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The evolution of cell types in animals: emerging principles from molecular studies

Arendt, Detlev·2008·Nature Reviews Genetics

DOI 10.1038/nrg2416

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Abstract

Cell types are fundamental units of multicellular life but their evolution is obscure. How did the first cell types emerge and become distinct in animal evolution? What were the sets of cell types that existed at important evolutionary nodes that represent eumetazoan or bilaterian ancestors? How did these ancient cell types diversify further during the evolution of organ systems in the descending evolutionary lines? The recent advent of cell type molecular fingerprinting has yielded initial insights into the evolutionary interrelationships of cell types between remote animal phyla and has allowed us to define some first principles of cell type diversification in animal evolution.

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Authors: Arendt, D.
Affiliations: European Molecular Biology Laboratory (DE)
Corresponding author: Arendt, Detlev
ORCID: Arendt, Detlev
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-11
Volume: 9
Issue: 11
Pages: 868-882
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2416
OpenAlex: W2072977772
Cited by: 525
References: 126
Citations by year: 2026: 25 · 2025: 33 · 2024: 44 · 2023: 50 · 2022: 30 · 2021: 33 · 2020: 37 · 2019: 27 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 45 · 2014: 31 · 2013: 19 · 2012: 17
FWCI: 1.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: cell type evolution, animal evolution, multicellularity
MeSH terms: Animals, Cell Differentiation, Endocrine System, Biological Evolution, Immune System, Nervous System, Phylogeny, DNA Fingerprinting, Cell Lineage

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The evolution of cell types in animals: emerging principles from molecular studies

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