JmjC-domain-containing proteins and histone demethylation

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Immunometabolism in the pathogenesis of systemic lupus erythematosus

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Mammalian Germ Cell Development: From Mechanism to In Vitro Reconstitution

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KDM4 Involvement in Breast Cancer and Possible Therapeutic Approaches

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RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation

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KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis

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Histone Methylation Participates in Gene Expression Control during the Early Development of the Pacific Oyster Crassostrea gigas

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Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases

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Dynamic Nuclear Organization of Constitutive Heterochromatin During Fetal Male Germ Cell Development in Mice1

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A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival

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Nutrients and Epigenetics

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DNA Methylation and Demethylation in Arabidopsis

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Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway

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Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation

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Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma

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Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape

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Histone modification and histone modification-targeted anti-cancer drugs in breast cancer: Fundamentals and beyond

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The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1

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Msc1 Acts Through Histone H2A.Z to Promote Chromosome Stability inSchizosaccharomyces pombe

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KIAA1718 is a histone demethylase that erases repressive histone methyl marks

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Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A

Wu, B., Chen, H., Cai, C., Jia-Zhu, F., Wu, C.-C., Huang, L., Wang, L., & Han, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.6867 · Cited by 38

Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145)

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Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation

Liu, K., Liu, Y., Lau, J. L., & Min, J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.04.001 · Cited by 37

Is JmjC Oxygenase Catalysis Limited to Demethylation?

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Lysine-specific demethylase 1 as a potential therapeutic target

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Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma

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Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage

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Histone H4K20 Demethylation by Two hHR23 Proteins

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Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006

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Histone Methylation and Oxidative Stress in Cardiovascular Diseases

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Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes

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Crystal structure of the PHF8 Jumonji domain, an Nε‐methyl lysine demethylase

Yue, W. W., Hozjan, V., Ge, W., Loenarz, C., Cooper, C. D. O., Schofield, C. J., Kavanagh, K. L., Oppermann, U. C. T., & McDonough, M. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.12.055 · Cited by 37

Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin

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IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis

Fan, D., Dai, Y., Wang, X., Wang, Z., He, H., Yang, H., Cao, Y., Deng, X. W., & Ma, L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks647 · Cited by 37

Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer

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Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta

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Identification of Lysine 37 of Histone H2B as a Novel Site of Methylation

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Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

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The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity

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Genome-wide identification and functional analysis of JmjC domain-containing genes in flower development of Rosa chinensis

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Histone methylation in pancreatic cancer and its clinical implications

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The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2

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Identification and characterization of histone lysine methylation modifiers in Fragaria vesca

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Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatinPreprint

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Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6

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ATM activation in hypoxia - causes and consequences

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Potential of epigenetic therapies in non-cancerous conditions

Mau, T., & Yung, R. L. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00438 · Cited by 37

IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma

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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

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Research progress of dual inhibitors targeting crosstalk between histone epigenetic modulators for cancer therapy

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A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia

Ren, Z., Kim, A., Huang, Y., Pi, W., Gong, W., Yu, X., Qi, J., Jin, J. J., Cai, L., Roeder, R. G., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122940119 · Cited by 35

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Itoh, Y., Aihara, K., Mellini, P., Tojo, T., Ota, Y., Tsumoto, H., Solomon, V. R., Zhan, P., SUZUKI, M. T., Ogasawara, D., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01323 · Cited by 34

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice

Northrup, D. L., Yagi, R., Cui, K., Proctor, W. R., Wang, C., Placek, K., Pohl, L. R., Wang, R., Ge, K., Zhu, J., et al. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0152-8 · Cited by 35

Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature

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The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer

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The molecular basis of cell memory in mammals: The epigenetic cycle

Espinosa-Martínez, M., Alcázar‐Fabra, M., & Landeira, D. (2024) · Science Advances · doi:10.1126/sciadv.adl3188 · Cited by 35

Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells

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Epigenetic regulation of germ cell differentiation

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Key roles of histone methyltransferase and demethylase in leukemogenesis

Yoshimi, A., & Kurokawa, M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22972 · Cited by 34

Writing and Rewriting the Epigenetic Code of Cancer Cells: From Engineered Proteins to Small Molecules

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The small molecule JIB-04 disrupts O 2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

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Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c

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The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction

Fellous, A., Earley, R. L., & Silvestre, F. (2018) · Gene · doi:10.1016/j.gene.2018.11.046 · Cited by 34

JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle

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Controlling flowering time by histone methylation and acetylation in arabidopsis and rice

Jeong, H. J., Yang, J., Yi, J., & An, G. (2015) · Journal of Plant Biology · doi:10.1007/s12374-015-0219-1 · Cited by 34

Changing story of the receptor for phosphatidylserine‐dependent clearance of apoptotic cells

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Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

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Demethylation of ERECTA receptor genes by IBM1 histone demethylase affects stomatal development

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Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer

He, M., Ning, W., Hu, Z., Huang, J., Dong, C., & Zhou, H. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112281 · Cited by 33

Comprehensive Genome-Wide Exploration of C2H2 Zinc Finger Family in Grapevine (Vitis vinifera L.): Insights into the Roles in the Pollen Development Regulation

Arrey-Salas, O., Caris-Maldonado, J. C., Hernández, B., & Gonzalez, E. (2021) · Genes · doi:10.3390/genes12020302 · Cited by 32

The Jumonji gene family in Crassostrea gigas suggests evolutionary conservation of Jmj-C histone demethylases orthologues in the oyster gametogenesis and development

Fellous, A., Favrel, P., Guo, X., & Rivière, G. (2014) · Gene · doi:10.1016/j.gene.2013.12.016 · Cited by 33

Epigenetic regulation of cardiac myocyte differentiation†

Oyama, K., El‐Nachef, D., Zhang, Y., Sdek, P., & MacLellan, W. R. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00375 · Cited by 33

Transcriptional and epigenetic networks in haematological malignancy

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Timing of Transcriptional Quiescence during Gametogenesis Is Controlled by Global Histone H3K4 Demethylation

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Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

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The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylationPreprint

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Effects of Iron Status on Adaptive Immunity and Vaccine Efficacy: A Review

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Coordinated Regulation of Retinoic Acid Signaling Pathway by KDM5B and Polycomb Repressive Complex 2

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Advances and challenges in understanding histone demethylase biology

Nowak, R. P., Tumber, A., Johansson, C., Che, K. H., Brennan, P. E., Owen, D. R., & Oppermann, U. C. T. (2016) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2016.06.021 · Cited by 32

The Functions of the Demethylase JMJD3 in Cancer

Sánchez, A., Khoufaf, F. Z. H., Idrissou, M., Penault-Llorca, F. M., Bignon, Y., Guy, L., & Bernard-Gallon, D. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020968 · Cited by 33

PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1

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Linkage mapping and QTL analysis of flowering time in faba bean

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The Fission Yeast Jmj2 Reverses Histone H3 Lysine 4 Trimethylation

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Temporal and Spatial Expression Patterns of Nine Arabidopsis Genes Encoding Jumonji C-Domain Proteins

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