Cited by 2,712Cancer-related Molecular PathwaysSignaling Pathways in DiseasePI3K/AKT/mTOR signaling in cancer

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p21 in cancer: intricate networks and multiple activities

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Abbas, Tarek, Dutta, Anindya·2009·Nature Reviews Cancer

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Abstract

One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals. This Review focuses on recent advances in our understanding of the regulation of p21 and its biological functions with emphasis on its p53-independent tumour suppressor activities and paradoxical tumour-promoting activities, and their implications in cancer.

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Martin-Caballero, J., Flores, J. M., Garcia-Palencia, P. & Serrano, M. Tumor susceptibility of p21Waf1/Cip1-deficient mice. Cancer Res. 61, 6234–6238 (2001). This study demonstrates that deletion of Cdkn1a in mice results in spontaneous tumours but with late onset.

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Authors: Abbas, T., & Dutta, A.
Affiliations: University of Virginia (US)
Corresponding author: Abbas, Tarek
Dutta, Anindya
ORCID: Abbas, Tarek
Dutta, Anindya
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-05-14
Volume: 9
Issue: 6
Pages: 400-414
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2657
PMC: PMC2722839
OpenAlex: W2162262059
Cited by: 2,712
References: 236
Citations by year: 2026: 99 · 2025: 156 · 2024: 161 · 2023: 206 · 2022: 182 · 2021: 205 · 2020: 204 · 2019: 180 · 2018: 191 · 2017: 196 · 2016: 148 · 2015: 160 · 2014: 142 · 2013: 151 · 2012: 122
FWCI: 9.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA089406, R01 CA 89406, T32CA009109)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: p21, cyclin-dependent kinase inhibitors, cell cycle arrest, therapeutic target, cell transformation
MeSH terms: Animals, Cell Cycle, Humans, Neoplasms, Tumor Suppressor Protein p53, Cyclin-Dependent Kinase Inhibitor p21

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