Targeting iron metabolism in drug discovery and delivery
Crielaard, Bart J., Lammers, Twan, Rivella, Stefano·2017·Nature Reviews Drug Discovery
Cites (352)
Items 201–353 of 353
- A Novel Model for Brain Iron Uptake: Introducing the Concept of RegulationIan A. Simpson, Padmavathi Ponnuru, Marianne Klinger, Roland L. Myers, Kavi Devraj, Christopher L. Coe, Gabriele R. Lubach, Anthony Carruthers, James R. Connor · 2014 · Journal of Cerebral Blood Flow & Metabolism
- Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrinWilfred Arthur Jefferies, Michael R. Food, Reinhard Gabathuler, Sylvia Rothenberger, Tatsuo Yamada, Osamu Yasuhara, Patrick L. McGeer · 1996 · Brain Research
- Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163Anders Etzerodt, Maciej Bogdan Maniecki, Jonas Heilskov Graversen, Holger Jon Møller, Vladimir P. Torchilin, Søren K. Moestrup · 2012 · Journal of Controlled Release
- Transferrin Receptor 2 Is Frequently and Highly Expressed in GlioblastomasAlessia Calzolari, Luigi Maria Larocca, Silvia Deaglio, Veronica Finisguerra, Alessandra Boe, Carla Raggi, Lucia Ricci-Vitani, Francesco Pierconti, Fabio Malavasi, Ruggero D. Maria et al. · 2010 · Translational Oncology
- The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of HemeSimon P. Duffy, Jennifer C. Shing, Punit Saraon, Lloyd Berger, Maribeth V. Eiden, Andrew Wilde, Chetankumar S. Tailor · 2010 · Molecular and Cellular Biology
- Regulated secretion of glycosylated human ferritin from hepatocytesSharmistha Ghosh, Sarah Hevi, Steven L. Chuck · 2003 · Blood
- Disordered hepcidin–ferroportin signaling promotes breast cancer growthShuping Zhang, Yue Chen, Wenli Guo, Lin Yuan, Daoqiang Zhang, Yong Xu, Elizabeta Nemeth, Tomas Ganz, Sijin Liu · 2014 · Cellular Signalling
- Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s diseasePey, Peixuan, Pearce, Ronald KB, Kalaitzakis, Michail E, Griffin, W Sue T, Gentleman, Steve M · 2014 · Acta Neuropathologica Communications
- Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicityYunyi Kang, Stefano Tiziani, Goonho Park, Marcus Kaul, Giovanni Paternostro · 2014 · Nature Communications
- Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brainsZhiren Zhang, Zhiyuan Zhang, Jens Schittenhelm, Yuzhang Wu, Richard Meyermann, Hermann J. Schluesener · 2011 · Journal of Neuroimmunology
- Regulation of TMPRSS6 by BMP6 and iron in human cells and miceDelphine Meynard, Valentina Vaja, Chia Chi Sun, Elena Corradini, Shanzhuo Chen, Carlos López-Otı́n, Lovorka Grgurević, Charles C. Hong, Marit Stirnberg, Michael Gütschow et al. · 2011 · Blood
- -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapiesStefano Rivella · 2015 · Haematologica
- Iron activates NF-κB in Kupffer cellsShe, Hongyun, Xiong, Shigang, Lin, Min, Zandi, Ebrahim, Giulivi, Cecilia, Tsukamoto, Hidekazu · 2002 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportinTaniguchi, Reiya, Kato, Hideaki E., Font, Josep, Deshpande, Chandrika N., Wada, Miki, Ito, Koichi, Ishitani, Ryuichiro, Jormakka, Mika, Nureki, Osamu · 2015 · Nature Communications
- Macular Degeneration in a Patient with Aceruloplasminemia, a Disease Associated with Retinal Iron OverloadJoshua L. Dunaief, Carine Ghassan Richa, Edward P. Franks, Robert L. Schultze, Tomás S. Alemán, John F. Schenck, Earl A. Zimmerman, D BROOKS · 2005 · Ophthalmology
- Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequencesXinsheng Wang, Sang Yong Lee, Zachary Simmons, Philip J. Boyer, Kevin R. Scott, Wenlei Liu, James R. Connor · 2004 · Journal of the Neurological Sciences
- Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brainsStanley W. Hulet, S K Powers, James R. Connor · 1999 · Journal of the Neurological Sciences
- Targeted tumor delivery and controlled release of neuronal drugs with ferritin nanoparticles to regulate pancreatic cancer progressionYifeng Lei, Yoh Hamada, Jun Li, Liman Cong, Nuoxin Wang, Ying Li, Wenfu Zheng, Xingyu Jiang · 2016 · Journal of Controlled Release
- A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primatesCooke, Keegan S., Hinkle, Beth, Salimi-Moosavi, Hossein, Foltz, Ian, King, Chadwick, Rathanaswami, Palaniswami, Winters, Aaron, Steavenson, Shirley, Begley, C. Glenn, Molineux, Graham et al. · 2013 · Blood
- Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male MiceCanali, Susanna, Core, Amanda B., Zumbrennen-Bullough, Kimberly B., Merkulova, Maria, Wang, Chia-Yu, Schneyer, Alan L., Pietrangelo, Antonello, Babitt, Jodie L. · 2016 · Endocrinology
- Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic proteinHealey, Eleanor G, Bishop, Benjamin, Elegheert, Jonathan, Bell, Christian H, Padilla-Parra, Sergi, Siebold, Christian · 2015 · Nature Structural & Molecular Biology
- Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generationSeung Min Jeong, Sunsook Hwang, Rho Hyun Seong · 2016 · Biochemical and Biophysical Research Communications
- Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humansvan Eijk, Lucas T., John, Aaron S. E., Schwoebel, Frank, Summo, Luciana, Vauléon, Stéphanie, Zöllner, Stefan, Laarakkers, Coby M., Kox, Matthijs, van der Hoeven, Johannes G., Swinkels, Dorine W. et al. · 2014 · Blood
- Molecular mechanisms of non‐transferrin‐bound and transferring‐bound iron uptake in primary hippocampal neuronsChangyi Ji, Daniel J. Kosman · 2015 · Journal of Neurochemistry
- Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome.J E Nielsen, L N Jensen, K. S. Krabbe · 1995 · Journal of Neurology Neurosurgery & Psychiatry
- Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortusGardenghi, Sara, Renaud, Tom M., Meloni, Alessandra, Casu, Carla, Crielaard, Bart J., Bystrom, Laura M., Greenberg-Kushnir, Noa, Sasu, Barbra J., Cooke, Keegan S., Rivella, Stefano · 2014 · Blood
- Iron and Neurodegeneration: Is Ferritinophagy the Link?Giorgio Biasiotto, Diego Di Lorenzo, Silvana Archetti, Isabella Zanella · 2015 · Molecular Neurobiology
- Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacyHuijuan Zhang, Lin Hou, Yandan Ji, Yandan Ji, Xiali Zhu, Zhenzhong Zhang · 2014 · Biomaterials
- Probing the substrate specificities of matriptase, matriptase‐2, hepsin and DESC1 with internally quenched fluorescent peptidesFrançois Béliveau, Antoine Désilets, Richard Leduc · 2009 · FEBS Journal
- Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism.M. Dekker, P. C. Giesbergen, O. Njajou, J. V. van Swieten, A. Hofman, M. Breteler, C. M. van Duijn · 2003 · Neuroscience Letters
- A novel gene expression signature for bone metastasis in breast carcinomasCemile Dilara Savci-Heijink, Hans Halfwerk, Jan Köster, Marc J. van de Vijver · 2016 · Breast Cancer Research and Treatment
- Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrierRyan C. McCarthy, Daniel J. Kosman · 2015 · Frontiers in Molecular Neuroscience
- Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyriaTroadec, Marie-Berengere, Warner, David, Wallace, Jared, Thomas, Kirk, Spangrude, Gerald J., Phillips, John, Khalimonchuk, Oleh, Paw, Barry H., Ward, Diane McVey, Kaplan, Jerry · 2011 · Blood
- Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in miceNai, Antonella, Rubio, Aude, Campanella, Alessandro, Gourbeyre, Ophélie, Artuso, Irene, Bordini, Jessica, Gineste, Aurélie, Latour, Chloé, Besson-Fournier, Céline, Lin, Herbert Y. et al. · 2016 · Blood
- Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite DirectionsMarie Lundholm, Christina Hägglöf, Maria L. Wikberg, Pär E. Stattin, Lars Egevad, Anders R. J. Bergh, Pernilla Wikström, Richard Palmqvist, Sofia Edin · 2015 · Scientific Reports
- Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6‐OHDA‐lesioned ratsJun Wang, Hong Fu Jiang, Junxia Xie · 2007 · European Journal of Neuroscience
- Prion Protein Regulates Iron Transport by Functioning as a FerrireductaseAjay Singh, Swati Haldar, Katharine Horback, Cynthia M. Tom, Lan Zhou, Howard J. Meyerson, Neena Singh · 2013 · Journal of Alzheimer s Disease
- Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in HumansRaêd Daher, Caroline Kannengiesser, Dounia Houamel, Thibaud Lefèbvre, Edouard Bardou‐Jacquet, Nicolas Ducrot, Caroline de Kerguenec, Anne‐Marie Jouanolle, Anne-Marie Robréau, Claire Oudin et al. · 2015 · Gastroenterology
- Abnormal Brain Iron Homeostasis in Human and Animal Prion DisordersAjay Vikram Singh, Alfred Orina Isaac, Xiu Luo, Maradumane L. Mohan, Mark L. Cohen, Fusong Chen, Qingzhong Kong, Jason C. Bartz, Neena Singh · 2009 · PLoS Pathogens
- Liver X Receptor Activation Stimulates Iron Export in Human Alternative MacrophagesGael F. P. Bories, Sophie Colin, Jonathan Vanhoutte, Bruno Derudas, Corinne Copin, Mélanie Fanchon, Mehdi Daoudi, Loïc Belloy, Stéphan Haulon, Christophe Zawadzki et al. · 2013 · Circulation Research
- Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expressionDeborah Trinder · 1996 · Hepatology
- Local iron homeostasis in the breast ductal carcinoma microenvironmentMarques, Oriana, Porto, Graça, Rêma, Alexandra, Faria, Fátima, Cruz Paula, Arnaud, Gomez-Lazaro, Maria, Silva, Paula, Martins da Silva, Berta, Lopes, Carlos · 2016 · BMC Cancer
- Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2Thomas H. Scheuermann, Daniel Stroud, Christopher E. Sleet, Liela Bayeh, Cameron Shokri, Hanzhi Wang, Charles G. Caldwell, Jamie C. Longgood, John B. MacMillan, Richard K. Bruick et al. · 2015 · Journal of Medicinal Chemistry
- ‘Ride on the ferrous wheel’ – The cycle of iron in macrophages in health and diseaseNairz, Manfred, Schroll, Andrea, Demetz, Egon, Tancevski, Ivan, Theurl, Igor, Weiss, Günter · 2015 · Immunobiology
- Cancer cells with irons in the fireLaura M. Bystrom, Stefano Rivella · 2014 · Free Radical Biology and Medicine
- Beyond hereditary hemochromatosis: New insights into the relationship between iron overload and chronic liver diseasesSilvia Rossana Fargion, Luca V. C. Valenti, Anna Ludovica Fracanzani · 2010 · Digestive and Liver Disease
- Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's diseaseRaj N. Kalaria, Susan M. Sromek, I. Grahovac, Sami I. Harik · 1992 · Brain Research
- Ferritin, transferrin and iron concentrations in the cerebrospinal fluid of multiple sclerosis patientsSteven M. LeVine, SHARON G. LYNCH, Ching‐Nan Ou, Michael J Wulser, Estella Tam, Nicole Boo · 1999 · Brain Research
- Transferrin Receptor–Independent Uptake of Differic Transferrin by Human Hepatoma Cells With Antisense Inhibition of Receptor ExpressionDeborah Trinder, Olga Zak, P Aisen · 1996 · Hepatology
- Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cellsSimonetta Geninatti Crich, Marta Cadenazzi, Stefania Lanzardo, Laura Conti, Roberto Ruiu, Diego Alberti, Federica Cavallo, Juan Carlos Cutrìn, Silvio Aime · 2015 · Nanoscale
- Hepcidin Destabilizes Atherosclerotic Plaque Via Overactivating Macrophages After ErythrophagocytosisJing Jing Li, Xiao Meng, Hai Sen Peng, Cheng Zhang, Hui Xia Lv, Yu Xia Zhao, Jian Min Yang, Mei Dong, Kai Zhang, Su Xia Liu et al. · 2012 · Arteriosclerosis Thrombosis and Vascular Biology
- Autosomal dominant iron overload due to a novel mutation of ferroportin1 associated with parenchymal iron loading and cirrhosisWallace, Daniel F., Clark, Roslyn M., Harley, Hugh A.J., Subramaniam, V.Nathan · 2004 · Journal of Hepatology
- Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductasesJuan Daniel Hernández Vargas, Bram Herpers, Andrew Tristan McKie, Sarah Gledhill, James M. McDonnell, M. van den Heuvel, K E Davies, Chris Paul Ponting · 2003 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Small-Molecule Screening Identifies the Selanazal Drug Ebselen as a Potent Inhibitor of DMT1-Mediated Iron UptakeHerbert A. Wetli, Peter D. Buckett, Marianne Wessling‐Resnick · 2006 · Chemistry & Biology
- Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulationJuan Guillermo Zarruk, Jennifer L. Berard, Rosmarini Passos dos Santos, Antje Kroner, Jaekwon Lee, Paolo Arosio, Samuel David · 2015 · Neurobiology of Disease
- Prion protein functions as a ferrireductase partner for ZIP14 and DMT1Ajai K. Tripathi, Swati Haldar, Juan Qian, Amber Beserra, Srinivas Suda, Ajay Vikram Singh, Ulrich Hopfer, Shu G. Chen, Michael D. Garrick, Jerrold R. Turner et al. · 2015 · Free Radical Biology and Medicine
- Safety, pharmacokinetics and pharmacodynamics of the anti‐hepcidin Spiegelmer lexaptepid pegol in healthy subjectsMalcolm J. Boyce, Steve Warrington, B Cortezi, Stefan K. Zöllner, Stephanie Vauléon, Dorine W. Swinkels, Luciana Summo, Frank Schwoebel, Kai Riecke · 2016 · British Journal of Pharmacology
- Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermediaCarla Casu, Mariam Aghajan, Paraskevi Rea Oikonomidou, Shuling Guo, Brett P. Monia, Stefano Rivella · 2015 · Haematologica
- High-throughput screening of small molecules identifies hepcidin antagonistsFung, Eileen, Sugianto, Priscilla, Hsu, Jason, Damoiseaux, Robert, Ganz, Tomas, Nemeth, Elizabeta · 2013 · Molecular Pharmacology
- Iron Chelation in Thalassemia MajorCaterina Borgna‐Pignatti, Maria Marsella · 2015 · Clinical Therapeutics
- Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?Marco Rausa, Alessia Pagani, Antonella Nai, Alessandro Campanella, Maria Enrica Gilberti, Pietro Apostoli, Clara Camaschella, Laura Silvestri · 2015 · PLoS ONE
- The small molecule, genistein, increases hepcidin expression in human hepatocytesZhen, Aileen W., Nguyen, Nancy H., Gibert, Yann, Motola, Shmulik, Buckett, Peter, Wessling-Resnick, Marianne, Fraenkel, Ernest, Fraenkel, Paula G. · 2013 · Hepatology
- Hepcidin and ferritin blood level as noninvasive tools for predicting breast cancerOrlandi, R., De Bortoli, M., Ciniselli, C.M., Vaghi, E., Caccia, D., Garrisi, V., Pizzamiglio, S., Veneroni, S., Bonini, C., Agresti, R. et al. · 2014 · Annals of Oncology
- Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivoMaura Poli, Michela Asperti, Annamaria Naggi, Natascia Campostrini, Domenico Girelli, Michela Corbella, Marina Benzi, Céline Besson‐Fournier, Hélène Coppin, Federica Maccarinelli et al. · 2014 · Blood
- Decreased Plasma Iron in Alzheimer’s Disease Is Due to Transferrin DesaturationDominic James Hare, James D. Doecke, Noel Garry Faux, Alan Rembach, Irene Volitakis, Christopher James Fowler, Rudolf Grimm, Philip Doble, Robert A. Cherny, Colin Louis Masters et al. · 2015 · ACS Chemical Neuroscience
- Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen in advanced neuroblastoma: Preliminary resultsAlberto Donfrancesco, Bruno De Bernardi, Modesto Carli, A. Mancini, M. A. Nigro, Luigi De Sio, Fiorina Casale, Serenella Bagnulo, Lawrence Helson, G Deb · 1995 · European Journal of Cancer
- Subcellular Localization of Iron and Heme Metabolism Related Proteins at Early Stages of ErythrophagocytosisConstance Delaby, Christiane Rondeau, Cécile Pouzet, Alexandra Willemetz, Nathalie Pilard, Michel Desjardins, François Canonne‐Hergaux · 2012 · PLoS ONE
- Overexpression of Transferrin Receptor and Ferritin Related to Clinical Symptoms and Destabilization of Human Carotid PlaquesLi, Wei, Xu, Li-Hua, Forssell, Claes, Sullivan, Jerome L., Yuan, Xi-Ming · 2008 · Experimental Biology and Medicine
- Dose‐Dependent Therapeutic Distinction between Active and Passive Targeting Revealed Using Transferrin‐Coated PGMA NanoparticlesRuhani Singh, Marck Nörret, Michael J. House, Yuriy Galabura, Michael Bradshaw, Diwei Ho, Robert C. Woodward, Timothy G. St. Pierre, Igor A. Luzinov, Nicole M. Smith et al. · 2015 · Small
- Identification of the First Low-Molecular-Weight Inhibitors of Matriptase-2Mihiret T. Sisay, Torsten Steinmetzer, Marit Stirnberg, Eva Maurer, Maya Hammami, Jürgen Bajorath, Michael Gütschow · 2010 · Journal of Medicinal Chemistry
- Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelinChloé Latour, Céline Besson‐Fournier, Delphine Meynard, Laura Silvestri, Ophélie Gourbeyre, Patricia Aguilar‐Martinez, Paul Joseph Schmidt, Mark D. Fleming, Marie‐Paule Roth, Hélène Coppin · 2015 · Hepatology
- Structure of the Repulsive Guidance Molecule (RGM)–Neogenin Signaling HubBell, Christian H., Healey, Eleanor, van Erp, Susan, Bishop, Benjamin, Tang, Chenxiang, Gilbert, Robert J.C., Aricescu, A. Radu, Pasterkamp, R. Jeroen, Siebold, Christian · 2013 · Science
- Iron-sulfur proteins hiding in plain sightTracey Ann Rouault · 2015 · Nature Chemical Biology
- Divalent metal transporter 1 is a hypoxia‐inducible geneZhong‐Ming Qian, Xiao Mei Wu, Ming Fan, Lin Yang, Fang Du, Wing‐Ho Yung, Ya Ke · 2010 · Journal of Cellular Physiology
- Expression and cellular localization of hepcidin mRNA and protein in normal rat brainRuma Raha‐Chowdhury, Animesh Alexander Raha, Serhiy Forostyak, Jingwei Zhao, Simon Stott, Adrian B. Bomford · 2015 · BMC Neuroscience
- Structure-Function Analysis of the Human Ferroportin Iron Exporter (SLC40A1): Effect of Hemochromatosis Type 4 Disease Mutations and Identification of Critical ResiduesGérald Le Gac, Chandran Ka, Rozenn Joubrel, Isabelle Gourlaouen, Pierre Lehn, Jean‐Paul Mornon, Claude Férec, Isabelle Callebaut · 2013 · Human Mutation
- Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence inβ-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical TrialJohn B. Porter, Donald K. Bowden, Marina P. Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicholas G. Martin, Adam Gater, Diana Rofail, Linda Abetz‐Webb et al. · 2012 · Anemia
- Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's DiseaseSubramanian Rajagopalan, Anand Rane, Shankar J. Chinta, Julie Kay Andersen · 2016 · Journal of Neuroscience
- Ferritin Is Independently Associated With the Presence of Coronary Artery Calcium in 12 033 MenKi‐Chul Sung, Seok‐Min Kang, Eun-Joo Cho, Jeong Bae Park, Sarah H. Wild, Christopher D. Byrne · 2012 · Arteriosclerosis Thrombosis and Vascular Biology
- Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions3Jeehyea Choi, Patarabutr Masaratana, Gladys Oluyemisi Latunde-Dada, Matthew J Arno, Robert James Simpson, Andrew Tristan McKie · 2012 · Journal of Nutrition
- Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's diseaseXianhui Dong, Weijuan Gao, Tie-mei Shao, Xie Hong-lin, Bai Jiang-tao, Zhao Jing-yi, Chai Xi-qing · 2014 · Journal of Trace Elements in Medicine and Biology
- Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egressY Chen, Z Zhang, Kuo Yang, Jin Du, Yong Xu, Sijin Liu · 2014 · Oncogene
- A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 geneBernard Grandchamp, Gilles Hetet, Caroline Kannengiesser, Claire Oudin, Carole Beaumont, Sylvie Rodrigues-Ferreira, Robert B. Amson, Adam Telerman, Peter Nielsen, ELISABETH KOHNE et al. · 2011 · Blood
- Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 formFatih, Nadia, Camberlein, Emilie, Island, Marie Laure, Corlu, Anne, Abgueguen, Emmanuelle, Détivaud, Lénaïck, Leroyer, Patricia, Brissot, Pierre, Loréal, Olivier · 2010 · Journal of Molecular Medicine
- Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stressAntónio Brito Camacho, Márcio Simão, Hang‐Korng Ea, Martine Esther Cohen-Solal, Pascal Richette, Jaime Branco, M. Leonor Cancela · 2015 · Osteoarthritis and Cartilage
- AceruloplasminemiaSatoshi Kono · 2012 · Current Drug Targets
- Testing the Iron Hypothesis in a Mouse Model of AtherosclerosisLéon Kautz, Victoria R. Gabayan, Xuping Wang, Judy Wu, James Onwuzurike, Grace Jung, Bo Qiao, Aldons Jake Lusis, Tomas Ganz, Elizabeta Nemeth · 2013 · Cell Reports
- Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesisM. A. Rey, Simon P. Duffy, J. K. Brown, J. A. Kennedy, John Edgar Dick, Yigal Dror, C S Tailor · 2008 · Haematologica
- Association of K832R and R952K SNPs of Wilson's Disease Gene with Alzheimer's DiseaseSerena Bucossi, Renato A Polimanti, Stefania Mariani, Mariacarla Ventriglia, Cristian Bonvicini, Simone Migliore, Dario Manfellotto, Carlo Salustri, Fabrizio Vernieri, Paolo Maria Rossini et al. · 2012 · Journal of Alzheimer s Disease
- Iron Deficiency in Parkinsonism: Region-Specific Iron Dysregulation in Parkinson's Disease and Multiple System AtrophyNaomi P. Visanji, Joanna F. Collingwood, Mary E. Finnegan, Anurag Tandon, Emily R. House, Lili‐Naz Hazrati · 2013 · Journal of Parkinson s Disease
- The Small-Molecule Iron Transport Inhibitor Ferristatin/NSC306711 Promotes Degradation of the Transferrin ReceptorLior Horonchik, Marianne Wessling‐Resnick · 2008 · Chemistry & Biology
- Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble formAlessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, C. Lacombe, Patrick Mayeux, Frédèrique Verdier, Clara Camaschella, Laura Silvestri · 2015 · Haematologica
- Disordered signaling governing ferroportin transcription favors breast cancer growthYue Chen, Shuping Zhang, Xiaoyan Wang, Wenli Guo, Lei Wang, Daoqiang Zhang, Lin Yuan, Zhihong Zhang, Yong Xu, Sijin Liu · 2014 · Cellular Signalling
- Distribution of 125I‐Ferrotransferrin Binding Sites in the Mesencephalon of Control Subjects and Patients with Parkinson's DiseaseBaptiste A. Faucheux, Étienne C. Hirsch, João Villares, Fekrije Selimi, Annick Prigent, France Javoy-Agid, Jean‐Jacques Hauw, Yves Agid · 1993 · Journal of Neurochemistry
- Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In VivoShaina L. Byrne, Peter D. Buckett, Jonghan Kim, Flora Luo, Jack C. Sanford, Juxing Chen, Caroline A. Enns, Marianne Wessling‐Resnick · 2013 · PLoS ONE
- Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomesAnita C. G. Chua, Matthew William Knuiman, Debbie Trinder, Mark Divitini, John Kevin Olynyk · 2016 · American Journal of Clinical Nutrition
- Transferrin receptors in the Parkinsonian midbrainChristopher M. Morris, Jeff Candy, S. Omar, C A Bloxham, J.A. Edwardson · 1994 · Neuropathology and Applied Neurobiology
- Molecular characterization of a third case of human atransferrinemiaAlexander S. Knisely, Terri Gelbart, Ernest Beutler · 2004 · Blood
- Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic β-cellsDavid M. Hudson, Susan B. Curtis, Valerie C. Smith, Tanya A. M. Griffiths, Ann Y.K. Wong, Charles H. Scudamore, Alison M. J. Buchan, Ross T. A. MacGillivray · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Serum Hepcidin Is Associated With Presence of Plaque in Postmenopausal Women of a General PopulationTessel E. Galesloot, Suzanne Holewijn, Lambertus A.L.M. Kiemeney, Jacqueline d Graaf, Sita H. H. M. Vermeulen, Dorine W. Swinkels · 2013 · Arteriosclerosis Thrombosis and Vascular Biology
- Prion Protein and Metal Interaction: Physiological and Pathological ImplicationsNeena Singh, Dola Das, Ajay Vikram Singh, Maradumane L. Mohan · 2010 · Caister Academic Press eBooks
- Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation‐induced anaemia in ratsTerrance D. Barrett, Heather L. Palomino, Theresa I. Brondstetter, Kimon C. Kanelakis, Xiaodong Wu, Wen Yan, Katherine P Merton, Freddy Schoetens, Ying Jing, Judy Skaptason et al. · 2015 · British Journal of Pharmacology
- Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in miceQi Feng, Mary C. Migas, Abdül Waheed, Robert S. Britton, Robert E. Fleming · 2012 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndromeCozzi, Anna, Santambrogio, Paolo, Privitera, Daniela, Broccoli, Vania, Rotundo, Luisa Ida, Garavaglia, Barbara, Benz, Rudolf, Altamura, Sandro, Goede, Jeroen S., Muckenthaler, Martina U. et al. · 2013 · Journal of Experimental Medicine
- Macrophages and liposomes in inflammatory disease: Friends or foes?Bart J. Crielaard, Twan Lammers, Mary E. Morgan, Linda Chaabane, Susanna Carboni, Beatrice Maria Greco, Paola Zaratin, Aletta D. Kraneveld, Gert Storm · 2011 · International Journal of Pharmaceutics
- Transmembrane Topology of the Mammalian Slc11a2 Iron TransporterMaciej Czachorowski, Steven Lam-Yuk-Tseung, Mathieu F. Cellier, Philippe Gros · 2009 · Biochemistry
- Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1)Jay A. Cadieux, Zaihui Zhang, Maryanne Mattice, Alison Brownlie, Jianmin Fu, Laszlo G. Ratkay, Rainbow Kwan, Jay Thompson, Joseph Sanghara, Jing Zhong et al. · 2011 · Bioorganic & Medicinal Chemistry Letters
- A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damageBaraibar, Martin A., Barbeito, Ana G., Muhoberac, Barry B., Vidal, Ruben · 2012 · Free Radical Biology and Medicine
- Carotid intima‐media thickness is increased and related to arterial stiffening in patients with beta‐thalassaemia majorYiu‐fai Cheung, PC Chow, Gcf Chan, Sy Ha · 2006 · British Journal of Haematology
- Do Hemochromatosis Mutations Protect Against Iron-Mediated Atherogenesis?Jerome L. Sullivan · 2009 · Circulation Cardiovascular Genetics
- Human STEAP3 maintains tumor growth under hypoferric conditionTaichi Isobe, Eishi Baba, Shuji Arita, Masato Komoda, Shingo Tamura, Tsuyoshi Shirakawa, Hiroshi Ariyama, Shigeo Takaishi, Hitoshi Kusaba, Takashi Ueki et al. · 2011 · Experimental Cell Research
- A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body IronGladys Oluyemisi Latunde-Dada, Dora I. A. Pereira, Bethan Tempest, Hibah Ilyas, Angela C. Flynn, Mohamad F. Aslam, Robert James Simpson, Jonathan J. Powell · 2014 · Journal of Nutrition
- Associations of Serum Ferritin and Transferrin % Saturation With All-cause, Cancer, and Cardiovascular Disease Mortality: Third National Health and Nutrition Examination Survey Follow-up StudyKi-Su Kim, Hye-Gyeong Son, Nam-Soo Hong, Duk‐Hee Lee · 2012 · Journal of Preventive Medicine and Public Health
- Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2Nicolás Montalbetti, Alexandre Simonin, Céline Simonin, Mahendra Awale, Jean‐Louis Reymond, Matthias A. Hediger · 2015 · Biochemical Pharmacology
- Recombinant Expression and Functional Characterization of Human Hephaestin: A Multicopper Oxidase with Ferroxidase ActivityTanya A. M. Griffiths, A. Grant Mauk, Ross T. A. MacGillivray · 2005 · Biochemistry
- Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for AtherosclerosisLeanne Satchell, David S. Leake · 2012 · Biochemistry
- Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitorsZaihui Zhang, Kodumuru Vishnumurthy, Serguei Sviridov, Shifeng Liu, Mikhail Ayratovich Chafeev, Sultan Chowdhury, Nagasree Chakka, Jianyu Sun, Simon J. Gauthier, Maryanne Mattice et al. · 2012 · Bioorganic & Medicinal Chemistry Letters
- Premature Atherosclerosis in Children With β-Thalassemia MajorOrhan Gürsel, Ahmet Emin Kürekçi, Emre Taşçılar, Talia İleri, Demet Altun, Serkan Tapan, İsmail Kurt, Murat Kocaoğlu, Ahmet Aydın, Vedat Okutan et al. · 2012 · Journal of Pediatric Hematology/Oncology
- Ebselen Decreases Oxygen Free Radical Production and Iron Concentrations in the Hearts of Chronically Iron-Overloaded MiceMatthew T. Davis, Wally J. Bartfay · 2004 · Biological Research For Nursing
- Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the LiverNingning Zhao, Julia E. Maxson, Richard H. Zhang, Mastura Wahedi, Caroline A. Enns, An‐Sheng Zhang · 2016 · Journal of Biological Chemistry
- Transforming Growth Factor β1 (TGF-β1) Activates Hepcidin mRNA Expression in HepatocytesSimeng Chen, Teng Feng, Maja Vujić Spasić, Sandro Altamura, Katja Breitkopf‐Heinlein, Jutta Altenöder, Thomas S. Weiß, Steven Dooley, Martina Ulrike Muckenthaler · 2016 · Journal of Biological Chemistry
- Heme Exporter FLVCR Is Required for T Cell Development and Peripheral SurvivalMary Philip, Scott A. Funkhouser, Edison Y. Chiu, Susan R. Phelps, Jeffrey J. Delrow, James Eric Cox, Pamela J. Fink, Janis L. Abkowitz · 2015 · The Journal of Immunology
- Abnormalities in Iron Metabolism in Multiple SclerosisLESLIE S. VALBERG, Peter R. Flanagan, Ann E. Kertesz, George C. Ebers · 1989 · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- AG490: An inhibitor of hepcidin expression<i>in vivo</i>Zhang, Shu-Ping · 2011 · World Journal of Gastroenterology
- A reappraisal of macrophage polarization in glioblastoma: Histopathological and immunohistochemical findings and review of the literatureChiara Mignogna, Francesco Signorelli, Marco Flavio Michele Vismara, Pio Zeppa, Caterina Camastra, Tullio Barni, Giuseppe Donato, Anna Di Vito · 2016 · Pathology - Research and Practice
- Desferrioxamine in chronic progressive Multiple Sclerosis: a pilot studySHARON G. LYNCH, Kathy Peters, Steven M. LeVine · 1996 · Multiple Sclerosis Journal
- Dietary Iron and Colorectal Cancer Risk: A Review of Human Population StudiesJoseph H. Ashmore, Connie Jo Rogers, Shannon L. Kelleher, Samuel M. Lesko, Terryl J. Hartman · 2015 · Critical Reviews in Food Science and Nutrition
- Small molecule inhibitors of divalent metal transporter-1Peter D. Buckett, Marianne Wessling‐Resnick · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Arthropathy in juvenile hemochromatosisGeorge Vaiopoulos, George V. Papanikolaou, Marianna Politou, Iyad Jibreel, Nikos Sakellaropoulos, Dimitris Loukopoulos · 2003 · Arthritis & Rheumatism
- Apolipoprotein E −/− Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage FunctionNiyati U. Mehta, Victor R. Grijalva, Susan Y. Hama, Alan C. Wagner, Mohamad Navab, Alan M. Fogelman, Srinivasa T. Reddy · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
- LY2928057, An Antibody Targeting Ferroportin, Is a Potent Inhibitor Of Hepcidin Activity and Increases Iron Mobilization In Normal Cynomolgus MonkeysWitcher, Derrick R, Leung, Donmienne, Hill, Karen A, De Rosa, David C, Xu, Jianghuai, Manetta, Joseph, Wroblewski, Victor J, Benschop, Robert J · 2013 · Blood
- Genetic upregulation of matriptase‐2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisationAndrew James Sanders, Christian Parr, Tracey Amanda Martin, Jane Lane, Malcolm David Mason, Wen G. Jiang · 2008 · Journal of Cellular Physiology
- Characterization of the ferritin receptors of human T lymphoid (MOLT-4) cells.Dennis Moss, Lawrie W. Powell, Paolo Arosio, June W. Halliday · 1992 · PubMed
- Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of AnemiaMukul Rameshchandra Jain, Amit Arvind Joharapurkar, Vrajesh B. Pandya, VISHAL G. PATEL, J. Joshi, Samadhan Govind Kshirsagar, K. Patel, P. Patel, R. Desai · 2015 · Drug Research
- Targeting the Hepcidin Pathway with RNAi Therapeutics for the Treatment of AnemiaAkin Akinc, Amy Chan-Daniels, Alfica Sehgal, Don Foster, Brian R. Bettencourt, Julia L. Hettinger, Tim Racie, Justin Aubin, Satya Kuchimanchi, Hila Epstein-Barash et al. · 2011 · Blood
- Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutationMałgorzata Hałoń, Jan Jacek Kaczor, Wiesław Ziółkowski, Damian Józef Flis, Andżelika Borkowska, Urszula Popowska, Walenty Michał Nyka, Michał Woźniak, Jędrzej Antosiewicz · 2014 · Free Radical Research
- En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase‐2 as a Target for Kunitz‐Type InhibitorsAnna‐Madeleine Beckmann, Eva Maurer, Verena Lülsdorff, Annika Wilms, Norbert Furtmann, Jürgen Bajorath, Michael Gütschow, Marit Stirnberg · 2016 · ChemBioChem
- A novel oral iron-complex formulation: Encapsulation of hemin in polymeric micelles and its in vitro absorptionKimberley Span, Johan J. F. Verhoef, Hedi Hunt, Cornelus F. van Nostrum, Vera Brinks, Huub Schellekens, Wim E. Hennink · 2016 · European Journal of Pharmaceutics and Biopharmaceutics
- Progressive Reactive Lymphoid Connective Tissue Disease and Development of Autoantibodies in Scavenger Receptor A5–Deficient MiceJuha Risto Matias Ojala, Timo Pikkarainen, Göran Elmberger, Karl Tryggvason · 2013 · American Journal Of Pathology
- Mutations in FLVCR2 associated with Fowler syndrome and survival beyond infancyMalin Kvarnung, Fulya Taylan, Daniel Nilsson, Margareta Albåge, Magnus Nordenskjöld, Britt‐Marie Anderlid, Ann Nordgren, Elisabeth Syk Lundberg · 2015 · Clinical Genetics
- FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell functionJohn Chong Han Byon, Jing Chen, Raymond T. Doty, Janis L. Abkowitz · 2013 · Blood
- Structure and metal ion binding of the first transmembrane domain of DMT1Dan Wang, Yuande Song, Jiantao Li, Chunyu Wang, Fei Li · 2010 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitroAhmed A. Alkhateeb, Peter D. Buckett, Andrew M. Gardeck, Jonghan Kim, Shaina L. Byrne, Paula Goodman Fraenkel, Marianne Wessling‐Resnick · 2015 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Delivery of Oligoribonucleotides to Human Hepatoma Cells Using Cationic Lipid Particles Conjugated to Ferric Protoporphyrin IX (Heme)Garry Β. Takle, Alain Roger Thierry, Sandra Flynn, BO PENG, LISA WHITE, Wayne Devonish, Richard A. Galbraith, Allan R. Goldberg, Shaji T. George · 1997 · Antisense and Nucleic Acid Drug Development
- Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membraneIzumi Yanatori, Yumiko Yasui, Yumiko Noguchi, Fumio Kishi · 2014 · Cell Biology International
- Development of hematin conjugated PLGA nanoparticle for selective cancer targetingMd. Lutful Amin, Dami Kim, SeJin Kim · 2016 · European Journal of Pharmaceutical Sciences
- Insights into Matriptase‐2 Substrate Binding and Inhibition Mechanisms by Analyzing Active‐Site‐Mutated VariantsEva Maurer, Mihiret T. Sisay, Marit Stirnberg, Torsten Steinmetzer, Jürgen Bajorath, Michael Gütschow · 2011 · ChemMedChem
- Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro modelIolanda Fotticchia, Daniela Guarnieri, Teresa Fotticchia, Andrea Patrizia Falanga, Raffaele Vecchione, Concetta Giancola, Paolo A. Netti · 2016 · Colloids and Surfaces B Biointerfaces
- Human STEAP3 mutations with no phenotypic red cell changesDun Liu, Sheng Yi, Xinhua Zhang, Ping Fang, Chenguang Zheng, Li Lin, Ren Cai, Yuhua Ye, Yuqiu Zhou, Yunhao Liang et al. · 2015 · Blood
- Low expression of ferroxidases is implicated in the iron retention in human atherosclerotic plaquesJiajie Ji, Yu Zhou, Shuangying Hao, Qi Wang, Kuanyu Li, Tong Qiao · 2015 · Biochemical and Biophysical Research Communications
- Phase 1 study of a hepcidin antagonist, LY2787106, in cancer-associated anemiaVadhan-Raj, Saroj, Abonour, Rafat, Goldman, Jonathan W., Smith, David A., Slapak, Christopher A., Tiu, Ramon V., Wang, Xuejing, Callies, Sophie, Cox, Joanne, Tuttle, Jay L. et al. · 2015 · Blood
- A Possible Role Of The Tetraspanin CD9 In Bone Marrow Retention and Engraftment Of Human CD34+ Hematopoietic Stem/Progenitor CellsKam Tong Leung, Karen Li, Kam Sze Tsang, Kathy Yuen Yee Chan, Pak Cheung Ng, Chi Kong Li · 2013 · Blood
- FP380JTZ-951, AN ORAL NOVEL HIF-PHD INHIBITOR, ELEVATES HEMOGLOBIN IN JAPANESE ANEMIC PATIENTS WITH CHRONIC KIDNEY DISEASE NOT ON DIALYSISTadao Akizawa, Koji Hanaki, Masanobu Arai · 2015 · Nephrology Dialysis Transplantation