Cited by 487Cancer, Stress, Anesthesia, and Immune ResponseEnhanced Recovery After SurgeryCancer Cells and Metastasis

The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.

Exploiting the critical perioperative period to improve long-term cancer outcomes

Open access

Horowitz, Maya, Neeman, Elad, Sharon, Eran, Ben-Eliyahu, Shamgar·2015·Nature Reviews Clinical Oncology

DOI 10.1038/nrclinonc.2014.224PMC PMC5497123

Open this paper in CoChat — free account

Abstract

Evidence suggests that the perioperative period and the excision of the primary tumour can promote the development of metastases—the main cause of cancer-related mortality. This Review first presents the assertion that the perioperative timeframe is pivotal in determining long-term cancer outcomes, disproportionally to its short duration (days to weeks). We then analyse the various aspects of surgery, and their consequent paracrine and neuroendocrine responses, which could facilitate the metastatic process by directly affecting malignant tissues, and/or through indirect pathways, such as immunological perturbations. We address the influences of surgery-related anxiety and stress, nutritional status, anaesthetics and analgesics, hypothermia, blood transfusion, tissue damage, and levels of sex hormones, and point at some as probable deleterious factors. Through understanding these processes and reviewing empirical evidence, we provide suggestions for potential new perioperative approaches and interventions aimed at attenuating deleterious processes and ultimately improving treatment outcomes. Specifically, we highlight excess perioperative release of catecholamines and prostaglandins as key deleterious mediators of surgery, and we recommend blockade of these responses during the perioperative period, as well as other low-risk, low-cost interventions. The measures described in this Review could transform the perioperative timeframe from a prominent facilitator of metastatic progression, to a window of opportunity for arresting and/or eliminating residual disease, potentially improving long-term survival rates in patients with cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrclinonc.2014.224

Cites

228 of 228 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Harrison's Principles of Internal Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,528
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474
Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001294 · Cited by 5,572
Cancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., & Folkman, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81848-6 · Cited by 4,486
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J., & Schreiber, R. D. (2001) · Nature · doi:10.1038/35074122 · Cited by 2,896
Perioperative Normothermia to Reduce the Incidence of Surgical-Wound Infection and Shorten Hospitalization
Kurz, A. M., Sessler, D. I., & Lenhardt, R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605093341901 · Cited by 2,748
Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial
Lacy, A. M., García‐Valdecasas, J. C., Delgado, S., Castells, A., Taurá, P., Piqué, J. M., & Visa, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09290-5 · Cited by 2,441
The stress response to trauma and surgery
DESBOROUGH, J. P. (2000) · British Journal of Anaesthesia · doi:10.1093/bja/85.1.109 · Cited by 2,304
Harrison's Principles of Internal Medicine
Somberg, J. C. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000179344.69594.75 · Cited by 2,123
Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial
van der Pas, M. H. G. M., Haglind, E., Cuesta, M. A., Fürst, A., Lacy, A. M., Hop, W. C. J., & Bonjer, H. J. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70016-0 · Cited by 1,714
Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature
Gupta, D., & Lis, C. G. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-69 · Cited by 1,485
Regulation of Immune Responses by Prostaglandin E2
Kaliński, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101029 · Cited by 1,477
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2
Walker, J. L., Piedmonte, M. R., Spirtos, N. M., Eisenkop, S. M., Schlaerth, J. B., Mannel, R. S., Spiegel, G., Barakat, R., Pearl, M. L., & Sharma, S. K. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.3248 · Cited by 1,288
Malignant Melanoma
Rodríguez‐Sains, R. S., Bart, R. S., Kopf, A. W., & Hölzle, E. (1979) · Cited by 1,287
Therapeutic potential of Toll-like receptor 9 activation
Krieg, A. Μ. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2059 · Cited by 1,244
The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials
Varadhan, K. K., Neal, K. R., Dejong, C. H. C., Fearon, K. C. H., Ljungqvist, O. H., & Lobo, D. N. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.01.004 · Cited by 1,198
Malignant Melanoma
Fawzy, F. I. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820210015002 · Cited by 1,030
Statin use and reduced cancer-related mortality
Nielsen, S. F., Nordestgaard, B. G., & Bojesen, S. E. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1201735 · Cited by 1,030
The Randomized Clinical Trial
Glaser, E. (1972) · New England Journal of Medicine · doi:10.1056/nejm197210192871623 · Cited by 970
Short term benefits for laparoscopic colorectal resection
Schwenk, W., Haase, O., Neudecker, J., & Müller, J. M. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003145.pub2 · Cited by 950
The Effects of Mild Perioperative Hypothermia on Blood Loss and Transfusion Requirement
Rajagopalan, S., Mascha, E. J., Na, J., & Sessler, D. I. (2008) · Anesthesiology · doi:10.1097/01.anes.0000296719.73450.52 · Cited by 900
Can Anesthetic Technique for Primary Breast Cancer Surgery Affect Recurrence or Metastasis?
Exadaktylos, A. K., Buggy, D. J., Moriarty, D. C., Mascha, E. J., & Sessler, D. I. (2006) · Anesthesiology · doi:10.1097/00000542-200610000-00008 · Cited by 880
Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
Rothwell, P. M., Price, J. F., Fowkes, F. G. R., Zanchetti, A., Roncaglioni, M. C., Tognoni, G., Lee, R., Belch, J. F., Wilson, M., Mehta, Z., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61720-0 · Cited by 839
Statins and the Risk of Colorectal Cancer
Poynter, J. N., Gruber, S. B., Higgins, P., Almog, R., Bonner, J. D., Rennert, H. S., Low, M., Greenson, J. K., & Rennert, G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043792 · Cited by 814
Statin Use and Reduced Cancer-Related Mortality
Klop, C., Driessen, J. H. M., & de Vries, F. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1214827 · Cited by 725
Activation of NK cell cytotoxicity
Smyth, M. J., Cretney, E., Kelly, J. M., Westwood, J. A., Street, S. E. A., Yagita∥, H., Takeda, K., van Dommelen, S. L. H., Degli‐Esposti, M. A., & Hayakawa, Y. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.07.034 · Cited by 714
Anesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence
Biki, B., Mascha, E. J., Moriarty, D. C., Fitzpatrick, J. M., Sessler, D. I., & Buggy, D. J. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817f5b73 · Cited by 597
Effect of anaesthetic technique and other perioperative factors on cancer recurrence
Snyder, G. L., & Greenberg, S. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq164 · Cited by 595
Postoperative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery
Jensen, L. S., Andersen, A. J., Christiansen, P. M., Hokland, P., Juhl, C. O., Madsen, G., Mortensen, J., Meller-Nielsen, C., Hanberg-Sørensen, F., & Hokland, M. (1992) · British journal of surgery · doi:10.1002/bjs.1800790613 · Cited by 556
Beta Blockers and Breast Cancer Mortality: A Population- Based Study
Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532
Long-term results of laparoscopic colorectal cancer resection
Kuhry, E., Schwenk, W., Gaupset, R., Romild, U. K., & Bonjer, H. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003432.pub2 · Cited by 531
Psychologic intervention improves survival for breast cancer patients
Andersen, B. L., Yang, H., Farrar, W. B., Golden‐Kreutz, D. M., Emery, C. F., Thornton, L. M., Young, D. C., & Carson, W. E. (2008) · Cancer · doi:10.1002/cncr.23969 · Cited by 508
Beta-Blocker Use Is Associated With Improved Relapse-Free Survival in Patients With Triple-Negative Breast Cancer
Melhem‐Bertrandt, A., Chávez‐MacGregor, M., Lei, X. J., Brown, E. N., Lee, R. T., Meric‐Bernstam, F., Sood, A. K., Conzen, S. D., Hortobágyi, G. N., & Gonzalez-Angulo, A. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.4441 · Cited by 471
Beta-Blocker Drug Therapy Reduces Secondary Cancer Formation in Breast Cancer and Improves Cancer Specific Survival
Powe, D. G., Voss, M. J., Zänker, K. S., Habashy, H. O., Green, A. R., Ellis, I. O., & Entschladen, F. (2010) · Oncotarget · doi:10.18632/oncotarget.197 · Cited by 462
Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression
Kim, R., Emi, M., Tanabe, K., & Arihiro, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4128 · Cited by 453
Suppression of Natural Killer Cell Activity and Promotion of Tumor Metastasis by Ketamine, Thiopental, and Halothane, but Not by Propofol: Mediating Mechanisms and Prophylactic Measures
Melamed, R., Bar-Yosef, S., Shakhar, G., Shakhar, K., & Ben‐Eliyahu, S. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000082995.44040.07 · Cited by 443
Self-citation
The Catecholamine, Cortisol, and Hemodynamic Responses to Mild Perioperative Hypothermia
Frank, S. M., Higgins, M. S., Breslow, M. J., Fleisher, L. A., Gorman, R. B., Sitzmann, J. V., Raff, H., & Beattle, C. (1995) · Anesthesiology · doi:10.1097/00000542-199501000-00012 · Cited by 415
Perioperative blood transfusions for the recurrence of colorectal cancer
Amato, A., & Pescatori, M. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005033 · Cited by 406
Effects of Allogeneic Red Blood Cell Transfusions on Clinical Outcomes in Patients Undergoing Colorectal Cancer Surgery
Acheson, A. G., Brookes, M., & Spahn, D. R. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31825b35d5 · Cited by 402
Stress and Immune Responses After Surgical Treatment for Regional Breast Cancer
Andersen, B. L., Farrar, W. B., Golden‐Kreutz, D. M., Kutz, L. A., MacCallum, R. C., Courtney, M. E., & Glaser, R. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.1.30 · Cited by 399
Multi-targeted therapy of cancer by omega-3 fatty acids
Berquin, I. M., Edwards, I. J., & Chen, Y. Q. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.044 · Cited by 368
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.
Thibault, A., Samid, D., Tompkins, A. C., Figg, W. D., Cooper, M. R., Hohl, R. J., Trepel, J. B., Liang, B., Patronas, N., Venzon, D. J., et al. (1996) · PubMed · Cited by 362
Presence of a growth-stimulating factor in serum following primary tumor removal in mice.
Fisher, B., Gündüz, N., Coyle, J., Rudock, C., & Saffer, E. (1989) · PubMed · Cited by 361
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial
Kawata, S., Yamasaki, E., Nagase, T., Inui, Y., Ito, N., Matsuda, Y., Inada, M., Tamura, S., Noda, S., Imai, Y., et al. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1716 · Cited by 351
Laparoscopy versus laparotomy for the management of early stage endometrial cancer
Galaal, K. A., Bryant, A., Fisher, A. D., Al‐Khaduri, M., Kew, F., & Lopes, A. D. B. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006655.pub2 · Cited by 342
Potential Prophylactic Measures Against Postoperative Immunosuppression: Could They Reduce Recurrence Rates in Oncological Patients?
Shakhar, G., & Ben‐Eliyahu, S. (2003) · Annals of Surgical Oncology · doi:10.1245/aso.2003.02.007 · Cited by 328
Self-citation
Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression
Yang, E. V., Kim, S.-J., Donovan, E. L., Chen, M., Gross, A. C., Marketon, J. I. W., Barsky, S. H., & Glaser, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.005 · Cited by 325
Laparoscopic versus open total mesorectal excision for rectal cancer
Breukink, S. O., Pierie, J.-P., & Wiggers, T. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005200.pub2 · Cited by 323
Significant Detection of Circulating Cancer Cells in the Blood by Reverse Transcriptase–Polymerase Chain Reaction During Colorectal Cancer Resection
Yamaguchi, K., Takagi, Y., Aoki, S., Futamura, M., & Saji, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200007000-00009 · Cited by 322
Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis?
Heaney, Á., & Buggy, D. J. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes421 · Cited by 322
Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial
Myles, P. S., Peyton, P. J., SILBERT, B. S., Hunt, J. O., Rigg, J. R. A., Sessler, D. I., & for the ANZCA Trials Group Investigators (2011) · BMJ · doi:10.1136/bmj.d1491 · Cited by 320
Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers.
Masur, K., Niggemann, B., Zänker, K. S., & Entschladen, F. (2001) · PubMed · Cited by 308
Effects of transfusion on immune function. Cancer recurrence and infection.
Blumberg, N., & Heal, J. M. (1994) · PubMed · Cited by 305
Morphine Inhibits Spontaneous and Cytokine-enhanced Natural Killer Cell Cytotoxicity in Volunteers
Yeager, M. P., Colacchio, T. A., Yu, C. T., Hildebrandt, L., Howell, A. L., Weiss, J. E., & Guyre, P. M. (1995) · Anesthesiology · doi:10.1097/00000542-199509000-00008 · Cited by 304
Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer
Graaf, M. R., Richel, D. J., Noorden, C. J. F. V., & Guchelaar, H. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.06.010 · Cited by 303
Laparoscopic versus open total mesorectal excision for rectal cancer
Breukink, S. O., Pierie, J. P. E. N., & Wiggers, T. (2005) · doi:10.1002/14651858.cd005200 · Cited by 301
Cell cycle-specific effects of lovastatin.
Jakóbisiak, M., Bruno, S., Skierski, J., & Darżynkiewicz, Z. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3628 · Cited by 296
Upregulation of Prostaglandin E2and Interleukins in the Central Nervous System and Peripheral Tissue during and after Surgery in Humans
Buvanendran, A., Kroin, J. S., Berger, R. A., Hallab, N. J., Saha, C., Negrescu, C., Moric, M. M., Caicedo, M. S., & Tuman, K. J. (2006) · Anesthesiology · doi:10.1097/00000542-200603000-00005 · Cited by 290
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283
Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis
Benish, M., Bartal, I., Goldfarb, Y., Levi, B., Avraham, R., Raz, A., & Ben-Eliyahu, S. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9890-5 · Cited by 281
Self-citation
Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30 000 patients
Liakopoulos, O. J., Choi, Y., Haldenwang, P. L., Strauch, J., Wittwer, T., Dörge, H., Stamm, C., Wassmer, G., & Wahlers, T. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn198 · Cited by 279
Improving Postoperative Immune Status and Resistance to Cancer Metastasis
Goldfarb, Y., Sorski, L., Benish, M., Levi, B. Z., Melamed, R., & Ben‐Eliyahu, S. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318211d7b5 · Cited by 262
Self-citation
Randomized clinical trial of laparoscopic versus open abdominal rectopexy for rectal prolapse
Solomon, M. J., Young, C. J., Eyers, A. A., & Roberts, R. A. (2002) · British journal of surgery · doi:10.1046/j.0007-1323.2001.01957.x · Cited by 260
Effects of Mild Perioperative Hypothermia on Cellular Immune Responses
Beilin, B., Shavit, Y., Razumovsky, J., Wolloch, Y., Zeidel, A., & Bessler, H. (1998) · Anesthesiology · doi:10.1097/00000542-199811000-00013 · Cited by 258
The Novel Role of the Mu Opioid Receptor in Lung Cancer Progression
Mathew, B., Lennon, F. E., Siegler, J. H., Mirzapoiazova, T., Mambetsariev, N., Sammani, S., Gerhold, L. M., Lariviere, P. J., Chen, C.-T., Garcia, J. G. N., et al. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31820568af · Cited by 258
In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats.
Shakhar, G., & Ben‐Eliyahu, S. (1998) · PubMed · Cited by 253
Self-citation
Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics
Antoni, M. H., Lutgendorf, S. K., Blomberg, B., Carver, C. S., Lechner, S., Diaz, A., Stagl, J., Arevalo, J. M. G., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.007 · Cited by 251
Surgery and stress promote cancer metastasis: New outlooks on perioperative mediating mechanisms and immune involvement
Neeman, E., & Ben‐Eliyahu, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.006 · Cited by 249
Self-citation
Perioperative blood transfusions and recurrence of colorectal cancer
Amato, A., & Pescatori, M. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005033.pub2 · Cited by 247
Celecoxib Inhibits Vascular Endothelial Growth Factor Expression in and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Sp1 Transcription Factor Activity
Wei, D., Wang, L., He, Y., Xiong, H. Q., Abbruzzese, J. L., & Xie, K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1945 · Cited by 246
Improving Survival Rates in Two Models of Spontaneous Postoperative Metastasis in Mice by Combined Administration of a β-Adrenergic Antagonist and a Cyclooxygenase-2 Inhibitor
Glasner, A., Avraham, R., Rosenne, E., Benish, M., Zmora, O., Shemer, S., Meiboom, H., & Ben‐Eliyahu, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903301 · Cited by 239
Self-citation
Perceived social support and tumor estrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients.
Levy, S. M., Herberman, R. B., Whiteside, T. L., Sanzo, K., Lee, J., & Kirkwood, J. M. (1990) · Psychosomatic Medicine · doi:10.1097/00006842-199001000-00006 · Cited by 235
Enhanced Recovery After Surgery (ERAS) Program Attenuates Stress and Accelerates Recovery in Patients After Radical Resection for Colorectal Cancer: A Prospective Randomized Controlled Trial
Ren, L., Zhu, D.-X., Wei, Y., Pan, X.-O., Liang, L., Xu, J.-M., Zhong, Y.-S., Xue, Z., Jin, L., Zhan, S.-K., et al. (2012) · World Journal of Surgery · doi:10.1007/s00268-011-1348-4 · Cited by 232
In Vivo β-Adrenergic Stimulation Suppresses Natural Killer Activity and Compromises Resistance to Tumor Metastasis in Rats
Shakhar, G., & Ben‐Eliyahu, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3251 · Cited by 231
Self-citation
Association between Epidural Analgesia and Cancer Recurrence after Colorectal Cancer Surgery
Gottschalk, A., Ford, J. G., Regelin, C. C., You, J., Mascha, E. J., Sessler, D. I., Durieux, M. E., & Nemergut, E. C. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181de6d0d · Cited by 224
Supplementation with fish oil increases first‐line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer
Murphy, R. A., Mourtzakis, M., Chu, Q. S.-C., Baracos, V. E., Reiman, T., & Mazurak, V. C. (2011) · Cancer · doi:10.1002/cncr.25933 · Cited by 222
Laparoscopy versus laparotomy for the management of early stage endometrial cancer
Galaal, K. A., Donkers, H., Bryant, A., & Lopes, A. D. B. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006655.pub3 · Cited by 222
Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach
Dimitroulakos, J., Nohynek, D., Backway, K. L., Hedley, D. W., Yeger, H., Freedman, M. H., Minden, M. D., & Penn, L. Z. (1999) · Blood · doi:10.1182/blood.v93.4.1308 · Cited by 218
Suppression of NK Cell Activity and of Resistance to Metastasis by Stress: A Role for Adrenal Catecholamines and β-Adrenoceptors
Ben‐Eliyahu, S., Shakhar, G., Page, G. G., Stefanski, V., & Shakhar, K. (2000) · NeuroImmunoModulation · doi:10.1159/000054276 · Cited by 218
Self-citation
Laparoscopic versus open total mesorectal excision for rectal cancer
Vennix, S., Pelzers, L., Bouvy, N. D., Beets, G. L., Pierie, J.-P., Wiggers, T., & Breukink, S. O. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005200.pub3 · Cited by 218
Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer
Garwood, E. R., Kumar, A. S., Baehner, F. L., Moore, D. H., Au, A., Hylton, N. M., Flowers, C. I., Garber, J. E., Lesnikoski, B., Hwang, E. S., et al. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0507-x · Cited by 215
Surgical Stress Promotes Tumor Growth in Ovarian Carcinoma
Lee, J., Shahzad, M. M. K., Lin, Y. G., Armaiz-Peña, G. N., Mangala, L. S., Han, H., Kim, H., Nam, E. J., Jennings, N. B., Halder, J., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2966 · Cited by 213
Blood Transfusion-Induced Immunomodulation
Landers, D. F., Hill, G. E., Wong, K. C., & Fox, I. J. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199601000-00035 · Cited by 210
β-Blockers and Survival among Danish Patients with Malignant Melanoma: A Population-Based Cohort Study
Lemeshow, S. A., Sørensen, H. T., Phillips, G. S., Yang, E. V., Antonsen, S., Riis, A. H., Lesinski, G. B., Jackson, R., & Glaser, R. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0249 · Cited by 208
The Perioperative Period is an Underutilized Window of Therapeutic Opportunity in Patients With Colorectal Cancer
van der Bij, G. J., Oosterling, S. J., Beelen, R. H. J., Meijer, S., Coffey, J. C., & van Egmond, M. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181a3ddbd · Cited by 207
Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a β-adrenergic antagonist and a prostaglandin synthesis inhibitor
Melamed, R., Rosenne, E., Shakhar, K., Schwartz, Y., Abudarham, N., & Ben‐Eliyahu, S. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.07.004 · Cited by 199
Self-citation
Stimulation of tumour growth by wound-derived growth factors
Abramovitch, R., Marikovsky, M., Meir, G., & Neeman, M. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690223 · Cited by 189
Effects of Fentanyl on Natural Killer Cell Activity and on Resistance to Tumor Metastasis in Rats
Shavit, Y., Ben‐Eliyahu, S., Zeidel, A., & Beilin, B. (2004) · NeuroImmunoModulation · doi:10.1159/000078444 · Cited by 189
Self-citation
ENDOCRINE AND METABOLIC CHANGES DURING SURGERY: ANAESTHETIC IMPLICATIONS
TRAYNOR, C., & Hall, G. M. (1981) · British Journal of Anaesthesia · doi:10.1093/bja/53.2.153 · Cited by 188
Epidural anesthesia and cancer recurrence rates after radical prostatectomy
Tsui, B. C. H., Rashiq, S., Schopflocher, D., Murtha, A. D., Broemling, S., Pillay, J., & Finucane, B. T. (2009) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-009-9214-7 · Cited by 186
Enhanced Recovery After Surgery: The Future of Improving Surgical Care
Varadhan, K. K., Lobo, D. N., & Ljungqvist, O. H. (2010) · Critical Care Clinics · doi:10.1016/j.ccc.2010.04.003 · Cited by 185
MENSTRUAL INFLUENCE ON SURGICAL CURE OF BREAST CANCER
Hrushesky, W. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90956-2 · Cited by 184
Morphine inhibition of lymphocyte activity is mediated by an opioid dependent mechanism
Bayer, B., Daussin, S., Hernandez, M. C., & Irvin, L. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90096-a · Cited by 183
The enhanced recovery after surgery (ERAS) pathway for patients undergoing colorectal surgery: an update of meta-analysis of randomized controlled trials
Lv, L., Shao, Y.-F., & Zhou, Y. (2012) · International Journal of Colorectal Disease · doi:10.1007/s00384-012-1577-5 · Cited by 181
Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis
Lin, L., Liu, C., Tan, H., Ouyang, H., Zhang, Y., & Zeng, W. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer055 · Cited by 179
Perioperative blood transfusions are associated with increased rates of recurrence and decreased survival in patients with high-grade soft-tissue sarcomas of the extremities.
Rosenberg, S. A., Seipp, C. A., White, D. E., & WESLEY, R. A. (1985) · Journal of Clinical Oncology · doi:10.1200/jco.1985.3.5.698 · Cited by 176
Timing of surgery during menstrual cycle and survival of premenopausal women with operable breast cancer
Badwe, R. A., Gregory, W. M., Chaudary, M. A., Richards, M. A., Bentley, A. E., Rubens, R. D., & Fentiman, I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92927-t · Cited by 176
Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development
Hakamada‐Taguchi, R., Uehara, Y., Kuribayashi, K., Numabe, A., Saito, K., Negoro, H., Fujita, T., Toyo‐oka, T., & Kato, T. (2003) · Circulation Research · doi:10.1161/01.res.0000101298.76864.14 · Cited by 173
Immunomodulation by perioperative administration of n-3 fatty acids
Weiss, G., Meyer, F. P., Matthies, B., Pross, M., Köenig, W., & Lippert, H. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2001461 · Cited by 171
Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study.
Wichmann, M. W., Hüttl, T. P., Winter, H., Spelsberg, F., Angele, M. K., Heiss, M. M., & Jauch, K.-W. (2005) · PubMed · doi:10.1001/archsurg.140.7.692 · Cited by 166
Morphine attenuates surgery-induced enhancement of metastatic colonization in rats
Page, G. G., Ben‐Eliyahu, S., Yirmiya, R., & Liebeskind, J. C. (1993) · Pain · doi:10.1016/0304-3959(93)90095-7 · Cited by 165
Self-citation
Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: therapeutic implications.
Dimitroulakos, J., Ye, L. Y., Benzaquen, M., Moore, M. J., Kamel‐Reid, S., Freedman, M. H., Yeger, H., & Penn, L. Z. (2001) · PubMed · Cited by 164
Reduction in mortality after epidural anaesthesia and analgesia in patients undergoing rectal but not colonic cancer surgery: a retrospective analysis of data from 655 patients in Central Sweden
Gupta, A., Björnsson, A., Fredriksson, M., Hallböök, O. J., & Eintrei, C. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer100 · Cited by 162
Beta-adrenergic receptors in human leukocyte subpopulations.
Landmann, R. (1992) · PubMed · Cited by 162
Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery
Forget, P., Machiels, J., Coulie, P. G., Berlière, M., Poncelet, A. J., TOMBAL, B. F., Stainier, A., Legrand, C., Canon, J.-L. R., Kremer, Y., et al. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3136-x · Cited by 161
n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients
Calder, P. C. (2004) · Lipids · doi:10.1007/s11745-004-1342-z · Cited by 160
Reciprocal Interactions Between Human Mesenchymal Stem Cells and γδ T Cells Or Invariant Natural Killer T Cells
Prigione, I., Benvenuto, F., Bocca, P., Battistini, L., Uccelli, A., & Pistoia, V. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0687 · Cited by 157
Ki-67 Staining Is a Strong Predictor of Distant Metastasis and Mortality for Men With Prostate Cancer Treated With Radiotherapy Plus Androgen Deprivation: Radiation Therapy Oncology Group Trial 92–02
Pollack, A. S., DeSilvio, M., Khor, L. Y., Li, R., Al‐Saleem, T., Hammond, M. E., Venkatesan, V., Lawton, C. A., Roach, M., Shipley, W. U., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.150 · Cited by 155
Mind and cancer
Ross, L., Boesen, E. H., Dalton, S. O., & Johansen, C. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00126-0 · Cited by 155
Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms
Wu, W. K. K., Sung, J. J. �., Lee, C. W., Yu, J. Q., & Cho, C. H. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.015 · Cited by 153
Blood Transfusion Promotes Cancer Progression: A Critical Role for Aged Erythrocytes
Atzil, S., Arad, M., Glasner, A., Abiri, N., Avraham, R., Greenfeld, K., Rosenne, E., Beilin, B., & Ben‐Eliyahu, S. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31818ddb72 · Cited by 152
Self-citation
Systemic and Peritoneal Inflammatory Response After Laparoscopic or Conventional Colon Resection in Cancer Patients
Wu, F., Sietses, C., Blomberg, B. M. E. V., van Leeuwen, P. A. M., Meijer, S., & Cuesta, M. A. (2003) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6516-2 · Cited by 149
Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells
Bernabé, D. G., Tamae, A. C., Biasoli, É. R., & Oliveira, S. H. P. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.012 · Cited by 149
Neuroendocrine influences on cancer progression
Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.005 · Cited by 145
Failure of cancer vaccines: the significant limitations of this approach to immunotherapy.
Bödey, B., Bodey, B., Siegel, S. E., & Kaiser, H. E. (2000) · PubMed · Cited by 143
Stress Management Intervention Reduces Serum Cortisol and Increases Relaxation During Treatment for Nonmetastatic Breast Cancer
Phillips, K. M., Antoni, M. H., Lechner, S. C., Blomberg, B. B., Llabre, M. M., Avisar, E., Glück, S., Derhagopian, R. P., & Carver, C. S. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318186fb27 · Cited by 143
Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro
Deegan, C. A., Murray, D. J., Doran, P., Ećimović, P., Moriarty, D. C., & Buggy, D. J. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep261 · Cited by 142
In response to: Varadhan KK, Neal KR, Dejong CH, Fearon KC, Ljungqvist O, Lobo DN. The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials. Clin Nutr 29 (2010) 434–440
Gatt, M., Khan, S., & Macfie, J. M. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.06.005 · Cited by 139
Prognostic impact of the type of anaesthesia used during the excision of primary cutaneous melanoma
Schlagenhauff, B., Ellwanger, U., Breuninger, H., Stroebel, W., Rassner, G., & Garbe, C. (2000) · Melanoma Research · doi:10.1097/00008390-200004000-00009 · Cited by 138
Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial
Wu, F., Hoekman, K., Sietses, C., Blomberg, B. M. E. V., Meijer, S., Bonjer, H. J., & Cuesta, M. A. (2004) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0660-6 · Cited by 136
The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats
Gaspani, L., Bianchi, M., Limiroli, E., Panerai, A. E., & Sacerdote, P. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00165-0 · Cited by 136
Impact of Psychotherapeutic Support for Patients With Gastrointestinal Cancer Undergoing Surgery: 10-Year Survival Results of a Randomized Trial
Küchler, T., Bestmann, B., Rappat, S., Henne‐Bruns, D., & Wood-Dauphinée, S. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.2883 · Cited by 135
Functions of skin-resident γδ T cells
MacLeod, A. S., & Havran, W. L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0702-x · Cited by 132
Laparoscopy versus laparotomy for FIGO stage I ovarian cancer
Falcetta, F. S., Lawrie, T. A., Medeiros, L. R., da Rosa, M. I., Edelweiss, M. I. A., Stein, A. T., Zelmanowicz, A. D. M., de Moraes, A. B., Zanini, R. R., Rosa, D. D., et al. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005344.pub4 · Cited by 129
Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis
Ben‐Eliyahu, S., Page, G. G., Yirmiya, R., & Taylor, A. (1996) · Nature Medicine · doi:10.1038/nm0496-457 · Cited by 128
Self-citation
GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults
Behzad, H., Huckriede, A. L. W., Haynes, L., Gentleman, B., Coyle, K. M., Wilschut, J., Kollmann, T. R., Reed, S. G., & McElhaney, J. E. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir769 · Cited by 128
Nutrition and physical activity influence on breast cancer incidence and outcome
Chlebowski, R. T. (2013) · The Breast · doi:10.1016/j.breast.2013.07.006 · Cited by 127
The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life
Winkels, R. M., Heine-Bröring, R. C., van Zutphen, M., van Harten-Gerritsen, S. A., Kok, D. E. G., van Duijnhoven, F. J., & Kampman, E. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-374 · Cited by 127
Prostaglandin E2 Suppresses NK Activity In Vivo and Promotes Postoperative Tumor Metastasis in Rats
Yakar, I., Melamed, R., Shakhar, G., Shakhar, K., Rosenne, E., Abudarham, N., Page, G. G., & Ben‐Eliyahu, S. (2003) · Annals of Surgical Oncology · doi:10.1245/aso.2003.08.017 · Cited by 124
Self-citation
Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival
Buijs, N., de van der Schueren, M. A. E., Langius, J. A. E., Leemans, C. R., Kuik, D. J., Vermeulen, M. A. R., & van Leeuwen, P. A. M. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29532 · Cited by 124
Statin medication use and the risk of biochemical recurrence after radical prostatectomy
Hamilton, R. J., Bañez, L. L., Aronson, W. J., Terris, M. K., Platz, E. A., Kane, C. J., Presti, J. C., Amling, C. L., & Freedland, S. J. (2010) · Cancer · doi:10.1002/cncr.25308 · Cited by 124
Do Stress Responses Promote Leukemia Progression? An Animal Study Suggesting a Role for Epinephrine and Prostaglandin-E2 through Reduced NK Activity
Inbar, S., Neeman, E., Avraham, R., Benish, M., Rosenne, E., & Ben‐Eliyahu, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019246 · Cited by 121
Self-citation
The Association Between Adiposity and Breast Cancer Recurrence and Survival: A Review of the Recent Literature
Azrad, M., & Demark‐Wahnefried, W. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0068-9 · Cited by 121
Effect of C-reactive protein reduction on paroxysmal atrial fibrillation
Dernellis, J. M., & Panaretou, M. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.06.032 · Cited by 119
A New Approach to Reducing Postsurgical Cancer Recurrence: Perioperative Targeting of Catecholamines and Prostaglandins
Neeman, E., Zmora, O., & Ben‐Eliyahu, S. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1087 · Cited by 113
Self-citation
Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells
Xiao, H., Zhang, Q., Lin, Y. Q., Reddy, B. S., & Yang, C. S. (2008) · International Journal of Cancer · doi:10.1002/ijc.23315 · Cited by 108
Prevention of Azoxymethane-Induced Colon Cancer by Combination of Low Doses of Atorvastatin, Aspirin, and Celecoxib in F 344 Rats
Reddy, B. S., Wang, C. X., Kong, A. T., Khor, T. O., Zheng, X., Steele, V. E., Kopelovich, L., & Rao, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4428 · Cited by 106
HMG–CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P–glycoprotein–expressing cells
Dimitroulakos, J., & Yeger, H. (1996) · Nature Medicine · doi:10.1038/nm0396-326 · Cited by 104
Hypothermia in Barbiturate-anesthetized Rats Suppresses Natural Killer Cell Activity and Compromises Resistance to Tumor Metastasis
Ben‐Eliyahu, S., Shakhar, G., Rosenne, E., Levinson, Y., & Beilin, B. (1999) · Anesthesiology · doi:10.1097/00000542-199909000-00026 · Cited by 102
Self-citation
Social confrontation and tumor metastasis in rats: Defeat and β-adrenergic mechanisms
Stefanski, V., & Ben‐Eliyahu, S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00014-5 · Cited by 100
Self-citation
How to approach major surgery where patients refuse blood transfusion (including Jehovah's Witnesses)
Gohel, M., Bulbulia, R., Slim, F., Poskitt, K. R., & Whyman, M. (2005) · Annals of The Royal College of Surgeons of England · doi:10.1308/1478708051414 · Cited by 99
Immune perturbations in patients along the perioperative period: Alterations in cell surface markers and leukocyte subtypes before and after surgery
Bartal, I. B.-A., Melamed, R., Greenfeld, K., Atzil, S., Glasner, A., Domankevich, V., Naor, R., Beilin, B., Yardeni, I. Z., & Ben‐Eliyahu, S. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.010 · Cited by 97
Self-citation
Combination regimen with statins and NSAIDs: A promising strategy for cancer chemoprevention
Xiao, H., & Yang, C. S. (2008) · International Journal of Cancer · doi:10.1002/ijc.23718 · Cited by 92
Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Vaccination with an Allogeneic Whole-Cell Melanoma Vaccine
Faries, M. B., Hsueh, E. C., Ye, X., Hoban, M., & Morton, D. L. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1540 · Cited by 91
Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: A randomized controlled trial
Berger, M. M., Delodder, F., Liaudet, L., Tozzi, P., Schlaepfer, J., Chiolero, R. L., & Tappy, L. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046573 · Cited by 90
Single-Injection Depot Progesterone Before Surgery and Survival in Women With Operable Breast Cancer: A Randomized Controlled Trial
Badwe, R. A., Hawaldar, R. W., Parmar, V. V., Nadkarni, M. S., Shet, T. M., Desai, S. B., Gupta, S., Jalali, R., Vanmali, V., Dikshit, R. P., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.0738 · Cited by 89
Phase I Clinical Trial of an Adenovirus/Prostate-Specific Antigen Vaccine for Prostate Cancer: Safety and Immunologic Results
Lubaroff, D. M., Konety, B. R., Link, B. K., Gerstbrein, J., Madsen, T., Shannon, M., Howard, J., Paisley, J., Boeglin, D., Ratliff, T. L., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1910 · Cited by 88
The Possible Immunosuppressive Effects of Perioperative Blood Transfusion in Cancer Patients
Biebuyck, J. F., Schriemer, P. A., Longnecker, D. E., & Mintz, P. D. (1988) · Anesthesiology · doi:10.1097/00000542-198803000-00017 · Cited by 87
In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins
Rosenne, E., Sorski, L., Shaashua, L., Neeman, E., Matzner, P., Levi, B. Z., & Ben‐Eliyahu, S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.007 · Cited by 86
Self-citation
The Humoral Response After Laparoscopic Versus Open Colorectal Surgery: A Meta-Analysis
Sammour, T., Kahokehr, A. A., Chan, S. Y. E., Booth, R. J., & Hill, A. G. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.05.046 · Cited by 81
Atorvastatin and Celecoxib Inhibit Prostate PC-3 Tumors in Immunodeficient Mice
Zheng, X., Cui, X., Avila, G. E., Huang, M., Liu, Y., Patel, J. A., Kong, A. N. T., Paulino, R., Shih, W. J., Lin, Y., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0242 · Cited by 79
Immune suppression while awaiting surgery and following it: Dissociations between plasma cytokine levels, their induced production, and NK cell cytotoxicity
Greenfeld, K., Avraham, R., Benish, M., Goldfarb, Y., Rosenne, E., Shapira, Y., Rudich, T., & Ben‐Eliyahu, S. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.006 · Cited by 76
Self-citation
Influence of sex‐steroid hormones on the regulation of lymphocyte beta 2‐adrenoceptors during the menstrual cycle.
Wheeldon, N., Newnham, D., Coutie, W. J., Peters, J., McDevitt, D., & Lipworth, B. (1994) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1994.tb04308.x · Cited by 76
Statins and monocytes
Ikeda, U., & Shimada, K. (1999) · The Lancet · doi:10.1016/s0140-6736(05)77885-5 · Cited by 76
Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients
Decaens, T. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i45.7319 · Cited by 74
Antimetastatic activity of a cyclooxygenase-2 inhibitor
Roche‐Nagle, G., Connolly, E., Eng, M. M. P., Bouchier‐Hayes, D. J., & Harmey, J. H. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601967 · Cited by 70
Correlates of depressed mood in ambulatory head and neck cancer patients
Kugaya, A., Akechi, T., Okamura, H., Mikami, I., & Uchitomi, Y. (1999) · Psycho-Oncology · doi:10.1002/(sici)1099-1611(199911/12)8:6 · Cited by 70
The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer
Uotila, P. J. (1996) · Cancer Immunology Immunotherapy · doi:10.1007/bf03354243 · Cited by 69
Chemoprevention by Pravastatin, a 3‐Hydroxy‐3‐methylglutaryl‐coenzyme A Reductase Inhibitor, of N‐Methyl‐N‐nitrosourea‐induced Colon Carcinogenesis in F344 Rats
Narisawa, T., Morotomi, M., Fukaura, Y., Hasebe, M., Ito, M., & Aizawa, R. (1996) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1996.tb02103.x · Cited by 66
Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo
Dewan, M. Z., Terunuma, H., Takada, M., Tanaka, Y., Abé, H., Sata, T., Toi, M., & Yamamoto, N. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9416-4 · Cited by 64
Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen‐presenting cells
Hegde, S., Fox, L. M., Wang, X., & Gumperz, J. E. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03293.x · Cited by 61
Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis
Afsharimani, B., Doornebal, C. W., Cabot, P. J., Hollmann, M. W., & Parat, M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12589 · Cited by 61
Killer dendritic cells and their potential for cancer immunotherapy
Larmonier, N., Fraszczak, J., Lakomy, D., Bonnotte, B., & Katsanis, E. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0736-1 · Cited by 61
Perioperative Nutrition Support in Cancer Patients
Huhmann, M. B., & August, D. A. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612455203 · Cited by 60
LASERS AND CARIES
BRADLEY, R. D. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90876-1 · Cited by 59
Prospects for targeting PD-1 and PD-L1 in various tumor types.
Kim, J. W., & Eder, J. P. (2014) · PubMed · Cited by 58
Cell-mediated immunity to tumor-associated antigens is a better predictor of survival in early stage breast cancer than stage, grade or lymph node status
McCoy, J. L., Rucker, R., & Petros, J. A. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006405504158 · Cited by 57
A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer.
Sooriakumaran, P., Coley, H. M., Fox, S. B., Macanas-Pirard, P., Lovell, D. P., Henderson, A., Eden, C. G., Miller, P. D., Langley, S. E. M., & Laing, R. W. (2009) · PubMed · Cited by 56
Alteration of murine mammary tumorigenesis by dietary enrichment with n-3 fatty acids in fish oil
Hubbard, N. E., Lim, D., & Erickson, K. L. (1998) · Cancer Letters · doi:10.1016/s0304-3835(97)00427-8 · Cited by 55
The theory and practice of bloodless surgery
Martyn, V., Farmer, S. L., Wren, M. N., Towler, S. C. B., Betta, J., Shander, A., Spence, R. K., & Leahy, M. F. (2002) · Transfusion and Apheresis Science · doi:10.1016/s1473-0502(02)00024-1 · Cited by 54
Prostaglandins and Gangliosides of Tumor Microenvironment: Their Role in Angiogenesis
Gullino, P. M. (1995) · Acta Oncologica · doi:10.3109/02841869509094005 · Cited by 54
Effects of Short-term Celecoxib Treatment in Patients with Invasive Transitional Cell Carcinoma of the Urinary Bladder
Dhawan, D., Craig, B. Α., Liang Cheng, C., Snyder, P. W., Mohammed, S. I., Stewart, J. C., Zheng, R., Loman, R. A., Foster, R. S., & Knapp, D. W. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0049 · Cited by 53
A Preliminary Study on the Postoperative Survival of Patients Given Aspirin After Resection for Squamous Cell Carcinoma of the Esophagus or Adenocarcinoma of the Cardia
Liu, J., Jamieson, G. G., Wu, T.-C., Zhu, G., & Drew, P. A. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0382-z · Cited by 52
Blood Transfusion and Outcome in Stage III Head and Neck Carcinoma
Johnson, J. T., Taylor, F. H., & Thearle, P. B. (1987) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1987.01860030083014 · Cited by 52
β-Adrenergic Receptors in Cancer: Therapeutic Implications
Pérez‐Sayáns, M., Martín, J. M. S., Barros, F., Díz, P., Rey, J. M. G., & Garcı́a, A. G. (2010) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504010x12828372551867 · Cited by 52
Increased susceptibility to metastasis during pro-oestrus/oestrus in rats: possible role of oestradiol and natural killer cells
Ben‐Eliyahu, S., Page, G., Shakhar, G., & Taylor, A. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.651 · Cited by 51
Self-citation
Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma
Matar, P., Rozados, V. R., Binda, M. M., Roggero, E., Bonfil, R. D., & Scharovsky, O. G. (1999) · Clinical & Experimental Metastasis · doi:10.1023/a:1026448026716 · Cited by 49
TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression
Zhao, J., Ni, H., Ma, Y., Li, D., Dai, J., Zhao, F., Yan, X., Lü, B., Xu, H., & Guo, Y. (2006) · Human Pathology · doi:10.1016/j.humpath.2006.08.005 · Cited by 48
How regional analgesia might reduce postoperative cancer recurrence
Cata, J., Gottumukkala, V., & Sessler, D. (2011) · European Journal of Pain Supplements · doi:10.1016/j.eujps.2011.08.017 · Cited by 47
Laparoscopy versus laparotomy for FIGO stage I ovarian cancer
Lawrie, T. A., Medeiros, L. R., Rosa, D. D., da Rosa, M. I., Edelweiss, M. I. A., Stein, A. T., Zelmanowicz, A. D. M., de Moraes, A. B., & Zanini, R. R. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005344.pub3 · Cited by 47
Statins and fibrates for preventing melanoma
Dellavalle, R. P., Drake, A. L., Graber, M., Pointer, L., Johnson, K. R., McNealy, K. M., & Schilling, L. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003697.pub2 · Cited by 46
Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex
Kuramoto, Y., Nishikawa, M., Hyoudou, K., Yamashita, F., & Hashida, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.002 · Cited by 46
Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer
Martin, L., Davies, G., Weigel, M. T., Betambeau, N., Hills, M. J., Salter, J., Walsh, G., A’Hern, R., & Dowsett, M. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1100-z · Cited by 43
Timing of surgery during menstrual cycle and survival of premenopausal women with operable breast cancer
Badwe, R., Gregory, W. M., Chaudary, M., Richards, M., Bentley, A., Rubens, R. D., & Fentiman, I. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90073-r · Cited by 41
Mechanisms and new approaches for the allogeneic blood transfusion-induced immunomodulatory effects
Kao, K.-J. (2000) · Transfusion Medicine Reviews · doi:10.1016/s0887-7963(00)80112-1 · Cited by 39
PROSPECTIVE COMPARISON OF THE IMMUNOLOGICAL AND STRESS RESPONSE FOLLOWING LAPAROSCOPIC AND OPEN SURGERY FOR LOCALIZED RENAL CELL CARCINOMA
Landman, J., Olweny, E. O., Sundaram, C. P., Chen, C. Y.-H., Rehman, J., Lee, D. I., Shalhav, A. L., Portis, A. J., McDougall, E. M., & Clayman, R. V. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000118649.56016.1c · Cited by 39
On the cell biology of pit cells, the liver-specific NK cells
Luo, D. D. (2000) · World Journal of Gastroenterology · doi:10.3748/wjg.v6.i1.1 · Cited by 38
Pitfalls on the roadmap to γδ T cell-based cancer immunotherapies
Martinet, L., Poupot, R., & Fournié, J. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.03.011 · Cited by 38
Increased surgery-induced metastasis and suppressed natural killer cell activity during proestrus/estrus in rats
Page, G. G., & Ben‐Eliyahu, S. (1997) · Breast Cancer Research and Treatment · doi:10.1023/a:1005826403235 · Cited by 37
Self-citation
Timing within the menstrual cycle, sex, and the use of oral contraceptives determine adrenergic suppression of NK cell activity
Shakhar, K., Shakhar, G., Rosenne, E., & Ben‐Eliyahu, S. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1490 · Cited by 37
Self-citation
Cytokine response in the postoperative period after surgical treatment of benign adnexal masses: comparison between laparoscopy and laparotomy
Torres, A., Torres, K., Paszkowski, T., Staśkiewicz, G. J., & Maciejewski, R. (2007) · Surgical Endoscopy · doi:10.1007/s00464-007-9260-6 · Cited by 35
Continuous stress disrupts immunostimulatory effects of IL-12
Levi, B. Z., Benish, M., Goldfarb, Y., Sorski, L., Melamed, R., Rosenne, E., & Ben‐Eliyahu, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.014 · Cited by 35
Self-citation
CpG-C Oligodeoxynucleotides Limit the Deleterious Effects of β-adrenoceptor Stimulation on NK Cytotoxicity and Metastatic Dissemination
Goldfarb, Y., Benish, M., Rosenne, E., Melamed, R., Levi, B. Z., Glasner, A., & Ben‐Eliyahu, S. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31819a2982 · Cited by 35
Self-citation
Synergism between immunostimulation and prevention of surgery-induced immune suppression: An approach to reduce post-operative tumor progression
Avraham, R., Benish, M., Inbar, S., Bartal, I. B.-A., Rosenne, E., & Ben‐Eliyahu, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.03.010 · Cited by 34
Self-citation
Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer
Hu, J. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i12.2690 · Cited by 34
Anxiety and pain suppress the natural killer cell activity in oral surgery outpatients
Koga, C., Itoh, K., Aoki, M., Suefuji, Y., Yoshida, M., Asosina, S., Esaki, K., & Kameyama, T. (2001) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1067/moe.2001.115465 · Cited by 32
Intraperitoneal hypothermia during surgery enhances postoperative tumor growth
Nduka, C. C., Puttick, M., Coates, P., Yong, L., Peck, D. H., & Darzi, A. W. (2001) · Surgical Endoscopy · doi:10.1007/s00464-001-9055-0 · Cited by 31
Peritumoral CpG Oligodeoxynucleotide Treatment Inhibits Tumor Growth and Metastasis of B16F10 Melanoma Cells
Kunikata, N., Sano, K., Honda, M., Ishii, K., Matsunaga, J., Okuyama, R., Takahashi, K., Watanabe, H. K., Tamura, G., Tagami, H., et al. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23233.x · Cited by 30

Research works printed but not linked: 3

Page, G. G., Ben-Eliyahu, S., Yirmiya, R. & Liebeskind, J. C. Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain 54, 21–28 (1993). · DOI
Kurz, A., Sessler, D. I. & Lenhardt, R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N. Engl. J. Med. 334, 1209–1215 (1996). · DOI
Rader, D. J. & Hobbs, H. H. in Harrisons Principles of Internal Medicine 16th edn Ch. 335 (ed. Kasper D. L.) 2286–2319 (McGraw-Hill, 2005).

Sorted by citations

ESPEN guideline: Clinical nutrition in surgery
Weimann, A., Braga, M., Carli, F., Higashiguchi, T., Hübner, M., Kłęk, S., Laviano, A., Ljungqvist, O. H., Lobo, D. N., Martindale, R. G., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.02.013 · Cited by 1,978
Cytotoxic CD8+ T cells in cancer and cancer immunotherapy
Raskov, H., Orhan, A., Christensen, J. P., & Gögenur, I. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01048-4 · Cited by 1,687
ESPEN expert group recommendations for action against cancer-related malnutrition
Arends, J., Baracos, V., Bertz, H., Bozzetti, F., Calder, P. C., Deutz, N. E. P., Erickson, N., Laviano, A., Lisanti, M. P., Lobo, D. N., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.06.017 · Cited by 1,305
Surgery for Cancer: A Trigger for Metastases
Tohme, S. T., Simmons, R. L., & Tsung, A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1536 · Cited by 822
Improving cancer immunotherapy through nanotechnology
Goldberg, M. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0186-9 · Cited by 628

See all 487

Authors: Horowitz, M., Neeman, E., Sharon, E., & Ben-Eliyahu, S.
Affiliations: Tel Aviv University (IL)
Rabin Medical Center (IL)
ORCID: Neeman, Elad
Sharon, Eran
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2015-01-20
Volume: 12
Issue: 4
Pages: 213-226
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/nrclinonc.2014.224
PMC: PMC5497123
OpenAlex: W2078505577
Semantic Scholar: e262754c5c3cffc0898230df898629f73cd9a8d0
Cited by: 487
References: 228
Citations by year: 2026: 36 · 2025: 33 · 2024: 39 · 2023: 48 · 2022: 60 · 2021: 60 · 2020: 55 · 2019: 40 · 2018: 42 · 2017: 38 · 2016: 22 · 2015: 14
FWCI: 5.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA172138)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: perioperative period, metastasis, surgical stress response, catecholamines, prostaglandins, anesthesia, analgesia, hypothermia, blood transfusion, tissue damage, sex hormones, nutritional status, paracrine signaling, neuroendocrine response, residual disease, cancer survival
MeSH terms: Humans, Immune Tolerance, Neoplasm Metastasis, Neoplasms, Nutritional Status, Prognosis, Recurrence, Stress, Physiological, Stress, Psychological, Treatment Outcome, Perioperative Care, Perioperative Period

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exploiting the critical perioperative period to improve long-term cancer outcomes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks