Cited by 367Cannabis and Cannabinoid ResearchGut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

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Endocannabinoids–at the crossroads between the gut microbiota and host metabolism

Cani, Patrice D., Plovier, Hubert, Van Hul, Matthias, Geurts, Lucie, Delzenne, Nathalie M., Druart, Céline, Everard, Amandine·2016·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2015.211

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Abstract

Various metabolic disorders are associated with changes in inflammatory tone. Among the latest advances in the metabolism field, the discovery that gut microorganisms have a major role in host metabolism has revealed the possibility of a plethora of associations between gut bacteria and numerous diseases. However, to date, few mechanisms have been clearly established. Accumulating evidence indicates that the endocannabinoid system and related bioactive lipids strongly contribute to several physiological processes and are a characteristic of obesity, type 2 diabetes mellitus and inflammation. In this Review, we briefly define the gut microbiota as well as the endocannabinoid system and associated bioactive lipids. We discuss existing literature regarding interactions between gut microorganisms and the endocannabinoid system, focusing specifically on the triad of adipose tissue, gut bacteria and the endocannabinoid system in the context of obesity and the development of fat mass. We highlight gut-barrier function by discussing the role of specific factors considered to be putative 'gate keepers' or 'gate openers', and their role in the gut microbiota-endocannabinoid system axis. Finally, we briefly discuss data related to the different pharmacological strategies currently used to target the endocannabinoid system, in the context of cardiometabolic disorders and intestinal inflammation.

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Background
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Background
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Background
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Influential
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Background
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Authors: Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A.
Affiliations: Walloon Excellence in Lifesciences and Biotechnology (BE)
UCLouvain (BE)
Corresponding author: Cani, Patrice D.
ORCID: Cani, Patrice D.
Plovier, Hubert
Geurts, Lucie
Delzenne, Nathalie M.
Druart, Céline
Everard, Amandine
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2015-12-18
Volume: 12
Issue: 3
Pages: 133-143
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2015.211
OpenAlex: W2206708469
Cited by: 367
References: 156
Citations by year: 2026: 23 · 2025: 30 · 2024: 27 · 2023: 37 · 2022: 51 · 2021: 55 · 2020: 45 · 2019: 25 · 2018: 30 · 2017: 24 · 2016: 20
FWCI: 3.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: endocannabinoid system, gut microbiota, host metabolism, intestinal permeability, intestinal barrier, bioactive lipids, obesity, adipose tissue, type 2 diabetes, cardiometabolic disease, intestinal inflammation, fat mass
MeSH terms: Gastrointestinal Microbiome, Animals, Humans, Gastrointestinal Tract, Receptors, Cannabinoid, Endocannabinoids

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Endocannabinoids–at the crossroads between the gut microbiota and host metabolism

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