Cited by 5,697Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Zheng, Yan, Ley, Sylvia H., Hu, Frank B.·2018·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2017.151

Open this paper in CoChat — free account

Abstract

Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life. Many cases of T2DM could be prevented with lifestyle changes, including maintaining a healthy body weight, consuming a healthy diet, staying physically active, not smoking and drinking alcohol in moderation. Most patients with T2DM have at least one complication, and cardiovascular complications are the leading cause of morbidity and mortality in these patients. This Review provides an updated view of the global epidemiology of T2DM, as well as dietary, lifestyle and other risk factors for T2DM and its complications.

Integrity signals

Registry

Crossref · 10.1038/nrendo.2017.151

Cites

156 of 156 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
Retracted
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.
Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070
International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,379
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Vos, T., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32154-2 · Cited by 13,220
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
(2015) · The Lancet · doi:10.1016/s0140-6736(14)61682-2 · Cited by 7,439

Flagged first, then by citations

Show all 156 references

Research works printed but not linked: 2

International Diabetes Federation. IDF Diabetes Atlas — 7th Edition. DiabetesAtlas http://www.diabetesatlas.org/ (2015).
Al-Siyabi, H., Al-Anquodi, Z., Al-Hinai, H. & Al-Hinai, S. Nizwa Healthy Lifestyle Project Evaluation Report 2010 (Ad Dakhiliyah, Oman: Ministry of Health, 2010).

Sorted by citations

Items 501–600 of 1,018

Capsaicin improves glucose homeostasis by enhancing glucagon‐like peptide‐1 secretion through the regulation of bile acid metabolism via the remodeling of the gut microbiota in male mice
Hui, S., Huang, L., Wang, X., Zhu, X., Zhou, M., Chen, M., Yi, L., & Mi, M. (2020) · The FASEB Journal · doi:10.1096/fj.201902618rr · Cited by 48
Effects of single bout resistance exercise on glucose levels, insulin action, and cardiovascular risk in type 2 diabetes: A narrative review
Brown, E. C., Franklin, B. A., Regensteiner, J. G., & Stewart, K. J. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107610 · Cited by 49
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y., Dong, X., Li, W., & Li, W. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12076 · Cited by 47
Effects of Plant-Based Diets on Weight Status in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Austin, G., Ferguson, J. J. A., & Garg, M. L. (2021) · Nutrients · doi:10.3390/nu13114099 · Cited by 47
A smart hydrogel patch with high transparency, adhesiveness and hemostasis for all-round treatment and glucose monitoring of diabetic foot ulcers
Liu, H., Li, Z., Che, S., Feng, Y., Guan, L., Yang, X., Zhao, Y., Wang, J., Zvyagin, A. V., Yang, B. J., et al. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01048h · Cited by 50
Diabetes Mellitus Is a Chronic Disease that Can Benefit from Therapy with Induced Pluripotent Stem Cells
Arroyave, F., Montaño, D., & Lizcano, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228685 · Cited by 52
Diabetes and Heart Failure: Multi-Omics Approaches
Tayanloo-Beik, A., Roudsari, P. P., Rezaei–Tavirani, M., Biglar, M., Tabatabaei‐Malazy, O., Arjmand, B., & Larijani, B. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.705424 · Cited by 46
Effect of educational interventions on knowledge of the disease and glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials
Shiferaw, W. S., Akalu, T. Y., Desta, M., Kassie, A. M., Petrucka, P. M., & Aynalem, Y. A. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049806 · Cited by 70
Associations between the fast-food environment and diabetes prevalence in the Netherlands: a cross-sectional study
Ntarladima, A.-M., Karssenberg, D., Poelman, M., Grobbee, D. E., Lü, M., Schmitz, O., Strak, M., Janssen, N., Hoek, G., & Vaartjes, I. C. H. (2022) · The Lancet Planetary Health · doi:10.1016/s2542-5196(21)00298-9 · Cited by 46
Association between hypoglycemia and dementia in patients with diabetes: a systematic review and meta-analysis of 1.4 million patients
Huang, L., Zhu, M., & Ji, J. (2022) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-022-00799-9 · Cited by 46
Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review
Stachura, A., Khanna, I., Krysiak, P., Paskal, W., & Wlodarski, P. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158621 · Cited by 53
Cassiae Semen: A comprehensive review of botany, traditional use, phytochemistry, pharmacology, toxicity, and quality control
Chen, Y., Chen, X., Yang, X., Gao, P., Yue, C., Wang, L., Wu, T., Jiang, T., Wu, H., Wang, Z., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116199 · Cited by 46
Timing of Exposure and Bisphenol-A: Implications for Diabetes Development
Tudurí, E., Marroquí, L., dos Santos, R. S., Quesada, I., Fuentes, E., & Alonso‐Magdalena, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00648 · Cited by 47
Microvascular complications among patients with diabetes: An emerging health problem in Saudi Arabia
Robert, A. A., & Dawish, M. A. A. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118820714 · Cited by 47
Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney Disease
Carré, J. E., & Affourtit, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112751 · Cited by 46
Efficacy of adjunctive photodynamic therapy on the clinical periodontal, HbA1c and advanced glycation end product levels among mild to moderate chronic periodontal disease patients with type 2 diabetes mellitus: A randomized controlled clinical trial
Mirza, S., Khan, A. A., Kheraif, A. A. A., Khan, S. Z., & Shafqat, S. S. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.08.003 · Cited by 49
High Mobility Group Box-1 and Diabetes Mellitus Complications: State of the Art and Future Perspectives
Biscetti, F., Rando, M. M., Nardella, E., Cecchini, A. L., Pecorini, G., Landolfi, R., & Flex, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246258 · Cited by 45
Evaluation of carvacrol on pituitary and sexual hormones and their receptors in the testicle of male diabetic rats
Shoorei, H., Khaki, A., Shokoohi, M., Khaki, A., Alihemmati, A., Moghimian, M., & Abtahi-Eivary, S.-H. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120909525 · Cited by 46
Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats
Lei, X., Huo, P., Wang, Y., Xie, Y., Shi, Q., Tu, H., Yao, J., Mo, Z., & Zhang, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00164 · Cited by 49
Zein-based nanoparticles for the oral delivery of insulin
Inchaurraga, L., Martínez‐López, A. L., Martín‐Arbella, N., & Irache, J. M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00796-3 · Cited by 46
Association of moderate and vigorous physical activity with incidence of type 2 diabetes and subsequent mortality: 27 year follow-up of the Whitehall II study
Yerramalla, M. S., Fayosse, A., Dugravot, A., Tabak, A. G., Kivimäki, M., Singh-Manoux, A., & Sabia, S. (2020) · Diabetologia · doi:10.1007/s00125-019-05050-1 · Cited by 45
Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy
Wang, M., Zhang, Z., Huo, Q., Wang, M., Sun, Y., Liu, H., Chang, J., He, B., & Liang, Y. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c22964 · Cited by 46
Identification of cross-talk pathways and ferroptosis-related genes in periodontitis and type 2 diabetes mellitus by bioinformatics analysis and experimental validation
Pan, S., Hu, B., Sun, J., Yang, Z., Yu, W., He, Z., Gao, X., & Song, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1015491 · Cited by 45
Diabetes risk prediction model based on community follow-up data using machine learning
Jiang, L., Xia, Z., Zhu, R., Gong, H., Wang, J., Li, J., & Wang, L. (2023) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2023.102358 · Cited by 45
The Health Effects of Low Glycemic Index and Low Glycemic Load Interventions on Prediabetes and Type 2 Diabetes Mellitus: A Literature Review of RCTs
Peres, M., Costa, H. S., Silva, M. A., & Albuquerque, T. G. (2023) · Nutrients · doi:10.3390/nu15245060 · Cited by 58
An updated systematic review and Meta-analysis of the prevalence of type 2 diabetes in Iran, 1996–2023
Hazar, N., Jokar, M., Namavari, N., Hosseini, S., & Rahmanian, V. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1322072 · Cited by 47
Association of C-peptide with diabetic vascular complications in type 2 diabetes
Wang, Y. A., Wan, H., Chen, Y., Xia, F., Zhang, W., Wang, C., Fang, S., Zhang, K., Li, Q., Wang, N., et al. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.04.004 · Cited by 45
Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions
Payne, S. C., Ward, G. M., MacIsaac, R. J., Hyakumura, T., Fallon, J. B., & Villalobos, J. (2020) · Physiological Reports · doi:10.14814/phy2.14479 · Cited by 44
Clinical, bacterial, and inflammatory outcomes of indocyanine green-mediated photodynamic therapy for treating periimplantitis among diabetic patients: A randomized controlled clinical trial
Labban, N. Y., Al‐Shibani, N., Al‐Kattan, R., Alfouzan, A. F., Binrayes, A., & Assery, M. K. A. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102350 · Cited by 45
Glucagon‐like peptide‐1 analogues and thyroid cancer: An analysis of cases reported in the European pharmacovigilance database
Mali, G., Ahuja, V., & Dubey, K. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13259 · Cited by 44
Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice
Corezola do Amaral, M. E., Kravets, V., Dwulet, J. M., Farnsworth, N. L., Piscopio, R., Schleicher, W. E., Miranda, J. G., & Benninger, R. K. P. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00132.2020 · Cited by 41
Diabetes and coronary artery disease: not just a risk factor
Grant, P. J., Cosentino, F., & Marx, N. (2020) · Heart · doi:10.1136/heartjnl-2019-316243 · Cited by 45
Diabetes mellitus and poor glycemic control increase the occurrence of coronal and root caries: a systematic review and meta-analysis
de Lima, A. K. A., dos Santos, J. A., Stefani, C. M., de Lima, A. D. A., & Damé‐Teixeira, N. (2020) · Clinical Oral Investigations · doi:10.1007/s00784-020-03531-x · Cited by 44
Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans
Park, S. J., Park, Y. J., Chang, J., Choi, S., Lee, G., Son, J. S., Kim, K. H., Oh, Y. H., & Park, S. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-01125-5 · Cited by 44
The effects of butyrate supplementation on glycemic control, lipid profile, blood pressure, nitric oxide level and glutathione peroxidase activity in type 2 diabetic patients: A randomized triple -blind, placebo-controlled trial
Khosravi, Z., Hadi, A., Tutunchi, H., Jafarabadi, M. A., Naeinie, F., Roshanravan, N., Ostadrahimi, A., & Fadel, A. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.03.008 · Cited by 45
Global, regional, and national burden and quality of care index in children and adolescents: A systematic analysis for the global burden of disease study 1990–2017
Hanifiha, M., Ghanbari, A., Keykhaei, M., Moghaddam, S. S., Rezaei, N., Zanous, M. P., Yoosefi, M., Ghasemi, E., Rezaei, N., Shahin, S., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267596 · Cited by 44
Incidence of Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease
Newton, K. P., Wilson, L., Crimmins, N. A., Fishbein, M. H., Molleston, J. P., Xanthakos, S. A., Behling, C., Schwimmer, J. B., Garner, D., Hertel, P. M., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.05.028 · Cited by 45
Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-β signaling
Zhang, Y., Cao, Y., Zheng, R., Xiong, Z., Zhu, Z., Gao, F., Man, W., Duan, Y., Lin, J. M., Zhang, X., et al. (2022) · Theranostics · doi:10.7150/thno.77043 · Cited by 44
Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence
Mokgalaboni, K., Lebelo, S. L., Modjadji, P., & Ghaffary, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1132650 · Cited by 44
Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Yuan, S., Li, X., Liu, Q., Wang, Z., Jiang, X., Burgess, S., & Larsson, S. C. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad090 · Cited by 51
The role and mechanisms of microvascular damage in the ischemic myocardium
Zhao, B.-H., Ruze, A., Zhao, L., Li, Q., Tang, J. Y., Xiefukaiti, N., Gai, M.-T., Deng, A.-X., Shan, X.-F., & Gao, X.-M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04998-z · Cited by 55
Precisely Constructing Renal-Clearable and LAP-Activatable Ratiometric Molecular Probes for Early Diagnosis of Acute and Chronic Kidney Injury Via Optimizing Asymmetric DPP Dyes
Wang, N., Lu, X., Wang, J., Fan, G., Han, R., Zhang, B., Zhao, W., & Zhang, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c03967 · Cited by 44
Identification and molecular mechanism of novel hypoglycemic peptide in ripened pu-erh tea: Molecular docking, dynamic simulation, and cell experiments
Wang, T., Bo, N., Sha, G., Guan, Y., Yang, D., Shan, X., Lv, Z., Chen, Q., Yang, G., Gong, S., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114930 · Cited by 44
Unveiling diabetes onset: Optimized XGBoost with Bayesian optimization for enhanced prediction
Khurshid, M. R., Manzoor, S., Sadiq, T., Hussain, L., Khan, M. S., & Dutta, A. K. (2025) · PLoS ONE · doi:10.1371/journal.pone.0310218 · Cited by 56
lncRNA Gm10451 regulates PTIP to facilitate iPSCs-derived β-like cell differentiation by targeting miR-338-3p as a ceRNA
Huang, Y. H., Xu, Y., Lu, Y., Zhu, S., Guo, Y., Sun, C., Xu, L., Chen, X., Zhao, Y., Yu, B., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119266 · Cited by 43
Dyslipidaemia prevalence and associated risk factors in the United Arab Emirates: a population-based study
Mahmoud, I., & Sulaiman, N. D. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031969 · Cited by 44
Chronic hyperglycemia induces tau hyperphosphorylation by downregulating OGT-involved O-GlcNAcylation in vivo and in vitro
Huang, R., Tian, S., Zhang, H., Zhu, W., & Wang, S. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.006 · Cited by 44
Efficacy of inulin supplementation in improving insulin control, HbA1c and HOMA-IR in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
Zhang, W., Tang, Y., Huang, J., Yang, Y., Qin-bing, Y., & Hu, H. (2020) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.19-103 · Cited by 47
Ginsenoside Re Attenuates High Glucose-Induced RF/6A Injury via Regulating PI3K/AKT Inhibited HIF-1α/VEGF Signaling Pathway
Xie, W., Zhou, P., Qu, M., Dai, Z., Zhang, X., Zhang, C., Dong, X., Sun, G., & Sun, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00695 · Cited by 44
Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention
Nagarathna, R., Bali, P., Anand, A., Srivastava, V., Patil, S. S., Sharma, G., Manasa, K., Pannu, V. S., Singh, A., & Nagendra, H. R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.507064 · Cited by 55
Impact of spirulina supplementation on obesity-related metabolic disorders: A systematic review and meta-analysis of randomized controlled trials
Bohórquez-Medina, S. L., Bohórquez-Medina, A. L., Benites-Zapata, V. A., Ignacio-Cconchoy, F. L., Toro-Huamanchumo, C. J., Bendezú-Quispe, G., Pacheco‐Mendoza, J., & Hernández, A. V. (2021) · NFS Journal · doi:10.1016/j.nfs.2021.09.003 · Cited by 48
Design and synthesis of new benzylidene-quinazolinone hybrids as potential anti-diabetic agents: In vitro α-glucosidase inhibition, and docking studies
Khalifa, M. M., Sakr, H. M., Ibrahim, A., Mansour, A. M., & Ayyad, R. R. A. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.131768 · Cited by 44
Microbiological effects in patients with leg ulcers and diabetic foot treated with Lucilia sericata larvae
Szczepanowski, Z., Grabarek, B. O., Boroń, D., Tukiendorf, A., Kulik‐Parobczy, I., & Miszczyk, L. (2021) · International Wound Journal · doi:10.1111/iwj.13605 · Cited by 43
Prevalence, awareness, treatment, and control of type 2 diabetes mellitus among the adult residents of tehran: Tehran Cohort Study
Oraii, A., Shafiee, A., Jalali, A., Alaeddini, F., Saadat, S., Masoudkabir, F., Vasheghani‐Farahani, A., Heidari, A., Sadeghian, S., Boroumand, M. A., et al. (2022) · BMC Endocrine Disorders · doi:10.1186/s12902-022-01161-w · Cited by 44
The Mechanism of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Uric Acid in Type 2 Diabetes Mellitus
Dong, M., Chen, H., Wen, S., Yuan, Y., Yang, L., Xu, D., & Zhou, L. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s399343 · Cited by 46
Selenium, diabetes, and their intricate sex-specific relationship
Demircan, K., Chillon, T. S., Bang, J., Gladyshev, V. N., & Schomburg, L. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.03.004 · Cited by 45
Sodium butyrate improves renal injury in diabetic nephropathy through AMPK/SIRT1/PGC-1α signaling pathway
Ye, K., Zhao, Y., Huang, W. Y., & Zhu, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-68227-8 · Cited by 43
Gene-Activating Framework Nucleic Acid-Targeted Upregulating Sirtuin-1 to Modulate Osteoimmune Microenvironment for Diabetic Osteoporosis Therapeutics
Cai, Z., Bai, L., Li, Q., Li, Y., Cai, X., & Lin, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c08727 · Cited by 46
Effects of mycoprotein on glycaemic control and energy intake in humans: a systematic review
Cherta-Murillo, A., Lett, A. M., Frampton, J. E., Chambers, E. S., Finnigan, T. J. A., & Frost, G. S. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000756 · Cited by 43
Curcumin derivatives for Type 2 Diabetes management and prevention of complications
Oliveira, S., Monteiro‐Alfredo, T., Silva, S., & Matafome, P. N. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01240-3 · Cited by 43
Date palm (Phoenix dactylifera L.) fruit's polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes
Châari, A., Abdellatif, B., Nabi, F., & Khan, R. H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.080 · Cited by 43
A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review
Vayghan, H. J., Varshosaz, P., Hajizadeh‐Sharafabad, F., Razmi, H., Amirpour, M., Tavakoli‐Rouzbehani, O. M., Alizadeh, M., & Maleki, V. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00503-6 · Cited by 44
Effects of a health education program to promote healthy lifestyle and glycemic control in patients with type 2 diabetes: A randomized controlled trial
Sanaeinasab, H., Saffari, M., Yazdanparast, D., Zarchi, A. A. K., Al‐Zaben, F., Koenig, H. G., & Pakpour, A. H. (2020) · Primary care diabetes · doi:10.1016/j.pcd.2020.09.007 · Cited by 49
A prediction nomogram for the 3-year risk of incident diabetes among Chinese adults
Wu, Y., Hu, H., Cai, J., Chen, R., Zuo, X., Cheng, H. W., & Yan, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-78716-1 · Cited by 42
Long-Acting Metformin Vs. Metformin Immediate Release in Patients With Type 2 Diabetes: A Systematic Review
Tan, J., Wang, Y., Liu, S., Shi, Q., Zhou, X., Zhou, Y., Yang, X., Chen, P., & Li, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.669814 · Cited by 43
A 2021 Update on the Use of Liraglutide in the Modern Treatment of ‘Diabesity’: A Narrative Review
Tilinca, M. C., Tiucă, R. A., Burlacu, A., & Varga, A. (2021) · Medicina · doi:10.3390/medicina57070669 · Cited by 45
Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms
Savarese, G., Butler, J., Lund, L. H., Bhatt, D. L., & Anker, S. D. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab271 · Cited by 45
Do gene–environment interactions have implications for the precision prevention of type 2 diabetes?
Sørensen, T. I. A., Metz, S., & Kilpeläinen, T. O. (2022) · Diabetologia · doi:10.1007/s00125-021-05639-5 · Cited by 43
Psidium guajava L.: A Systematic Review of the Multifaceted Health Benefits and Economic Importance
Takeda, L. N., Laurindo, L. F., Guiguer, É. L., Bishayee, A., Araújo, A. C., Úbeda, L. C. C., Goulart, R. D. Á., & Barbalho, S. M. (2022) · Food Reviews International · doi:10.1080/87559129.2021.2023819 · Cited by 44
Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes
Gu, J., Wu, Y., Huang, W., Fan, X., Chen, X., Zhou, B., Lin, Z., & Feng, X. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24430 · Cited by 43
β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?
Knudsen, J. G., & Rorsman, P. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.015 · Cited by 42
Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review
Mahdavi, A., Bagherniya, M., Mirenayat, M. S., Atkin, S. L., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_13 · Cited by 44
The global burden of type 2 diabetes attributable to high body mass index in 204 countries and territories, 1990–2019: An analysis of the Global Burden of Disease Study
Zhang, X., Wang, X., Wang, M., Hu, B., Tang, W. F., Wu, Y., Gu, J., Tian, N., & Li, Q. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.966093 · Cited by 44
Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases
Lima, C., Falcão, M. A. P., da Rosa, J. G. S., Disner, G. R., & Lopes‐Ferreira, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012402 · Cited by 42
Assessment of drug related problems among type 2 diabetes mellitus patients with hypertension in Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia
Ayele, Y., Melaku, K., Dechasa, M., Ayalew, M. B., & Horsa, B. A. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3838-z · Cited by 42
Serum sclerostin and irisin as predictive markers for atherosclerosis in Egyptian type II diabetic female patients: A case control study
Saadeldin, M. K., Elshaer, S. S., Emara, I. A., Maged, M., & Abdel‐Aziz, A. K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206761 · Cited by 45
Regulation of insulin resistance by targeting the insulin‐like growth factor 1 receptor with microRNA‐122‐5p in hepatic cells
Dong, L., Hou, X., Liu, F., Tao, H., Zhang, Y., Zhao, H., & Song, G. (2019) · Cell Biology International · doi:10.1002/cbin.11129 · Cited by 44
Cigarette Smoking and Mortality in Patients With Pancreatic Cancer
Ben, Q., Liu, J., Sun, Y., Wang, L., Zou, D., & Yuan, Y. (2019) · Pancreas · doi:10.1097/mpa.0000000000001383 · Cited by 42
BuZangTongLuo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice
Zheng, J., Chen, M., Ye, C., Sun, X., Jiang, N., Zou, X., Yang, H., & Liu, H. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112330 · Cited by 42
The Effect of Vitamin D Supplementation on Insulin Sensitivity: A Systematic Review and Meta-analysis
Pramono, A., Jocken, J. W. E., Blaak, E. E., & van Baak, M. A. (2020) · Diabetes Care · doi:10.2337/dc19-2265 · Cited by 43
The association of the level of self-care on adherence to treatment in patients diagnosed with type 2 diabetes
Krzemińska, S. A., Lomper, K., Chudiak, A., Ausili, D., & Uchmanowicz, I. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01628-z · Cited by 42
Fluorophore-Dapagliflozin Dyad for Detecting Diabetic Liver/Kidney Damages via Fluorescent Imaging and Treating Diabetes via Inhibiting SGLT2
Yu, W., Huang, J., Lin, M., Wei, G., Yang, F., Tang, Z., Zeng, F., & Wu, S. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00223 · Cited by 42
The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review
Zhao, C., Wu, X., Yi, H., Chen, R., & Fan, G. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100033 · Cited by 43
Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes
Öhman, T., Teppo, J., Datta, N., Mäkinen, S., Varjosalo, M. T., & Koistinen, H. A. (2021) · iScience · doi:10.1016/j.isci.2021.102712 · Cited by 39
Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?
Shoshan‐Barmatz, V., Anand, U., Crystal, E. N., Carlo, M. D., & Shteinfer‐Kuzmine, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730048 · Cited by 42
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis
Li, Y., Chen, Q., Liu, Y., Bi, L., Jin, L., Xu, K., & Peng, R. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01731-2 · Cited by 42
Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study
Jin, X., Chen, Y., Feng, H., Zhou, M., Chan, J. W. Y., Liu, Y., Kong, A. P. S., Tan, X., Wing, Y.-K., Liang, Y. Y., et al. (2024) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.03.001 · Cited by 42
Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus
Mohamadi, M., Ghaedi, H., Kazerouni, F., Omidvar, M. E., Kalbasi, S., Shanaki, M., Miraalamy, G., & Rahimipour, A. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1664760 · Cited by 41
An Organ-Specific Metabolite Annotation Approach for Ambient Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations of a Whole Mouse Body
Zhu, Y., Zang, Q., Luo, Z., He, J., Zhang, R., & Abliz, Z. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00557 · Cited by 44
Potential role of Limosilactobacillus fermentum as a probiotic with anti-diabetic properties: A review
Lacerda, D. C., da Costa, P. C. T., Pontes, P. B., dos Santos, L. A. C., Neto, J. P. R. C., Silva-Luis, C. C., Brito, V. P. D. S., & Alves, J. L. D. B. (2022) · World Journal of Diabetes · doi:10.4239/wjd.v13.i9.717 · Cited by 43
Challenges of Type 2 Diabetes Mellitus Management From the Perspective of Patients: Conventional Content Analysis
Nikpour, S., Mehrdad, N., Sanjari, M., Aalaa, M., Heshmat, R., Mafinejad, M. K., Larijani, B. A., Nomali, M., & Ghezeljeh, T. N. (2022) · Interactive Journal of Medical Research · doi:10.2196/41933 · Cited by 47
Long‐Term Activation of Glucagon‐like peptide‐1 receptor by Dulaglutide Prevents Diabetic Heart Failure and Metabolic Remodeling in Type 2 Diabetes
Xie, S., Zhang, M., Shi, W., Xing, Y., Huang, Y. Q., Fang, W., Liu, S., Chen, M., Zhang, T., Chen, S., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026728 · Cited by 42
Role of potential bioactive metabolites from traditional Chinese medicine for type 2 diabetes mellitus: An overview
Li, X., Geng-Ji, J.-J., Quan, Y.-Y., Qi, L., Sun, Q., Huang, Q., Jiang, H., Sun, Z., Liu, H., & Xie, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1023713 · Cited by 45
Physiological effects of resistant starch and its applications in food: a review
Han, J., Wu, J., Liu, X., JianRong, S., & Xu, J. (2023) · Food Production Processing and Nutrition · doi:10.1186/s43014-023-00156-x · Cited by 51
Osteogenesis of bone marrow mesenchymal stem cell in hyperglycemia
Luo, M., Zhao, Z., & Yi, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150068 · Cited by 43
20(R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis
Li, W., Li, W., Chang, W.-G., Shi, H., Zhang, W.-X., Wang, Z., & Li, W. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156202 · Cited by 41
Global, regional, and national trends in type 2 diabetes mellitus burden among adolescents and young adults aged 10–24 years from 1990 to 2021: a trend analysis from the Global Burden of Disease Study 2021
Xu, S., Sun, M., & Xiang, Y. (2025) · World Journal of Pediatrics · doi:10.1007/s12519-024-00861-8 · Cited by 51
Plant Derived Exosome-Like Nanoparticles and Their Therapeutic Applications in Glucolipid Metabolism Diseases
Liu, R., Zhang, F., He, X., & Huang, K. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12480 · Cited by 51
Glucose-lowering and hypolipidemic activities of polysaccharides from Cordyceps taii in streptozotocin-induced diabetic mice
Liu, R., Dai, R., Luo, Y., & Xiao, J. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2646-x · Cited by 41
Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank
Tan, X. W., Ciuculete, D. M., Schiöth, H. B., & Benedict, C. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12994 · Cited by 41

Authors: Zheng, Y., Ley, S. H., & Hu, F. B.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: Hu, Frank B.
ORCID: Zheng, Yan
Ley, Sylvia H.
Hu, Frank B.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2017-12-08
Volume: 14
Issue: 2
Pages: 88-98
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2017.151
OpenAlex: W2774743973
Cited by: 5,697
References: 156
Citations by year: 2026: 476 · 2025: 771 · 2024: 926 · 2023: 899 · 2022: 858 · 2021: 781 · 2020: 596 · 2019: 302 · 2018: 79
FWCI: 38.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 2 diabetes, global epidemiology, diabetes complications, cardiovascular complications, risk factors, dietary risk factors, lifestyle risk factors, sedentary lifestyle, unhealthy diet, genetic susceptibility, prenatal exposure, diabetes prevention, body weight, physical activity, smoking, alcohol consumption, diabetes mortality, Asia
MeSH terms: Diabetes Mellitus, Type 2, Diet, Humans, Life Style, Morbidity, Risk Factors, Global Health, Disease Management, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks