cited by 207

p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export

Alt, J. R., Gladden, A. B., & Diehl, J. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108867200 · Cited by 199

p21 WAF1/Cip1 functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential

Topley, G., Okuyama, R., Gonzales, J. G., Conti, C. J., & Dotto, G. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9089 · Cited by 197

Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation

Sarmento, L. M., Huang, H., Limón, A., Gordon, W., Fernandes, J., Tavares, M. J., Miele, L., Cardoso, A. A., Classon, M., & Carlesso, N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050559 · Cited by 191

The Cdx-1 and Cdx-2 homeobox genes in the intestine

Freund, J., Domon–Dell, C., Kédinger, M., & Duluc, I. (1998) · Biochemistry and Cell Biology · doi:10.1139/o99-001 · Cited by 189

The Intricacies of p21 Phosphorylation: Protein/Protein Interactions, Subcellular Localization and Stability

Child, E. S., & Mann, D. J. (2006) · Cell Cycle · doi:10.4161/cc.5.12.2863 · Cited by 185

Phase II prostate cancer vaccine trial: Report of a study involving 37 patients with disease recurrence following primary treatment

Murphy, G. P., Tjoa, B. A., Simmons, S. J., Ragde, H., Rogers, M., Elgamal, A., Kenny, G. M., Troychak, M. J., Salgaller, M. L., & Boynton, A. L. (1999) · The Prostate · doi:10.1002/(sici)1097-0045(19990401)39:1 · Cited by 185

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer☆

Reeves, H. L., Narla, G., Ogunbiyi, O. A., Haq, A., Katz, A. M., Benzeno, S., Hod, E. A., Harpaz, N., Goldberg, S., & Kremer-Tal, S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.005 · Cited by 184

Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

Bates, S., Ryan, K. M., Phillips, A. C., & Vousden, K. H. (1998) · Oncogene · doi:10.1038/sj.onc.1202104 · Cited by 176

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Gottifredi, V., Karni-Schmidt, O., Shieh, S.-Y., & Prives, C. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1066-1076.2001 · Cited by 174

TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas

Yasui, K., Arii, S., Zhao, C. N., Imoto, I., Ueda, M., Nagai, H., Emi, M., & Inazawa, J. (2002) · Hepatology · doi:10.1053/jhep.2002.33683 · Cited by 171

Statins in tumor suppression

Sassano, A., & Platanias, L. C. (2008) · Cancer Letters · doi:10.1016/j.canlet.2007.11.036 · Cited by 171

Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice

Wang, Y., Elson, A., & Leder, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14590 · Cited by 170

Functional Interaction of STAT3 Transcription Factor with the Cell Cycle Inhibitor p21 WAF1/CIP1/SDI1 *

Coqueret, O., & Gascan, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001601200 · Cited by 169

Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/ neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients

Xia, W., Chen, J., Zhou, X. C., Sun, P.-R., Lee, D., Liao, Y., Zhou, B. P., & Hung, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0527 · Cited by 167

Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines.

Ms, S., Rochefort, H., & Garcia, M. (1995) · PubMed · Cited by 162

H2O2 Induces a Transient Multi-phase Cell Cycle Arrest in Mouse Fibroblasts through Modulating Cyclin D and p21Cip1 Expression

Barnouin, K., Dubuisson, M., Child, E. S., de Mattos, S. F., Glassford, J., Medema, R. H., Mann, D. J., & Lam, E. W. ‐. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111123200 · Cited by 161

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

Medema, R. H., Klompmaker, R., Smits, V. A., & Rijksen, G. (1998) · Oncogene · doi:10.1038/sj.onc.1201558 · Cited by 161

Cell cycle checkpoints and their impact on anticancer therapeutic strategies

Eastman, A. R. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10699 · Cited by 161

Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy

Liu, S., Bishop, W. R., & Liu, M. (2003) · Drug Resistance Updates · doi:10.1016/s1368-7646(03)00044-x · Cited by 160

The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers.

Chen, L.-C., Manjeshwar, S., Lu, Y., Moore, D. H., Ljung, B., Kuo, W., Dairkee, S. H., Wernick, M., Collins, C. C., & Smith, H. S. (1998) · PubMed · Cited by 157

Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.

Ee, H. C., Erler, T., Bhathal, P. S., Young, G. P., & James, R. J. (1995) · Europe PMC (PubMed Central) · Cited by 155

p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

Brugarolas, J., Bronson, R. T., & Jacks, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.503 · Cited by 153

AP4 encodes a c-MYC-inducible repressor of p21

Jung, P., Menssen, A., Mayr, D. C., & Hermeking, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801773105 · Cited by 153

Increased levels of p21WAF1/Cip1 in human brain tumors.

Jung, J., Bruner, J. M., Ruan, S., Langford, L. A., Kyritsis, A. P., Kobayashi, Y., Levin, V. A., & Zhang, W. (1995) · PubMed · Cited by 153

Overexpression of p21(WAF1/CIP1) is an early event in the development of pancreatic intraepithelial neoplasia.

Biankin, A. V., Kench, J. G., Morey, A. L., Lee, C. S. L., Biankin, S. A., Head, D. R., Hugh, T. B., Henshall, S. M., & Sutherland, R. L. (2001) · PubMed · Cited by 148

Regulation of p21WAF1/CIP1 Stability by WISp39, a Hsp90 Binding TPR Protein

Jascur, T., Brickner, H., Salles-Passador, I., Barbier, V., El Khissiin, A., Smith, B., Fotedar, R., & Fotedar, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.049 · Cited by 145

Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.

Yang, W., Mathew, J., Velcich, A., Edelmann, W., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. H. (2001) · PubMed · Cited by 145

Cytosine Methylation and DNA Repair

Walsh, C. P., & Xu, G. L. (2006) · Springer eBooks · doi:10.1007/3-540-31390-7_11 · Cited by 143

Control of E2F activity by p21Waf1/Cip1

Delavaine, L., & Thangue, N. B. L. (1999) · Oncogene · doi:10.1038/sj.onc.1202923 · Cited by 143

Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up.

Caffo, O., Doglioni, C., Veronese, S. M., Bonzanini, M., Marchetti, A., Buttitta, F., Fina, P., Leek, R., Morelli, L., Palma, P., et al. (1996) · PubMed · Cited by 142

Frequent inactivation of the tumor suppressor Kruppel-like factor 6 ( KLF6 ) in hepatocellular carcinoma

Kremer-Tal, S., Reeves, H. L., Narla, G., Thung, S. N., Schwartz, M., DiFeo, A. V., Katz, A. M., Bruix, J., Bioulac‐Sage, P., Martignetti, J. A., et al. (2004) · Hepatology · doi:10.1002/hep.20460 · Cited by 141

Overexpression of Id‐1 is associated with poor clinical outcome in node negative breast cancer

SCHOPPMANN, S. F., Schindl, M., Bayer, G., Aumayr, K., Dienes, J., Horvat, R., Rudas, M., Gnant, M., Jakesz, R., & Birner, P. (2003) · International Journal of Cancer · doi:10.1002/ijc.11009 · Cited by 139

Serological evidence of an association betweenChlamydia pneumoniae infection and lung cancer

Laurila, A. L., Anttila, T., Läärä, E., Bloigu, A. H., Virtamo, J., Albanes, D., Leinonen, M., & Saikku, P. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970220)74:1 · Cited by 138

Deletion, Mutation, and Loss of Expression of KLF6 in Human Prostate Cancer

Chen, C., Hyytinen, E., Sun, X., Helin, H. J., Koivisto, P. A., Frierson, H. F., Vessella, R. L., & Dong, J. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63930-2 · Cited by 137

Kruppel-Like Factor 6 Is Frequently Down-Regulated and Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Ito, G., Uchiyama, M., Kondo, M., Mori, S., Usami, N., Maeda, O., Kawabe, T., Hasegawa, Y., Shimokata, K., & Sekido, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0185 · Cited by 136

Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors.

Schindl, M., SCHOPPMANN, S. F., Ströbel, T., Heinzl, H., Leisser, C., Horvat, R., & Birner, P. (2003) · PubMed · Cited by 136

Over Expression of ID-1 in Prostate Cancer

Ouyang, X., Wang, X., LEE, D. T. W., Tsao, S. W., & Wong, Y. C. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)65044-6 · Cited by 135

Reciprocal Regulation via Protein-Protein Interaction between c-Myc and p21 in DNA Replication and Transcription

Kitaura, H., Shinshi, M., Uchikoshi, Y., Ono, T., Tsurimoto, T., Yoshikawa, H., Iguchi‐Ariga, S. M. M., & Ariga, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10477 · Cited by 135

p53-dependent Down-regulation of Telomerase Is Mediated by p21

Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133

A Novel Transcriptional Repression Domain Mediates p21WAF1/CIP1 Induction of p300 Transactivation

Snowden, A. W., Anderson, L. A., Webster, G., & Perkins, N. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2676-2686.2000 · Cited by 126

Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas

Bukholm, I. K., & Nesland, J. M. (2000) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050034 · Cited by 126

Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F

Hiyama, H., Iavarone, A., & Reeves, S. A. (1998) · Oncogene · doi:10.1038/sj.onc.1201667 · Cited by 125

CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling

da Costa, L. T., He, T., Yu, J., Sparks, A. B., Morin, P. J., Polyák, K., Laken, S., Vogelstein, B., & Kinzler, K. W. (1999) · Oncogene · doi:10.1038/sj.onc.1202872 · Cited by 125

Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest

Takubo, K., Ohmura, M., Azuma, M., Nagamatsu, G., Yamada, W., Arai, F., Hirao, A., & Suda, T. (2008) · Cell stem cell · doi:10.1016/j.stem.2007.10.023 · Cited by 122

Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)

Mandal, M., Bandyopadhyay, D., Goepfert, T. M., & Kumar, R. (1998) · Oncogene · doi:10.1038/sj.onc.1201529 · Cited by 122

Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2

Dang, D. T., Mahatan, C. S., Dang, L. H., Agboola, I. A., & Yang, V. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204645 · Cited by 120

Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells

伊藤, 源. (2005) · 名古屋大学 eBooks · Cited by 119

c-Myc Suppresses p21WAF1/CIP1 Expression during Estrogen Signaling and Antiestrogen Resistance in Human Breast Cancer Cells

Mukherjee, S., & Conrad, S. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502278200 · Cited by 117

Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia.

Polyák, K., Hamilton, S. R., Vogelstein, B., & Kinzler, K. W. (1996) · Europe PMC (PubMed Central) · Cited by 116

The conflicting roles of the cdk inhibitor p21(CIP1/WAF1) in apoptosis

Gartel, A. L. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.04.023 · Cited by 116

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

Swarbrick, A., Roy, E., Allen, T., & Bishop, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801505105 · Cited by 111

p21 delays tumor onset by preservation of chromosomal stability

Barboza, J., Liu, G., Ju, Z., El‐Naggar, A. K., & Lozano, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606343104 · Cited by 110

Subcellular localisation of cyclin B, Cdc2 and p21WAF1/CIP1 in breast cancer

Winters, Z., Hunt, N., Bradburn, M. J., Royds, J. A., Turley, H., Harris, A. L., & Norbury, C. J. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00327-6 · Cited by 110

p21CIP1 and Cdc25A: Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases

Saha, P., Eichbaum, Q. G., Silberman, E. D., Mayer, B. J., & Dutta, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4338 · Cited by 108

Cytoplasmic p21 WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

Winters, Z., Leek, R., Bradburn, M. J., Norbury, C. J., & Harris, A. L. (2003) · Breast Cancer Research · doi:10.1186/bcr654 · Cited by 106

Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest.

Park, M., Chae, H.-D., Yun, J., Jung, M., Kim, Y. S., Kim, S., Han, M. H., & Shin, D. Y. (2000) · PubMed · Cited by 105

Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo

Mantel, C., Luo, Z., Canfield, J., Braun, S. E., Deng, C., & Broxmeyer, H. (1996) · Blood · doi:10.1182/blood.v88.10.3710.bloodjournal88103710 · Cited by 102

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

Soria, G., Podhajcer, O. L., Prives, C. L., & Gottifredi, V. (2005) · Oncogene · doi:10.1038/sj.onc.1209315 · Cited by 100

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

Minucci, S., Monestiroli, S., Giavara, S., Ronzoni, S., Marchesi, F., Insinga, A., Diverio, D., Gasparini, P., Capillo, M., Colombo, E., et al. (2002) · Blood · doi:10.1182/blood-2001-11-0089 · Cited by 100

Interstitial fluid pressure in cervical carcinoma

Milosevic, M., Fyles, A., Wong, R. K. W., Pintilie, M., Kavanagh, M.-C., Levin, W., Manchul, L., Keane, T. J., & Hill, R. P. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980615)82:12 · Cited by 100

Redox Activation of p21 Cip1/WAF1/Sdi1 : A Multifunctional Regulator of Cell Survival and Death

O’Reilly, M. A. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.108 · Cited by 98

CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene

Bai, Y.-Q., Miyaké, S., Iwai, T., & Yuasa, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206634 · Cited by 98

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

Philipp, J., Vo, K., Gurley, K. E., Seidel, K. D., & Kemp, C. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202840 · Cited by 98

The role of human papillomavirus oncoproteins E6 and E7 in apoptosis

Finzer, P., Aguilar‐Lemarroy, A., & Rösl, F. (2002) · Cancer Letters · doi:10.1016/s0304-3835(02)00431-7 · Cited by 96

p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer

Anttila, M., Kosma, V.-M., Hongxiu, J., Puolakka, J. O., Juhola, M., Saarikoski, S., & Syrjänen, K. J. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690298 · Cited by 94

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation

Soria, G., Speroni, J., Podhajcer, O. L., Prives, C., & Gottifredi, V. (2008) · Journal of Cell Science · doi:10.1242/jcs.027730 · Cited by 94

High levels of constitutive WAF1/Cip1 protein are associated with chemoresistance in acute myelogenous leukemia.

Zhang, W., Kornblau, S. M., Kobayashi, T., Gambel, A. M., Claxton, D. F., & Deisseroth, A. B. (1995) · PubMed · Cited by 93

Genetic instability in cancer cells by impaired cell cycle checkpoints

Nakanishi, M., Shimada, M., & Niida, H. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00289.x · Cited by 93

Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells

Ueki, T., Nishidate, T., Park, J. H., Lin, M., Shimo, A., Hirata, K., Nakamura, Y., & Katagiri, T. (2008) · Oncogene · doi:10.1038/onc.2008.186 · Cited by 91

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

Adnane, J., Jackson, R. J., Nicosia, S. V., Cantor, A. B., Pledger, W. J., & Sebti, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203956 · Cited by 91

Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon

Poole, A. J., Heap, D., Carroll, R. E., & Tyner, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207994 · Cited by 90

p21 expression as a predictor for favorable prognosis in squamous cell carcinoma of the lung.

Komiya, T., Hosono, Y., Hirashima, T., Masuda, N., Yasumitsu, T., Nakagawa, K., Kikui, M., Ohno, A., Fukuoka, M., & Kawase, I. (1997) · PubMed · Cited by 89

Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells

Dai, J. L., Schutte, M. E. M., Bansal, R. K., Wilentz, R. E., Sugar, A. Y., & Kern, S. E. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199909)26:1 · Cited by 88

Role of p21WAF1 in the Cellular Response to UV

Fotedar, R., Bendjennat, M., & Fotedar, A. (2004) · Cell Cycle · doi:10.4161/cc.3.2.658 · Cited by 86

Aberrant Expression of Cyclin D1 Is Associated with Poor Prognosis in Early Stage Cervical Cancer of the Uterus

Bae, D., Cho, S. B., Kim, Y., Whang, J.-D., Song, S.-Y., Park, C.-S., Kim, D. S., & Lee, J. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2001.6196 · Cited by 85

Proliferation- and apoptosis-associated factors in advanced prostatic carcinomas before and after androgen deprivation therapy: prognostic significance of p21/WAF1/CIP1 expression

Baretton, G. B., Klenk, U., Diebold, J., Schmeller, N. T., & Löhrs, U. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690390 · Cited by 84

Role of L2DTL, Cell Cycle-Regulated Nuclear and Centrosome Protein, in Aggressive HepatocellularCarcinoma

Pan, H., Chou, H.-Y. E., Liu, S.-H., Peng, S., Liu, C.-L., & Hsu, H. (2006) · Cell Cycle · doi:10.4161/cc.5.22.3500 · Cited by 84

p21-dependent Inhibition of Colon Cancer Cell Growth by Mevastatin Is Independent of Inhibition of G1 Cyclin-dependent Kinases

Ukomadu, C., & Dutta, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307194200 · Cited by 84

p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex

Shiyanov, P. A., Bagchi, S., Adami, G. R., Kokontis, J. M., Hay, N., Arroyo, M., Morozov, A., & Raychaudhuri, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.737 · Cited by 83

Colorectal carcinomas with high microsatellite instability: Defining a distinct immunologic and molecular entity with respect to prognostic markers

Edmonston, T. B. (2000) · Human Pathology · doi:10.1053/hupa.2000.20383 · Cited by 83

Cdk2-dependent Phosphorylation of the NF-Y Transcription Factor and Its Involvement in the p53-p21 Signaling Pathway

Yun, J., Chae, H.-D., Choi, T., Kim, E. H., Bang, Y., Chung, J., Choi, K. S., Mantovani, R., & Shin, D. Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305178200 · Cited by 82

ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development

Shen, K. C., Heng, H. H., Wang, Y., Lu, S., Liu, G., Deng, C., Brooks, S. C., & Wang, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1471 · Cited by 82

P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis

Hafkamp, H. C., Mooren, J. J., Claessen, S. M. H., Klingenberg, B., Voogd, A. C., Bot, F., Klußmann, J. P., Hopman, A. H. N., Manni, J. J., Kremer, B., et al. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.23 · Cited by 81

Nuclear Receptor Hepatocyte Nuclear Factor 4α1 Competes with Oncoprotein c-Myc for Control of the p21/WAF1 Promoter

Hwang‐Verslues, W. W., & Sladek, F. M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0298 · Cited by 81

Loss of the cell cycle inhibitors p21Cip1 and p27Kip1 enhances tumorigenesis in knockout mouse models

Jackson, R. J., Adnane, J., Coppola, D., Cantor, A. B., Sebti, S. M., & Pledger, W. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205946 · Cited by 77

Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma

de la Cueva, E., Garcı́a-Cao, I., Herranz, M., López, P., Garcı́a, P., Flores, J. M., Serrano, M., Fernández‐Piqueras, J., & Martín‐Caballero, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209432 · Cited by 77

Expression of p21WAF1/CIP1 in adenocarcinoma of the uterine cervix: a possible immunohistochemical marker of a favorable prognosis.

Lü, X., Toki, T., Konishi, I., Nikaido, T., & Fujii, S. (1998) · PubMed · Cited by 76

Ubiquitination of p21Cip1/WAF1 by SCFSkp2: Substrate Requirement and Ubiquitination Site Selection

Wang, W., Nacusi, L. P., Sheaff, R. J., & Liu, X. (2005) · Biochemistry · doi:10.1021/bi051071j · Cited by 75

p21WAF1/CIP1 Selectively Controls the Transcriptional Activity of Estrogen Receptor α

Fritah, A., Saucier, C., Mešter, J., Redeuilh, G., & Sabbah, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2419-2430.2005 · Cited by 75

Activation and repression of p21WAF1/CIP1 transcription by RB binding proteins

Gartel, A. L., Goufman, E., Tevosian, S. G., Shih, H. H., Yee, A. S., & Tyner, A. L. (1998) · Oncogene · doi:10.1038/sj.onc.1202240 · Cited by 74

Is p21 an oncogene?

Gartel, A. L. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0163 · Cited by 74

The human papilloma virus 16E6 gene sensitizes human mammary epithelial cells to apoptosis induced by DNA damage.

Xu, C., Meikrantz, W., Schlegel, R., & Sager, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7829 · Cited by 72

Down‐regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer

Ogino, S., Kawasaki, T., Kirkner, G. J., Ogawa, A., Dorfman, I., Loda, M. F., & Cs, F. (2006) · The Journal of Pathology · doi:10.1002/path.2030 · Cited by 71

Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells.

Gong, J., Ammanamanchi, S., Ko, T. C., & Brattain, M. G. (2003) · PubMed · Cited by 69

PDK1‐dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein

Scott, M. T., Ingram, A., & Ball, K. L. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf684 · Cited by 69

Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.

Lebel, M., Cardiff, R. D., & Leder, P. (2001) · PubMed · Cited by 68

Regulatory Roles of p21 and Apurinic/Apyrimidinic Endonuclease 1 in Base Excision Repair

Tom, S., Ranalli, T. A., Podust, V. N., & Bambara, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109626200 · Cited by 65

p53, p21 and p27 protein expression in head and neck cancer and their prognostic value.

Kapranos, N., Stathopoulos, G. P., Manolopoulos, L., Kokka, E., Papadimitriou, C., Bibas, A. G., Yiotakis, J., & Adamopoulos, G. K. (2001) · PubMed · Cited by 64

Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.

Weinberg, W. C., Fernández‐Salas, E., Morgan, D. L., Shalizi, A., Mirosh, E., Stanulis, E., Deng, C., Hennings, H., & Yuspa, S. H. (1999) · PubMed · Cited by 64

Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.

Bearss, D. J., Lee, R. J., Troyer, D. A., Pestell, R. G., & Windle, J. J. (2002) · PubMed · Cited by 62

Novel polymorphism in p21waf1/cip1 cyclin dependent kinase inhibitor gene: association with human esophageal cancer

Bahl, R., Arora, S., Nath, N., Mathur, M., Shukla, N. K., & Ralhan, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203325 · Cited by 62

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO

Peterson, L. F., Yan, M., & Zhang, D. (2007) · Blood · doi:10.1182/blood-2006-03-012575 · Cited by 61

BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK

Beck, S. E., Jung, B. H., Rosario, E. D., Gómez, J., & Carethers, J. M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.01.017 · Cited by 61

Regulation of Kruppel-like Factor 6 Tumor Suppressor Activity by Acetylation

Li, D., Yea, S., Dolios, G., Martignetti, J. A., Narla, G., Wang, R., Walsh, M. J., & Friedman, S. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1040 · Cited by 59

The Xeroderma Pigmentosum Group E Gene Product DDB2 Activates Nucleotide Excision Repair by Regulating the Level of p21Waf1/Cip1

Stoyanova, T. I., Yoon, T., Kopanja, D., MOKYR, M. B., & Raychaudhuri, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00880-07 · Cited by 57

Inactivation of p21 Enhances Intestinal Tumor Formation in Muc2−/− Mice

Yang, W., Velcich, A., Lozonschi, I., Liang, J., Nicholas, C., Zhuang, M., Bancroft, L. K., & Augenlicht, L. H. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62342-5 · Cited by 57

Functional Analysis of a p21 Mutant (Arg94→ Trp) Identified in a Human Breast Carcinoma

Balbı́n, M., Hannon, G. J., Pendás, A. M., Ferrando, A. A., Vizoso, F. J., Fueyo, A., & López-Otı́n, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15782 · Cited by 55

Aberrant expression of p21WAF1/CIP1 and p27KIP1 in cervical carcinoma

Cheung, T. H., Lo, K. W. K., Yu, M. M. Y., Yim, S. F., Poon, C. S., Chung, T. K. H., & Wong, Y. F. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00624-3 · Cited by 54

p21WAF1/CIP1 protein expression in primary ovarian cancer.

Ferrandina, G., Stoler, A., Fagotti, A., Fanfani, F., Sacco, R., Pasqua, A. D., Mancuso, S., & Scambia, G. (2000) · International Journal of Oncology · doi:10.3892/ijo.17.6.1231 · Cited by 54

The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

Kehn‐Hall, K., Deng, L., de la Fuente, C., Strouss, K. M., Wu, K., Maddukuri, A., Baylor, S., Rufner, R., Pumfery, A. M., Bottazzi, M. E., et al. (2004) · Retrovirology · doi:10.1186/1742-4690-1-6 · Cited by 54

Somatic cell type specific gene transfer reveals a tumor‐promoting function for p21Waf1/Cip1

Liu, Y., Yeh, N., Zhu, X.-H., Leversha, M. A., Cordon‐Cardo, C., Ghossein, R. A., Singh, B., Holland, E. C., & Koff, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601886 · Cited by 52

Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer

Forootan, S. S., Wong, Y. C., Dodson, A. R., Wang, X., Lin, K., Smith, P. H., Foster, C. S., & Ke, Y. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.02.011 · Cited by 51

A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription

Gartel, A. L., Najmabadi, F., Goufman, E., & Tyner, A. L. (2000) · Oncogene · doi:10.1038/sj.onc.1203411 · Cited by 50

Phosphorylation of the Cyclin-Dependent Kinase Inhibitor p21Cip1 on Serine 130 Is Essential for Viral Cyclin-Mediated Bypass of a p21Cip1-Imposed G1 Arrest

Järviluoma, A., Child, E. S., Sarek, G., Sirimongkolkasem, P., Peters, G. G., Ojala, P. M., & Mann, D. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2430-2440.2006 · Cited by 49

Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer.

Ralhan, R., Agarwal, S., Mathur, M., Wasylyk, B., & Srivastava, A. (2000) · PubMed · Cited by 47

High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus–associated chronic liver diseases

Wagayama, H., Shiraki, K., Sugimoto, K., Ito, T., Fujikawa, K., Yamanaka, T., Takase, K., & Nakano, T. (2002) · Human Pathology · doi:10.1053/hupa.2002.124724 · Cited by 46

Expression of retinoblastoma gene product and p21 (WAF1/Cip 1) protein in gliomas: correlations with proliferation markers, p53 expression and survival

Korkolopoulou, P. A., Kouzelis, K., Christodoulou, P. N., Papanikolaou, A., & Thomas-Tsagli, E. (1998) · Acta Neuropathologica · doi:10.1007/s004010050848 · Cited by 45

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression

Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395

Cell cycle regulation: p53-p21-RB signaling

Engeland, K. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00988-z · Cited by 1,367

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage.

Karimian, A., Ahmadi, Y., & Yousefi, B. (2016) · DNA Repair · doi:10.1016/j.dnarep.2016.04.008 · Cited by 1,110

The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

Bitar, S. A., & Gali‐Muhtasib, H. U. (2019) · Cancers · doi:10.3390/cancers11101475 · Cited by 231

The Dual Role Played by p21 May Influence the Apoptotic or Anti-Apoptotic Fate in Cancer

Piccolo, M. T., & Crispi, S. (2012) · Journal of cancer research updates · doi:10.6000/1929-2279.2012.01.02.5 · Cited by 65

p21WAF1/CIP1 and cancer: A shifting paradigm?

Gartel, A. L. (2009) · BioFactors · doi:10.1002/biof.26 · Cited by 73

Abstract 3470: The antagonistic functional duality of p21WAF1/CIP1in cells derived from multicellular tumor spheroids

Das, V., Annadurai, N., Holub, D., & Hajdúch, M. (2019) · Molecular and Cellular Biology / Genetics · doi:10.1158/1538-7445.sabcs18-3470

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

El‐Deiry, W. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-2055 · Cited by 268