The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The emerging roles of YAP and TAZ in cancer
Open accessAbstract
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.
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Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
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Self-citationThe LKB1-AMPK pathway: metabolism and growth control in tumour suppression
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Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
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Self-citationCalvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478
Hippo Pathway Activity Influences Liver Cell Fate
Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857
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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
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Cited by
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206
Self-citationMechanisms of Hippo pathway regulation
Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667
Self-citationForce triggers YAP nuclear entry by regulating transport across nuclear pores
Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
Kim, J., Piao, H.-L., Kim, B.-J., Yao, F., Han, Z., Wang, Y., Xiao, Z., Siverly, A. N., Lawhon, S. E., Ton, B. N., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0252-3 · Cited by 771
Metadata
- Authors
- Moroishi, T., Hansen, C. G., & Guan, K.-L.
- Venue
- Nature Reviews Cancer
- Published
- 2015-01-16
- Volume
- 15
- Issue
- 2
- Pages
- 73-79
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2004480757
- Cited by
- 1,145
- References
- 16
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- green
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