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MYC: connecting selective transcriptional control to global RNA production
Abstract
Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels. Here, we argue that differential gene regulation by MYC is the sole unifying model that is consistent with all available data. Among other effects, MYC endows cells with physiological and metabolic changes that have the potential to feed back on global RNA production, processing and turnover. The field is progressing steadily towards a full characterization of the MYC-regulated genes and pathways that mediate these biological effects and - by the same token - endow MYC with its pervasive oncogenic potential.
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“This could offer one explanation for the interference effect observed during concurrent training: rather than entirely suppressing ribosome biogenesis, endurance-oriented stimuli may bias translational machinery toward proteins involved in oxidative metabolism and mitochondrial adaptation, whereas resistance exercise may favor ribosomal configurations more suitable for myofibrillar accretion [188,”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [193]
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Ontogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma
Ryan, R. J. H., & Wilcox, R. A. (2019) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2019.04.003 · Cited by 3
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FC1000: normalized gene expression changes of systematically perturbed human cells
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Specificity of anti-MYC antibodies
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The multi-faceted roles of MYC in the prognosis of chronic lymphocytic leukemia
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Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation
Vardaka, P., Kemp, B., Stephenson, S., Stephenson, S., Care, M. A., Umpierrez, M., O'Callaghan, E., O’Callaghan, E., Owen, R. G., Hodson, D. J., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202402814 · Cited by 6
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Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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Association between genetic variations at 8q24 and prostate cancer risk in Mexican Men
Silva-Ramírez, B., Macías-González, E. J., Frausto-Valdes, O. S., Calao-Pérez, M. B., Ibarra-Pérez, D. I., Torres-García, J. E., Aragón-Tovar, A., Peñuelas-Urquides, K., González-Escalante, L. A., & de León, M. B. (2021) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-021-00461-x · Cited by 2
Per- and Polyfluoroalkyl Substances Disrupt Mouse Embryo Compaction by Targeting c-MYC
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Metadata
- Authors
- Kress, T. R., Sabò, A., & Amati, B.
- Affiliations
- Italian Institute of Technology (IT)
- Corresponding author
- Amati, Bruno
- Venue
- Nature reviews. Cancer
- Published
- 2015-09-18
- Volume
- 15
- Issue
- 10
- Pages
- 593-607
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1878169898
- Cited by
- 521
- References
- 201
- Citations by year
- 2026: 27 · 2025: 41 · 2024: 52 · 2023: 52 · 2022: 47 · 2021: 57 · 2020: 48 · 2019: 42 · 2018: 58 · 2017: 52 · 2016: 40 · 2015: 5
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- c-Myc, transcriptional regulation, RNA biogenesis, global transcriptome, differential gene regulation, cell proliferation, carcinogenesis, cellular metabolism, RNA processing, RNA turnover
- MeSH terms
- Humans, RNA, Messenger, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc
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