Cited by 546Evolution and Genetic DynamicsGenetic and phenotypic traits in livestockGenetic Associations and Epidemiology

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Uncovering cryptic genetic variation

Gibson, Greg, Dworkin, Ian·2004·Nature Reviews Genetics

DOI 10.1038/nrg1426

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Abstract

Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations, and is thought to modify the penetrance of common diseases, the response of livestock and crops to artificial selection and the capacity of populations to respond to the emergence of a potentially advantageous macro-mutation. We argue in this review that cryptic genetic variation is pervasive but under-appreciated, we highlight recent progress in determining the nature and identity of genes that underlie cryptic genetic effects and we outline future research directions.

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Authors: Gibson, G., & Dworkin, I.
Affiliations: North Carolina State University (US)
Corresponding author: Gibson, Greg
ORCID: Gibson, Greg
Dworkin, Ian
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2004-09
Volume: 5
Issue: 9
Pages: 681-690
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1426
OpenAlex: W2079319076
Cited by: 546
References: 90
Citations by year: 2026: 21 · 2025: 15 · 2024: 22 · 2023: 19 · 2022: 14 · 2021: 24 · 2020: 32 · 2019: 30 · 2018: 28 · 2017: 18 · 2016: 40 · 2015: 38 · 2014: 28 · 2013: 36 · 2012: 34
FWCI: 2.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: cryptic genetic variation, susceptibility genes, gene perturbation, selective breeding, disease penetrance, adaptive potential
MeSH terms: Animals, Drosophila melanogaster, Selection, Genetic, Genetic Variation, Linkage Disequilibrium, Quantitative Trait, Heritable

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Uncovering cryptic genetic variation

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