p53 and E2f: partners in life and death

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063

Network motifs: theory and experimental approaches

Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,231

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications

van Harten, A. M., & Brakenhoff, R. H. (2021) · Cancers · doi:10.3390/cancers13112774 · Cited by 33

Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma

Feng, X., Guo, J., An, G., Wu, Y., Liu, Z., Meng, B., He, N., Zhao, X., Chen, S., Zhu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202104491 · Cited by 31

Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool

Nakajima, R., Zhao, L., Zhou, Y., Shirasawa, M., Uchida, A., Murakawa, H., Fikriyanti, M., Iwanaga, R., Bradford, A. P., Araki, K., et al. (2023) · Genes · doi:10.3390/genes14020393 · Cited by 32

Aqueous Extract of Curcuma aromatica Induces Apoptosis and G2/M Arrest in Human Colon Carcinoma LS-174-T Cells Independent of p53

Hu, B., Shen, K., An, H., Wu, Y., & Du, Q. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0853 · Cited by 30

Deregulation of Rb-E2F1 Axis Causes Chromosomal Instability by Engaging the Transactivation Function of Cdc20–Anaphase-Promoting Complex/Cyclosome

Nath, S., Chowdhury, A., Dey, S., Roychoudhury, A., Ganguly, A., Bhattacharyya, D., & Roychoudhury, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00868-14 · Cited by 30

Zinc finger protein ZBTB20 promotes cell proliferation in non‐small cell lung cancer through repression of FoxO1

Zhao, J., Ren, K., & Tang, J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.10.005 · Cited by 30

Knockdown of Golgi phosphoprotein 73 blocks the trafficking of matrix metalloproteinase‐2 in hepatocellular carcinoma cells and inhibits cell invasion

Liu, Y., Zhang, X., Zhou, S., Shi, J., Xu, Y. L., He, J., Feng, L., Wei, A., Zhou, L., & Chen, Z. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14055 · Cited by 30

A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor

Yi, Y., Polosukhina, D., Love, H. D., Hembd, A., Pickup, M. W., Moses, H. L., Lovvorn, H. N., Zent, R., & Clark, P. E. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.04.090 · Cited by 29

AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts

González‐Gironès, D. M., Moncunill‐Massaguer, C., Iglesias‐Serret, D., Cosialls, A. M., Pérez‐Perarnau, A., Palmeri, C. M., Rubio‐Patiño, C., Villunger, A., Pons, G., & Gil, J. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0850-6 · Cited by 30

Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective

Sun, T., & Cui, J. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.08.017 · Cited by 29

Virus-Mediated Inhibition of Apoptosis in the Context of EBV-Associated Diseases: Molecular Mechanisms and Therapeutic Perspectives

Wyżewski, Z., Mielcarska, M. B., Gregorczyk-Zboroch, K. P., & Myszka, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137265 · Cited by 30

Study on the material basis and action mechanisms of sophora davidii (Franch.) skeels flower extract in the treatment of non-small cell lung cancer

Ye, B., Chen, P., Lin, C., Zhang, C., & Li, L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116815 · Cited by 28

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma

Pitman, R. T., Wojdyla, L. M., & Puri, N. (2013) · Oncotarget · doi:10.18632/oncotarget.1047 · Cited by 29

Loss of MAP3K1 enhances proliferation and apoptosis during retinal development

Mongan, M., Wang, J., Liu, H., Fan, Y., Jin, C., Kao, W. Y., & Xia, Y. (2011) · Development · doi:10.1242/dev.065003 · Cited by 30

SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis

Yang, B., WANG, L., Luo, X., Chen, L., Yang, Z., & Liu, L. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2768 · Cited by 28

Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma

Kuczyk, M. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1367 · Cited by 28

Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53

He, T., Guo, J., Song, H., Zhu, H., Di, X., Min, H., Wang, Y., Chen, G., Dai, W., Ma, J., et al. (2017) · Pathology & Oncology Research · doi:10.1007/s12253-017-0215-5 · Cited by 28

Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals

Tian, X., Huang, B. Y., Zhang, X., Lu, M., Liu, F., Onuchic, J. N., & Wang, W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702412114 · Cited by 28

MSTD: an efficient method for detecting multi-scale topological domains from symmetric and asymmetric 3D genomic maps

Ye, Y., Gao, L., & Zhang, S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz201 · Cited by 27

A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targetingWIP1

Wang, B., Li, D., Sidler, C. L., Rodriguez‐Juarez, R., Singh, N., Heyns, M., Ilnytskyy, Y., Bronson, R. T., & Kovalchuk, O. (2015) · Oncotarget · doi:10.18632/oncotarget.3157 · Cited by 27

Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic

Khan, F. M., Schmitz, U., Nikolov, S. G., Engelmann, D., Pützer, B. M., Wolkenhauer, O., & Vera, J. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.05.007 · Cited by 27

Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas

Jiao, J., Niu, W., Wang, Y., Baggerly, K., Ye, Y., Wu, X., Davenport, D., Almeda, J. L., Betancourt-Garcia, M. M., Forse, R. A., et al. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0235 · Cited by 27

Generation of knockout mice using engineered nucleases

Sung, Y. H., Jin, Y., Kim, S., & Lee, H. (2014) · Methods · doi:10.1016/j.ymeth.2014.02.009 · Cited by 27

Transcription factors and cognate signalling cascades in the regulation of autophagy

Chandra, V., Bhagyaraj, E., Parkesh, R., & Gupta, P. (2016) · Biological Reviews · doi:10.1111/brv.12177 · Cited by 26

YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution

Faraji, F., Ramirez, S. I., Clubb, L. M., Sato, K., Burghi, V., Hoang, T. S., Officer, A., Quiroz, P. Y. A., Galloway, W. M. G., Mikulski, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55660-6 · Cited by 28

The miRNA network: micro-regulator of cell signaling in cancer

Mei, Q., Li, X., Guo, M., Fu, X., & Han, W. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.953935 · Cited by 26

Transcription Factors in Breast Cancer—Lessons From Recent Genomic Analyses and Therapeutic Implications

Zacksenhaus, E., Liu, J.-K., Jiang, Z., Yao, Y., Xia, L., Shrestha, M., & Ben‐David, Y. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.10.003 · Cited by 28

RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells

Carper, M. B., Denvir, J., Bošković, G., Primerano, D. A., & Claudio, P. P. (2014) · Genes & Cancer · doi:10.18632/genesandcancer.43 · Cited by 26

E2F1 activates MFN2 expression by binding to the promoter and decreases mitochondrial fission and mitophagy in HeLa cells

Bucha, S., Mukhopadhyay, D., & Bhattacharyya, N. P. (2019) · FEBS Journal · doi:10.1111/febs.14980 · Cited by 26

Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells

Prudnikova, T. Y., Mostovich, L. A., Доманицкая, Н. В., Pavlova, T. V., Kashuba, V. I., Zabarovsky, E. R., & Витальевна, Г. Э. (2010) · Cancer Cell International · doi:10.1186/1475-2867-10-27 · Cited by 26

Identifying module biomarkers from gastric cancer by differential correlation network

Liu, X., & Chang, X. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s113281 · Cited by 25

Advances in the targeted therapy of liposarcoma

Guan, Yu, X., Wang, H., Wang, H., Zhang, J., Li, G., Cao, J., & Teng, L. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s72722 · Cited by 25

Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma

Fang, E., Wang, J., Hong, M., Zheng, L., & Tong, Q. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.103 · Cited by 25

E2F1 Reduces Sorafenib’s Sensitivity of Esophageal Carcinoma Cells via Modulating the miR-29c-3p/COL11A1 Signaling Axis

Ma, Z., Zhu, T., Wang, H., Wang, B., Fu, L., & Yu, G. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467216666230306101653 · Cited by 24

KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

Jiang, X., Wang, T., Zhao, B. X., Sun, H., Dong, Y., Ma, Y., Li, Z., Wu, Y., Wang, K., Guan, X., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101966 · Cited by 26

Combined analysis identifies six genes correlated with augmented malignancy from non-small cell to small cell lung cancer

Zhang, C., Min, L., Zhang, L.-Y., Ma, Y., Yang, Y., & Shou, C. (2015) · Tumor Biology · doi:10.1007/s13277-015-3938-5 · Cited by 24

A novel oncoprotein Pirh2: rising from the shadow of MDM2

Wang, Z., Yang, B. R., Dong, L., Peng, B., He, X., & Liu, W. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01899.x · Cited by 24

CGGBP1 regulates cell cycle in cancer cells

Singh, U., Roswall, P., Uhrbom, L., & Westermark, B. (2011) · BMC Molecular Biology · doi:10.1186/1471-2199-12-28 · Cited by 24

Functions and epigenetic aspects of miR-15/16: Possible future cancer therapeutics

Ramaiah, M. J. (2018) · Gene Reports · doi:10.1016/j.genrep.2018.06.012 · Cited by 24

FOXD1 Repression Potentiates Radiation Effectiveness by Downregulating G3BP2 Expression and Promoting the Activation of TXNIP-Related Pathways in Oral Cancer

Lin, C.-H., Lee, H., Chang, W., Lee, F., Chen, L.-C., Lu, L., & Lin, Y. (2020) · Cancers · doi:10.3390/cancers12092690 · Cited by 24

Inhibitory effect of vitamin C on intrinsic aging in human dermal fibroblasts and hairless mice

Jeong, J.-H., Kim, M., Kim, C., & Hwang, J. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0252-6 · Cited by 25

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic Opportunities

Li, M., & Chen, C.-W. D. (2022) · Biomedicines · doi:10.3390/biomedicines10061325 · Cited by 23

Virus-induced host genomic remodeling dysregulates gene expression, triggering tumorigenesis

Dong, W., Wang, H., Li, M., Li, P., & Ji, S. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1359766 · Cited by 23

pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737

Bertin-Ciftci, J., Barré, B., Pen, J. L., Maillet, L., Couriaud, C., Juin, P. P., & Braun, F. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.6 · Cited by 23

Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides

Puri, N., Pitman, R. T., Mulnix, R. E., Erickson, T., Iness, A. N., Vitali, C., Zhao, Y., & Salgia, R. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.09.010 · Cited by 23

MicroRNAs in human glioblastoma from bench to beside

Chen, J. (2015) · Frontiers in bioscience · doi:10.2741/4300 · Cited by 23

E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling

Jorgez, C. J., Seth, A., Wilken, N., Bournat, J. C., Chen, C. H., & Lamb, D. J. (2021) · Development · doi:10.1242/dev.191189 · Cited by 23

An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis

Cao, M., Zou, X., Li, C., Lin, Z., Wang, N., Zou, Z., Ye, Y., Seemann, J., Levine, B., Tang, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37340-z · Cited by 22

Dynamic analysis of the combinatorial regulation involving transcription factors and microRNAs in cell fate decisions

Yan, F., Liu, H., & Liu, Z. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.06.022 · Cited by 22

Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer

Cui, C., Jia, Q., Deng, Q., Chen, R., Zhai, D., & Yu, J. (2016) · BioMed Research International · doi:10.1155/2016/1804137 · Cited by 22

Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury

Aubrecht, T. G., Faden, A. I., Sabirzhanov, B. E., Glaser, E. P., Roelofs, B. A., Polster, B. M., Makarevich, O. D., & Stoica, B. A. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1156-y · Cited by 22

Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid's anti-metastatic effect in 4T1 tumor bearing mice

Gao, J., Shui, Y.-M., Jiang, W., Huang, E., Shou, Q., Ji, X., He, B., Lv, G., & He, T. (2016) · Oncotarget · doi:10.18632/oncotarget.12375 · Cited by 22

Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC

Wang, S., Wang, L., Sun, D., Chai, C., Hsi, E., Kuo, H., Yokoyama, K. K., & Hsu, S. (2016) · Oncotarget · doi:10.18632/oncotarget.9228 · Cited by 21

The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F

Nakajima, R., Deguchi, R., Komori, H., Zhao, L., Zhou, Y., Shirasawa, M., Angelina, A., Goto, Y., Tohjo, F., Nakahashi, K., et al. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.092 · Cited by 21

Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation

Riehl, A., Bauer, T., Brors, B., Busch, H. S., Mark, R., Németh, J., Gebhardt, C., Bierhaus, A., Nawroth, P. P., Eils, R., et al. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-537 · Cited by 21

Carotid body growth during chronic postnatal hyperoxia

Dmitrieff, E. F., Piro, S. E., Broge, T. A., Dunmire, K. B., & Bavis, R. W. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.11.006 · Cited by 21

Regulating the genome surveillance system: miRNAs and the p53 super family

Bailey, S. G., Sánchez-Elsner, T., Stephanou, A., Cragg, M. S., & Townsend, P. A. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0456-1 · Cited by 22

MEF/ELF4 transactivation by E2F1 is inhibited by p53

Taura, M., Suico, M. A., Fukuda, R., Koga, T., Shuto, T., Sato, T., Morino‐Koga, S., Okada, S., & Kai, H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq762 · Cited by 21

Identification of informative genes and pathways using an improved penalized support vector machine with a weighting scheme

Chan, W. H., Mohamad, M. S., Deris, S., Zaki, N., Kasim, S. B., Omatu, S., Corchado, J. M., & Alashwal, H. (2016) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2016.08.004 · Cited by 21

Heterogeneous Reciprocal Graphical Models

Ni, Y., Müller, P., Zhu, Y., & Ji, Y. (2017) · Biometrics · doi:10.1111/biom.12791 · Cited by 23

E2F1 acts as a negative feedback regulator of c-Myc-induced hTERT transcription during tumorigenesis

Zhang, Y., Zhang, A., Shen, C., Zhang, B., RAO, Z., Wang, R., Yang, S., Ning, S., Mao, G.-P., & Fang, D.-C. (2014) · Oncology Reports · doi:10.3892/or.2014.3287 · Cited by 21

TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond

Wu, Q., Nandi, D., & Sharma, D. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10226-2 · Cited by 22

Tumor suppressor p53 status does not determine the differentiation-associated G1cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D3and antioxidants

Thompson, T., Danilenko, M., Vassilev, L. T., & Studzinski, G. P. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.4.12366 · Cited by 20

Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice

Devkota, S., Sung, Y. H., Choi, J., Lee, J., Ha, N. Y., Kim, H., Cho, B. C., Song, J., & Lee, H. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.06.034 · Cited by 20

Effect of HPV E6/E7 siRNA with Chemotherapeutic Agents on the Regulation of TP53/E2F Dynamic Behavior for Cell Fate Decisions

Rajasekaran, N., Jung, H. S., Bae, S. H., Chelakkot, C., Hong, S., Choi, J., Yim, D., Oh, Y., Choi, Y., & Shin, Y. K. (2017) · Neoplasia · doi:10.1016/j.neo.2017.07.005 · Cited by 20

Antiproliferative Effect of Vine Stem Extract fromSpatholobus SuberectusDunn on Rat C6 Glioma Cells Through Regulation of ROS, Mitochondrial Depolarization, and P21 Protein Expression

Kim, H., Yi, S. S., Lee, H., Heo, T., Park, S., Jun, H. S., Song, K., & Kim, S. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1460673 · Cited by 20

E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program

Jiang, X., Nevins, J. R., Shats, I., & Chi, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127951 · Cited by 20

Co-culture with human fetal epidermal keratinocytes promotes proliferation and migration of human fetal and adult dermal fibroblasts

WANG, Z., Liu, X., Zhang, D., Wang, X., Zhao, F., Shi, P., & Pang, X. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2798 · Cited by 19

Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk

Wang, F., Wang, P., Wang, B., Fu, Z., Yuan, Y., Yan, S.-L., Zhao, W., & Wang, Y. (2013) · Tumor Biology · doi:10.1007/s13277-013-1359-x · Cited by 19

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision

Sun, C., Zhang, X., & Wang, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194768 · Cited by 19

E2F1 promotes cancer cell sensitivity to cisplatin by regulating the cellular DNA damage response through miR-26b in esophageal squamous cell carcinoma

Zhang, K., Zhang, B., Bai, Y., & Dai, L. (2019) · Journal of Cancer · doi:10.7150/jca.33983 · Cited by 19

Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex

Gong, W., Gohla, R. M., Bowlin, K. M., Koyano‐Nakagawa, N., Garry, D. J., & Shi, X. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.629956 · Cited by 19

Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes

Khan, R., Puszyński, K., & Kozłowska, E. (2024) · Genes · doi:10.3390/genes15050577 · Cited by 19

S-phase-coupled apoptosis in tumor suppression

Cho, Y., & Liang, P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0666-x · Cited by 19

E2F1 inhibits MDM2 expression in a p53-dependent manner

Tian, X., Chen, Y., Hu, W., & Wu, M. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.003 · Cited by 18

La sénescence cellulaire

Brondello, J., Prieur, A., Philipot, D., Lemaı̂tre, J.-M., Lenaers, G., Piette, J., & Dulić, V. (2012) · médecine/sciences · doi:10.1051/medsci/2012283017 · Cited by 28

Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas

Malhotra, S., Winans, S., Lam, G., Justice, J., Morgan, R. W., & BEEMON, K. L. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006708 · Cited by 19

Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes

Komori, H., Goto, Y., Kurayoshi, K., Ozono, E., Iwanaga, R., Bradford, A. P., Araki, K., & Ohtani, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-26860-0 · Cited by 18

The Naturally Occurring ∆40p53 Isoform Inhibits eRNA Transcription and Enables Context-Specific Regulation During p53 Activation

Levandowski, C. B., Jones, T., Gruca, M. A., Ramamoorthy, S., Dowell, R. D., & Taatjes, D. J. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3001364 · Cited by 18

Transduction of Fetal Mice With a Feline Lentiviral Vector Induces Liver Tumors Which Exhibit an E2F Activation Signature

Condiotti, R., Goldenberg, D., Giladi, H., Perlman, T. S., Waddington, S. N., Buckley, S. M. K., Heim, D., Cheung, W., Themis, M., Coutelle, C., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.193 · Cited by 18

Ei24, a Novel E2F Target Gene, Affects p53-independent Cell Death upon Ultraviolet C Irradiation

Sung, Y. H., Jin, Y., Kang, Y., Devkota, S., Lee, J., Roh, J.-I., & Lee, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.477570 · Cited by 17

Recent translational research into targeted therapy for liposarcoma

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Fang, Y., & Gu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.771065 · Cited by 17

MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation

Deb, S. P., Singh, S., & Deb, S. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_12 · Cited by 18

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Zhou, Y., Frings, O., Branca, R. M., Boekel, J., le Sage, C., Fredlund, E., Agami, R., & Orre, L. M. (2016) · Oncogene · doi:10.1038/onc.2016.242 · Cited by 17

E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx

Li, Y., Sturgis, E. M., Zhu, L., Cao, X., Wei, Q., Zhang, H., & Li, G. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22595 · Cited by 17

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VentX trans-Activates p53 and p16ink4a to Regulate Cellular Senescence

Wu, X., Gao, H., Ke, W., Hager, M. H., Xiao, S., Freeman, M. R., & Zhu, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206078 · Cited by 17

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Amin, A. R. M. R., Thakur, V. S., Gupta, K., Jackson, M. W., Harada, H., Agarwal, M. K., Shin, D. M., Wald, D. N., & Agarwal, M. L. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0732 · Cited by 18

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Scalia, P., Williams, S. J., Fujita‐Yamaguchi, Y., & Giordano, A. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2108117 · Cited by 17

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Tennen, R. I., Haye, J. E., Wijayatilake, H. D., Arlow, T., Ponzio, D. Y., & Gammie, A. E. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.11.002 · Cited by 17

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Thangue, N. B. L. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240054 · Cited by 72

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