Cited by 5,697Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Zheng, Yan, Ley, Sylvia H., Hu, Frank B.·2018·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2017.151

Open this paper in CoChat — free account

Abstract

Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life. Many cases of T2DM could be prevented with lifestyle changes, including maintaining a healthy body weight, consuming a healthy diet, staying physically active, not smoking and drinking alcohol in moderation. Most patients with T2DM have at least one complication, and cardiovascular complications are the leading cause of morbidity and mortality in these patients. This Review provides an updated view of the global epidemiology of T2DM, as well as dietary, lifestyle and other risk factors for T2DM and its complications.

Integrity signals

Registry

Crossref · 10.1038/nrendo.2017.151

Cites

156 of 156 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
Retracted
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070
International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,379
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32154-2 · Cited by 13,220
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
(2015) · The Lancet · doi:10.1016/s0140-6736(14)61682-2 · Cited by 7,439

Flagged first, then by citations

Show all 156 references

Research works printed but not linked: 2

International Diabetes Federation. IDF Diabetes Atlas — 7th Edition. DiabetesAtlas http://www.diabetesatlas.org/ (2015).
Al-Siyabi, H., Al-Anquodi, Z., Al-Hinai, H. & Al-Hinai, S. Nizwa Healthy Lifestyle Project Evaluation Report 2010 (Ad Dakhiliyah, Oman: Ministry of Health, 2010).

Sorted by citations

Items 801–900 of 1,018

Surface enhanced Raman scattering active substrate based on hydrogel microspheres for pretreatment-free detection of glucose in biological samples
Wang, Q., Sun, D., Ma, X., Huang, R., Xu, J., Xu, X., Cai, L., & Xu, L. (2023) · Talanta · doi:10.1016/j.talanta.2023.124657 · Cited by 33
Identifying Barriers and Facilitators to Diet and Physical Activity Behaviour Change in Type 2 Diabetes Using a Design Probe Methodology
Cradock, K. A., Quinlan, L. R., Finucane, F. M., Gainforth, H. L., Martin Ginis, K. A., Barros, A. C. D., Sanders, E. B. N., & ÓLaighin, G. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020072 · Cited by 32
Lactobacillus plantarum ZJUFB2 Prevents High Fat Diet-Induced Insulin Resistance in Association With Modulation of the Gut Microbiota
Zhong, H., Wang, J., Abdullah, Hafeez, M. A., Guan, R., & Feng, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.754222 · Cited by 32
Circulating levels of adropin and diabetes: a systematic review and meta-analysis of observational studies
Soltani, S., Beigrezaei, S., Malekahmadi, M., Clark, C. C. T., & Abdollahi, S. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01327-0 · Cited by 33
High-throughput screening and investigation of the inhibitory mechanism of α-glucosidase inhibitors in teas using an affinity selection-mass spectrometry method
Gao, J., Zhou, M., Chen, D., Xu, J., Wang, Z., Peng, J., Lin, Z., Yu, S., Lin, Z., & Dai, W. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.136179 · Cited by 32
Assessing the usefulness of a newly proposed metabolic score for visceral fat in predicting future diabetes: results from the NAGALA cohort study
Yang, R., Kuang, M., Qiu, J., Yu, C., Sheng, G., & Zou, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1172323 · Cited by 32
Variation in type 2 diabetes prevalence across different populations: the key drivers
Gong, J. Y., Sajjadi, S. F., Motala, A. A., Shaw, J. E., & Magliano, D. J. (2025) · Diabetologia · doi:10.1007/s00125-025-06478-4 · Cited by 37
Obesity and Its Comorbidities: Current Treatment Options, Emerging Biological Mechanisms, Future Perspectives and Challenges
Wang, L., Wang, Q., Xiong, Y., Shi, W. F., & Xiao, Q. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s540103 · Cited by 41
Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes
Vaiserman, A. M., & Lushchak, O. V. (2019) · International Journal of Genomics · doi:10.1155/2019/3821409 · Cited by 37
Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose
Wang, B., Chou, K., Queenan, B. N., Pennathur, S., & Bazan, G. C. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904595 · Cited by 32
Self-Care Adherence And Barriers To Good Glycaemic Control In Nepalese Type 2 Diabetes Mellitus Patients: A Hospital-Based Cross-Sectional Study
Pokhrel, S., Shrestha, S., Timilsina, A., Sapkota, M., Bhatt, M. P., & Pardhe, B. D. (2019) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s216842 · Cited by 37
The Effect of Flaxseed Enriched Yogurt on the Glycemic Status and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus: Randomized, Open-labeled, Controlled Study
Hasaniani, N., Rahimlou, M., Ahmadi, A. R., Mehdizadeh, A., & Alizadeh, M. (2019) · Clinical Nutrition Research · doi:10.7762/cnr.2019.8.4.284 · Cited by 32
Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus
Lu, L., Ma, J., Sun, M., Wang, X., Gao, E., Lu, L., Ren, J. T., Yang, L., & Yang, J. Z. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1535201 · Cited by 32
Associations of food addiction with metabolic control, medical complications and depression among patients with type 2 diabetes
Nicolau, J., Romerosa, J. M., Rodrı́guez, I., Sanchís, P., Bonet, A., Arteaga, M., Fortuny, R., & Masmiquel, L. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01519-3 · Cited by 37
HMGB1 impairs endothelium‐dependent relaxation in diabetes through TLR4/eNOS pathway
Zhu, Z., Peng, X., Li, X., Tu, T., Yang, H., Teng, S., Zhang, W., Xing, Z., Tang, J., Hu, X., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000242r · Cited by 32
Pathogenesis and remission of type 2 diabetes: what has the twin cycle hypothesis taught us?
Al-Mrabeh, A. H. (2020) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000201 · Cited by 35
Association between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
Wang, Y., Wan, H., Chen, C., Chen, Y., Xia, F., Han, B., Qin, L., Wang, N., & Lu, Y. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-0121-x · Cited by 32
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction
Xu, C., Zhou, X., Xie, T., Zhou, Y., Zhang, Q., Jiang, S., Zhang, R., Liao, L., & Dong, J. (2020) · Theranostics · doi:10.7150/thno.43145 · Cited by 32
High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures
Zuliani, I., Lanzillotta, C., Tramutola, A., Barone, E., Marzia Perluigi, A., Rinaldo, S., Paone, A., Cutruzzolà, F., Bellanti, F., Spinelli, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073746 · Cited by 32
The Role of Astaxanthin on Chronic Diseases
Zhang, X., Hou, Y., Li, J., & Wang, J. (2021) · Crystals · doi:10.3390/cryst11050505 · Cited by 31
MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes
Vezza, T., Marañón, A., Canet, F., Díaz-Pozo, P., Marti, M., D’Ocón, P., Apostolova, N., Rocha, M., & Víctor, V. M. (2021) · Antioxidants · doi:10.3390/antiox10050802 · Cited by 34
Relationship between periodontitis and microangiopathy in type 2 diabetes mellitus: a meta‐analysis
Zhang, X., Wang, M., Wang, X., Qu, H., Zhang, R., Gu, J., Wu, Y., Ni, T., Tang, W., & Li, Q. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12916 · Cited by 37
Nocturnal Oxygen Saturation Parameters as Independent Risk Factors for Type 2 Diabetes Mellitus among Obstructive Sleep Apnea Patients
Gabryelska, A., Chrzanowski, J., Sochal, M., Kaczmarski, P., Turkiewicz, S., Ditmer, M., Karuga, F. F., Czupryniak, L., & Białasiewicz, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173770 · Cited by 32
Targeting gut microbiota in type 2 diabetes mellitus: Potential roles of dietary flavonoids
Han, S., Luo, Y., Hu, Z., Qin, D., & Luo, F. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101500 · Cited by 33
Arterial Stiffness, Genetic Risk, and Type 2 Diabetes: A Prospective Cohort Study
Wang, M., Huang, J., Wu, T., & Qi, L. (2022) · Diabetes Care · doi:10.2337/dc21-1921 · Cited by 32
A Mobile Application to Improve Diabetes Self-Management Using Rapid Prototyping: Iterative Co-Design Approach in Asian Settings
Kwan, Y. H., Ong, Z. Q., Choo, D. Y. X., Phang, J. K., Yoon, S., & Low, L. L. (2023) · Patient Preference and Adherence · doi:10.2147/ppa.s386456 · Cited by 32
Early diabetic kidney disease: Focus on the glycocalyx
Yu, H., Song, Y.-Y., & Li, X. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.460 · Cited by 36
Tau suppresses microtubule-regulated pancreatic insulin secretion
Mangiafico, S. P., Tuo, Q., Li, X.-L., Liu, Y., Haralambous, C., Ding, X., Ayton, S., Wang, Q., Laybutt, D. R., Chan, J. Y., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02267-w · Cited by 35
Complicações por diabetes mellitus no Brasil: estudo de base nacional, 2019
Neves, R. G., Tomasi, E., Duro, S. M. S., Saes-Silva, E., & Saes, M. D. O. (2023) · Ciência & Saúde Coletiva · doi:10.1590/1413-812320232811.11882022 · Cited by 32
MiR-21 antagomir improves insulin resistance and lipid metabolism disorder in streptozotocin-induced type 2 diabetes mellitus rats
Wang, Y., Yang, L.-Z., Yang, D.-G., Zhang, Q., Deng, Z.-N., Wang, K., & Mao, X.-J. (2020) · Annals of Palliative Medicine · doi:10.21037/apm.2020.02.28 · Cited by 32
Dexmedetomidine alleviates oxidative stress and mitochondrial dysfunction in diabetic peripheral neuropathy via the microRNA-34a/SIRT2/S1PR1 axis
Lin, Y., Wei, Y., Wei, Y., Yu, H., Zhang, W., Li, C., He, Y., Yao, G., & Zhang, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109910 · Cited by 31
Mortality trend of ischemic heart disease (2008–2022): A retrospective analysis of epidemiological data
Wolf, S., Schievano, E., Amidei, C. B., Kucher, N., Valerio, L., Barco, S., & Fedeli, U. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.132042 · Cited by 31
Plant-Derived Flavonoids as AMPK Activators: Unveiling Their Potential in Type 2 Diabetes Management through Mechanistic Insights, Docking Studies, and Pharmacokinetics
Moon, D. O. (2024) · Applied Sciences · doi:10.3390/app14198607 · Cited by 40
Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha
Sun, Y., Yang, J., Liu, W., Yao, G., Xu, F., Hayashi, T., Onodera, S., & Ikejima, T. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03572-1 · Cited by 31
The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels
Bayle, M., Neasta, J., Dall’Asta, M., Gautheron, G., Virsolvy, A., Quignard, J., Youl, E., Magous, R., Guichou, J., Crozier, A., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14821 · Cited by 34
Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice
Dedual, M. A., Wueest, S., Borsigova, M., & Konrad, D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2019 · Cited by 33
Genome-wide differential expression profiling of lncRNAs and mRNAs associated with early diabetic cardiomyopathy
Pant, T., Dhanasekaran, A., Bai, X., Zhao, M., Thorp, E. B., Forbess, J. M., Bosnjak, Z. J., & Ge, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-51872-9 · Cited by 31
Differently Expressed Genes (DEGs) Relevant to Type 2 Diabetes Mellitus Identification and Pathway Analysis via Integrated Bioinformatics Analysis
Che, X., Zhao, R., Xu, H., Liu, X., Zhao, S., & Ma, H. (2019) · Medical Science Monitor · doi:10.12659/msm.918407 · Cited by 31
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes
Sun, L., Wang, X., Gu, T., Hu, B., Luo, J., Qin, Y., & Wan, C. (2020) · Toxicology · doi:10.1016/j.tox.2020.152502 · Cited by 31
Therapeutic potential of melatonin as a chronobiotic and cytoprotective agent in diabetes mellitus
Wajid, F., Poolacherla, R., Mim, F. K., Bangash, A., & Rutkofsky, I. H. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00585-2 · Cited by 33
Antisense Oligonucleotides as Potential Therapeutics for Type 2 Diabetes
Chen, S., Sbuh, N., & Veedu, R. N. (2020) · Nucleic Acid Therapeutics · doi:10.1089/nat.2020.0891 · Cited by 30
Screening of novel potential antidiabetic Lactobacillus plantarum strains based on in vitro and in vivo investigations
Zhong, H., Abdullah, Zhang, Y., Zhao, M., Zhang, J., Zhang, H., Xi, Y., Cai, H., & Feng, F. (2020) · LWT · doi:10.1016/j.lwt.2020.110526 · Cited by 31
A Newly Developed Synbiotic Yogurt Prevents Diabetes by Improving the Microbiome–Intestine–Pancreas Axis
Miller, B. C., Mainali, R., Nagpal, R., & Yadav, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041647 · Cited by 33
Efficacy and safety of combination therapy with sodium–glucose cotransporter 2 inhibitors and renin–angiotensin system blockers in patients with type 2 diabetes: a systematic review and meta-analysis
Tian, B., Deng, Y., Cai, Y., Han, M., & Xu, G. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab048 · Cited by 30
Association between nonalcoholic fatty liver disease and incident diabetes mellitus among Japanese: a retrospective cohort study using propensity score matching
Zheng, X., Cao, C., He, Y., Wang, X., Wu, J., & Hu, H. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01485-x · Cited by 31
Sleep Quality and Associated Factors in Adults with Type 2 Diabetes: A Retrospective Cohort Study
Kuo, C., Lu, S., Huang, C., Liao, W., & Lee, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18063025 · Cited by 31
Association between insulin resistance and lung function trajectory over 4 years in South Korea: community-based prospective cohort
Kim, S. H., Kim, H. S., Min, H. K., & Lee, S. W. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01478-7 · Cited by 31
The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes
Lv, S.-Y., Li, X.-T., & Wang, H.-G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663528 · Cited by 29
Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study
Thondre, P. S., Lightowler, H. J., Ahlstrom, L., & Gallagher, A. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00571-2 · Cited by 31
Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data
Gong, R., Liu, Y., Luo, G., Liu, W., Jin, Z., Xu, Z., Li, Z., Yang, L., & Wei, X. (2021) · International Journal of Endocrinology · doi:10.1155/2021/9949579 · Cited by 31
Retinal Vascular Signs as Screening and Prognostic Factors for Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Current Evidence
Aronov, M., Allon, R., Stave, D., Belkin, M., Margalit, E., Fabian, I. D., & Rosenzweig, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11070665 · Cited by 31
Incidence of Diabetic Nephropathy and Its Predictors among Type 2 Diabetes Mellitus Patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Kebede, S. A., Tusa, B. S., Weldesenbet, A. B., Tessema, Z. T., & Ayele, T. A. (2021) · Journal of Nutrition and Metabolism · doi:10.1155/2021/6757916 · Cited by 35
Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice
Cabello-Olmo, M., Oneca, M., Pajares, M. J., Jiménez, M., Ayo, J., Encío, I., Barajas, M., & Araña, M. (2022) · Nutrients · doi:10.3390/nu14030692 · Cited by 33
β-cell mitochondria in diabetes mellitus: a missing puzzle piece in the generation of hPSC-derived pancreatic β-cells?
Diané, A., Al-Shukri, N. A., Mu-u-min, R., & Al-Siddiqi, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03327-5 · Cited by 35
Nailfold capillary patterns correlate with age, gender, lifestyle habits, and fingertip temperature
Nakajima, T., Nakano, S., Kikuchi, A., & Matsunaga, Y. T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269661 · Cited by 30
Enhancement of nutraceutical and anti-diabetic potential of fenugreek (Trigonella foenum-graecum). Sprouts with natural elicitors
Laıla, O., Murtaza, I., Bashir, S. M., Ali, S. I., Ali, S. A., Paray, B. A., Gulnaz, A., Vlădulescu, C., & Mansoor, S. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.11.001 · Cited by 31
Rural-urban disparities in the associations of residential greenness with diabetes and prediabetes among adults in southeastern China
Yu, W., Li, X., Zhong, W., Dong, S., Feng, C., Yu, B., Lin, X., Yin, Y., Chen, T., Yang, S., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160492 · Cited by 35
NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome
Samario-Román, J., Larqué, C., Pánico, P., Ortiz-Huidobro, R. I., Velasco, M., Escalona, R., & Hiriart, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031957 · Cited by 32
Prevalence and Course of Endocrinopathy in POEMS Syndrome
Caimari, F., Keddie, S., Lunn, M. P., D’Sa, S., & Baldeweg, S. E. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01516 · Cited by 31
Predicting three-month fasting blood glucose and glycated hemoglobin changes in patients with type 2 diabetes mellitus based on multiple machine learning algorithms
Tao, X., Jiang, M. H., Liu, Y., Hu, Q., Zhu, B., Hu, J., Guo, W., Wu, X., Xiong, Y., Shi, X., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-43240-5 · Cited by 30
The Future of Patient Education: AI-Driven Guide for Type 2 Diabetes
Hernandez, C. A., Gonzalez, A. E. V., Polianovskaia, A., Sanchez, R. A., Arce, V. M., Mustafa, A., Vypritskaya, E., Gutierrez, O. P., Bashir, M., & Sedeh, A. E. (2023) · Cureus · doi:10.7759/cureus.48919 · Cited by 30
Management of type 2 diabetes in patients with compensated liver cirrhosis: Short of evidence, plenty of potential
Arvanitakis, K., Koufakis, T., Kalopitas, G., Papadakos, S. P., Kotsa, K., & Germanidis, G. S. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102935 · Cited by 33
Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice
Gao, X., Sun, H., Wei, Y.-D., Niu, J., Hao, S., Sun, H., Tang, G., Qi, C., & Ge, J. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155805 · Cited by 31
Evaluation of Dietary Intakes and Nutritional Knowledge in Thai Patients with Type 2 Diabetes Mellitus
Thewjitcharoen, Y., Chotwanvirat, P., Jantawan, A., Siwasaranond, N., Saetung, S., Nimitphong, H., Himathongkam, T., & Reutrakul, S. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9152910 · Cited by 33
Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents
Denova‐Gutiérrez, E., Muñoz-Aguirre, P., López-González, D., Flores, M., Medeiros-Domingo, M., Tamborrel, N., & Clark, P. (2019) · Nutrients · doi:10.3390/nu11092109 · Cited by 30
“Omics” and “epi-omics” underlying the β-cell adaptation to insulin resistance
Jesus, D. F. D., & Kulkarni, R. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.003 · Cited by 33
Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type 2 diabetes mellitus: A systematic review and meta-analysis
Guraya, S. Y., & Strate, T. G. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i8.865 · Cited by 30
Methylglyoxal and soluble RAGE in type 2 diabetes mellitus: Association with oxidative stress
Reyaz, A., Alam, S., Chandra, K., Kohli, S., & Agarwal, S. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00543-y · Cited by 30
The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin
Kopel, J. J., Higuchi, K., Ristić, B., Sato, T., Ramachandran, S., & Ganapathy, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-65621-w · Cited by 30
Momordica charantia silver nanoparticles modulate SOCS/JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats
Elekofehinti, O. O., Oyedokun, V. O., Iwaloye, O., Lawal, A. O., & Ejelonu, O. C. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00739-w · Cited by 30
Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus
Park, C. S., Han, K., Choi, E., Kim, D. H., Lee, H., Lee, S., & Oh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-84307-5 · Cited by 31
Plasma Targeted Metabolomics Analysis for Amino Acids and Acylcarnitines in Patients with Prediabetes, Type 2 Diabetes Mellitus, and Diabetic Vascular Complications
Li, X., Li, Y., Liang, Y., Hu, R., Xu, W., & Liu, Y. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0209 · Cited by 30
White Blood Cell Count as a Predictor of Incident Type 2 Diabetes Mellitus Among Non-Obese Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study
Park, J. M., Lee, H. S., Park, J.-Y., Jung, D., & Lee, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s300026 · Cited by 30
Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish
Lee, H., Gao, Y., Ko, E. J., Lee, J., Lee, H.-K., Lee, S., Choi, M., Shin, S., Park, Y. H., Moon, H., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.125956 · Cited by 30
Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging
Huang, L. T., Zhang, Q., Tang, T., Yang, M., Chen, C., Tao, J., & Liang, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.693890 · Cited by 31
Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches
Cvetko, A., Mangino, M., Tijardović, M., Kifer, D., Falchi, M., Keser, T., Perola, M., Spector, T. D., Lauc, G., Menni, C., et al. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002263 · Cited by 31
Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction
Xiong, L., Chen, L., Wu, L., He, W., Chen, D., Peng, Z., Li, J., Zhu, X., Su, L., Li, Y., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05591-4 · Cited by 31
Genetically Predicted Causality of 28 Gut Microbiome Families and Type 2 Diabetes Mellitus Risk
Xiang, K., Zhang, J., Xu, Y., Zhong, X., Ni, J., & Pan, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.780133 · Cited by 29
Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients
Liu, H., Wang, F., Liu, X., Xie, Y., Xia, H., Wang, S., & Sun, G. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01630-0 · Cited by 30
Shared Molecular Mechanisms among Alzheimer’s Disease, Neurovascular Unit Dysfunction and Vascular Risk Factors: A Narrative Review
Falsetti, L., Viticchi, G., Zaccone, V., Guerrieri, E., Moroncini, G., Luzzi, S., & Silvestrini, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020439 · Cited by 30
Identification of the effective α-amylase inhibitors from Dalbergia odorifera: Virtual screening, spectroscopy, molecular docking, and molecular dynamic simulation
Zhang, J., Ding, W., Tang, Z., Kong, Y., Liu, J., & Cao, X. (2022) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2022.121448 · Cited by 30
Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice
He, X., Wang, C., Zhu, Y., Jiang, X., Qiu, Y., Yin, F., Xiong, W., Liu, B., & Huang, Y. (2022) · Algal Research · doi:10.1016/j.algal.2022.102791 · Cited by 32
Socioeconomic disparities in diabetes prevalence and management among the adult population in Bangladesh
Ahsan, K. Z., Iqbal, A., Jamil, K., Haider, M. M., Khan, S., Chakraborty, N., & Streatfield, P. K. (2022) · PLoS ONE · doi:10.1371/journal.pone.0279228 · Cited by 35
Effects of Metformin, Insulin on Hematological Parameters of COVID-19 Patients with Type 2 Diabetes
Petakh, P., Грига, В. И., Mohammed, I. B., Loshak, K., Poliak, I., & Kamyshnyi, O. (2022) · Medical Archives · doi:10.5455/medarh.2022.76.329-332 · Cited by 30
Nanomaterials for diabetic wound healing: Visualization and bibliometric analysis from 2011 to 2021
Zhang, J., Liu, H., Che, T., Yin, Z., Nan, X., & Wu, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1124027 · Cited by 30
Schizophrenia as a risk factor for cardiovascular and metabolic health outcomes: a comparative risk assessment
Ali, S., Santomauro, D. F., Ferrari, A. J., & Charlson, F. (2023) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796023000045 · Cited by 33
Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate
Su, J., Tang, L., Luo, Y., Xu, J., & Ouyang, S. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115830 · Cited by 32
Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca2+ Leak Directed to Mitochondria in Pancreatic Islets and beta-Cells
Klec, C., Madreiter‐Sokolowski, C. T., Stryeck, S., Sachdev, V., Duta-Mare, M., Gottschalk, B., Depaoli, M. R., Rost, R., Hay, J., Waldeck‐Weiermair, M., et al. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000005 · Cited by 30
Effect of dual PPAR-α/γ agonist saroglitazar on diabetic retinopathy and oxygen-induced retinopathy
Joharapurkar, A. A., PATEL, V. G., Kshirsagar, S. G., Patel, M. S., Savsani, H. H., & Jain, M. R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174032 · Cited by 29
A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management
Aedh, A. I., Alshahrani, M. S., Huneif, M. A., Pryme, I. F., & Oruch, R. (2023) · Nutrients · doi:10.3390/nu15040921 · Cited by 33
Comprehensive Extraction and Chemical Characterization of Bioactive Compounds in Tepals of Crocus sativus L.
Ruggieri, F., Maggi, M. A., Rossi, M., & Consonni, R. (2023) · Molecules · doi:10.3390/molecules28165976 · Cited by 29
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus
Le, J., Chen, Y., Yang, W., Chen, L., & Ye, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.004 · Cited by 30
Prevalence of Complementary and Alternative Medicine Use and Its Associated Factors among Iranian Diabetic Patients: A Cross-Sectional Study
Ghorat, F., Mosavat, S. H., Hadigheh, S., Kouhpayeh, S. A., Naghizadeh, M. M., Rashidi, A. A., & Hashempur, M. H. (2024) · Current Therapeutic Research · doi:10.1016/j.curtheres.2024.100746 · Cited by 29
Advanced microbiome therapeutics as a novel modality for oral delivery of peptides to manage metabolic diseases
Vazquez-Uribe, R., Hedin, K. A., Licht, T. R., Nieuwdorp, M., & Sommer, M. O. A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.04.021 · Cited by 26
Potential Role of Phytochemicals as Glucagon-like Peptide 1 Receptor (GLP-1R) Agonists in the Treatment of Diabetes Mellitus
Abiola, J. O., Oluyemi, A. A., Idowu, O. T., Oyinloye, O. M., Ubah, C. S., Owolabi, O. V., Somade, O. T., Onikanni, S. A., Ajiboye, B. O., Osunsanmi, F. O., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17060736 · Cited by 35
Disuse-induced insulin resistance susceptibility coincides with a dysregulated skeletal muscle metabolic transcriptome
Mahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Stubben, C., Howard, M. T., & Drummond, M. J. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01093.2018 · Cited by 29
Major Depression and Comorbid Diabetes - Findings from the European Group for the Study of Resistant Depression
Fugger, G., Dold, M., Bartova, L., Kautzky, A., Souery, D., Mendlewicz, J., Serretti, A., Zohar, J., Montgomery, S., Frey, R., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109638 · Cited by 30
The association between sleep efficiency and diabetes mellitus in community‐dwelling individuals with or without sleep‐disordered breathing
Yan, B., Zhao, B., Fan, Y., Yang, J., Zhu, F., Chen, Y., & Ma, X. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12987 · Cited by 29
Effect of intravitreal ranibizumab pretreatment on vitrectomy in young patients with proliferative diabetic retinopathy
Chen, H., Wang, C., Dou, H., Feng, X., Xu, Y., & Ma, Z. (2020) · Annals of Palliative Medicine · doi:10.21037/apm.2020.01.10 · Cited by 29
Single-Anastomosis Duodenal Jejunal Bypass Improve Glucose Metabolism by Regulating Gut Microbiota and Short-Chain Fatty Acids in Goto-Kakisaki Rats
Yu, X., Wu, Z., Song, Z., Zhang, H., Zhan, J., Yu, H., Huang, H., Yang, B., Xie, L., Dai, X., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00273 · Cited by 30

Authors: Zheng, Y., Ley, S. H., & Hu, F. B.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: Hu, Frank B.
ORCID: Zheng, Yan
Ley, Sylvia H.
Hu, Frank B.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2017-12-08
Volume: 14
Issue: 2
Pages: 88-98
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2017.151
OpenAlex: W2774743973
Cited by: 5,697
References: 156
Citations by year: 2026: 476 · 2025: 771 · 2024: 926 · 2023: 899 · 2022: 858 · 2021: 781 · 2020: 596 · 2019: 302 · 2018: 79
FWCI: 38.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 2 diabetes, global epidemiology, diabetes complications, cardiovascular complications, risk factors, dietary risk factors, lifestyle risk factors, sedentary lifestyle, unhealthy diet, genetic susceptibility, prenatal exposure, diabetes prevention, body weight, physical activity, smoking, alcohol consumption, diabetes mortality, Asia
MeSH terms: Diabetes Mellitus, Type 2, Diet, Humans, Life Style, Morbidity, Risk Factors, Global Health, Disease Management, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks