Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252

The intestinal epithelium: central coordinator of mucosal immunity

Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.04.002 · Cited by 933

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., Toda, S., Sugihara, H., Fujimoto, K., Weissman, I. L., Capecchi, M. R., et al. (2009) · Nature Medicine · doi:10.1038/nm.1951 · Cited by 906

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2695 · Cited by 805

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750

Mend Your Fences

Martini, E., Krug, S. M., Siegmund, B., Neurath, M. F., & Becker, C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.007 · Cited by 668

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

Moor, A. E., Harnik, Y., Ben-Moshe, S., Massasa, E. E., Rozenberg, M., Eilam, R., Bahar Halpern, K., & Itzkovitz, S. (2018) · Cell · doi:10.1016/j.cell.2018.08.063 · Cited by 480

γδ T cells in homeostasis and host defence of epithelial barrier tissues

Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

Günther, C., Neumann, H., Neurath, M. F., & Becker, C. (2013) · Gut · doi:10.1136/gutjnl-2011-301364 · Cited by 462

Role of oxygen gradients in shaping redox relationships between the human intestine and its microbiota

Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396

Drosophila melanogaster as a model for human intestinal infection and pathology

Apidianakis, Y., & Rahme, L. G. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.003970 · Cited by 292

Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice

Lombardo, Y., Scopelliti, A., Cammareri, P., Todaro, M., Iovino, F., Ricci–Vitiani, L., Gulotta, G., Dieli, F., de Maria, R., & Stassi, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.10.005 · Cited by 222

Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling

Spee, B., Carpino, G., Schotanus, B. A., Katoonizadeh, A., Borght, S. V., Gaudio, E., & Roskams, T. (2010) · Gut · doi:10.1136/gut.2009.188367 · Cited by 208

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

Shin, W., Hinojosa, C. D., Ingber, D. E., & Kim, H. J. (2019) · iScience · doi:10.1016/j.isci.2019.04.037 · Cited by 186

Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation

Khalturin, K., Anton-Erxleben, F., Milde, S., Plötz, C., Wittlieb, J., Hemmrich, G., & Bosch, T. C. G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.06.013 · Cited by 125

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S., & Suzuki, A. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.08.020 · Cited by 91

Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells

Kuzmichev, A. N., Kim, S.-K., D’Alessio, A. C., Chenoweth, J. G., Wittko, I. M., Campanati, L., & McKay, R. D. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.013 · Cited by 69

Stem cells and lineages of the intestine: a developmental and evolutionary perspective

Takashima, S., Gold, D., & Hartenstein, V. (2013) · Development Genes and Evolution · doi:10.1007/s00427-012-0422-8 · Cited by 67

Metformin Improves Ileal Epithelial Barrier Function in Interleukin-10 Deficient Mice

Xue, Y., Zhang, H., Sun, X., & Zhu, M.-J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0168670 · Cited by 61

The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

Valentin-Vega, Y. A., Okano, H., & Lozano, G. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.109 · Cited by 58

Annexin A2 Regulates β1 Integrin Internalization and Intestinal Epithelial Cell Migration

Rankin, C. R., Hilgarth, R. S., Leoni, G., Kwon, M., Den Beste, K. A., Parkos, C. A., & Nusrat, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.440909 · Cited by 55

Engineering cell heterogeneity into organs-on-a-chip

Mertz, D. R., Ahmed, T., & Takayama, S. (2018) · Lab on a Chip · doi:10.1039/c8lc00413g · Cited by 33