Transcription factors and cognate signalling cascades in the regulation of autophagy

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Cellular survival: a play in three Akts

Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536 · see citing works

TFEB Links Autophagy to Lysosomal Biogenesis

Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330 · see citing works

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

The Role of Atg Proteins in Autophagosome Formation

Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

Signal integration by JNK and p38 MAPK pathways in cancer development

Wagner, E. F., & Nebreda, Á. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2694 · Cited by 2,583 · see citing works

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,578 · see citing works

A Gene Network Regulating Lysosomal Biogenesis and Function

Sardiello, M., Palmieri, M., di Ronza, A., Medina, D. L., Valenza, M., Gennarino, V. A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R. S., et al. (2009) · Science · doi:10.1126/science.1174447 · Cited by 2,543 · see citing works

Autophagy in Health and Disease: A Double-Edged Sword

Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,531 · see citing works

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,494 · see citing works

PI3K/Akt signalling pathway and cancer

Vara, J. Á. F., Casado, E., de Castro, J., Cejas, P., Belda-Iniesta, C., & González-Barón, M. (2003) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2003.07.007 · Cited by 2,446 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097 · see citing works

mTOR regulation of autophagy

Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

A ubiquitin-like system mediates protein lipidation

Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., et al. (2000) · Nature · doi:10.1038/35044114 · Cited by 2,064 · see citing works

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,932 · see citing works

The functions and regulation of the PTEN tumour suppressor

Song, M. S., Salmena, L., & Pandolfi, P. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3330 · Cited by 1,926 · see citing works

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Inoki, K., Li, Y., Xu, T., & Guan, K.-L. (2003) · Genes & Development · doi:10.1101/gad.1110003 · Cited by 1,911 · see citing works

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works

Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Androgen Receptor in Prostate Cancer

Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780 · see citing works

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693 · see citing works

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ganley, I. G., Lam, D., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900573200 · Cited by 1,559 · see citing works

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-09 · Cited by 1,501 · see citing works

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

Autophagy as a cell death and tumor suppressor mechanism

Gözüaçık, D., & Kimchi, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207521 · Cited by 1,386 · see citing works

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380 · see citing works

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

Martina, J. A., Chen, Y., Guček, M., & Puertollano, R. (2012) · Autophagy · doi:10.4161/auto.19653 · Cited by 1,360 · see citing works

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329 · see citing works

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · cited 1× · see citing works

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works

The AMP‐Activated Protein Kinase: Fuel Gauge of the Mammalian Cell?

Hardie, D. G., & Carling, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00259.x · Cited by 1,317 · see citing works

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Yousefi, S., Perozzo, R., Schmid, I., Ziemiecki, A., Schaffner, T. J., Scapozza, L., Brunner, T., & Simon, H. (2006) · Nature Cell Biology · doi:10.1038/ncb1482 · Cited by 1,300 · see citing works

Coping with stress: eIF2 kinases and translational control

Wek, R. C., Jiang, H.-Y., & Anthony, T. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340007 · Cited by 1,290 · see citing works

A Unified Nomenclature for Yeast Autophagy-Related Genes

Klionsky, D. J., Cregg, J. M., Dunn, W. A., Emr, S. D., Sakai, Y., Sandoval, I. V., Sibirny, A. А., Subramani, S. E., Thumm, M., Marten Veenhuis, A., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00296-x · Cited by 1,267 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.026 · Cited by 1,234 · see citing works

The Role of Autophagy in Cancer: Therapeutic Implications

Yang, Z. J., Chee, C. E., Huang, S., & Sinicrope, F. A. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0047 · Cited by 1,217 · see citing works

Emerging regulation and functions of autophagy

Boya, P., Reggiori, F., & Codogno, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2788 · Cited by 1,216 · see citing works

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176 · see citing works

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162 · see citing works

SNARE-mediated membrane fusion

Chen, Y. A., & Scheller, R. H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052017 · Cited by 1,133 · see citing works

The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy

Hanada, T., Noda, N. N., Satomi, Y., Ichimura, Y., Fujioka, Y., Takao, T., Inagaki, F., & Ohsumi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700195200 · Cited by 1,123 · cited 1× · see citing works

Autophagy and signaling: their role in cell survival and cell death

Codogno, P., & Meijer, A. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401751 · Cited by 1,092 · see citing works

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health

Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090 · see citing works

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works

Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.009 · Cited by 1,072 · see citing works

Post‐translational modifications and activation of p53 by genotoxic stresses

Appella, E., & Anderson, C. W. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02225.x · Cited by 1,071 · see citing works

The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,034 · see citing works

Endoplasmic Reticulum Stress Triggers Autophagy

Yorimitsu, T., Nair, U., Yang, Z., & Klionsky, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607007200 · Cited by 941 · see citing works

The molecular machinery of autophagy: unanswered questions

Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 935 · see citing works

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., & Momoi, T. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401984 · Cited by 934 · see citing works

Nuclear factor-?B: its role in health and disease

Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933 · see citing works

Regulation of PTEN Transcription by p53

Stambolic, V., MacPherson, D. P., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., & Mak, T. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00323-9 · Cited by 913 · see citing works

Autophagosome Formation in Mammalian Cells.

Mizushima, N., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function · doi:10.1247/csf.27.421 · Cited by 877 · see citing works

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00302-2 · Cited by 868 · see citing works

Autophagy, Immunity, and Microbial Adaptations

Deretic, V. P., & Levine, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.016 · Cited by 865 · see citing works

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., & Greenberg, M. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.952-965.2001 · Cited by 860 · see citing works

Management of cellular energy by the AMP‐activated protein kinase system

Hardie, D. G., Scott, J. W., Pan, D. A., & Hudson, E. R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00560-x · Cited by 855 · see citing works

Bcl-2 family members: Dual regulators of apoptosis and autophagy

Levine, B., Sinha, S. C., & Kroemer, G. (2008) · Autophagy · doi:10.4161/auto.6260 · Cited by 834 · see citing works

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development · doi:10.1101/gad.11.24.3471 · Cited by 818 · see citing works

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

Kim, J., Kim, Y. C., Fang, C., Russell, R. C., Kim, J. H., Fan, W., Liu, R., Zhong, Q., & Guan, K. (2013) · Cell · doi:10.1016/j.cell.2012.12.016 · Cited by 806 · see citing works

Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

Li, M., Brooks, C. L., Wu-Baer, F., Chen, D., Baer, R., & Gu, W. (2003) · Science · doi:10.1126/science.1091362 · Cited by 804 · cited 1× · see citing works

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

Williams, A., Sarkar, S., Cuddon, P., Ttofi, E. K., Saiki, S., Siddiqi, F. H., Jahreiss, L., Fleming, A., Pask, D., Goldsmith, P., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.79 · Cited by 800 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

Liang, C., Lee, J.-S., Inn, K.-S., Gack, M. U., Li, Q., Roberts, E. A., Vergne, I., Deretic, V., Feng, P., Akazawa, C., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1740 · Cited by 792 · see citing works

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

Yuk, J., Shin, D., Lee, H., Yang, C., Jin, H. S., Kim, K., Lee, Z., Lee, S.-H., Kim, J., & Jo, E. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.08.004 · Cited by 787 · see citing works

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Nazio, F., Strappazzon, F., Antonioli, M., Bielli, P., Cianfanelli, V., Bordi, M., Gretzmeier, C., Dengjel, J., Piacentini, M., Fimia, G. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2708 · Cited by 783 · see citing works

The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

Geng, J., & Klionsky, D. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.163 · Cited by 781 · see citing works

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

Funderburk, S. F., Wang, Q. J., & Yue, Z. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.002 · Cited by 778 · see citing works

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

Nobukuni, T., Joaquin, M., Roccio, M., Dann, S. G., Kim, S. Y., Gulati, P., Byfield, M. P., Backer, J., Natt, F., Bos, J. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506925102 · Cited by 753 · see citing works

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

Tallóczy, Z., Jiang, W., Virgin, H. W., Leib, D. A., Scheuner, D. L., Kaufman, R. J., Eskelinen, E., & Levine, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012485299 · Cited by 741 · see citing works

The E2F transcriptional network: old acquaintances with new faces

Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715 · see citing works

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

Palacios, E. H., & Weiss, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208074 · Cited by 714 · see citing works

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

Polson, H. E. J., de Lartigue, J., Rigden, D. J., Reedijk, M., Urbé, S., Clague, M. J., & Tooze, S. A. (2010) · Autophagy · doi:10.4161/auto.6.4.11863 · Cited by 712 · see citing works

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

Hariharan, N., Maejima, Y., Nakae, J., Paik, J., DePinho, R. A., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.110.227371 · Cited by 688 · see citing works

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

Martina, J. A., Diab, H. I., Lishu, L., Jeong-A, L., Patange, S., Raben, N., & Puertollano, R. (2014) · Science Signaling · doi:10.1126/scisignal.2004754 · Cited by 677 · see citing works

The Beclin 1 interactome

He, C., & Levine, B. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.01.001 · Cited by 659 · see citing works

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature · doi:10.1038/nature11895 · Cited by 625 · see citing works

Integrating signals from RTKs to ERK/MAPK

Mckay, M., & Morrison, D. K. (2007) · Oncogene · doi:10.1038/sj.onc.1210394 · Cited by 616 · see citing works

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

Zhao, Y., Yang, J. H., Liao, W., Liu, X., Zhang, H., Wang, S., Wang, D., Feng, J., Yu, L., & Zhu, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2069 · Cited by 607 · see citing works

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586 · see citing works

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

Orsi, A., Razi, M., Dooley, H. C., Robinson, D. J., Weston, A., Collinson, L., & Tooze, S. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0746 · Cited by 570 · see citing works

Activating transcription factor 4

Ameri, K., & Harris, A. L. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.020 · Cited by 557 · see citing works

Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer

Catz, S. D., & Johnson, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204926 · Cited by 538 · see citing works

Control of Macrophage Activation and Function by PPARs

Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531 · see citing works

Translational Regulation of Yeast GCN4

Hinnebusch, A. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.21661 · Cited by 526 · see citing works

p53 and E2f: partners in life and death

Polager, S., & Ginsberg, D. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2718 · Cited by 498 · see citing works

The ULK1 complex

Wong, P., Puente, C., Ganley, I. G., & Jiang, X. (2013) · Autophagy · doi:10.4161/auto.23323 · Cited by 494 · see citing works

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

Kimura, T., Takabatake, Y., Takahashi, A., & Isaka, Y. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2464 · Cited by 494 · see citing works

The pleiotropic role of autophagy: from protein metabolism to bactericide

Mizushima, N. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401728 · Cited by 480 · see citing works

Small molecule regulators of autophagy identified by an image-based high-throughput screen

Zhang, L., Yu, J., Pan, H., Hu, P., Yan, H., Cai, W., Zhu, H., Yu, A. D., Xie, X., Ma, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709695104 · Cited by 470 · see citing works

NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy

Djavaheri‐Mergny, M., Amelotti, M., Mathieu, J., Besançon, F., Bauvy, C., Souquère, S., Pierron, G., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602097200 · Cited by 467 · see citing works

The return of the nucleus: transcriptional and epigenetic control of autophagy

Füllgrabe, J., Klionsky, D. J., & Joseph, B. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3716 · Cited by 463 · see citing works

Intracellular Protein Catabolism and its Control During Nutrient Deprivation and Supply

Mortimore, G. E., & Pösö, A. R. (1987) · Annual Review of Nutrition · doi:10.1146/annurev.nu.07.070187.002543 · Cited by 457 · see citing works

Regulation of TFEB and V‐ATPases by mTORC1

Peña‐Llopis, S., Vega-Rubín-de-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X., Corey, D. R., & Brugarolas, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.257 · Cited by 456 · see citing works

Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis

Kim, J. E., & Chen, J. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2748 · Cited by 454 · see citing works

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

Sengupta, A., Molkentin, J. D., & Yutzey, K. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024406 · Cited by 428 · see citing works

Role of the AMP-activated protein kinase in the cellular stress response

Corton, J. M., Gillespie, J. G., & Hardie, D. G. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00070-1 · Cited by 423 · see citing works

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

Juan, L.-J., Shia, W.-J., Chen, M.-H., Yang, W., Seto, E., Lin, Y.-S., & Wu, C.-W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000202200 · Cited by 415 · see citing works

PPARγ AND G LUCOSE H OMEOSTASIS

Picard, F., & Auwerx, J. H. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102808 · Cited by 412 · see citing works

IFN-γ- and TNF-Independent Vitamin D-Inducible Human Suppression of Mycobacteria: The Role of Cathelicidin LL-37

Martineau, A. R., Wilkinson, K. A., Newton, S. M., Floto, R. A., Norman, A. W., Skolimowska, K., Davidson, R. N., Sørensen, O. E., Kampmann, B., Griffiths, C. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7190 · Cited by 410 · see citing works

Autophagy and other vacuolar protein degradation mechanisms

Seglen, P. O., & Bohley, P. (1992) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923509 · Cited by 405 · see citing works

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., & Gustafsson, J.-Α. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1440 · Cited by 395 · see citing works

Regulation of autophagy by ATF4 in response to severe hypoxia

Rzymski, T., Milani, M., Pike, L., Buffa, F. M., Mellor, H. R., Winchester, L. M., Pires, I. M., Hammond, E. M., Ragoussis, J., & Harris, A. L. (2010) · Oncogene · doi:10.1038/onc.2010.191 · Cited by 387 · see citing works

Antibacterial effects of vitamin D

Hewison, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.226 · Cited by 385 · see citing works

Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

Weinmann, A. S., Bartley, S. M., Zhang, T., Zhang, M. Q., & Farnham, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6820-6832.2001 · Cited by 384 · see citing works

Autophagosome Precursor Maturation Requires Homotypic Fusion

Moreau, K., Ravikumar, B., Renna, M., Puri, C., & Rubinsztein, D. C. (2011) · Cell · doi:10.1016/j.cell.2011.06.023 · Cited by 382 · see citing works

The autophagy effector Beclin 1: a novel BH3-only protein

Sinha, S. C., & Levine, B. (2008) · Oncogene · doi:10.1038/onc.2009.51 · Cited by 376 · see citing works

<i>BNIP3</i> Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369 · see citing works

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Lin, S.-Y., Li, T. Y., Liu, Q., Zhang, C., Li, X., Chen, Y., Zhang, S.-M., Lian, G., Liu, Q., Ruan, K., et al. (2012) · Science · doi:10.1126/science.1217032 · Cited by 365 · see citing works

Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch.

Marquez, R. T., & Xu, L. (2012) · PubMed · Cited by 364 · see citing works

Neurodegenerative lysosomal disorders: A continuum from development to late age

Nixon, R. A., Yang, D.-S., & Lee, J.-H. (2008) · Autophagy · doi:10.4161/auto.6259 · Cited by 362 · see citing works

Stress Signals Utilize Multiple Pathways To Stabilize p53

Ashcroft, M. A., Taya, Y., & Vousden, K. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3224-3233.2000 · Cited by 356 · see citing works

A dual role of p53 in the control of autophagy

Tasdemir, E., Maiuri, M. C., Morselli, E., Criollo, A., D’Amelio, M., Djavaheri‐Mergny, M., Cecconi, F., Tavernarakis, N., & Kroemer, G. (2008) · Autophagy · doi:10.4161/auto.6486 · Cited by 345 · see citing works

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

Koumenis, C., Alarcon, R. M., Hammond, E. M., Sutphin, P. D., Hoffman, W., Murphy, M. E., Derr, J. L., Taya, Y., Lowe, S. W., Kastan, M. B., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1297-1310.2001 · Cited by 343 · see citing works

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

Papinski, D., Schuschnig, M., Reiter, W., Wilhelm, L., Barnes, C. A., Maiolica, A., Hansmann, I., Pfaffenwimmer, T., Kijańska, M., Stoffel-Studer, I., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.011 · Cited by 343 · see citing works

Regulation of the autophagy protein LC3 by phosphorylation

Cherra, S. J., Kulich, S. M., Uechi, G. T., Balasubramani, M., Mountzouris, J. A., Day, B. W., & Chu, C. T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002108 · Cited by 341 · see citing works

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2008.84 · Cited by 334 · see citing works

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1

Sanchez, A. M. J., Csibi, A., Raibon, A., Cornille, K., Gay, S., Bernardi, H., & Candau, R. B. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23399 · Cited by 329 · see citing works

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

Wang, J., Whiteman, M. W., Lian, H., Wang, G., Singh, A. K., Huang, D., & Denmark, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026013 · Cited by 319 · see citing works

E2F – at the crossroads of life and death

Polager, S., & Ginsberg, D. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.003 · Cited by 300 · see citing works

Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent Kinase Pho85p

Wang, Z., Wilson, W. A., Fujino, M., & Roach, P. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5742-5752.2001 · Cited by 300 · see citing works

DNA damage‐inducible phosphorylation of p53 at N‐terminal sites including a novel site, Ser20, requires tetramerization

Shieh, S.-Y., Taya, Y., & Prives, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1815 · Cited by 299 · see citing works

Erk1/2-dependent Phosphorylation of Gα-interacting Protein Stimulates Its GTPase Accelerating Activity and Autophagy in Human Colon Cancer Cells

Ogier‐Denis, É., Pattingre, S., Benna, J. E., & Codogno, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006198200 · Cited by 287 · see citing works

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

Vidal, R. L., Figueroa, A., Court, F. A., Thielen, P., Molina, C., Wirth, C., Caballero, B., Kiffin, R., Segura‐Aguilar, J., Cuervo, A. M., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds040 · Cited by 281 · see citing works

Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancer

Baldwin, A. S. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01095.x · Cited by 277 · see citing works

P38 MAPK Links Oxidative Stress to Autophagy-Related Gene Expression in Cachectic Muscle Wasting

McClung, J. M., Judge, A. R., Powers, S. K., & Yan, Z. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00192.2009 · Cited by 277 · see citing works

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

Chauhan, S., Jinesh, G. G., Chauhan, S. C., Manyam, G. C., Wang, J., Kamat, A. M., & Boyd, D. D. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.024 · Cited by 276 · see citing works

Lipid metabolome-wide effects of the PPARγ agonist rosiglitazone

Watkins, S. M., Reifsnyder, P. C., Pan, H.-J., German, J. B., & Leiter, E. H. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200169-jlr200 · Cited by 274 · see citing works

Convergence of Multiple Autophagy and Cytoplasm to Vacuole Targeting Components to a Perivacuolar Membrane Compartment Prior tode Novo Vesicle Formation

Kim, J., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109134200 · Cited by 272 · see citing works

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy

Vara‐Ciruelos, D., Salazar‐Roa, M., Olea‐Herrero, N., Guzmán, M., Velasco, G., & Díaz‐Laviada, I. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.32 · Cited by 268 · see citing works

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

Chen, Q., Xie, W., Kuhn, D. J., Voorhees, P. M., Lopez‐Girona, A., Mendy, D., Corral, L. G., Krenitsky, V. P., Xu, W., Parseval, L. M., et al. (2008) · Blood · doi:10.1182/blood-2007-09-112904 · Cited by 265 · see citing works

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

Li, D., Wang, L. L., Deng, R., Tang, J., Shen, Y., Guo, J.-F., Wang, Y.-P., Xia, L.-P., Feng, G.-K., Liu, Q. Q., et al. (2008) · Oncogene · doi:10.1038/onc.2008.441 · Cited by 260 · see citing works

E2F1 regulates autophagy and the transcription of autophagy genes

Polager, S., Ofir, M., & Ginsberg, D. (2008) · Oncogene · doi:10.1038/onc.2008.117 · Cited by 260 · see citing works

The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias

Tzifi, F., Economopoulou, C., Gourgiotis, D., Ardavanis, A. S., Papageorgiou, S. G., & Scorilas, A. (2011) · Advances in Hematology · doi:10.1155/2012/524308 · Cited by 257 · see citing works

p65/RelA Modulates BECN1 Transcription and Autophagy

Copetti, T., Bertoli, C., Dalla, E., Demarchi, F., & Schneider, C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01396-08 · Cited by 256 · see citing works

Structure of Atg5·Atg16, a Complex Essential for Autophagy

Matsushita, M., Suzuki, N. N., Obara, K., Fujioka, Y., Ohsumi, Y., & Inagaki, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609876200 · Cited by 249 · see citing works

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

Webber, J. L., & Tooze, S. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.321 · Cited by 248 · see citing works

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

van der Vos, K. E., Eliasson, P., Proikas‐Cezanne, T., Vervoort, S. J., van Boxtel, R., Putker, M., van Zutphen, I. J., Mauthe, M., Zellmer, S., Pals, C. E. G. M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2536 · Cited by 246 · see citing works

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

Wu, Y., Tan, H., Huang, Q. B., Ong, C. N., & Shen, H. (2009) · Autophagy · doi:10.4161/auto.9099 · Cited by 241 · see citing works

A comprehensive map of the mTOR signaling network

Caron, É., Ghosh, S., Matsuoka, Y., Ashton‐Beaucage, D., Therrien, M., Lemieux, S., Perreault, C., Roux, P. P., & Kitano, H. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.108 · Cited by 241 · see citing works

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

Lu, Q., Yang, P., Huang, X., Hu, W., Guo, B., Wu, F., Lin, L., Kovács, A. L., Yu, L., & Zhang, H. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.06.024 · Cited by 236 · see citing works

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

Ma, D., Panda, S., & Lin, J. D. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.322 · Cited by 234 · see citing works

Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells

Connolly, E., Braunstein, S., Formenti, S., & Schneider, R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3955-3965.2006 · Cited by 233 · see citing works

Eating the enemy within: autophagy in infectious diseases

Orvedahl, A., & Levine, B. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.130 · Cited by 232 · see citing works

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

Anguiano, J., Garner, T. P., Mahalingam, M., Das, B. C., Gavathiotis, E., & Cuervo, A. M. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1230 · Cited by 226 · see citing works

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

Mack, H. I. D., Zheng, B., Asara, J. M., & Thomas, S. Μ. (2012) · Autophagy · doi:10.4161/auto.20586 · Cited by 221 · see citing works

Autophagy inhibition enhances vorinostat‐induced apoptosis via ubiquitinated protein accumulation

Carew, J. S., Medina, E. C., Esquivel, J., Mahalingam, D., Swords, R. T., Kelly, K. R., Zhang, H., Huang, P., Mita, A. C., Mita, M. M., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00832.x · Cited by 219 · see citing works

JNK regulates FoxO-dependent autophagy in neuronsPreprint

Xu, P., Das, M., Reilly, J., & Davis, R. J. (2011) · Genes & Development · doi:10.1101/gad.1984311 · Cited by 216 · see citing works

The influence of the src‐family kinases, Lck and Fyn, on T cell differentiation, survival and activation

Zamoyska, R., Basson, M. A., Filby, A. J., Legname, G., Lovatt, M., & Seddon, B. P. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00015.x · Cited by 211 · see citing works

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

Gammoh, N., Florey, O., Overholtzer, M., & Jiang, X. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2475 · Cited by 209 · see citing works

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

Kanazawa, T., Taneike, I., Akaishi, R., Yoshizawa, F., Furuya, N., Fujimura, S., & Kadowaki, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306337200 · Cited by 208 · see citing works

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

Yang, Y., Fiskus, W. C., Yong, B., Atadja, P. W., Takahashi, Y., Pandita, T. K., Wang, H., & Bhalla, K. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217692110 · Cited by 204 · see citing works

UME6 is a key regulator of nitrogen repression and meiotic development.Preprint

Strich, R., Surosky, R. T., Steber, C. M., Dubois, E. L., Messenguy, F., & Esposito, R. E. (1994) · Genes & Development · doi:10.1101/gad.8.7.796 · Cited by 196 · see citing works

Autophagy in infection

Deretic, V. P. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.009 · Cited by 194 · see citing works

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

Zhou, J., Liao, W., Yang, J. H., Ma, K., Li, X., Wang, Y., Wang, D., Wang, L., Zhang, Y., Yin, Y., et al. (2012) · Autophagy · doi:10.4161/auto.21830 · Cited by 194 · see citing works

Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells

Kim, H., & Ahn, Y. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s60 · Cited by 194 · see citing works

Chaperone-Mediated Autophagy

Bejarano, E., & Cuervo, A. M. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-102js · Cited by 193 · see citing works

The isoform‐specific functions of the c‐Jun N‐terminal Kinases (JNKs): differences revealed by gene targeting

Bogoyevitch, M. A. (2006) · BioEssays · doi:10.1002/bies.20458 · Cited by 190 · see citing works

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

Russo, R., Berliocchi, L., Adornetto, A., Varano, G. P., Cavaliere, F., Nucci, C., Rotiroti, D., Morrone, L. A., Bagetta, G., & Corasaniti, M. T. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.29 · Cited by 186 · see citing works

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPARγ and TR4 for Survival

Mahajan, S., Dkhar, H. K., Chandra, V., Dave, S., Nanduri, R., Janmeja, A. K., Agrewala, J. N., & Gupta, P. K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103038 · Cited by 185 · see citing works

Regulation of Autophagy by Kinases

Sridharan, S., Jain, K., & Basu, A. (2011) · Cancers · doi:10.3390/cancers3022630 · Cited by 182 · see citing works

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

Hardie, D. G., Carling, D., & Sim, A. T. R. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90084-4 · Cited by 178 · see citing works

The complex interplay between autophagy and NF-κB signaling pathways in cancer cells.

Trocoli, A., & Djavaheri‐Mergny, M. (2011) · PubMed Central · Cited by 177 · see citing works

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

Jimenez, G. S., Khan, S. H., Stommel, J. M., & Wahl, G. M. (1999) · Oncogene · doi:10.1038/sj.onc.1203013 · Cited by 176 · see citing works

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

Chang, C.-P., Su, Y., Hu, C.-W., & Lei, H.-Y. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.146 · Cited by 175 · see citing works

IFN-γ Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

Matsuzawa, T., Kim, B.-H., Shenoy, A. R., Kamitani, S., Miyake, M., & MacMicking, J. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102041 · Cited by 173 · see citing works

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

Seo, Y., Jeon, T.-I., Chong, H. K., Biesinger, J., Xie, X. S., & Osborne, T. F. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.005 · Cited by 172 · see citing works

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

Chen, D., Gao, F., Li, B., Wang, H., Xu, Y., Zhu, C., & Wang, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.101469 · Cited by 168 · see citing works

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors

Wu, Z., Chang, P., Yang, J. C., Chu, C.-Y., Wang, L., Chen, N., Ma, A.-H., Desai, S. J., Lo, S. H., Evans, C. P., et al. (2010) · Genes & Cancer · doi:10.1177/1947601909358324 · Cited by 165 · see citing works

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor

Zhao, J., Brault, J. J., Schild, A., & Goldberg, A. L. (2008) · Autophagy · doi:10.4161/auto.5633 · Cited by 164 · see citing works

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

McEwan, D. G., & Đikić, I. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.12.006 · Cited by 161 · see citing works

Peroxisome proliferator-activated receptors and cancer: challenges and opportunities

Youssef, J., & Badr, M. Z. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01383.x · Cited by 156 · see citing works

Vitamin D: newly discovered actions require reconsideration of physiologic requirements

Bikle, D. D. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.01.003 · Cited by 152 · see citing works

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

Pike, L., Singleton, D. C., Buffa, F. M., Abramczyk, O., Phadwal, K., Li, J., Simon, A. K., Murray, J. T., & Harris, A. L. (2012) · Biochemical Journal · doi:10.1042/bj20120972 · Cited by 147 · see citing works

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor‐α‐induced cell death in MCF‐7 cells

Sivaprasad, U., & Basu, A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00282.x · Cited by 143 · see citing works

ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death.

Cheng, Y., Qiu, F., Tashiro, S.-I., Onodera, S., & Ikejima, T. (2008) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2008.09.018 · Cited by 140 · see citing works

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

Sheng, Z., Ma, L., Sun, J. E., Zhu, L. J., & Green, M. R. (2011) · Blood · doi:10.1182/blood-2010-12-322537 · Cited by 139 · see citing works

The emerging role of E2F-1 in the DNA damage response and checkpoint control

Stevens, C., & Thangue, N. B. L. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.034 · Cited by 136 · see citing works

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

Mikhed, Y., Görlach, A., Knaus, U. G., & Daiber, A. (2015) · Redox Biology · doi:10.1016/j.redox.2015.05.008 · Cited by 181 · see citing works

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

Lebovitz, C. B., Robertson, A. G., Goya, R., Jones, S. J. M., Morin, R. D., Marra, M. A., & Gorski, S. M. (2015) · Autophagy · doi:10.1080/15548627.2015.1067362 · Cited by 133 · see citing works

A gene toolbox for monitoring autophagy transcription

Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death &amp; Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131 · see citing works

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117 · see citing works

Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation

Kumar, S. R., Nanduri, R., Bhagyaraj, E., Kalra, R., Ahuja, N., Chacko, A. P., Tiwari, D., Sethi, K., Saini, A., Chandra, V., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1822088 · Cited by 77 · see citing works

A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons

Lei, Z., Cao, G., & Wei, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1364-0 · Cited by 67 · see citing works

NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy

Chandra, V., Bhagyaraj, E., Nanduri, R., Ahuja, N., & Gupta, P. K. (2015) · Autophagy · doi:10.1080/15548627.2015.1091140 · Cited by 55 · see citing works

Prognostic significance of an autophagy‑related long non‑coding RNA signature in patients with oral and oropharyngeal squamous cell carcinoma

Jiang, Q., Xue, D., Shi, F., & Qiu, J. (2020) · Oncology Letters · doi:10.3892/ol.2020.12290 · Cited by 29 · see citing works

AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy

Nanduri, R., Kalra, R., Bhagyaraj, E., Chacko, A. P., Ahuja, N., Tiwari, D., Kumar, S. R., Jain, M., Parkesh, R., & Gupta, P. K. (2019) · Autophagy · doi:10.1080/15548627.2019.1571717 · Cited by 22 · see citing works

Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation

Barthez, M., Poplineau, M., Elrefaey, M., Caruso, N., Graba, Y., & Saurin, A. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-66377-z · Cited by 22 · see citing works

Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?

Wu, N. N., & Ren, J. T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-6260-6_15 · Cited by 19 · see citing works

Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy

Kalra, R., Tiwari, D., Dkhar, H. K., Bhagyaraj, E., Kumar, R., Bhardwaj, A., & Gupta, P. K. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1990277 · Cited by 13 · see citing works

Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application

Li, H., Liu, J.-T., Chen, Y., Wang, W., Han, Y., Yao, Q., & Qi, Y. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118855 · Cited by 11 · see citing works

The new horizon of biomarker in melanoma patients

Li, Z., Wei, J., Zheng, H., Zhang, Y., Song, M., Cao, H., & Jin, Y. (2022) · Medicine · doi:10.1097/md.0000000000028553 · Cited by 9 · see citing works

Expression of ZKSCAN3 protein suppresses proliferation, migration, and invasion of pancreatic cancer through autophagy

Nonoyama, K., Matsuo, Y., Sugita, S., Eguchi, Y., Denda, Y., Murase, H., Kato, T., Imafuji, H., Saito, K., Morimoto, M., et al. (2024) · Cancer Science · doi:10.1111/cas.16173 · Cited by 7 · see citing works

Targeting autophagy with small-molecule activators for potential therapeutic purposes

Fan, Z., Wan, L., Wei, J., Liu, B., & Wu, D. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115722 · Cited by 6 · see citing works

Analysis of Autophagy-Related Genes and Associated Noncoding RNAs and Transcription Factors in Digestive System Tumors

Lin, L., Xia, L., Tang, D., Dai, Y., & Chen, W. (2019) · Future Oncology · doi:10.2217/fon-2019-0341 · Cited by 4 · see citing works

Regulatory Effect of Non-Coding RNAs on Programmed Cell Death in Melanoma: Novel Therapeutic Crosstalk for Targeted Therapy

Naghibi, A. F., Taha, S. R., Zadeh, M. S., Daneshdoust, D., Bagheri, K. H., Farkhondeh, T., Samini, M., Pourhanifeh, M. H., & Samarghandian, S. (2025) · Current Cancer Drug Targets · doi:10.2174/0115680096329727250129173510 · Cited by 3 · see citing works

Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression

Kumar, S. R., Arora, R., Gupta, S. D., Ahuja, N., Bhagyaraj, E., Nanduri, R., Kalra, R., Khare, A. K., Kumawat, S., Kaushal, V., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023012228 · Cited by 2 · see citing works

Characteristics of Autophagy Induced by Enterovirus71 (EV71) Viral Protein

Li, H., Jinxue, G., Liu, D., Hui, L., & Wu, Q. (2018) · Journal of Tropical Diseases · doi:10.4172/2329-891x.1000286 · Cited by 2 · see citing works

Effects of Glutamine Starvation on SHVV Replication by Quantitative Proteomics Analysis

Liu, J., Zhang, Y., Liu, X., Zhang, H., Liu, Y., Chen, K., Tang, M., & Sun, L. (2022) · Fishes · doi:10.3390/fishes7060315 · Cited by 1 · see citing works

Studies of polyglutamine expanded Ataxin-7 toxicity

Yu, X. (2015) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Overview of Autophagy and Cardiometabolic Syndrome

Aroor, A. R., Jia, G., & Sowers, J. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00001-8

Functional characterisation of Drosophila M1BP

Barthez, M. (2019) · doi:10.70675/38635cdczfedaz4361zb0a3z7b6850e707ed

Integrated approaches to target nuclear receptors for managing the co-morbidity of tuberculosis and diabetes

Arora, R., Ahuja, N., Kumawat, S., Kaushal, V., Sharma, R., & Gupta, P. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1824354

BindingDB Entry 50022358: Targeting autophagy with small-molecule activators for potential therapeutic purposes.

BindingDB (2025) · UC San Diego · doi:10.7270/q2gf107z

Transcriptional control of autophagy: mechanisms, dynamics, and pharmacological modulation

Qin, W., Yang, L., Deng, X., Yuan, W., Guo, D., Xiao, S., Zhang, R., Zhang, Q., Chen, X., Zhou, C., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2753996

Transcriptional regulation of mammalian autophagy at a glance

Füllgrabe, J., Ghislat, G., Cho, D., & Rubinsztein, D. C. (2016) · Journal of Cell Science · doi:10.1242/jcs.188920 · Cited by 195 · see citing works

Autophagy: Starvation Relieves Transcriptional Repression of ATG Genes

Devenish, R. J., & Prescott, M. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.045 · Cited by 9 · see citing works

A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy

Bernard, A., Jin, M., Xu, Z., & Klionsky, D. J. (2015) · Autophagy · doi:10.1080/15548627.2015.1099796 · Cited by 77 · see citing works

A comprehensive glossary of autophagy-related molecules and processes

Klionsky, D. J., Codogno, P., Cuervo, A. M., Deretic, V. P., Elazar, Z., Fueyo-Margareto, J., Gewirtz, D. A., Kroemer, G., Levine, B., Mizushima, N., et al. (2010) · Autophagy · doi:10.4161/auto.6.4.12244 · Cited by 184 · see citing works