The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
Open accessAbstract
The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of hereditary hypophosphatemic and hyperphosphatemic disorders, as well as acquired disorders of phosphate metabolism, such as chronic kidney disease. FGF-23 is secreted by osteoblasts and osteocytes in bone and principally targets the kidney to regulate the reabsorption of phosphate, the production and catabolism of 1,25-dihydroxyvitamin D and the expression of α-Klotho, an anti-ageing hormone. Secreted FGF-23 plays a central role in complex endocrine networks involving local bone-derived factors that regulate mineralization of extracellular matrix and systemic hormones involved in mineral metabolism. Inactivating mutations of PHEX, DMP1 and ENPP1, which cause hereditary hypophosphatemic disorders and primary defects in bone mineralization, stimulate FGF23 gene transcription in osteoblasts and osteocytes, at least in part, through canonical and intracrine FGF receptor pathways. These FGF-23 regulatory pathways may enable systemic phosphate and vitamin D homeostasis to be coordinated with bone mineralization. FGF-23 also functions as a counter-regulatory hormone for 1,25-dihydroxyvitamin D in a bone–kidney endocrine loop. FGF-23, through regulation of additional genes in the kidney and extrarenal tissues, probably has broader physiological functions beyond regulation of mineral metabolism that account for the association between FGF-23 and increased mortality and morbidity in chronic kidney disease.
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Self-citationInsulin signaling in osteoblasts integrates bone remodeling and energy metabolism
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Endocrine functions of bone in mineral metabolism regulation
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Self-citationImmunohistochemical Localization of Klotho Protein in Brain, Kidney, and Reproductive Organs of Mice
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Self-citationAcute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men
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Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone
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Estrogens and androgens in skeletal physiology and pathophysiology
Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
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Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
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Shi, H., & Chen, M. (2024) · European journal of medical research · doi:10.1186/s40001-024-01918-0 · Cited by 87
Rothenbuhler, A., Fadel, N., Debza, Y., Bacchetta, J., Diallo, M. T., Adamsbaum, C., Linglart, A., & Di Rocco, F. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3614 · Cited by 78
Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone
Rolvien, T., Krause, M., Jeschke, A., Yorgan, T., Püschel, K., Schinke, T., Busse, B., Demay, M. B., & Amling, M. (2017) · Bone · doi:10.1016/j.bone.2017.06.022 · Cited by 74
Metadata
- Authors
- Quarles, L. D.
- Venue
- Nature Reviews Endocrinology
- Published
- 2012-01-17
- Volume
- 8
- Issue
- 5
- Pages
- 276-286
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2166377418
- Cited by
- 269
- References
- 9
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
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