Three short perioperative infusions of n-3 PUFAs reduce systemic inflammation induced by cardiopulmonary bypass surgery: A randomized controlled trial
Open accessAbstract
Background Fish oil (FO) has antiinflammatory effects, which might reduce systemic inflammation induced by a cardiopulmonary bypass (CPB).Objective We tested whether perioperative infusions of FO modify the cell membrane composition, inflammatory responses, and clinical course of patients undergoing elective coronary artery bypass surgery.Design A prospective randomized controlled trial was conducted in cardiac surgery patients who received 3 infusions of 0.2 g/kg FO emulsion or saline (control) 12 and 2 h before and immediately after surgery. Blood samples (7 time points) and an atrial biopsy (during surgery) were obtained to assess the membrane incorporation of PUFAs. Hemodynamic data, catecholamine requirements, and core temperatures were recorded at 10-min intervals; blood triglycerides, nonesterified fatty acids, glucose, lactate, inflammatory cytokines, and carboxyhemoglobin concentrations were measured at selected time points.Results Twenty-eight patients, with a mean ± SD age of 65.5 ± 9.9 y, were enrolled with no baseline differences between groups. Significant increases in platelet EPA (+0.86%; P = 0.0001) and DHA (+0.87%; P = 0.019) were observed after FO consumption compared with at baseline. Atrial tissue EPA concentrations were higher after FO than after control treatments (+0.5%; P < 0.0001). FO did not significantly alter core temperature but decreased the postoperative rise in IL-6 (P = 0.018). Plasma triglycerides increased transiently after each FO infusion. Plasma concentrations of glucose, lactate, and blood carboxyhemoglobin were lower in the FO than in the control group on the day after surgery. Arrhythmia incidence was low with no significant difference between groups. No adverse effect of FO was detected.Conclusions Perioperative FO infusions significantly increased PUFA concentrations in platelet and atrial tissue membranes within 12 h of the first FO administration and decreased biological and clinical signs of inflammation. These results suggest that perioperative FO may be beneficial in elective cardiac surgery with CPB.
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PUFAs may ameliorate the adipose tissue inflammatory responses, with beneficial effects on insulin sensitivity.
“As shown in animal model studies [46,47,48], PUFAs may ameliorate the adipose tissue’s inflammatory responses, with beneficial effects on insulin sensitivity [49].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [49]
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- Authors
- Berger, M. M., Delodder, F., Liaudet, L., Tozzi, P., Schlaepfer, J., Chiolero, R. L., & Tappy, L.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 97
- Issue
- 2
- Pages
- 246-254
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2142103288
- Cited by
- 90
- References
- 41
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 7 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 8 · 2014: 13 · 2013: 3
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Keywords
- fish oil, omega-3 fatty acids, cardiopulmonary bypass, systemic inflammation, coronary artery bypass grafting, eicosapentaenoic acid, docosahexaenoic acid, platelets, atrial tissue, interleukin-6, postoperative arrhythmia, plasma triglycerides, carboxyhemoglobin
- MeSH terms
- Aged, Anti-Inflammatory Agents, Non-Steroidal, Blood Platelets, Cardiopulmonary Bypass, Cell Membrane, Double-Blind Method, Fat Emulsions, Intravenous, Fish Oils, Follow-Up Studies, Heart Atria, Heart Diseases, Hospitals, University, Humans, Infusions, Intravenous, Male, Middle Aged, Cohort Studies, Fatty Acids, Omega-3, Systemic Inflammatory Response Syndrome, Perioperative Care
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