The vagus nerve and the inflammatory reflex – linking immunity and metabolism

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755

Adipokines in inflammation and metabolic disease

Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737

The inflammatory reflex

Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728

Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes

Fernández-Cabezudo, M. J., George, J. A., Bashir, G. H., Mohamed, Y. A., Al-Mansori, A., Qureshi, M. M., Lorke, D. E., Petroianu, G. A., & al-Ramadi, B. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01038 · Cited by 19

Role of specialized sensory neuron subtypes in modulating peripheral immune responses

Crosson, T., Bretaud, N., & Ugolini, S. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.008 · Cited by 17

The Role of Gut Microbiota in Modulating Immune Signaling Pathways in Autoimmune Diseases

Younis, N. K., Alfarttoosi, K. H., Sanghvi, G. V., Roopashree, R., Kashyap, A., Krithiga, T., Taher, W. M., Alwan, M., Jawad, M. J., & Al-Nuaimi, A. M. A. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08883-9 · Cited by 19

Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction

Wu, M. A., Casella, F., Perego, F., Suffritti, C., Afifi, N. A., Tobaldini, E., Zanichelli, A., Cogliati, C. B., Montano, N., & Cicardi, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187110 · Cited by 17

The Potential Mechanisms of High-Velocity, Low-Amplitude, Controlled Vertebral Thrusts on Neuroimmune Function: A Narrative Review

Haavik, H., Niazi, I. K., Kumari, N., Amjad, I., Duehr, J., & Holt, K. R. (2021) · Medicina · doi:10.3390/medicina57060536 · Cited by 19

Choline supplementation attenuates experimental sepsis-associated acute kidney injury

Hasson, D. C., Watanabe‐Chailland, M., Romick‐Rosendale, L. E., Koterba, A., Miner, D. S., Lahni, P. M., Ma, Q., Goldstein, S. L., Devarajan, P., & Standage, S. W. (2022) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00033.2022 · Cited by 20

Mediterranean diet, interoception and mental health: Is it time to look beyond the ‘Gut-brain axis’?

Young, H. A., Freegard, G., & Benton, D. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113964 · Cited by 19

Prospective multicenter study of heart rate variability with ANI monitor as predictor of mortality in critically ill patients with COVID-19

Aragón‐Benedí, C., Caballero-Lozada, A. F., Pérez-Calatayud, Á. A., Yanten, A. M. M., Oliver-Forniés, P., Boselli, E., Jonckheere, J. D., Bergese, S. D., Ubieto, J. M., Pascual‐Bellosta, A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-25537-z · Cited by 17

Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats

Agarwal, V., Kaushik, A. S., Chaudhary, R., Rehman, M., Srivastava, S., & Mishra, V. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02611-5 · Cited by 17

The impact of escitalopram on vagally mediated cardiovascular function to stress and the moderating effects of vigorous physical activity: a randomized controlled treatment study in healthy participants

Hanson, C. S., Outhred, T., Brunoni, A. R., Malhi, G. S., & Kemp, A. H. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00259 · Cited by 18

Gastric vagal motoneuron function is maintained following experimental spinal cord injury

Swartz, E. M., & Holmes, G. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12452 · Cited by 17

Effects of α-conotoxin ImI on TNF-α, IL-8 and TGF-β expression by human macrophage-like cells derived from THP-1 pre-monocytic leukemic cells

Padilla, A., Keating, P., Hartmann, J. X., & Marí, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-11586-2 · Cited by 17

Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model

Hu, X., Zhang, H., Song, Y., Zhuang, L., Yang, Q., Pan, M., & Chen, F. (2019) · Bioscience Reports · doi:10.1042/bsr20191672 · Cited by 17

Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

Ishibashi, T., Morita, S., Kishimoto, S., Uraki, S., Takeshima, K., Furukawa, Y., Inaba, H., Ariyasu, H., Iwakura, H., Furuta, H., et al. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13211 · Cited by 17

A mixed methods evaluation of an individualised yoga therapy intervention for rheumatoid arthritis: Pilot study

Cartwright, T., Cahill, M., & Sadana, V. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102339 · Cited by 17

Supplementing chestnut tannins in the broiler diet mediates a metabolic phenotype of the ceca

Lee, A., Pont, G. C. D., Farnell, M. B., Jarvis, S., Battaglia, M., Arsenault, R. J., & Kogut, M. H. (2020) · Poultry Science · doi:10.1016/j.psj.2020.09.085 · Cited by 17

Increased Concentrations of Circulating Interleukins following Non-Invasive Vagus Nerve Stimulation: Results from a Randomized, Sham-Controlled, Crossover Study in Healthy Subjects

Veiz, E., Kieslich, S.-K., Czesnik, D., Herrmann‐Lingen, C., Meyer, T., & Staab, J. (2022) · NeuroImmunoModulation · doi:10.1159/000524646 · Cited by 16

Role of Cholinergic Receptors in Colorectal Cancer: Potential Therapeutic Implications of Vagus Nerve Stimulation?

Pelissier-Rota, M., Lainé, M., Ducarouge, B., Bonaz, B., & Jacquier-Sarlin, M. (2013) · Journal of Cancer Therapy · doi:10.4236/jct.2013.46128 · Cited by 17

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trialPreprint

Tan, G., Huguenard, A. L., Donovan, K. M., Demarest, P., Liu, X., Li, Z., Adamek, M., Lavine, K. J., Vellimana, A. K., Kummer, T. T., et al. (2024) · eLife · doi:10.7554/elife.100088 · Cited by 17

Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors

Sun, H., Wang, T., Jiang, X., Li, M., He, X., Ma, Y., Li, X., Jin, W., & Jiao, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02412-9 · Cited by 18

The autonomic nervous system in the regulation of glucose and lipid metabolism

Wangler, S., Jarczok, M. N., Ennis, M., Herhaus, B., Wagner, R., Sehgal, R., & Heni, M. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01221-w · Cited by 17

The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes

Blasi, C. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2419-2 · Cited by 16

Online Questionnaire with Fibromyalgia Patients Reveals Correlations among Type of Pain, Psychological Alterations, and Effectiveness of Non-Pharmacological Therapies

Demori, I., Molinari, E., Rapallo, F., Mucci, V., Marinelli, L., Losacco, S., & Burlando, B. (2022) · Healthcare · doi:10.3390/healthcare10101975 · Cited by 16

Fundamental Neurochemistry Review: Incorporating a greater diversity of cell types, including microglia, in brain organoid cultures improves clinical translation

Wenzel, T. J., Le, J., He, J., Alcorn, J., & Mousseau, D. D. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15741 · Cited by 17

Current Trends in Nanotheranostics: A Concise Review on Bioimaging and Smart Wearable Technology

Sharma, A. K. (2023) · Nanotheranostics · doi:10.7150/ntno.82886 · Cited by 17

Bridging the Gap: Investigating the Link between Inflammasomes and Postoperative Cognitive Dysfunction

Zhang, S., Liu, C., Sun, J., Li, Y., Lu, J. Y., Xiong, X., Hu, L., Zhao, H., & Zhou, H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0501 · Cited by 17

Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease

Lataro, R. M., Brognara, F., Iturriaga, R., & Paton, J. F. R. (2023) · Autonomic Neuroscience · doi:10.1016/j.autneu.2023.103137 · Cited by 16

Effects of Vibroacoustic Stimulation on Psychological, Physiological, and Cognitive Stress

Fooks, C., & Niebuhr, O. (2024) · Sensors · doi:10.3390/s24185924 · Cited by 21

Preoperative smoking history is associated with decreased risk of early postoperative cognitive dysfunction in patients of advanced age after noncardiac surgery: a prospective observational cohort study

Wang, R., Wang, G., Liu, Y., & Zhang, M. (2018) · Journal of International Medical Research · doi:10.1177/0300060518808162 · Cited by 16

Presidential Address 2011: Autonomic modes of control and health

Berntson, G. G. (2018) · Psychophysiology · doi:10.1111/psyp.13306 · Cited by 16

A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?

Mannon, E. C., Sun, J., Wilson, K., Brands, M. W., Quinones, P. M., Baban, B., & O'Connor, P. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.007 · Cited by 16

The Nicotinic Receptor Alpha7 Impacts the Mouse Lung Response to LPS through Multiple Mechanisms

Enioutina, E. Y., Myers, E. J., Tvrdík, P., Hoidal, J. R., Rogers, S. W., & Gahring, L. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121128 · Cited by 16

α7 nicotinic acetylcholine receptors are involved in suppression of the antibody immune response

Koval, L., Kalashnyk, O., Lykhmus, O., & Skok, M. V. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.01.012 · Cited by 16

Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Kinfe, T. M., Buchfelder, M., Chaudhry, S. R., Chakravarthy, K. V., Deer, T. R., Russo, M. A., Georgius, P., Hurlemann, R., Rasheed, M. A., Muhammad, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194737 · Cited by 17

Family history of psoriasis, psychological stressors, and tobacco use are associated with the development of tumor necrosis factor-α inhibitor-induced psoriasis: A case-control study

Ya, J., Hu, J. Z., Nowacki, A. S., Khanna, U., Mazloom, S. E., Kabbur, G., Husni, M. E., & Fernandez, A. P. (2020) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2020.06.081 · Cited by 16

Tackling Inflammation in Heart Failure With Preserved Ejection Fraction: Resurrection of Vagus Nerve Stimulation?

Kittipibul, V., & Fudim, M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024481 · Cited by 16

The Gut Microbiome Controls Liver Tumors via the Vagus NervePreprint

Bauer, K. C., Trehan, R., Ruf, B., Myojin, Y., Benmebarek, M.-R., Ma, C., Seifert, M., Nur, A., Qi, J., Huang, P., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.576951 · Cited by 18

Heart rate variability and overtraining in soccer players: A systematic review

Lipka, A., Luthardt, C., Tognaccioli, T., Cairo, B., & de Abreu, R. M. (2025) · Physiological Reports · doi:10.14814/phy2.70357 · Cited by 20

Transcutaneous auricular vagus nerve stimulation regulates gut microbiota mediated peripheral inflammation and metabolic disorders to suppress depressive-like behaviors in CUMS rats

Zhang, X., He, X., Zhao, Y., Zou, Q., Liang, Y., Zhang, J., Feng, B., Rong, P., & Wang, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1576686 · Cited by 16

Importance of timing optimization for closed-loop applications of vagus nerve stimulation

Mylavarapu, R. V., Kanumuri, V. V., Vaccari, J. P. D. R., Misra, A., McMillan, D. W., & Ganzer, P. D. (2023) · Bioelectronic Medicine · doi:10.1186/s42234-023-00110-9 · Cited by 15

Regenerative bioelectronics: A strategic roadmap for precision medicine

Panda, A. K., & Basu, B. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122271 · Cited by 14

Sympathetic nerve blocks promote anti-inflammatory response by activating the JAK2-STAT3–mediated signaling cascade in rat myocarditis models: A novel mechanism with clinical implications

Park, H., Park, H., Mun, D., Kim, M. S., Pak, H., Lee, M., & Joung, B. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.09.039 · Cited by 15

A walk through the progression of resuscitation medicine

Shoaib, M., & Becker, L. B. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14507 · Cited by 15

Low-Level Vagus Nerve Stimulation Reverses Obstructive Sleep Apnea-Related Atrial Fibrillation by Ameliorating Sympathetic Hyperactivity and Atrial Myocyte Injury

Guo, Y., Xiaokereti, J., Meng, Q., Cao, G., Sun, H., Zhou, X., Zhang, L., & Tang, B. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.620655 · Cited by 15

Differences in inflammation among black and white individuals: A systematic review and meta-analysis

Wiley, C. R., Williams, D. P., Sigrist, C., Brownlow, B. N., Markser, A. M., Hong, S., STERNBERG, E. M., Kapuku, G. K., Koenig, J., & Thayer, J. F. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.019 · Cited by 15

Central neural circuits underlying itch sensation

Sun, Y.-G. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00981-8 · Cited by 14

The gut microbiome shapes social behaviour across animal species

Griffiths, J. A., Nirmalkar, K., Wu, W., Krajmalnik‐Brown, R., & Mazmanian, S. K. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01262-y · Cited by 19

Nicotine induces TIPE2 upregulation and Stat3 phosphorylation contributes to cholinergic anti-inflammatory effect

Sui, H. X., Ke, S. Z., Xu, D., Lü, N., Wang, Y. N., Zhang, Y. H., & GAO, F. G. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4080 · Cited by 13

A Hypothalamic-Controlled Neural Reflex Promotes Corneal Inflammation

Vitar, R. M. L., Fonteyne, P., Chaabane, L., Rama, P., & Ferrari, G. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.13.21 · Cited by 14

Using neural biomarkers to personalize dosing of vagus nerve stimulation

Berthon, A., Wernisch, L., Stoukidi, M., Thornton, M., Tessier-Lariviere, O., Fortier-Poisson, P., Mamen, J., Pinkney, M., Lee, S., Sarkans, E., et al. (2024) · Bioelectronic Medicine · doi:10.1186/s42234-024-00147-4 · Cited by 13

Glucagon-like peptide-1 (GLP-1) receptor agonists for weight management: A review for the gynecologic oncologist

Riedinger, C. J., Sakach, J. C., Maples, J. M., Fulton, J., Chippior, J., OʼDonnell, B., O’Malley, D. M., & Chambers, L. (2024) · Gynecologic Oncology · doi:10.1016/j.ygyno.2024.07.008 · Cited by 17

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments

Guan, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70069 · Cited by 14

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice

Buras, E. D., Yang, L., Saha, P., Kim, J., Mehta, P., Yang, Y., Hilsenbeck, S. G., Kojima, H., Chen, W., Smith, C. W., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271452 · Cited by 14

Neurologic complications of sepsis

Schmutzhard, E., & Pfausler, B. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63599-0.00036-3 · Cited by 15

The Efficacy and Safety of Acupuncture for Preventing Radiation Pneumonitis in Patients With Lung Cancer: A Prospective, Single-Blinded, Randomized Pilot Proof-of-Principle Study

Kong, M., Lee, S. H., Kim, J.-H., Lee, B.-J., & Kim, K. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420908327 · Cited by 14

The surviving sepsis campaign: basic/translational science research priorities

Deutschman, C. S., Hellman, J., Ferrer, R., Backer, D. D., Coopersmith, C. M., Coopersmith, C. M., Backer, D. D., Antonelli, M. M., Deutschman, C. S., Evans, L., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00312-4 · Cited by 13

Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome

Deng, J., Li, H., Guo, Y., Zhang, G., Fischer, H., Stavrakis, S., & Yu, X. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01144-w · Cited by 14

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans

Ziegler, D., Strom, A., Straßburger, K., Nowotny, B., Zahiragic, L., Nowotny, P., Carstensen‐Kirberg, M., Herder, C., Szendroedi, J., & Roden, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124242 · Cited by 14

The Neuroimmune Communicatome in Inflammation

Olofsson, P. S., Metz, C. N., & Pavlov, V. A. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch59 · Cited by 14

Circadian Rhythms, Sleep, and the Autonomic Nervous System

Garbarino, S., Lanteri, P., Feeling, N. R., Jarczok, M. N., Quintana, D. S., Koenig, J., & Sannita, W. G. (2019) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000236 · Cited by 15

Crosstalk Among Disrupted Glutamatergic and Cholinergic Homeostasis and Inflammatory Response in Mechanisms Elicited by Proline in Astrocytes

Loureiro, S., Sidegum, D. S. V., Biasibetti, H., Pereira, M. S., de Oliveira, D. D., Pessoa-Pureur, R., & Wyse, A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-9067-0 · Cited by 15

Core features and inherent diversity of post-acute infection syndromes

Trautmann, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1509131 · Cited by 13

Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis

Li, Z., Sun, X., Wang, Y., Zhang, F., Wang, L., Ai, C., Zhang, X., Yin, X., Liu, C., Li, C. L., et al. (2025) · Basic Research in Cardiology · doi:10.1007/s00395-025-01138-5 · Cited by 17

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Wang, H., Chen, Y., Zhao, A., Shen, Z., & Zhang, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1709060 · Cited by 18

Nociceptive innervation limits tertiary lymphoid structures to promote lung cancer

Ho, Y., Bregni, G., Stazi, M., Peinado, P., Chen, P., Ballabio, C., Boulat, V., Vadera, S., Guan, Y., Liu, Z., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.038 · Cited by 14

Covid-19, nervous system pathology, and Parkinson's disease: Bench to bedside

Emmi, A., Boura, I., Raeder, V., Mathew, D., Sulzer, D., Goldman, J. E., & Leta, V. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.06.006 · Cited by 14

Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups

Bibi, S., Habib, R., Shafiq, S., Abbas, S. S., Khan, S., Eqani, S. A. M. A. S., Nepovimová, E., Khan, M. S., Kuča, K., & Nurulain, S. M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163359 · Cited by 13

Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure

Dasari, T. W., Chakraborty, P., Mukli, P., Akhtar, K. H., Yabluchanskiy, A., Cunningham, M. W., Csiszár, A., & Po, S. S. (2023) · Clinical Autonomic Research · doi:10.1007/s10286-023-00997-z · Cited by 13

Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in cardiovascular system of aged male rats

Prauchner, G. R. K., Júnior, O. V. R., Rieder, A. S., & Wyse, Â. T. D. S. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111028 · Cited by 13

Recent advances in targeting obesity, with a focus on TGF-β signaling and vagus nerve innervation

John, S., Bhowmick, K., PARK, A. W., Huang, H., Yang, X., & Mishra, L. (2025) · Bioelectronic Medicine · doi:10.1186/s42234-025-00172-x · Cited by 15

Sculpting the Sculptors: Methods for Studying the Fetal Cholinergic Signaling on Systems and Cellular Scales

Frasch, M. G., Burns, P., Benito, J., Cortes, M., Cao, M., Fecteau, G., & Desrochers, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7828-1_18 · Cited by 12

Maternal high fat diet consumption reduces liver alpha7 nicotinic cholinergic receptor expression and impairs insulin signalling in the offspring

COSTA, S. O., de Souza, C. M., LANZA, P. G., Sartori, J. O., Ignácio-Souza, L. M., Candreva, T., Rodrigues, H. G., Torsoni, A. S., Milanski, M., & Torsoni, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-019-56880-3 · Cited by 14

Sequencing Analysis and Identification of the Primary Peptide Component of the Dialyzable Leukocyte Extract “Transferon Oral”: The Starting Point to Understand Its Mechanism of Action

Vallejo‐Castillo, L., Favari, L., Vázquez‐Leyva, S., Mellado‐Sánchez, G., Macías-Palacios, Z., López‐Juárez, L. E., Valencia-Flores, L., Medina‐Rivero, E., Chacón‐Salinas, R., Pavón, L., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.569039 · Cited by 13

Lower values of a novel index of Vagal-Neuroimmunomodulation are associated to higher all-cause mortality in two large general population samples with 18 year follow up

Jarczok, M. N., Koenig, J., & Thayer, J. F. (2021) · Scientific Reports · doi:10.1038/s41598-021-82168-6 · Cited by 12

Autonomic nervous function and low-grade inflammation in children with sleep-disordered breathing

Wu, Y., Tian, L., Ma, D., Wu, P., Tang, Y., Cui, X., & Xu, Z. (2021) · Pediatric Research · doi:10.1038/s41390-021-01691-4 · Cited by 13

Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis

Hao, M., Liu, X., & Guo, S. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00955-w · Cited by 13

Cardiovascular Response to Intraneural Right Vagus Nerve Stimulation in Adult Minipig

Agnesi, F., Zinno, C., Strauss, I., Dushpanova, A., Casieri, V., Bernini, F., Terlizzi, D., Gabisonia, K., Paggi, V., Lacour, S. P., et al. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2023.03.002 · Cited by 13

Grounding the Human Body Improves Facial Blood Flow Regulation: Results of a Randomized, Placebo Controlled Pilot Study

Chevalier, G. (2014) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2014.45039 · Cited by 12

The Impact of Stressor Exposure and Glucocorticoids on Anxiety and Fear

Hassell, J. E., Nguyen, K., Gates, C. A., & Lowry, C. A. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_63 · Cited by 13

Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus

Pham, G. S., Shimoura, C. G., Chaudhari, S. K., Kulp, D. V., & Mathis, K. W. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2020 · Cited by 13

Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke

Payne, P., Fiering, S., Leiter, J. C., Zava, D. T., & Crane-Godreau, M. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00067 · Cited by 12

Unilateral Cervical Vagotomy Modulates Immune Cell Profiles and the Response to a Traumatic Brain Injury

Newell‐Rogers, M. K., Duong, A., Nazarali, R., Tobin, R. P., Rogers, S. K., & Shapiro, L. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179851 · Cited by 12

Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management

Aboseif, A., Bireley, J. D., Li, Y., Polston, D. W., & Abbatemarco, J. (2023) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.90a.22093 · Cited by 12

Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators reveal a pro-inflammatory state in overweight women

Metz, C. N., Xue, X., Chatterjee, P. K., Adelson, R. P., Roth, J., Brines, M. L., Tracey, K. J., Gregersen, P. K., & Pavlov, V. A. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03588-4 · Cited by 16

Syncope and silent hypoxemia in COVID-19: Implications for the autonomic field

Baker, J. R., Incognito, A. V., Wilson, R. J. A., & Raj, S. R. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102842 · Cited by 12

Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected With Salmonella enterica Serovar Enteritidis

Kogut, M. H., Genovese, K. J., Byrd, J. A., Swaggerty, C. L., He, H., Farnell, Y. Z., & Arsenault, R. J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.899395 · Cited by 12

Modern Approaches for the Treatment of Heart Failure: Recent Advances and Future Perspectives

Popa, I. P., Haba, M. Ș. C., Maranducă, M. A., Tănase, D. M., Șerban, D. N., Șerban, L., Iliescu, R., & Tudorancea, I. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091964 · Cited by 13

The Hepatic Nerves Regulated Inflammatory Effect in the Process of Liver Injury: Is Nerve the Key Treating Target for Liver Inflammation?

Yang, K., Huang, Z., Wang, S., Zhao, Z., Yi, P., Chen, Y., Xiao, M., Quan, J., & Hu, X. (2023) · Inflammation · doi:10.1007/s10753-023-01854-x · Cited by 12

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.Preprint

Rothbard, J., Kurnellas, M. P., Ousman, S., Brownell, S., Rothbard, J. J., & Steinman, L. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034223 · Cited by 11

Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients

Pinto, T. P., Inácio, J. C., de Aguiar, E., Ferreira, A. S., Sudo, F. K., Tovar-Moll, F., & Rodrigues, E. C. (2023) · Brain Stimulation · doi:10.1016/j.brs.2023.03.001 · Cited by 11

Orexin A alleviates LPS-induced acute lung injury by inhibiting macrophage activation through JNK-mediated autophagy.

Nie, Y., Liang, J., Sun, J., Li, J., Zhai, X., & Zhao, P. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111018 · Cited by 10

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Monobenzone-Induced Vitiligo in Mice

Luo, S., Meng, X., Ai, J., Zhang, Z., Dai, Y., & Yu, X. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063411 · Cited by 11

The beneficial effects of social support and prosocial behavior on immunity and health: A psychoneuroimmunology perspective

Trachtenberg, E. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100758 · Cited by 16

Transcutaneous auricular vagus nerve stimulation mitigates gouty inflammation by reducing neutrophil infiltration in BALB/c mice

Shin, J. H., Lee, C., & Song, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-77272-2 · Cited by 11

Unraveling the Role of LRP1 in Alzheimer’s Disease: A Focus on Aβ Clearance and the Liver-Brain Axis

Yang, W., Wei, Z., & Wang, T. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02339-2 · Cited by 14

The interplay between heart rate variability, inflammation, and lipid accumulation: Implications for cardiometabolic risk

Wiley, C. R., Pourmand, V., Stevens, S., Jarczok, M. N., Fischer, J. E., Boschiero, D., Poggiogalle, E., Koenig, J., Thayer, J. F., & Williams, D. P. (2025) · Physiological Reports · doi:10.14814/phy2.70313 · Cited by 13

Incorporating Internal and External Training Load Measurements in Clinical Decision Making After ACL Reconstruction: A Clinical Commentary

Taylor, J. B., Ford, K. R., Queen, R. M., Owen, E. C., & Gisselman, A. S. (2021) · International Journal of Sports Physical Therapy · doi:10.26603/001c.21152 · Cited by 11

Childhood Abuse, Body Shame, and Addictive Plastic Surgery

Constantian, M. B. (2018) · Routledge eBooks · doi:10.4324/9781315657721 · Cited by 12

Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis

Engström, G., Hamrefors, V., Fedorowski, A., Persson, A., Johansson, M. E., Ostenfeld, E., Goncalves, I., Markstad, H., Johnson, L. S. B., Persson, M., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024053 · Cited by 11

Understanding the Pivotal Role of the Vagus Nerve in Health from Pandemics

Rangon, C.-M., & Niezgoda, A. (2022) · Bioengineering · doi:10.3390/bioengineering9080352 · Cited by 11

The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response

Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 50

Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome

Metz, C. N., & Pavlov, V. A. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00195.2018 · Cited by 61

The vagus neurometabolic interface and clinical disease

Battinelli, E., Valdés‐Ferrer, S. I., & Steinberg, B. E. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0086-1 · Cited by 34

Regulation of visceral adipose tissue inflammation and metabolism by signals in the vagus nerve

Liu, T., Caravaca, A. S., Shavva, V. S., Tarnawski, L., Ahmed, O., Zhang, Y., Guo, Q., Cai, M., Schipper, R., Hagberg, C. E., et al. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118293

Vagus nerve stimulation for the management of obesity, type 2 diabetes mellitus, and metabolic syndrome

Das, U. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-816996-4.00021-6