The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
MicroRNAs in the Hox network: an apparent link to posterior prevalence
Open accessAbstract
Homeobox (Hox) transcription factors confer anterior–posterior (AP) axial coordinates to vertebrate embryos. Hox genes are found in clusters that also contain genes for microRNAs (miRNAs). Our analysis of predicted miRNA targets indicates that Hox cluster-embedded miRNAs preferentially target Hox mRNAs. Moreover, the presumed Hox target genes are predominantly situated on the 3′ side of each Hox miRNA locus. These results suggest that Hox miRNAs help repress more anterior programmes, thereby reinforcing posterior prevalence, which is the hierarchical dominance of posterior over anterior Hox gene function that is observed in bilaterians. In this way, miRNA-mediated regulation seems to recapitulate interactions at other levels of gene expression, some more ancestral, within a network under stabilizing selection.
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Prediction of Mammalian MicroRNA Targets
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Self-citationIdentification of Novel Genes Coding for Small Expressed RNAs
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Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Silencing of microRNAs in vivo with ‘antagomirs’
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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
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Self-citationThe rise and fall of Hox gene clusters
Duboule, D. (2007) · Development · doi:10.1242/dev.001065 · Cited by 525
Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements
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Cited by
Small silencing RNAs: an expanding universe
Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,325
The Hox genes and their roles in oncogenesis
Shah, N., & Sukumar, S. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2826 · Cited by 835
Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning
Kondrashov, N., Pusic, A., Stumpf, C. R., Shimizu, K., Hsieh, A. C., Xue, S., Ishijima, J., Shiroishi, T., & Barna, M. (2011) · Cell · doi:10.1016/j.cell.2011.03.028 · Cited by 586
Regulation of mammalian cell differentiation by long non‐coding RNAs
Hu, W., Alvarez‐Dominguez, J. R., & Lodish, H. F. (2012) · EMBO reports · doi:10.1038/embor.2012.145 · Cited by 309
MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
Hoss, A. G., Kartha, V. K., Dong, X., Latourelle, J. C., Dumitriu, A., Hadzi, T. C., MacDonald, M. E., Gusella, J. F., Akbarian, S., Chen, J.-F., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004188 · Cited by 111
Metadata
- Authors
- Yekta, S., Tabin, C. J., & Bartel, D. P.
- Venue
- Nature Reviews Genetics
- Published
- 2008-10
- Volume
- 9
- Issue
- 10
- Pages
- 789-796
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1999210109
- Cited by
- 197
- References
- 9
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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