The DOI matches its Crossref record; 200 of the 201 references it cites were found in a registry or an index.
MYC: connecting selective transcriptional control to global RNA production
Abstract
Two opposing models have been proposed to describe the function of the MYC oncoprotein in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active loci; the other that MYC differentially controls discrete sets of genes, the products of which affect global transcript levels. Here, we argue that differential gene regulation by MYC is the sole unifying model that is consistent with all available data. Among other effects, MYC endows cells with physiological and metabolic changes that have the potential to feed back on global RNA production, processing and turnover. The field is progressing steadily towards a full characterization of the MYC-regulated genes and pathways that mediate these biological effects and - by the same token - endow MYC with its pervasive oncogenic potential.
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“This could offer one explanation for the interference effect observed during concurrent training: rather than entirely suppressing ribosome biogenesis, endurance-oriented stimuli may bias translational machinery toward proteins involved in oxidative metabolism and mitochondrial adaptation, whereas resistance exercise may favor ribosomal configurations more suitable for myofibrillar accretion [188,”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [193]
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1 retracted
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Identification of c- MYC as a Target of the APC Pathway
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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
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1 of the 201 references couldn’t be matched to a known paper.
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Items 501–519 of 519
MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription
Sundaram, R. K., Parihar, K., Monson, S., Radhakrishnan, R., & Lim, B. (2026) · NAR Cancer · doi:10.1093/narcan/zcag010
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A MYCN–GAL–SREBP1 lipogenic axis drives proliferation in silent corticotroph adenomas
Han, C., Wu, J., Xie, J., Li, J., He, Z., Zhang, B., Dong, Y., Fang, Q., Ye, J., Tang, Z., et al. (2026) · Neuro-Oncology · doi:10.1093/neuonc/noag141
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PTEN: Redefining tumor suppressor functions in cancer by regulating transcription
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Functional Interpretation of Differential Gene Expression in Cancer: From Lists to Mechanisms
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Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability
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Uncovering pan-cancer signatures of chemoresistance
Inayatullah, M., Demirdizen, E., Keepers, Z., Correia, C. M., Hashemi, S. M., Tripathi, K. K., Sadhukhan, S., Bardhan, I., Mariappan, A., Rassool, F. V., et al. (2026) · Genome Medicine · doi:10.1186/s13073-026-01763-2
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Kuang, W., Wang, D., Song, M., Liu, J., Li, J., Wang, W., Chen, A., Chen, Y., Ding, J., Wang, L., et al. (2026) · Targetome · doi:10.48130/targetome-0026-0052
MYC/MAX balance dictates cell progenitor fate by altering the HOX program in the Drosophila eye
Monticelli, S., Milazzo, G., Zadran, S. K., Santulli, M., Balboni, N., Strocchi, S., Giorgio, E. D., Mestdagh, P., Giangrande, A., Bernardoni, R., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1958701
BindingDB Entry 50002796: Synthetic molecules for disruption of the MYC protein-protein interface.
BindingDB (2020) · UC San Diego · doi:10.7270/q2fj2kdb
Metadata
- Authors
- Kress, T. R., Sabò, A., & Amati, B.
- Affiliations
- Italian Institute of Technology (IT)
- Corresponding author
- Amati, Bruno
- Venue
- Nature reviews. Cancer
- Published
- 2015-09-18
- Volume
- 15
- Issue
- 10
- Pages
- 593-607
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1878169898
- Cited by
- 521
- References
- 201
- Citations by year
- 2026: 27 · 2025: 41 · 2024: 52 · 2023: 52 · 2022: 47 · 2021: 57 · 2020: 48 · 2019: 42 · 2018: 58 · 2017: 52 · 2016: 40 · 2015: 5
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- c-Myc, transcriptional regulation, RNA biogenesis, global transcriptome, differential gene regulation, cell proliferation, carcinogenesis, cellular metabolism, RNA processing, RNA turnover
- MeSH terms
- Humans, RNA, Messenger, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc
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