The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Endocannabinoids–at the crossroads between the gut microbiota and host metabolism
Abstract
Various metabolic disorders are associated with changes in inflammatory tone. Among the latest advances in the metabolism field, the discovery that gut microorganisms have a major role in host metabolism has revealed the possibility of a plethora of associations between gut bacteria and numerous diseases. However, to date, few mechanisms have been clearly established. Accumulating evidence indicates that the endocannabinoid system and related bioactive lipids strongly contribute to several physiological processes and are a characteristic of obesity, type 2 diabetes mellitus and inflammation. In this Review, we briefly define the gut microbiota as well as the endocannabinoid system and associated bioactive lipids. We discuss existing literature regarding interactions between gut microorganisms and the endocannabinoid system, focusing specifically on the triad of adipose tissue, gut bacteria and the endocannabinoid system in the context of obesity and the development of fat mass. We highlight gut-barrier function by discussing the role of specific factors considered to be putative 'gate keepers' or 'gate openers', and their role in the gut microbiota-endocannabinoid system axis. Finally, we briefly discuss data related to the different pharmacological strategies currently used to target the endocannabinoid system, in the context of cardiometabolic disorders and intestinal inflammation.
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“The ECS and GM interact to regulate intestinal homeostasis resulting in relevant functional effects in the gut and CNS (238, 246, 248, 250).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [238]
Citations
Cites
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Gut microbiome and health: mechanistic insights
de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204
Self-citationNeurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058
“We then discovered that live A. muciniphila increased the endogenous production of specific bioactive lipids that belongs to the endocannabinoid family and are known to have anti-inflammatory activities and regulating the endogenous production of gut peptides involved in glucose regulation and gut barrier, respectivel…”
BackgroundCannabinoids and the expanded endocannabinoid system in neurological disorders
Cristino, L., Bisogno, T., & Di Marzo, V. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0284-z · Cited by 970
Metadata
- Authors
- Cani, P. D., Plovier, H., Van Hul, M., Geurts, L., Delzenne, N. M., Druart, C., & Everard, A.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- UCLouvain (BE)
- Corresponding author
- Cani, Patrice D.
- ORCID
- Venue
- Nature Reviews Endocrinology
- Published
- 2015-12-18
- Volume
- 12
- Issue
- 3
- Pages
- 133-143
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2206708469
- Cited by
- 367
- References
- 156
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 27 · 2023: 37 · 2022: 51 · 2021: 55 · 2020: 45 · 2019: 25 · 2018: 30 · 2017: 24 · 2016: 20
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- endocannabinoid system, gut microbiota, host metabolism, intestinal permeability, intestinal barrier, bioactive lipids, obesity, adipose tissue, type 2 diabetes, cardiometabolic disease, intestinal inflammation, fat mass
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Gastrointestinal Tract, Receptors, Cannabinoid, Endocannabinoids
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