Cited by 1,290Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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JmjC-domain-containing proteins and histone demethylation

Klose, Robert J., Kallin, Eric M., Zhang, Yi·2006·Nature Reviews Genetics

DOI 10.1038/nrg1945

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Abstract

Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.

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“demethylation reaction (Klose et al., 2006) (Figure 2D).”
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Authors: Klose, R. J., Kallin, E. M., & Zhang, Y.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Zhang, Yi
ORCID: Klose, Robert J.
Zhang, Yi
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 715-727
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1945
OpenAlex: W1982409009
Cited by: 1,290
References: 106
Citations by year: 2026: 40 · 2025: 47 · 2024: 53 · 2023: 69 · 2022: 57 · 2021: 83 · 2020: 64 · 2019: 73 · 2018: 84 · 2017: 58 · 2016: 66 · 2015: 83 · 2014: 80 · 2013: 57 · 2012: 68
FWCI: 4.01
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: Jumonji C domain, histone demethylation, histone methylation, chromatin modification, epigenetic inheritance, protein evolution, gene expression regulation
MeSH terms: Histone Methyltransferases, Amino Acid Sequence, Animals, Gene Expression Regulation, Histones, Humans, Molecular Sequence Data, Nuclear Proteins, Oxidoreductases, N-Demethylating, Phylogeny, Histone-Lysine N-Methyltransferase, Protein Methyltransferases, Transcription, Genetic, Sequence Alignment, Protein Structure, Tertiary, Amino Acid Motifs, Epigenesis, Genetic

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JmjC-domain-containing proteins and histone demethylation

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