MYC: connecting selective transcriptional control to global RNA production

Molecular Cell Biology

Lodish, H. F. (1986) · Cited by 5,650

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

Stat3 as an Oncogene

Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,681

Reflecting on 25 years with MYC

Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

Hayward, W. S., Neel, B. G., & Astrin, S. M. (1981) · Nature · doi:10.1038/290475a0 · Cited by 1,569

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,543

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,411

Emerging landscape of oncogenic signatures across human cancers

Ciriello, G., Miller, M. L., Aksoy, B. A., Şenbabaoğlu, Y., Schultz, N. D., & Sander, C. (2013) · Nature Genetics · doi:10.1038/ng.2762 · Cited by 1,401

An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells

Kim, J., Chu, J., Shen, X., Wang, J., & Orkin, S. H. (2008) · Cell · doi:10.1016/j.cell.2008.02.039 · Cited by 1,361

Widespread microRNA repression by Myc contributes to tumorigenesis

Chang, T.-C., Yu, D., Lee, Y., Wentzel, E. A., Arking, D. E., West, K. M., Dang, C. V., Thomas‐Tikhonenko, A., & Mendell, J. T. (2007) · Nature Genetics · doi:10.1038/ng.2007.30 · Cited by 1,346

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

Adelman, K., & Lis, J. T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3293 · Cited by 1,221

The Many Pathways of RNA Degradation

Houseley, J. M., & Tollervey, D. W. (2009) · Cell · doi:10.1016/j.cell.2009.01.019 · Cited by 1,220

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179

Transcriptional regulation and transformation by Myc proteins

Adhikary, S., & Eilers, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1703 · Cited by 1,157

Molecular cell biology

(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90455-5 · Cited by 1,130

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,106

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092

Context-dependent control of alternative splicing by RNA-binding proteins

Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963

MYC as a regulator of ribosome biogenesis and protein synthesis

van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

Soufi, A., Donahue, G., & Zaret, K. S. (2012) · Cell · doi:10.1016/j.cell.2012.09.045 · Cited by 933

Myc’s broad reach

Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927

Reversible tumorigenesis by MYC in hematopoietic lineages.

Felsher, D., & Bishop, J. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80367-6 · Cited by 917

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885

Getting up to speed with transcription elongation by RNA polymerase II

Jonkers, I., & Lis, J. T. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3953 · Cited by 876

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

Weng, A. P., Millholland, J. M., Yashiro–Ohtani, Y., Arcangeli, M.-L., Lau, A. N., Wai, C., Bianco, C. D., Rodríguez, C. G., Sai, H., Tobias, J. W., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 863

Modelling Myc inhibition as a cancer therapy

Soucek, L., Whitfield, J. R., Martins, C. P., Finch, A. J., Murphy, D. J., Sodir, N. M., Karnezis, A. N., Swigart, L. B., Nasi, S., & Evan, G. I. (2008) · Nature · doi:10.1038/nature07260 · Cited by 846

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 841

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factorsPreprint

Wang, J., Zhuang, J., Iyer, S., Lin, X.-Y., Whitfield, T. W., Greven, M. C., Pierce, B. G., Dong, X., Kundaje, A. B., Cheng, Y., et al. (2012) · Genome Research · doi:10.1101/gr.139105.112 · Cited by 827

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Palomero, T., Lim, W. K., Odom, D. T., Sulis, M. L., Real, P. J., Margolin, A. A., Barnes, K., O’Neil, J., Neuberg, D. S., Weng, A. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606108103 · Cited by 821

Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

Berman, D. M., Karhadkar, S. S., Hallahan, A. R., Pritchard, J. I., Eberhart, C. G., Watkins, D. N., Chen, J., Cooper, M. K., Taipale, J., Olson, J. M., et al. (2002) · Science · doi:10.1126/science.1073733 · Cited by 802

Myc Function and Regulation

Marcu, K. B., Bossone, S., & Patel, A. J. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004113 · Cited by 802

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

Soufi, A., Garcia, M. F., Jaroszewicz, A., Osman, N., Pellegrini, M., & Zaret, K. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.017 · Cited by 780

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo

Zeitlinger, J., Stark, A., Kellis, M., Hong, J., Nechaev, S., Adelman, K., Levine, M., & Young, R. A. (2007) · Nature Genetics · doi:10.1038/ng.2007.26 · Cited by 766

An expansive human regulatory lexicon encoded in transcription factor footprints

Neph, S. J., Vierstra, J. D., Stergachis, A. B., Reynolds, A. P., Haugen, E., Vernot, B., Thurman, R. E., John, S., Sandstrom, R. S., Johnson, A., et al. (2012) · Nature · doi:10.1038/nature11212 · Cited by 760

Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes

Cai, L., Sutter, B. M., Li, B., & Tu, B. P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.004 · Cited by 701

Metabolic Regulation of Epigenetics

Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 671

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

Jain, M., Arvanitis, C., Chu, K., Dewey, W. C., Leonhardt, E. A., Trinh, M., Sundberg, C. D., Bishop, J. M., & Felsher, D. W. (2002) · Science · doi:10.1126/science.1071489 · Cited by 661

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Grandori, C., Gomez-Roman, N., Felton-Edkins, Z. A., Ngouenet, C., Galloway, D. A., Eisenman, R. N., & White, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1224 · Cited by 659

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658

Drosophila myc Regulates Cellular Growth during Development

Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Cell · doi:10.1016/s0092-8674(02)00738-9 · Cited by 636

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Chipumuro, E., Marco, E., Christensen, C. L., Kwiatkowski, N. P., Zhang, T., Hatheway, C. M., Abraham, B. J., Sharma, B., Yeung, C. M., Altabef, A. B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.024 · Cited by 631

MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 625

Myc deletion rescues Apc deficiency in the small intestine

Sansom, O. J., Méniel, V. S., Muncan, V., Phesse, T. J., Wilkins, J. A., Reed, K. R., Vass, J. K., Athineos, D., Clevers, H. C., & Clarke, A. R. (2007) · Nature · doi:10.1038/nature05674 · Cited by 618

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.10.012 · Cited by 616

Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615

Repression of p15INK4b expression by Myc through association with Miz-1

Staller, P., Peukert, K., Kiermaier, A. C., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bártek, J., Massagué, J., Hänel, F., et al. (2001) · Nature Cell Biology · doi:10.1038/35070076 · Cited by 595

The Myc oncoprotein as a therapeutic target for human cancer

Vita, M. F., & Arsenian‐Henriksson, M. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.015 · Cited by 575

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Nair, S. K., & Burley, S. K. (2003) · Cell · doi:10.1016/s0092-8674(02)01284-9 · Cited by 551

Global mapping of c-Myc binding sites and target gene networks in human B cells

Zeller, K. I., Zhao, X., Lee, C. W. H., Chiu, K. P., Yao, F., Yustein, J. T., Ooi, H., Orlov, Y. L., Shahab, A., Yong, H. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604129103 · Cited by 521

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Arabi, A., Wu, S., Ridderstråle, K., Bierhoff, H., Shiue, C.-N., Fátyol, K., Fahlén, S., Hydbring, P., Söderberg, O., Grummt, I., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1225 · Cited by 507

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Walz, S., Lorenzin, F., Morton, J. P., Wiese, K. E., von Eyß, B., Herold, S., Rycak, L., Dumay‐Odelot, H., Karim, S. A., Bartkuhn, M., et al. (2014) · Nature · doi:10.1038/nature13473 · Cited by 502

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Hsu, T. Y. T., Simon, L. M., Neill, N. J., Marcotte, R., Sayad, A., Bland, C. S., Echeverria, G. V., Sun, T., Kurley, S. J., Tyagi, S., et al. (2015) · Nature · doi:10.1038/nature14985 · Cited by 498

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

Sabò, A., Kress, T. R., Pelizzola, M., de Pretis, S., Gorski, M. M., Tesi, A., Morelli, M. J., Bora, P., Doni, M., Verrecchia, A., et al. (2014) · Nature · doi:10.1038/nature13537 · Cited by 496

Bim is a suppressor of Myc-induced mouse B cell leukemia

Egle, A., Harris, A. W., Bouillet, P., & Cory, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401471101 · Cited by 495

E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression

Chen, C.-R., Kang, Y., Siegel, P. M., & Massagué, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00801-2 · Cited by 495

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

Seoane, J., Pouponnot, C., Staller, P., Schader, M. B., Eilers, M., & Massagué, J. (2001) · Nature Cell Biology · doi:10.1038/35070086 · Cited by 489

Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAsPreprint

Tilgner, H., Knowles, D. G., Johnson, R., Davis, C., Chakrabortty, S. K., Djebali, S., Curado, J., Snyder, M. P., Gingeras, T., & Guigó, R. (2012) · Genome Research · doi:10.1101/gr.134445.111 · Cited by 486

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Zeller, K. I., Jegga, A. G., Aronow, B. J., O’Donnell, K. A., & Dang, C. V. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r69 · Cited by 483

Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations

Zhang, Y., Wong, C., Birnbaum, R. Y., Li, G., Favaro, R., Ngan, C. Y., Lim, J., Tai, E., Poh, H. M., Wong, E., et al. (2013) · Nature · doi:10.1038/nature12716 · Cited by 482

Myc represses transcription through recruitment of DNA methyltransferase corepressor

Brenner, C., Deplus, R., Mirjolet, C., Loriot, A. E., Viré, E. A., Smet, C. D., Gutiérrez, A., Danovi, D., Bernard, D., Boon, T., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600509 · Cited by 468

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

Anczuków, O., Rosenberg, A. Z., Akerman, M., Das, S., Zhan, L., Karni, R., Muthuswamy, S. K., & Krainer, A. R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2207 · Cited by 464

Ras Enhances Myc Protein Stability

Sears, R. C., Leone, G. W., DeGregori, J. V., & Nevins, J. R. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80308-1 · Cited by 463

The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

Schoenfelder, S., Furlan-Magaril, M., Mifsud, B., Tavares-Cadete, F., Sugar, R., Javierre, B.-M., Nagano, T., Katsman, Y., Sakthidevi, M., Wingett, S. W., et al. (2015) · Genome Research · doi:10.1101/gr.185272.114 · Cited by 460

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Barna, M., Pusic, A. D., Zollo, O., Costa, M. J. D. C., Kondrashov, N., Rego, E. M., Rao, P. H., & Ruggero, D. (2008) · Nature · doi:10.1038/nature07449 · Cited by 454

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

Hemann, M. T., Bric, A., Teruya‐Feldstein, J., Herbst, A., Nilsson, J. A., Cordon‐Cardo, C., Cleveland, J. L., Tansey, W. P., & Lowe, S. W. (2005) · Nature · doi:10.1038/nature03845 · Cited by 452

Control of Transcriptional Elongation

Kwak, H., & Lis, J. T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155440 · Cited by 441

Single Mammalian Cells Compensate for Differences in Cellular Volume and DNA Copy Number through Independent Global Transcriptional Mechanisms

Padovan-Merhar, O. M., Nair, G. P., Biaesch, A. G., Mayer, A., Scarfone, S., Foley, S. W., Wu, A. R., Churchman, L. S., Singh, A., & Raj, A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.005 · Cited by 435

Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

Langdon, W. Y., Harris, A. W., Cory, S., & Adams, J. M. (1986) · Cell · doi:10.1016/0092-8674(86)90361-2 · Cited by 433

mRNAs containing extensive secondary structure in their 5′ non‐coding region translate efficiently in cells overexpressing initiation factor eIF‐4E.

Koromilas, A. E., Lazaris-Karatzas, A., & Sonenberg, N. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05508.x · Cited by 431

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

Frank, S. R., Parisi, T., Taubert, S., Fernandez, P. C., Fuchs, M., Chan, H., Livingston, D. M., & Amati, B. B. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor861 · Cited by 419

Myc represses the p21 (WAF1/CIP1) promoter and interacts with Sp1/Sp3

Gartel, A. L., Ye, X., Goufman, E., Shiyanov, P. A., Hay, N., Najmabadi, F., & Tyner, A. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081074898 · Cited by 416

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

Kiuchi, N., Nakajima, K., Ichiba, M., Fukada, T., Narimatsu, M., Mizuno, K., Hibi, M., & Hirano, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.63 · Cited by 401

Myc influences global chromatin structure

Knoepfler, P. S., Zhang, X.-Y., Cheng, P. F., Gafken, P. R., McMahon, S. B., & Eisenman, R. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601152 · Cited by 395

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

Grewal, S., Li, L., Orian, A., Eisenman, R. N., & Edgar, B. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1223 · Cited by 387

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

Koh, C. M., Bezzi, M., Low, D. H. P., Ang, W. X., Teo, S. X., Gay, F. P. H., Al‐Haddawi, M., Tan, S., Osato, M., Sabò, A., et al. (2015) · Nature · doi:10.1038/nature14351 · Cited by 385

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

Orian, A., van Steensel, B., Delrow, J. J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W. M., Cowley, S. M., Yost, C., et al. (2003) · Genes & Development · doi:10.1101/gad.1066903 · Cited by 385

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Olio, V. D., Zardo, G., Nervi, C., Bernard, L., & Amati, B. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1434 · Cited by 373

Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells

Schweingruber, C., Rufener, S. C., Zünd, D., Yamashita, A., & Mühlemann, O. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.02.005 · Cited by 369

c-Myc enhances protein synthesis and cell size during B lymphocyte development

Iritani, B. M., & Eisenman, R. N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13180 · Cited by 364

Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

Pérez‐Roger, I., Kim, S., Griffiths, B. L., Sewing, A., & Land, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5310 · Cited by 331

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

Liu, Y.-C., Li, F., Handler, J., Huang, C. R. L., Xiang, Y., Neretti, N., Sedivy, J. M., Zeller, K. I., & Dang, C. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002722 · Cited by 317

New cell cycle compartments identified by multiparameter flow cytometry

Darżynkiewicz, Z., Traganos, F., & Melamed, M. R. (1980) · Cytometry · doi:10.1002/cyto.990010203 · Cited by 314

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Thomas, L. R., Wang, Q., Grieb, B. C., Phan, J., Foshage, A. M., Sun, Q., Olejniczak, E. T., Clark, T., Dey, S., Lorey, S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.028 · Cited by 310

Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

Vennström, B., Sheiness, D. K., Zabielski, J., & Bishop, J. M. (1982) · Journal of Virology · doi:10.1128/jvi.42.3.773-779.1982 · Cited by 307

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

Herold, S., Wanzel, M., Beuger, V., Frohme, C., Beul, D., Hillukkala, T., Syväoja, J. E., Saluz, H., Haenel, F., & Eilers, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00633-0 · Cited by 305

Control of cell growth by c-Myc in the absence of cell division

Schuhmacher, M., Staege, M. S., Pajic, A., Polack, A., Weidle, U. H., Bornkamm, G. W., Eick, D., & Kohlhuber, F. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80507-7 · Cited by 288

Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

Yang, W. E., Shen, J., Wu, M., Arsura, M., Fitzgerald, M. J., Suldan, Z., Kim, D. W., Hofmann, C. S., Pianetti, S., Romieu, R., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204245 · Cited by 277

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis

Sicklick, J. K., Li, Y.-X., Jayaraman, A., Kannangai, R., Qi, Y. P., Vivekanandan, P., Ludlow, J. W., Owzar, K., Chen, W., Torbenson, M. S., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi292 · Cited by 276

Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S. E., Goff, S. P., & Calame, K. L. (1993) · Science · doi:10.1126/science.8266081 · Cited by 272

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

Eberhardy, S. R., & Farnham, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207441200 · Cited by 271

Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

Sharma, V. M., Calvo, J. A., Draheim, K., Cunningham, L. A., Hermance, N. M., Beverly, L. J., Krishnamoorthy, V., Bhasin, M., Capobianco, A. J., & Kelliher, M. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01091-06 · Cited by 265

Myc Requires Distinct E2F Activities to Induce S Phase and Apoptosis

Leone, G. W., Sears, R. C., Huang, E. S., Rempel, R. E., Nuckolls, F., Park, C., Giangrande, P. H., Wu, L., Saavedra, H. I., Field, S. J., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00275-1 · Cited by 265

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

Cunningham, J. T., Moreno, M. V., Lodi, A., Ronen, S. M., & Ruggero, D. (2014) · Cell · doi:10.1016/j.cell.2014.03.052 · Cited by 260

Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.

Rosenwald, I. B., Rhoads, D. B., Callanan, L., Isselbacher, K. J., & Schmidt, E. V. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6175 · Cited by 256

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Gandin, V., Miluzio, A., Barbieri, A. M., Beugnet, A., Kiyokawa, H., Marchisio, P. C., & Biffo, S. (2008) · Nature · doi:10.1038/nature07267 · Cited by 241

An Essential E Box in the Promoter of the Gene Encoding the mRNA Cap-Binding Protein (Eukaryotic Initiation Factor 4E) Is a Target for Activation by c-myc

Jones, R. M., Branda, J. A., Johnston, K. A., Polymenis, M., Gadd, M. A., Rustgi, A. K., Callanan, L., & Schmidt, E. V. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4754 · Cited by 240

Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

Feng, X., Liang, Y.-Y., Liang, M., Zhai, W., & Lin, X. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00430-0 · Cited by 232

Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway

Warner, B. J., Blain, S. W., Seoane, J., & Massagué, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.5913 · Cited by 230

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes

Pérez‐Roger, I., Solomon, D. L., Sewing, A., & Land, H. (1997) · Oncogene · doi:10.1038/sj.onc.1201197 · Cited by 230

Apoptosis Triggered by Myc-Induced Suppression of Bcl-X L or Bcl-2 Is Bypassed during Lymphomagenesis

Eischen, C. M., Woo, D. D. L., Roussel, M. F., & Cleveland, J. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5063-5070.2001 · Cited by 223

Transforming Growth Factor β-Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Frederick, J. P., Liberati, N. T., Waddell, D. S., Shi, Y., & Wang, X. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2546-2559.2004 · Cited by 221

Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins

Bouchard, C., Marquardt, J., Brás, A., Medema, R. H., & Eilers, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600279 · Cited by 220

The c‐myc Promoter: Still MysterY and Challenge

(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint

Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 204

Coordinating genome expression with cell size

Marguerat, S., & Bähler, J. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.07.003 · Cited by 203

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Carroll, P. A., Diolaiti, D., McFerrin, L. G., Gu, H., Djukovic, D., Du, J., Cheng, P. F., Anderson, S., Ulrich, M. L., Hurley, J. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.024 · Cited by 202

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

Das, S., Anczuków, O., Akerman, M., & Krainer, A. R. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.12.001 · Cited by 202

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

Notari, M., Neviani, P., Santhanam, R., Blaser, B. W., Chang, J.-S., Galietta, A., Willis, A. E., Roy, D., Caligiuri, M. A., Marcucci, G., et al. (2005) · Blood · doi:10.1182/blood-2005-09-3732 · Cited by 202

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

Nikiforov, M. A., Chandriani, S. J., O’Connell, B. C., Petrenko, O., Kotenko, I., Beavis, A. J., Sedivy, J. M., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5793-5800.2002 · Cited by 201

The eukaryotic RNA exosome

Januszyk, K., & Lima, C. D. (2014) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2014.01.011 · Cited by 199

MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

Poortinga, G., Hannan, K., Snelling, H., Walkley, C. R., Jenkins, A., Sharkey, K., Wall, M., Brandenburger, Y., Palatsides, M., Pearson, R., et al. (2004) · EMBO Journal · doi:10.1038/sj.emboj.7600335 · Cited by 198

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

Mao, D. Y. L., Watson, J. D., Yan, P. S., Baršytė-Lovejoy, D., Khosravi, F., Wong, W. W.-L., Farnham, P., Huang, T. H. ‐., & Penn, L. Z. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00297-5 · Cited by 183

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Kanazawa, S., Soucek, L., Evan, G. I., Okamoto, T., & Peterlin, B. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206800 · Cited by 181

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

Nikiforov, M. A., Riblett, M., Tang, W. H. W., Grachtchouk, V., Zhuang, D., Fernández, Y., Verhaegen, M. E., Varambally, S., Chinnaiyan, A. M., Jakubowiak, A. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708380104 · Cited by 178

Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters

Cheng, A. S. L., Jin, V. X., Fan, M., Smith, L. T., Liyanarachchi, S., Yan, P. S., Leu, Y., Chan, M. W. Y., Plass, C., Nephew, K. P., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.016 · Cited by 177

Endogenous Myc maintains the tumor microenvironmentPreprint

Sodir, N. M., Swigart, L. B., Karnezis, A. N., Hanahan, D., Evan, G. I., & Soucek, L. (2011) · Genes & Development · doi:10.1101/gad.2038411 · Cited by 177

An E-Box-Mediated Increase in cad Transcription at the G1/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

Miltenberger, R. J., Sukow, K. A., & Farnham, P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2527 · Cited by 174

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

Ji, H., Wu, G. Y., Zhan, X., Nolan, A., Koh, C. M., Marzo, A. D., Doan, H. M., Fan, J., Cheadle, C., Fallahi, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026057 · Cited by 169

Mammalian MYC Proteins and Cancer

Tansey, W. P. (2014) · New Journal of Science · doi:10.1155/2014/757534 · Cited by 166

AREsite: a database for the comprehensive investigation of AU-rich elements

Gruber, A. R., Fallmann, J., Kratochvill, F., Kovarik, P., & Hofacker, I. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq990 · Cited by 162

Large-Scale Identification of c-MYC-Associated Proteins Using a Combined TAP/MudPIT Approach

Koch, H., Zhang, R., Verdoodt, B., Bailey, A. O., Zhang, C.-D., Yates, J. R., Menssen, A., & Hermeking, H. (2007) · Cell Cycle · doi:10.4161/cc.6.2.3742 · Cited by 162

Bax is a transcriptional target and mediator of c-myc-induced apoptosis.

Mitchell, K., Ricci, M. S., Miyashita, T., Dicker, D. T., Jin, Z., Reed, J. C., & El‐Deiry, W. S. (2000) · PubMed · Cited by 161

c-myc protein expression in untransformed fibroblasts.

Waters, C. M., Littlewood, T. D., Hancock, D. C., Moore, J. P., & Evan, G. I. (1991) · PubMed · Cited by 160

Global target mRNA specification and regulation by the RNA-binding protein ZFP36

Mukherjee, N., Jacobs, N. C., Hafner, M., Kennington, E. A., Nusbaum, J. D., Tuschl, T., Blackshear, P. J., & Ohler, U. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r12 · Cited by 157

The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding

Cowling, V. H., & Cole, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01828-06 · Cited by 155

Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry

Morrish, F. M., Noonan, J., Olsen, C. P., Gafken, P. R., Fitzgibbon, M., Kelleher, J. K., VanGilst, M., & Hockenbery, D. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141606 · Cited by 152

Conditional transgenic models define how MYC initiates and maintains tumorigenesis

Arvanitis, C., & Felsher, D. W. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.012 · Cited by 148

The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

Kress, T. R., Cannell, I. G., Brenkman, A. B., Samans, B., Gaestel, M., Roepman, P., Burgering, B. M. T., Bushell, M., Rosenwald, A., & Eilers, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.023 · Cited by 148

Connecting Variability in Global Transcription Rate to Mitochondrial Variability

das Neves, R. P., Jones, N. S., Andreu, L. F., Gupta, R., Enver, T., & Iborra, F. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000560 · Cited by 139

Taming of the beast: shaping Myc-dependent amplification

Wolf, E., Lin, C. Y., Eilers, M., & Levens, D. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.006 · Cited by 138

Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cellsPreprint

Lee, B.-K., Bhinge, A., Battenhouse, A., McDaniell, R. M., Liu, Z., Song, L., 倪, 运., Birney, E., Lieb, J. D., Furey, T. S., et al. (2011) · Genome Research · doi:10.1101/gr.127597.111 · Cited by 138

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5APreprint

Hubert, C. G., Bradley, R. K., Ding, Y., Toledo, C. M., Herman, J., Skutt-Kakaria, K., Girard, E. J., Davison, J., Berndt, J. D., Corrin, P. D., et al. (2013) · Genes & Development · doi:10.1101/gad.212548.112 · Cited by 134

Myc and its interactors take shape

Tu, W. B., Helander, S., Pilstål, R., Hickman, K. A., Lourenco, C., Jurišica, I., Raught, B., Wallner, B., Sunnerhagen, M., & Penn, L. Z. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.06.002 · Cited by 130

Transcriptional Repression: The Dark Side of Myc

Herkert, B., & Eilers, M. (2010) · Genes & Cancer · doi:10.1177/1947601910379012 · Cited by 130

A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition

Smith, A. P., Verrecchia, A., Fagà, G., Doni, M., Perna, D., Martinato, F., Guccione, E., & Amati, B. B. (2008) · Oncogene · doi:10.1038/onc.2008.395 · Cited by 128

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X L

Maclean, K. H., Keller, U. B., Galindo, C. R., Nilsson, J. A., & Cleveland, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7256-7270.2003 · Cited by 128

c-MYC-Induced Genomic InstabilityPreprint

Kuzyk, R., & Mai, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014373 · Cited by 127

Tristetraprolin Impairs Myc-Induced Lymphoma and Abolishes the Malignant State

Rounbehler, R. J., Fallahi, M., Yang, C., Steeves, M. A., Li, W., Doherty, J. R., Schaub, F. X., Sanduja, S., Dixon, D. A., Blackshear, P. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.033 · Cited by 122

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

Gebhardt, A., Frye, M., Herold, S., Benitah, S. A., Braun, K., Samans, B., Watt, F. M., Elsässer, H.-P., & Eilers, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506057 · Cited by 118

MicroRNAs as regulators and mediators of c-MYC function

Jackstadt, R., & Hermeking, H. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.04.003 · Cited by 117

Induction of cyclin E–cdk2 kinase activity, E2F‐dependent transcription and cell growth by Myc are genetically separable events

Beier, R., Bürgin, A., Kiermaier, A. C., Fero, M. L., Karsunky, H., Saffrich, R., Möröy, T., Ansorge, W. J., Roberts, J., & Eilers, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5813 · Cited by 114

Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts

Perna, D., Fagà, G., Verrecchia, A., Gorski, M. M., Barozzi, I., Narang, V., Khng, J., Lim, K., Sung, W.-K., Sanges, R., et al. (2011) · Oncogene · doi:10.1038/onc.2011.359 · Cited by 113

The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenancePreprint

van Riggelen, J., Müller, J., Otto, T., Beuger, V., Yetil, A., Choi, P. S., Kosan, C., Möröy, T., Felsher, D. W., & Eilers, M. (2010) · Genes & Development · doi:10.1101/gad.585710 · Cited by 113

Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma

Seitz, V., Butzhammer, P., Hirsch, B., Hecht, J., Gütgemann, I., Ehlers, A., Lenze, D., Oker, E., Sommerfeld, A., von der Wall, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026837 · Cited by 109

Genome Recognition by MYCPreprint

Sabò, A., & Amati, B. B. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014191 · Cited by 107

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Wall, M., Poortinga, G., Hannan, K. M., Pearson, R. B., Hannan, R. D., & McArthur, G. A. (2008) · Blood · doi:10.1182/blood-2007-09-111856 · Cited by 105

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

Izumi, H., Molander, C., Penn, L. Z., Ishisaki, A., Kohno, K., & Funa, K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1533 · Cited by 103

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

Chou, C., Pinto, A. K., Curtis, J. D., Persaud, S. P., Cella, M., Lin, C., Edelson, B. T., Allen, P. M., Colonna, M., Pearce, E. L., et al. (2014) · Nature Immunology · doi:10.1038/ni.2943 · Cited by 97

Regulation of Cyclin D1 RNA Stability by SNIP1

Bracken, C. P., Wall, S. J., Barré, B., Panov, K. I., Ajuh, P., & Perkins, N. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1217 · Cited by 97

Myc Regulates the Transcription of the PRC2 Gene To Control the Expression of Developmental Genes in Embryonic Stem Cells

Neri, F., Zippo, A., Křepelová, A., Cherubini, A., Rocchigiani, M., & Oliviero, S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06148-11 · Cited by 95

P-TEFb is a Crucial Co-Factor for Myc Transactivation

Gargano, B., Amente, S., Majello, B., & Lania, L. (2007) · Cell Cycle · doi:10.4161/cc.6.16.4554 · Cited by 89

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogrammingPreprint

Hirsch, C. L., Coban‐Akdemir, Z., Wang, L., Jayakumaran, G., Trcka, D., Weiss, A., Hernández, J. J., Pan, Q., Han, H. R., Xu, X., et al. (2015) · Genes & Development · doi:10.1101/gad.255109.114 · Cited by 88

Sequence specificity incompletely defines the genome-wide occupancy of Myc

Guo, J., Li, T., Schipper, J. L., Nilson, K. A., Fordjour, F. K., Cooper, J. J., Gordân, R., & Price, D. H. (2014) · Genome biology · doi:10.1186/s13059-014-0482-3 · Cited by 86

MYC regulates the non-coding transcriptome

Hart, J. R., Roberts, T. C., Weinberg, M. S., Morris, K. V., & Vogt, P. K. (2014) · Oncotarget · doi:10.18632/oncotarget.3033 · Cited by 85

MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase

Kaur, M., & Cole, M. D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2522 · Cited by 84

Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

Lin, C.-H., Lin, C. W., Tanaka, H., Fero, M. L., & Eisenman, R. N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007839 · Cited by 80

Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

Cole, M. D., & Cowling, V. H. (2009) · Oncogene · doi:10.1038/onc.2008.463 · Cited by 75

Feedback Regulation of c-Myc by Ribosomal Protein L11

Dai, M., Sears, R. C., & Lu, H. (2007) · Cell Cycle · doi:10.4161/cc.6.22.4895 · Cited by 75

Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins

Yu, Q., Ciemerych, M. A., & Siciński, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208853 · Cited by 74

Reversible Kinetic Analysis of Myc Targets In vivo Provides Novel Insights into Myc-Mediated Tumorigenesis

Lawlor, E. R., Soucek, L., Swigart, L. B., Shchors, K., Bialucha, C. U., & Evan, G. I. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3826 · Cited by 74

Myc Function in DrosophilaPreprint

Gallant, P. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014324 · Cited by 74

C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells

Kwan, K. Y., Shen, J., & Corey, D. P. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.11.001 · Cited by 73

Inhibition of cell differentiation: A critical mechanism for MYC-mediated carcinogenesis?

León, J., Ferrándiz, N., Acosta, J. C., & Delgado, M. D. (2009) · Cell Cycle · doi:10.4161/cc.8.8.8126 · Cited by 69

SNIP1 Is a Candidate Modifier of the Transcriptional Activity of c-Myc on E Box-Dependent Target Genes

Fujii, M., Lyakh, L. A., Bracken, C. P., Fukuoka, J., Hayakawa, M., Tsukiyama, T., Soll, S. J., Harris, M. D., Rocha, S., Roche, K. C., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.006 · Cited by 66

Premetazoan Ancestry of the Myc–Max Network

Young, S. L., Diolaiti, D., Conacci‐Sorrell, M., Ruiz‐Trillo, I., Eisenman, R. N., & King, N. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr132 · Cited by 65

S-Adenosyl Homocysteine Hydrolase Is Required for Myc-Induced mRNA Cap Methylation, Protein Synthesis, and Cell Proliferation

Fernández-Sánchez, M. E., Gonatopoulos-Pournatzis, T., Preston, G., Lawlor, M. A., & Cowling, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-09 · Cited by 62

Cellular MYCro Economics: Balancing MYC Function with MYC ExpressionPreprint

Levens, D. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014233 · Cited by 60

Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc

Schneider, A., Peukert, K., Eilers, M., & Hänel, F. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60801-8_14 · Cited by 57

c-MYC–miRNA circuitry

Tao, J., Zhao, X., & Tao, J. (2014) · Cell Cycle · doi:10.4161/cc.27646 · Cited by 56

Miz1 is required to maintain autophagic flux

Wolf, E., Gebhardt, A., Kawauchi, D., Walz, S., von Eyß, B., Wagner, N., Renninger, C., Krohne, G., Asan, E., Roussel, M. F., et al. (2013) · Nature Communications · doi:10.1038/ncomms3535 · Cited by 56

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

Kim, T., Cui, R., Jeon, Y.-J., Fadda, P., Alder, H., & Croce, C. M. (2015) · Oncotarget · doi:10.18632/oncotarget.3909 · Cited by 55

Overexpression of the c-myc Oncogene Inhibits Nonsense-mediated RNA Decay in B Lymphocytes

Wang, D., Wengrod, J., & Gardner, L. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.266361 · Cited by 53

Determination of Copy Number of c-Myc Protein per Cell by Quantitative Western Blotting

Rudolph, C., Adam, G., & Simm, A. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.3095 · Cited by 53

Drosophila Myc: A master regulator of cellular performance

Grifoni, D., & Bellosta, P. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.06.021 · Cited by 51

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

Fogal, V., Babić, I., Chao, Y. S., Pastorino, S., Mukthavaram, R., Jiang, P., Cho, Y., Pingle, S. C., Crawford, J. R., Piccioni, D. E., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2708 · Cited by 47

Cellular MYCro Economics: Balancing MYC Function with MYC ExpressionPreprint

Levens, D. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022483 · Cited by 46

Transcriptional control of DNA replication licensing by Myc

Valovka, T., Schönfeld, M., Raffeiner, P., Breuker, K., Dunzendorfer-Matt, T., Hartl, M., & Bister, K. (2013) · Scientific Reports · doi:10.1038/srep03444 · Cited by 43

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

Yap, C.-S., Peterson, A. L., Castellani, G., Sedivy, J. M., & Neretti, N. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16249 · Cited by 41

The Mechanism of Discrimination between Cognate and Non-Specific DNA by Dimeric b/HLH/LZ Transcription Factors

Sauvé, S., Naud, J., & Lavigne, P. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.044 · Cited by 40

Repression of SRF target genes is critical for Myc‐dependent apoptosis of epithelial cells

Wiese, K. E., Haikala, H. M., von Eyß, B., Wolf, E., Esnault, C., Rosenwald, A., Treisman, R., Klefström, J. T., & Eilers, M. (2015) · The EMBO Journal · doi:10.15252/embj.201490467 · Cited by 32

The chromodomain-containing histone acetyltransferase TIP60 acts as a code reader, recognizing the epigenetic codes for initiating transcription

Kim, C.-H., Kim, J.-W., Jang, S., An, J., Seo, S., & Choi, K. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.993914 · Cited by 26

Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice.

Vaux, D. L., Adams, J. M., Alexander, W. S., & Pike, B. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.11.3854 · Cited by 21

Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing

Davis‐Turak, J., Allison, K. A., Shokhirev, M. N., Пономаренко, П. М., Tsimring, L. S., Glass, C. K., Johnson, T., & Hoffmann, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1338 · Cited by 19

Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif

Barrilleaux, B. L., Burow, D. A., Lockwood, S. H., Yu, A. S., Segal, D. J., & Knoepfler, P. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101151 · Cited by 18

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M.-J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J.-R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.006 · Cited by 1,429

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,044

Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials

Lu, H., Zhou, Q., He, J., Jiang, Z., Peng, C., Tong, R., & Shi, J. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00315-3 · Cited by 891

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Robertson, A. G., Shih, J., Yau, C. S. F., Gibb, E. A., Oba, J., Mungall, K. L., Hess, J. M., Uzunangelov, V., Walter, V., Danilova, L., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.003 · Cited by 908

The role of ubiquitination in tumorigenesis and targeted drug discovery

Deng, L., Meng, T., Chen, L., Wei, W., & Wang, P. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0107-0 · Cited by 744

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

Sabò, A., Kress, T. R., Pelizzola, M., de Pretis, S., Gorski, M. M., Tesi, A., Morelli, M. J., Bora, P., Doni, M., Verrecchia, A., et al. (2014) · Nature · doi:10.1038/nature13537 · Cited by 496

Fine-tuned amplification in cells

Dang, C. V. (2014) · Nature · doi:10.1038/nature13518 · Cited by 29

MYC function and regulation in physiological perspective

Jha, R., Kouzine, F., & Levens, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268275 · Cited by 107

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

Walz, S., Lorenzin, F., Morton, J. P., Wiese, K. E., von Eyß, B., Herold, S., Rycak, L., Dumay‐Odelot, H., Karim, S. A., Bartkuhn, M., et al. (2014) · Nature · doi:10.1038/nature13473 · Cited by 502

Measuring MYC-Mediated Metabolism in Tumorigenesis

Tang, H., Goldman, A. R., Zhang, X., Speicher, D. W., & Dang, C. V. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1476-1_11 · Cited by 10