Cited by 1,040Vagus Nerve Stimulation ResearchAdipokines, Inflammation, and Metabolic DiseasesGut microbiota and health

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The vagus nerve and the inflammatory reflex – linking immunity and metabolism

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Pavlov, Valentin A., Tracey, Kevin J.·2012·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2012.189PMC PMC4082307

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Abstract

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.

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Authors: Pavlov, V. A., & Tracey, K. J.
Affiliations: Feinstein Institute for Medical Research (US)
Corresponding author: Pavlov, Valentin A.
ORCID: Pavlov, Valentin A.
Tracey, Kevin J.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2012-11-21
Volume: 8
Issue: 12
Pages: 743-754
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2012.189
PMC: PMC4082307
OpenAlex: W1981020037
Cited by: 1,040
References: 148
Citations by year: 2026: 149 · 2025: 121 · 2024: 111 · 2023: 87 · 2022: 96 · 2021: 88 · 2020: 82 · 2019: 59 · 2018: 73 · 2017: 60 · 2016: 33 · 2015: 37 · 2014: 25 · 2013: 17 · 2012: 1
FWCI: 2.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM089807, R01GM057226)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: vagus nerve, cholinergic anti-inflammatory pathway, obesity, chronic inflammation, insulin resistance, type 2 diabetes, metabolic homeostasis, immune activation, vagus nerve stimulation therapy
MeSH terms: Animals, Diabetes Mellitus, Type 2, Homeostasis, Humans, Inflammation, Obesity, Reflex, Vagus Nerve, Signal Transduction, Metabolic Networks and Pathways

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