The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Uncovering cryptic genetic variation
Abstract
Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations, and is thought to modify the penetrance of common diseases, the response of livestock and crops to artificial selection and the capacity of populations to respond to the emergence of a potentially advantageous macro-mutation. We argue in this review that cryptic genetic variation is pervasive but under-appreciated, we highlight recent progress in determining the nature and identity of genes that underlie cryptic genetic effects and we outline future research directions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This is as true of threshold-dependent characters and cryptic variation93 as it is of continuous variation.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [93]
Citations
Cites
Introduction to Quantitative Genetics.
Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447
The genetical theory of natural selection
Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
Genetics and Analysis of Quantitative Traits
(2002) · Journal of Animal Breeding and Genetics · doi:10.1046/j.1439-0388.2002.00356.x · Cited by 6,176
Introduction to Quantitative Genetics
J.-M., G., & Falconer, D. S. (1962) · Population · doi:10.2307/1525780 · Cited by 3,773
Hsp90 as a capacitor for morphological evolution
Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138
A vision for the future of genomics research
Collins, F. S., Green, E. D., Guttmacher, A. E., Guyer, M. S., & on behalf of the US National Human Genome Research Institute (2003) · Nature · doi:10.1038/nature01626 · Cited by 1,752
McAlpine, J. F., Peterson, B. V., Shewell, G. E., Teskey, H. J., Vockeroth, J. R., & Wood, D. M. (1981) · Research Branch, Agriculture Canada, eBooks · Cited by 1,611
Genetics of gene expression surveyed in maize, mouse and man
Schadt, E. E., Monks, S. A., Drake, T. A., Lusis, A. J., Che, N., Colinayo, V. V., Ruff, T. G., Milligan, S. B., Lamb, J. R., Cavet, G., et al. (2003) · Nature · doi:10.1038/nature01434 · Cited by 1,501
GENETIC ASSIMILATION OF AN ACQUIRED CHARACTER
Waddington, C. H. (1953) · Evolution · doi:10.1111/j.1558-5646.1953.tb00070.x · Cited by 1,494
Research works printed but not linked: 5
- Ptashne, M. A Genetic Switch: Phage Lambda and Higher Organisms (Blackwell Scientific, Oxford, 1992).
- Dworkin, I. in Variation (eds Hallgrimsson, B. & Hall, B. K.) Ch. 14 (Academic, San Francisco, 2004).
- Gibson, G. et al. Extensive non-additivity of gene expression in Drosophila. Genetics (in the press).
- Waddington, C. H. The Stratgey of the Genes (Allen and Unwin, London, 1957).
- Rendel, J. M. Canalization and gene control. (Logos, New York, 1967).
Cited by
Sorted by citations
Adaptation from standing genetic variation
BARRETT, R., & SCHLUTER, D. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2007.09.008 · Cited by 2,091
Sporns, O., & Betzel, R. F. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033634 · Cited by 1,334
“In genetics, such external fluctuations could relate to the effects of cryptic genetic variation, which uncovers novel phenotypes under conditions of environmental change (Gibson & Dworkin 2004), thus potentially promoting increased robustness.”
BackgroundRare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278
“This is as true of threshold-dependent characters and cryptic variation”
BackgroundSelf-citationEarly Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?
Hanson, M. A., & Gluckman, P. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00029.2013 · Cited by 1,188
Phenotypic plasticity's impacts on diversification and speciation
Pfennig, D. W., Wund, M. A., Snell-Rood, E. C., Cruickshank, T., Schlichting, C. D., & Moczek, A. P. (2010) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2010.05.006 · Cited by 1,170
Metadata
- Authors
- Gibson, G., & Dworkin, I.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Gibson, Greg
- Venue
- Nature Reviews Genetics
- Published
- 2004-09
- Volume
- 5
- Issue
- 9
- Pages
- 681-690
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2079319076
- Cited by
- 546
- References
- 90
- Citations by year
- 2026: 21 · 2025: 15 · 2024: 22 · 2023: 19 · 2022: 14 · 2021: 24 · 2020: 32 · 2019: 30 · 2018: 28 · 2017: 18 · 2016: 40 · 2015: 38 · 2014: 28 · 2013: 36 · 2012: 34
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- cryptic genetic variation, susceptibility genes, gene perturbation, selective breeding, disease penetrance, adaptive potential
- MeSH terms
- Animals, Drosophila melanogaster, Selection, Genetic, Genetic Variation, Linkage Disequilibrium, Quantitative Trait, Heritable
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
