NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival
Open accessAbstract
Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived mediator, induces cell survival in uncompensated oxidative stress (OS), neurodegenerations or ischemic stroke. The molecular principles underlying this protection remain unresolved. We report here that, in retinal pigment epithelial cells, NPD1 induces nuclear translocation and cREL synthesis that, in turn, mediates BIRC3 transcription. NPD1 activates NF-κB by an alternate route to canonical signaling, so the opposing effects of TNFR1 and NPD1 on BIRC3 expression are not due to interaction/s between NF-κB pathways. RelB expression follows a similar pattern as BIRC3, indicating that NPD1 also is required to activate cREL-mediated RelB expression. These results suggest that cREL, which follows a periodic pattern augmented by the lipid mediator, regulates a cluster of NPD1-dependent genes after cREL nuclear translocation. BIRC3 silencing prevents NPD1 induction of survival against OS. Moreover, brain NPD1 biosynthesis and selective neuronal BIRC3 abundance are increased by DHA after experimental ischemic stroke followed by remarkable neurological recovery. Thus, NPD1 bioactivity governs key counter-regulatory gene transcription decisive for retinal and brain neural cell integrity when confronted with potential disruptions of homeostasis.
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NPD1 at 100 nM rescues dopaminergic neurons from apoptosis and sustains the dendritic arbor of surviving neurons.
“Under these conditions, we uncovered that NPD1 (100 nM) rescue dopaminergic neurons from apoptosis and sustains dendritic arbor of surviving neurons (Calandria et al., 2015).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Calandria et al., 2015
DHA and NPD1 display potent neuroprotective bioactivity when given 1 hour after 2 hours of MCAo in rats.
“DHA and NPD1 display potent neuroprotective bioactivity when given 1 hour after 2 hours of MCAo in rats (Bazan et al., 2012; Belayev et al., 2018, 2017, 2011; Calandria et al., 2015; Eady et al., 2012; Hong et al., 2015, 2014; Serhan et al., 2011).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Calandria et al., 2015
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The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,866 · see citing works
Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation
Viatour, P., Merville, M., Bours, V., & Chariot, A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.009 · Cited by 1,497 · see citing works
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL
Heinemeyer, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.1.362 · Cited by 1,462 · see citing works
ARPE-19, A Human Retinal Pigment Epithelial Cell Line with Differentiated Properties
Dunn, K. C., Aotaki-Keen, A. E., Putkey, F. R., & Hjelmeland, L. M. (1996) · Experimental Eye Research · doi:10.1006/exer.1996.0020 · Cited by 1,334 · see citing works
Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science · doi:10.1126/science.1099962 · Cited by 1,186 · see citing works
Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions
Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081880 · Cited by 908 · see citing works
Lukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 873 · see citing works
Feoktistova, M., Geserick, P., Kellert, B., Panayotova‐Dimitrova, D., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Häcker, G. A., & Leverkus, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.011 · Cited by 855 · see citing works
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802 · see citing works
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
Gyrd-Hansen, M., & Meier, P. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2889 · Cited by 790 · see citing works
Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · cited 16× · see citing works
“NPD1 upregulates Bcl-2, Bcl-xl and Bfl-1/A1 and attenuates the expression of Bax, Bad and Bid.12,13 Furthermore, NPD1 reduces caspase 3 activation induced by oxidative and proteotoxic stress.14,15 To define the mechanisms by which NPD1 modulates neural cell survival, we used human retinal pigment epithelial (RPE) cell…”
InfluentialThe Retinal Pigment Epithelium in Health and Disease
Sparrrow, J. R., Hicks, D., & Hamel, C. (2010) · Current Molecular Medicine · doi:10.2174/156652410793937813 · Cited by 625 · see citing works
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
Feng, S., Yang, Y., Mei, Y., Ma, L., Zhu, D.-E., Höti, N., Castanares, M. A., & Wu, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.05.016 · Cited by 445 · see citing works
Bazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works
The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
Eckelman, B. P., & Salvesen, G. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510863200 · Cited by 391 · see citing works
Estimating transcription factor bindability on DNA.
Tsunoda, T., & Takagi, T. (1999) · Bioinformatics · doi:10.1093/bioinformatics/15.7.622 · Cited by 389 · see citing works
Programmed necrosis: backup to and competitor with apoptosis in the immune system
Han, J., Zhong, C., & Zhang, D. (2011) · Nature Immunology · doi:10.1038/ni.2159 · Cited by 365 · see citing works
TRED: a transcriptional regulatory element database, new entries and other development
Jiang, C., Xuan, Z., Zhao, F., & Zhang, M. Q. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1041 · Cited by 329 · see citing works
Mathematical model of NF-κB regulatory module
Lipniacki, T., Paszek, P., Brasier, A. R., Luxon, B. A., & Kimmel, M. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.01.001 · Cited by 284 · see citing works
Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors
Serhan, C. N., Krishnamoorthy, S., Recchiuti, A., & Chiang, N. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611109060629 · Cited by 278 · see citing works
Rosenbaum, D. M., Degterev, A., David, J., Rosenbaum, P. S., Roth, S., Grotta, J. C., Cuny, G. D., Yuan, J., & Savitz, S. I. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22314 · Cited by 248 · see citing works
Zhao, Y., Calon, F., Julien, C., Winkler, J. W., Petasis, N. A., Lukiw, W. J., & Bazan, N. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015816 · Cited by 243 · see citing works
Regulation of the apoptosis–necrosis switch
Nicotera, P., & Melino, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207559 · Cited by 238 · see citing works
New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
Long, J. S., & Ryan, K. M. (2012) · Oncogene · doi:10.1038/onc.2012.7 · Cited by 213 · see citing works
Transcription of the RelB gene is regulated by NF-κB
Bren, G. D., Solan, N. J., Miyoshi, H., Pennington, K. N., Pobst, L. J., & Payá, C. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204868 · Cited by 208 · see citing works
Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling
Mukherjee, P. K., Marcheselli, V. L., Barreiro, S., Hu, J., Bok, D., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705949104 · Cited by 170 · see citing works
Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke
Belayev, L., Khoutorova, L., Atkins, K. D., Eady, T. N., Hong, S., Lü, Y., Obenaus, A., & Bazan, N. G. (2010) · Translational Stroke Research · doi:10.1007/s12975-010-0046-0 · Cited by 163 · see citing works
Excitotoxins in Neuronal Apoptosis and Necrosis
Nicotera, P., & Lipton, S. A. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199906000-00001 · Cited by 151 · see citing works
Tae, G., Scatena, M., Stayton, P. S., & Hoffman, A. S. (2005) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856206774879090 · Cited by 149 · see citing works
Hong, S.-Y., Yoon, W. H., Park, J. H., Kang, S. G., Ahn, J.-H., & Lee, T. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001202200 · Cited by 119 · see citing works
Sustained Oscillations of NF-κB Produce Distinct Genome Scanning and Gene Expression Profiles
Sung, M., Salvatore, L., Lorenzi, R. D., Indrawan, A., Pasparakis, M., Hager, G. L., Bianchi, M. E., & Agresti, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007163 · Cited by 117 · see citing works
Calandria, J. M., Marcheselli, V. L., Mukherjee, P. K., Uddin, J., Winkler, J. W., Petasis, N. A., & Bazan, N. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003988 · Cited by 104 · see citing works
Marcheselli, V. L., Mukherjee, P. K., Arita, M., Hong, S., Antony, R., Sheets, K. G., Winkler, J. W., Petasis, N. A., Serhan, C. N., & Bazan, N. G. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.10.010 · Cited by 101 · see citing works
Assembling the building blocks: structure and function of inhibitor of apoptosis proteins
Mace, P. D., Shirley, S., & Day, C. L. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.45 · Cited by 96 · see citing works
NF-κB and cancer: a paradigm of Yin-Yang.
Xiao, G., & Fu, J. (2011) · Europe PMC (PubMed Central) · Cited by 93 · see citing works
Valerio, A., Dossena, M., Bertolotti, P., Boroni, F., Sarnico, I., Faraco, G., Chiarugi, A., Frontini, A., Giordano, A., Liou, H., et al. (2008) · Stroke · doi:10.1161/strokeaha.108.528588 · Cited by 92 · see citing works
Pizzi, M., Sarnico, I., Lanzillotta, A., Battistin, L., & Spano, P. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06767.x · Cited by 63 · see citing works
Huang, J.-F., Shang, L., Zhang, M., Wang, H., Chen, D., Tong, J., Huang, H., Yan, X., Zeng, L., & Xiong, K. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-16 · Cited by 56 · see citing works
Ueberla, K. M., Lu, Y., Chung, E., & Haseltine, W. A. (1993) · PubMed · Cited by 54 · see citing works
Calandria, J. M., Mukherjee, P. K., Vaccari, J. C. D. R., Zhu, M., Petasis, N. A., & Bazan, N. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287078 · Cited by 30 · see citing works
Cloning and transcription factor-binding sites of the human c-rel proto-oncogene promoter
Viswanathan, M., Yu, M., Mendoza, L., & Yunis, J. J. (1996) · Gene · doi:10.1016/0378-1119(95)00773-3 · Cited by 14 · see citing works
Flagged first, then by citations
1 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
ER stress and impaired autophagy flux in neuronal degeneration and brain injury
Yin, Y., Sun, G., Li, E., Kiselyov, K. I., & Sun, D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.008 · Cited by 212 · see citing works
Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis
Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204 · see citing works
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works
Belayev, L., Hong, S.-H., Menghani, H., Marcell, S. J., Obenaus, A., Freitas, R. S., Khoutorova, L., Balaszczuk, V., Jun, B., Oriá, R. B., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1136-3 · Cited by 103 · see citing works
Self-citationAstrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury
Livne‐Bar, I., Wei, J., Liu, H., Alqawlaq, S., Won, G.-J., Tuccitto, A., Gronert, K., Flanagan, J. G., & Sivak, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci77398 · Cited by 95 · see citing works
Asatryan, A., & Bazan, N. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.783076 · Cited by 95 · see citing works
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases
Lanzillotta, A., Porrini, V., Bellucci, A., Benarese, M., Branca, C., Parrella, E., Spano, P., & Pizzi, M. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00098 · Cited by 92 · see citing works
Yang, H. S., Onos, K. D., Choi, K., Keezer, K. J., Skelly, D. A., Carter, G. W., & Howell, G. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108739 · Cited by 69 · see citing works
Belayev, L., Mukherjee, P. K., Balaszczuk, V., Calandria, J. M., Obenaus, A., Khoutorova, L., Hong, S., & Bazan, N. G. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.55 · Cited by 61 · see citing works
Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury
Yin, Y., Li, E., Sun, G., Yan, H. Q., Foley, L. M., Andrzejczuk, L., Attarwala, I. Y., Hitchens, T. K., Kiselyov, K. I., Dixon, C. E., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0504-8 · Cited by 55 · see citing works
Dihydroxylated E,E,Z-docosatrienes. An overview of their synthesis and biological significance
Balas, L., & Durand, T. (2015) · Progress in Lipid Research · doi:10.1016/j.plipres.2015.10.002 · Cited by 46 · see citing works
Han, Y., KyeongJin, L., Saha, A., Han, J., Choi, H., Noh, M., Lee, Y., & Lee, M. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.094 · Cited by 40 · see citing works
Mockenhaupt, K., Gonsiewski, A. K., & Kordula, T. (2021) · Cells · doi:10.3390/cells10071609 · Cited by 38 · see citing works
Miyazawa, K., Fukunaga, H., Tatewaki, Y., Takano, Y., Yamamoto, S., Mutoh, T., & Taki, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165783 · Cited by 38 · see citing works
Chen, Y., Chen, K.-D., Su, M.-C., Chin, C., Chen, C., Liou, C., Chen, T.-W., Chang, Y., Huang, K.-T., Wang, C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176575 · Cited by 35 · see citing works
Neuroprotectin D1 Protects Against Postoperative Delirium-Like Behavior in Aged Mice
Zhou, Y., Wang, J., Li, X., Li, K., Chen, L., Zhang, Z., & Peng, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.582674 · Cited by 32 · see citing works
Zirpoli, H., Sosunov, S. A., Niatsetskaya, Z. V., Mayurasakorn, K., Kollareth, D. J. M., Serhan, C. N., Ten, V. S., & Deckelbaum, R. J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113495 · Cited by 31 · see citing works
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Ueno, Y., Miyamoto, N., Yamashiro, K., Tanaka, R., & Hattori, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225549 · Cited by 29 · see citing works
Sun, J., Huang, P., Liang, J., Li, J., Shen, M., She, X., Feng, Y., Luo, X., Liu, T., & Sun, X. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.502 · Cited by 29 · see citing works
Kaya, Ζ., Belder, N., Sever, M., Erdener, Ş. E., Dönmez‐Demir, B., Bağcı, C., Köroğlu, M. N., Bilgüvar, K., & Dalkara, T. (2025) · Brain · doi:10.1093/brain/awaf015 · Cited by 27 · see citing works
Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration
Kim, C., Livne‐Bar, I., Gronert, K., & Sivak, J. M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801076 · Cited by 26 · see citing works
Chiang, N., de la Rosa, X., Libreros, S., Pan, H., Dreyfuss, J. M., & Serhan, C. N. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013374118 · Cited by 24 · see citing works
c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling
Sekiya, Y., Yamamoto, E., Niimi, K., Nishino, K., Nakamura, K., Kotani, T., Kajiyama, H., Shibata, K., & Kikkawa, F. (2017) · Oncology · doi:10.1159/000458529 · Cited by 18 · see citing works
Calandria, J. M., Sharp, M., & Bazan, N. G. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0206-6 · Cited by 18 · see citing works
Carmo, S. D., Kautzmann, M.-A. I., Bhattacharjee, S., Jun, B., Steinberg, C., Emmerson, J. T., Malcolm, J. C., Bonomo, Q., Bazan, N. G., & Cuello, A. C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03184-7 · Cited by 18 · see citing works
Yogarajah, T., Ong, K. C., Perera, D., & Wong, K. T. (2016) · Archives of Virology · doi:10.1007/s00705-016-3157-4 · Cited by 15 · see citing works
Gordon, W. C., Kautzmann, M.-A. I., Jun, B., Cothern, M. L., Fang, Z., & Bazan, N. G. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109639 · Cited by 14 · see citing works
Self-citationZia, B., Elmeky, M., Azimullah, S., Jha, N. K., Meeran, M. F. N., & Ojha, S. K. (2025) · Current Neuropharmacology · doi:10.2174/011570159x365720250225080257 · Cited by 13 · see citing works
Eicosanoid signaling in neuroinflammation associated with Alzheimer's disease
Lohitaksha, K., Kumari, D., Shukla, M., Byagari, L., Ashireddygari, V. R., Tammineni, P., Reddanna, P., & Gorla, M. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176694 · Cited by 12 · see citing works
Calandria, J. M., Do, K. V., Kala-Bhattacharjee, S., Obenaus, A., Belayev, L., & Bazan, N. G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01231-6 · Cited by 10 · see citing works
Calandria, J. M., Bhattacharjee, S., Maness, N. J., Kautzmann, M.-A. I., Asatryan, A., Gordon, W. C., Do, K. V., Jun, B., Mukherjee, P. K., Petasis, N. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91794-z · Cited by 9 · see citing works
Thyroid hormone promotes fetal neurogenesis
Salas-Lucia, F., Escamilla, S., Charest, A., Jiang, H., Stout, R. F., & Bianco, A. C. (2025) · JCI Insight · doi:10.1172/jci.insight.194445 · Cited by 8 · see citing works
Asatryan, A., Calandria, J. M., Kautzmann, M.-A. I., Jun, B., Gordon, W. C., Do, K. V., Bhattacharjee, S., Pham, T. L., Bermúdez, V., Mateos, M. V., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.926629 · Cited by 8 · see citing works
Zhang, X., Ma, L., Liu, M., Zhu, T., Huang, Z., Xiong, Y., Wang, Z., & Shi, J. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148477 · Cited by 8 · see citing works
Hu, M., & Shao, Z. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2124876 · Cited by 6 · see citing works
Mitochondrial citrate transport represents a metabolic liability in MYCN-amplified neuroblastoma
Chen, C., Bao, Q., Huang, H., Wang, L., Jiang, J., Liu, H., Wang, Y., Qing, G., & Fang, Y. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2025.12.061 · Cited by 3 · see citing works
Wang, Y., Liang, Y., Zhou, Y., Cui, Z., Gu, J., Xiong, S., & Chen, J. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110445 · Cited by 3 · see citing works
Bazan, N. G. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-17121-0_51 · Cited by 2 · see citing works
Bazan, N. G. (2016) · Future Neurology · doi:10.2217/fnl-2016-0008 · Cited by 1 · see citing works
Brain Self-protection by Bioactive Lipids
Ng, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-94431-4_11 · Cited by 1 · see citing works
Bazan, N. G. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02436-6 · Cited by 1 · see citing works
Análise da interação proteica na evolução do câncer
Rodrigues, L. H. R., Bugs, C. A., & Simão, É. M. (2015) · Scientia Plena · doi:10.14808/sci.plena.2015.119901 · Cited by 1 · see citing works
What is the Therapeutic Potential of Neuroprotectin D1 for Epilepsy?
Bazan, N. G., & Musto, A. E. (2015) · Future Neurology · doi:10.2217/fnl.15.25
Analysis of Protein Interaction in the Cancer Development
Rodrigues, L. H. R., Bugs, C. A., & Simão, É. M. (2015)
Zhou, Y., Wang, J., Li, X., Li, K., Chen, L., Zhang, Z., & Peng, M. (2020) · doi:10.21203/rs.3.rs-28936/v1
Muñoz, Y., Palacios-Avendaño, N., Álvarez, D., Ortíz, M., Montiel, J. F., Valenzuela, R., & Maliqueo, M. A. (2026) · Nutrients · doi:10.3390/nu18193142
- Authors
- Calandria, J. M., Asatryan, A., Balaszczuk, V, Knott, E. J., Jun, B. K., Mukherjee, P. K., Belayev, L., & Bazan, N. G.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Corresponding author
- Bazan, N G
- Venue
- Cell Death & Differentiation
- Published
- 2015-01-30
- Volume
- 22
- Issue
- 8
- Pages
- 1363-1377
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC4495360
- OpenAlex
- W2009117300
- Cited by
- 47
- References
- 44
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 8 · 2016: 3 · 2015: 8
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell Death and Differentiation (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Research to Prevent Blindness
- University of Southern California
- Ögonfonden
- Yonsei University
- National Institutes of Health (EY0-05121, GM-103340)
- National Eye Institute (R01EY005121)
- National Institute of General Medical Sciences (GM-103340, P30GM103340)
- Brain Injury Research Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- neuroprotectin D1, cIAP2, c-Rel, RelB, NF-κB signaling, docosahexaenoic acid, retinal pigment epithelial cells, neuronal survival, oxidative stress, ischemic stroke, TNF receptor 1, transcriptional regulation, neuroprotection
- MeSH terms
- Baculoviral IAP Repeat-Containing 3 Protein, Cell Survival, Cells, Cultured, Docosahexaenoic Acids, Humans, Signal Transduction, Oxidative Stress, Proto-Oncogene Proteins c-rel, Ubiquitin-Protein Ligases, Inhibitor of Apoptosis Proteins, Transcription Factor RelB
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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