Cited by 527Developmental Biology and Gene RegulationMarine Invertebrate Physiology and EcologyGenomics and Phylogenetic Studies

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The evolution of cell types in animals: emerging principles from molecular studies

Arendt, Detlev·2008·Nature Reviews Genetics

DOI 10.1038/nrg2416

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Abstract

Cell types are fundamental units of multicellular life but their evolution is obscure. How did the first cell types emerge and become distinct in animal evolution? What were the sets of cell types that existed at important evolutionary nodes that represent eumetazoan or bilaterian ancestors? How did these ancient cell types diversify further during the evolution of organ systems in the descending evolutionary lines? The recent advent of cell type molecular fingerprinting has yielded initial insights into the evolutionary interrelationships of cell types between remote animal phyla and has allowed us to define some first principles of cell type diversification in animal evolution.

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Phylogenetic Systematics
Hennig, W. (1965) · Annual Review of Entomology · doi:10.1146/annurev.en.10.010165.000525 · Cited by 4,248
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
microRNA Functions
Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,750
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555
MicroRNA Expression in Zebrafish Embryonic Development
Wienholds, E., Kloosterman, W. P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H. R., Kauppinen, S., & Plasterk, R. H. A. (2005) · Science · doi:10.1126/science.1114519 · Cited by 1,551
Handbuch der Mikroskopischen Anatomie des Menschen
Möllendorff, W. V., & Bargmann, W. (1958) · Springer eBooks · doi:10.1007/978-3-662-30619-2 · Cited by 1,515
A receptor for phosphatidylserine-specific clearance of apoptotic cells
Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491
The genome of the social amoeba Dictyostelium discoideum
Eichinger, L., Pachebat, J. A., Glöckner, G., Rajandream, M.-A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, Q., et al. (2005) · Nature · doi:10.1038/nature03481 · Cited by 1,351
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139
Neural Crest and the Origin of Vertebrates: A New Head
Gans, C., & Northcutt, R. G. (1983) · Science · doi:10.1126/science.220.4594.268 · Cited by 1,053
The triple origin of skull in higher vertebrates: a study in quail-chick chimeras
Couly, G. F., Coltey, P. M., & Douarin, N. M. L. (1993) · Development · doi:10.1242/dev.117.2.409 · Cited by 1,032
The frailty of adaptive hypotheses for the origins of organismal complexity
Lynch, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702207104 · Cited by 829
Pax 6: mastering eye morphogenesis and eye evolution
Gehring, W. J., & Ikeo, K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01776-x · Cited by 758
THE EVOLUTION OF ADAPTIVE IMMUNITY
Pancer, Z., & Cooper, M. D. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090542 · Cited by 541
Molecular taxonomy of major neuronal classes in the adult mouse forebrain
Sugino, K., Hempel, C. M., Miller, M. N., Hattox, A. M., Shapiro, P., Wu, C., Huang, Z. J., & Nelson, S. B. (2006) · Nature Neuroscience · doi:10.1038/nn1618 · Cited by 521
Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene
Prud'homme, B., Gompel, N., Rokas, A., Kassner, V. A., Williams, T. M., Yeh, S.-D., True, J. R., & Carroll, S. B. (2006) · Nature · doi:10.1038/nature04597 · Cited by 507
Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
Denes, A. S., Jékely, G., Steinmetz, P. R. H., Raible, F., Snyman, H., Prud'homme, B., Ferrier, D. E. K., Balavoine, G., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.02.040 · Cited by 480
Self-citation
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
Buck, L. B. (2000) · Cell · doi:10.1016/s0092-8674(00)80698-4 · Cited by 475
Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain
Arendt, D., Tessmar-Raible, K., Snyman, H., Dorresteijn, A. W., & Wittbrodt, J. (2004) · Science · doi:10.1126/science.1099955 · Cited by 458
Self-citation
Evolution of the vertebrate eye: Opsins, photoreceptors, retina and eye cup
Lamb, T. D., Collin, S. P., & Pugh, E. N. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2283 · Cited by 454
Thicker Than Blood
Evans, C. J., Hartenstein, V., & Banerjee, U. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00335-6 · Cited by 436
Olfactory Inputs to Hypothalamic Neurons Controlling Reproduction and Fertility
Yoon, H., Enquist, L. W., & Dulac, C. G. (2005) · Cell · doi:10.1016/j.cell.2005.08.039 · Cited by 435
Evolution of eyes and photoreceptor cell types
Arendt, D. (2003) · The International Journal of Developmental Biology · doi:10.1387/ijdb.14756332 · Cited by 430
Self-citation
On the Evolution of Photoreceptors and Eyes
Salvini-Plawen, L. V., & Mayr, E. (1977) · Springer eBooks · doi:10.1007/978-1-4615-6953-4_4 · Cited by 429
From Gene to Organismal Phylogeny: Reconciled Trees and the Gene Tree/Species Tree Problem
Page, R., & Charleston, M. (1997) · Molecular Phylogenetics and Evolution · doi:10.1006/mpev.1996.0390 · Cited by 428
Phylogenomics of Eukaryotes: Impact of Missing Data on Large Alignments
Philippe, H., Snell, E. A., Bapteste, E. P., Lopez, P., Holland, P. W. H., & Casañe, D. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh182 · Cited by 402
Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
Franc, N. C., Heitzler, P., B., R. A., Ezekowitz, & White, K. (1999) · Science · doi:10.1126/science.284.5422.1991 · Cited by 388
Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.04.041 · Cited by 384
Self-citation
Developmental expression of a novel murine homeobox gene (Chx10): Evidence for roles in determination of the neuroretina and inner nuclear layer
Liu, I. S. C., Chen, J.-D., Ploder, L., Vidgen, D., van der Kooy, D., Kalnins, V. I., & Mclnnes, R. R. (1994) · Neuron · doi:10.1016/0896-6273(94)90354-9 · Cited by 383
EST Analysis of the Cnidarian Acropora millepora Reveals Extensive Gene Loss and Rapid Sequence Divergence in the Model Invertebrates
Kortschak, R. D., Samuel, G., Saint, R., & Miller, D. J. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.030 · Cited by 353
Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein
Tanabe, Y., William, C. M., & Jessell, T. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81783-3 · Cited by 341
Runx1 Determines Nociceptive Sensory Neuron Phenotype and Is Required for Thermal and Neuropathic Pain
Chen, C.-L., Broom, D. C., Liu, Y., de Nooij, J. C., Li, Z., Cen, C., Samad, O. A., Jessell, T. M., Woolf, C. J., & Ma, Q. (2006) · Neuron · doi:10.1016/j.neuron.2005.10.036 · Cited by 339
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Palmer, C., Diehn, M., Alizadeh, A. A., & Brown, P. O. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-115 · Cited by 331
Control of Cardiac Development by an Evolutionarily Conserved Transcriptional Network
Cripps, R. M., & Olson, E. N. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0666 · Cited by 330
Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry
Moroz, L. L., Edwards, J. R., Puthanveettil, S. V., Kohn, A. B., Ha, T. J., Heyland, A., Knudsen, B., Sahni, A., Yu, F., Liu, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.052 · Cited by 330
The Closest Unicellular Relatives of Animals
Lang, B. F., O'Kelly, C., Nerad, T., Gray, M. W., & Burger, G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01187-9 · Cited by 326
Comprehensive Analysis of Photoreceptor Gene Expression and the Identification of Candidate Retinal Disease Genes
Blackshaw, S., Fraioli, R. E., Furukawa, T., & Cepko, C. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00574-8 · Cited by 303
Transcriptional networks regulating neuronal identity in the developing spinal cord
Lee, S., & Pfaff, S. L. (2001) · Nature Neuroscience · doi:10.1038/nn750 · Cited by 290
A core transcriptional network for early mesoderm development in Drosophila melanogaster
Sandmann, T., Girardot, C., Brehme, M., Tongprasit, W., Stolc, V., & Furlong, E. E. M. (2007) · Genes & Development · doi:10.1101/gad.1509007 · Cited by 286
Blood Cells and Blood Cell Development in the Animal Kingdom
Hartenstein, V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093317 · Cited by 286
The neuroendocrine system of invertebrates: a developmental and evolutionary perspective
Hartenstein, V. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06964 · Cited by 284
Encephalopsin: A Novel Mammalian Extraretinal Opsin Discretely Localized in the Brain
Blackshaw, S., & Snyder, S. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03681.1999 · Cited by 283
Human cell type diversity, evolution, development, and classification with special reference to cells derived from the neural crest
Vickaryous, M. K., & Hall, B. K. (2006) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793106007068 · Cited by 281
The 2R hypothesis: an update
Kasahara, M. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.009 · Cited by 258
Vertebrate-Type Intron-Rich Genes in the Marine Annelid Platynereis dumerilii
Raible, F., Tessmar-Raible, K., Osoegawa, K., Wincker, P., Jubin, C., Balavoine, G., Ferrier, D., Benes, V., de Jong, P., Weissenbach, J., et al. (2005) · Science · doi:10.1126/science.1119089 · Cited by 257
Self-citation
A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
Kramer, I., Sigrist, M., de Nooij, J. C., Taniuchi, I., Jessell, T. M., & Arber, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.008 · Cited by 247
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.Preprint
Pattyn, A., Vallstedt, A., Dias, J. M., Samad, O. A., Krumlauf, R., Rijli, F., Brunet, J., & Ericson, J. (2003) · Genes & Development · doi:10.1101/gad.255803 · Cited by 247
Evolution of pigment synthesis pathways by gene and genome duplication in fish
Braasch, I., Schartl, M., & Volff, J. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-74 · Cited by 243
Ancient Evolutionary Origin of the Neural Crest Gene Regulatory Network
Sauka‐Spengler, T., Meulemans, D., Jones, M. C., & Bronner-Fraser, M. E. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.005 · Cited by 240
Cephalochordate Melanopsin: Evolutionary Linkage between Invertebrate Visual Cells and Vertebrate Photosensitive Retinal Ganglion Cells
Koyanagi, M., Kubokawa, K., Tsukamoto, H., Shichida, Y., & Terakita, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.063 · Cited by 237
Reconstructing the eyes of Urbilateria
Arendt, D., & Wittbrodt, J. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2001.0971 · Cited by 234
Self-citation
Origin and early evolution of vertebrate skeletonization
Donoghue, P. C. J., & Sansom, I. J. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10217 · Cited by 232
Neuroid Conduction and the Evolution of Conducting Tissues
Mackie, G. O. (1970) · The Quarterly Review of Biology · doi:10.1086/406645 · Cited by 230 · cited 1×
“Another prominent example is the cnidarian epithelial muscle cell that functions as an epidermal cell, is capable of mechanosensory reception and transmission, and contracts like a muscle cel”
Background
Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue Collier
Crozatier, M., Ubeda, J.-M., Vincent, A., & Meister, M. F. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020196 · Cited by 228
Protein Family Expansions and Biological Complexity
Vogel, C., & Chothia, C. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020048 · Cited by 227
The system of cerebrospinal fluid-contacting neurons. Its supposed role in the nonsynaptic signal transmission of the brain.
Béla, V. I. G. H., Silva, M. J. M. E., Frank, C. L., Vincze, C., Czirok, S., Szabó, A., Lukáts, Á., & Szél, Á. (2004) · PubMed · doi:10.14670/hh-19.607 · Cited by 219
The embryonic development of the Drosophila visual system
Green, P. A., Hartenstein, A. Y., & Hartenstein, V. (1993) · Cell and Tissue Research · doi:10.1007/bf00333712 · Cited by 212
Cytological Basis of Photoresponsive Behavior in a Sponge Larva
Leys, S. P., & Degnan, B. M. (2001) · The Biological Bulletin · doi:10.2307/1543611 · Cited by 212
Evolution of Gonadotropin-Releasing Hormone (GnRH) Neuronal Systems (Part 1 of 2)
Muske, L. E. (2008) · Brain Behavior and Evolution · doi:10.1159/000114156 · Cited by 198
The system of cerebrospinal fluid-contacting neurons.
VIGH-TEICHMANN, I., & VIGH, B. (1983) · Archivum histologicum japonicum · doi:10.1679/aohc.46.427 · Cited by 195
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiationPreprint
Penn, B. H., Bergstrom, D. A., Dilworth, F. J., Bengal, E., & Tapscott, S. J. (2004) · Genes & Development · doi:10.1101/gad.1234304 · Cited by 193
Development of pigment-cup eyes in the polychaete Platynereis dumerilii and evolutionary conservation of larval eyes in Bilateria
Arendt, D., Tessmar, K., de Campos-Baptista, M.-I. M., Dorresteijn, A., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.5.1143 · Cited by 192
Self-citation
Six3inactivation reveals its essential role for the formation and patterning of the vertebrate eye
Carl, M., Loosli, F., & Wittbrodt, J. (2002) · Development · doi:10.1242/dev.129.17.4057 · Cited by 180
Evolution of striated muscle: Jellyfish and the origin of triploblasty
Seipel, K., & Schmid, V. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.03.032 · Cited by 172
Nanosecond-scale kinetics of nematocyst discharge
Nüchter, T., Benoit, M., Engel, U., Özbek, S., & Holstein, T. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.089 · Cited by 171
Pax–Six–Eya–Dach network during amphioxus development: Conservation in vitro but context specificity in vivo
Kozmík, Z., Holland, N. D., Kreslova, J., Oliveri, D., Schubert, M., Jonasova, K., Holland, L. Z., Pestarino, M., Beneš, V., & Candiani, S. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.009 · Cited by 170
Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin
Pancer, Z. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.230096397 · Cited by 169
Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin
Isoldi, M. C., Rollag, M. D., Castrucci, A. M. D. L., & Provencio, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409252102 · Cited by 166
Ancient colour vision: multiple opsin genes in the ancestral vertebrates
Collin, S. P., Knight, M. A., Davies, W. I. L., POTTER, I. C., Hunt, D. M., & Trezise, A. E. O. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.044 · Cited by 165
Precraniate origin of cranial motoneurons
Dufour, H. D., Chettouh, Z., Deyts, C., de Rosa, R., Goridis, C., Joly, J., & Brunet, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600805103 · Cited by 165
Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain
de Velasco, B., Erclik, T., Shy, D., Sclafani, J., Lipshitz, H. D., McInnes, R. R., & Hartenstein, V. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.035 · Cited by 162
Evolution and Functional Diversity of Jellyfish Opsins
Suga, H., Schmid, V. J., & Gehring, W. J. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.059 · Cited by 160
Pteropsin: A vertebrate-like non-visual opsin expressed in the honey bee brain
Velarde, R. A., Sauer, C. D., Walden, K. K. O., Fahrbach, S. E., & Robertson, H. M. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.09.001 · Cited by 156
The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons
Marmigère, F., Montelius, A., Wegner, M., Groner, Y., Reichardt, L. F., & Ernfors, P. (2006) · Nature Neuroscience · doi:10.1038/nn1631 · Cited by 141
On the origins of the adaptive immune system: novel insights from invertebrates and cold-blooded vertebrates
Kasahara, M., Suzuki, T., & Pasquier, L. D. (2003) · Trends in Immunology · doi:10.1016/j.it.2003.11.005 · Cited by 139
Cytology and evolution
Willmer, E. N. (1960) · Academic Press eBooks · Cited by 137
Coelomocytes Express SpBf, a Homologue of Factor B, the Second Component in the Sea Urchin Complement System
Smith, L. C., Shih, C.-S., & Dachenhausen, S. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6784 · Cited by 125
Insights from Amphioxus into the Evolution of Vertebrate Cartilage
Meulemans, D., & Bronner-Fraser, M. E. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000787 · Cited by 122
The Origins of Novel Protein Interactions during Animal Opsin Evolution
Plachetzki, D. C., Degnan, B. M., & Oakley, T. H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001054 · Cited by 122
A simple visual system without neurons in jellyfish larvae
Nordström, K., Wallén, Seymour, J., & Nilsson, D. (2003) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2003.2504 · Cited by 121
Handbuch der mikroskopischen Anatomie des Menschen
Purser, B. N. (1980) · Pathology · doi:10.1016/s0031-3025(16)37635-8 · Cited by 121
Amphioxus homologs of Go‐coupled rhodopsin and peropsin having 11‐cis‐ and all‐trans‐retinals as their chromophores
Koyanagi, M., Terakita, A., Kubokawa, K., & Shichida, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03616-5 · Cited by 114
Development and evolution of chordate cartilage
Rychel, A. L., & Swalla, B. J. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21157 · Cited by 114
Left-right asymmetric expression of BbPtx, a Ptx-related gene, in a lancelet species and the developmental left-sidedness in deuterostomes
Yasui, K., Zhang, S., Uemura, M., & Saiga, H. (2000) · Development · doi:10.1242/dev.127.1.187 · Cited by 114
Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina
Livne-Bar, I., Pacal, M., Cheung, M., Hankin, M., Trogadis, J. E., Chen, D., Dorval, K. M., & Bremner, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600083103 · Cited by 112
Spectral sensitivity in a sponge larva
Leys, S. P., Cronin, T., Degnan, B. M., & Marshall, N. J. (2002) · Journal of Comparative Physiology A · doi:10.1007/s00359-002-0293-y · Cited by 99
SpC3, the complement homologue from the purple sea urchin, Strongylocentrotus purpuratus , is expressed in two subpopulations of the phagocytic coelomocytes
Gross, P. S., Clow, L. A., & Smith, L. C. (2000) · Immunogenetics · doi:10.1007/s002510000234 · Cited by 99
Photoreceptor cells and eyes in Annelida
Purschke, G., Arendt, D., Hausen, H., & Müller, M. C. M. (2006) · Arthropod Structure & Development · doi:10.1016/j.asd.2006.07.005 · Cited by 98
Self-citation
A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction inCionaembryos
Hudson, C., & Yasuo, H. (2006) · Development · doi:10.1242/dev.02466 · Cited by 98
Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells
Chow, R. L., Snow, B., Novak, J., Looser, J., Freund, C. L., Vidgen, D., Ploder, L., & McInnes, R. R. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00585-8 · Cited by 98
Olfactory Origins and Evolution of the Brain-Pituitary Endocrine System: Facts and Speculation
Gorbman, A. (1995) · General and Comparative Endocrinology · doi:10.1006/gcen.1995.1016 · Cited by 96
Mesodermal anatomies in cnidarian polyps and medusae
Seipel, K., & Schmid, V. J. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.062150ks · Cited by 95
Neuronal evolution: analysis of regulatory genes in a first-evolved nervous system, the hydra nervous system
Miljkovic‐Licina, M., Gauchat, D., & Galliot, B. (2004) · Biosystems · doi:10.1016/j.biosystems.2004.05.030 · Cited by 93
The evolutionary emergence of cell type-specific genes inferred from the gene expression analysis of Hydra
Hwang, J. S., Ohyanagi, H., Hayakawa, S., Osato, N., Nishimiya‐Fujisawa, C., Ikeo, K., David, C. N., Fujisawa, T., & Gojobori, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703331104 · Cited by 91
Phylogenetic relationship of muscle tissues deduced from superimposition of gene trees
Oota, S., & Saitou, N. (1999) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026170 · Cited by 88
The origins of colour vision in vertebrates
Collin, S. P., & Trezise, A. E. O. (2004) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2004.tb05051.x · Cited by 82
Motor neuron specification in worms, flies and mice: conserved and 'lost' mechanisms.
Thor, S., & Thomas, J. B. (2002) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(02)00340-4 · Cited by 77
The blood/vascular system in a phylogenetic perspective
Hartenstein, V., & Mandal, L. (2006) · BioEssays · doi:10.1002/bies.20497 · Cited by 77
FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos
Yasuo, H., & Hudson, C. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.075 · Cited by 76
The Question of Functional Homology of Hatschek's Pit of Amphioxus (Branchiostoma belcheri) and the Vertebrate Adenohypophysis(Endocrinology)
Nozaki, M., & Gorbman, A. (1992) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5281/zenodo.16248946 · Cited by 73
Repression of Six3 by a corepressor regulates rhodopsin expression
Manavathi, B., Peng, S., Rayala, S. K., Talukder, A. H., Wang, M. H., Wang, R., Balasenthil, S., Agarwal, N. A., Frishman, L. J., & Kumar, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705878104 · Cited by 67
Wnt Signaling Induces Vulva Development in the Nematode Pristionchus pacificus
Tian, H., Schlager, B., Xiao, H., & Sommer, R. J. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.048 · Cited by 63
Extensive duplications of phototransduction genes in early vertebrate evolution correlate with block (chromosome) duplications
Nordström, K., Larsson, T., & Larhammar, D. (2004) · Genomics · doi:10.1016/j.ygeno.2003.11.008 · Cited by 62
Developmental and evolutionary aspects of the basic helix–loop–helix transcription factors Atonal-like 1 and Achaete-scute homolog 2 in the jellyfish
Seipel, K., Yanze, N., & Schmid, V. J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.035 · Cited by 62
The evolution of neurosecretory centers in bilaterian forebrains: insights from protostomes
Tessmar-Raible, K. (2007) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2007.04.007 · Cited by 53
CHX10 Targets a Subset of Photoreceptor Genes
Dorval, K. M., Bobechko, B. P., Fujieda, H., Chen, S., Zack, D. J., & Bremner, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509470200 · Cited by 53
Genetic network of the eye in Platyhelminthes: expression and functional analysis of some players during planarian regeneration
Saló, E., Pineda, D., Marsal, M., González, J., Gremigni, V., & Batistoni, R. (2002) · Gene · doi:10.1016/s0378-1119(01)00863-0 · Cited by 52
Note on the Infusoria flagellata and the Spongiae ciliatae
James‐Clark, H. (1871) · American Journal of Science · doi:10.2475/ajs.s3-1.2.113 · Cited by 52
Expression of the amphioxus Pit-1 gene (AmphiPOU1F1/Pit-1) exclusively in the developing preoral organ, a putative homolog of the vertebrate adenohypophysis
Candiani, S., Holland, N. D., Oliveri, D., Parodi, M., & Pestarino, M. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.10.023 · Cited by 51
Transcriptional regulation of neuronal phenotype in mammals
Ma, Q. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113449 · Cited by 50
Genes and homology in nervous system evolution: Comparing gene functions, expression patterns, and cell type molecular fingerprints
Arendt, D. (2005) · Theory in Biosciences · doi:10.1007/bf02814483 · Cited by 50
Self-citation
Key transitions during the evolution of animal phototransduction: novelty, "tree-thinking," co-option, and co-duplication
Plachetzki, D. C., & Oakley, T. H. (2007) · Integrative and Comparative Biology · doi:10.1093/icb/icm050 · Cited by 50
New genes in the evolution of the neural crest differentiation program
Martínez‐Morales, J. R., Henrich, T., Ramialison, M., & Wittbrodt, J. (2007) · Genome biology · doi:10.1186/gb-2007-8-3-r36 · Cited by 50
Hierarchical phylogenetics as a quantitative analytical framework for evolutionary developmental biology
Serb, J. M., & Oakley, T. H. (2005) · BioEssays · doi:10.1002/bies.20291 · Cited by 47
Equivalent progenitor cells in the zebrafish anterior preplacodal field give rise to adenohypophysis, lens, and olfactory placodes
Toro, S., & Varga, Z. M. (2007) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2007.04.003 · Cited by 44
cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophages
Li, J., Pritchard, D. K., Wang, X., Park, D. R., Bumgarner, R. E., Schwartz, S. M., & Liles, W. C. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0206124 · Cited by 44
Cytology and Evolution
(1924) · Nature · doi:10.1038/114949a0 · Cited by 43
New insights into the evolutionary history of photoreceptor cells
Plachetzki, D. C., Serb, J. M., & Oakley, T. H. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.07.001 · Cited by 42
The role of TGFβ signaling in the formation of the dorsal nervous system is conserved betweenDrosophilaand chordates
Rusten, T. E., Cantera, R., Kafatos, F. C., & Barrio, R. (2002) · Development · doi:10.1242/dev.129.15.3575 · Cited by 32
Furcation, field-splitting, and the evolutionary origins of novelty in arthropod photoreceptors
Oakley, T. H., Plachetzki, D. C., & Rivera, A. S. (2007) · Arthropod Structure & Development · doi:10.1016/j.asd.2007.08.002 · Cited by 30
Analysis of the immune-related transcriptome of a lophotrochozoan model, the marine annelid Platynereis dumerilii
Altincicek, B., & Vilcinskas, A. (2007) · Frontiers in Zoology · doi:10.1186/1742-9994-4-18 · Cited by 29
Making mesoderm--upstream and downstream of Xbra
Smith, J. C. (2001) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11291849 · Cited by 28
Some considerations on the fine structure of rhabdomeric photoreceptors in the amphioxus, Branchiostoma lanceolatum (Cephalochordata).
Ms, R., & Anadón, R. (1991) · PubMed · Cited by 23
Strategies for studying microtubule transport in the neuron
Baas, P. W. (2000) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(20000115)48:2 · Cited by 18
Mucus secretion and transport in amphioxus larvae: organization and ultrastructure of the food trapping system, and implications for head evolution
Lacalli, T. C. (2007) · Acta Zoologica · doi:10.1111/j.1463-6395.2007.00310.x · Cited by 13
Insights into the Coupling of Duplication Events and Macroevolution from an Age Profile of Animal Transmembrane Gene Families
Ding, G., Kang, J., Liu, Q., Shi, T., Pei, G., & Li, Y. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020102 · Cited by 11

Flagged first, then by citations

Research works printed but not linked: 3

Valentine, J. W. in Keywords and Concepts in Evolutionary Devlopmental Biology (eds Hall, B. K. & Olson, W. M.) 35–53 (Harvard Univ. Press, Cambridge, 2003).
Welsch, L. T. & Welsch, U. Histologische und elekronmikroskopische Untersuchungen an der präoralen Wimpergrube von Saccoglossus horsti (Hemichordata) und der Hatschekschen Grube von Branchiostoma lanceolatum (Acrania). Ein Beirag zur phylogenetischen Entwicklung der Adenohypophyse. Zool. Jahrb. Anat. 100, 564–578 (1978).
Haeckel, E. Die Gastraea-Theorie, die phylogenetische Classification des Thierreiches und die Homologie der Keimblätter. Jena Z. Naturwiss. 8, 1–55 (1874).

Sorted by citations

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses
Huerta‐Cepas, J., Szklarczyk, D., Heller, D., Hernández-Plaza, A., Forslund, S. K., Cook, H., Mende, D. R., Letunić, I., Rattei, T., Jensen, L. J., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1085 · Cited by 4,934
A census of human transcription factors: function, expression and evolution
Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573
Single-cell sequencing-based technologies will revolutionize whole-organism science
Shapiro, E., Biezuner, T., & Linnarsson, S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3542 · Cited by 1,177
The origin and evolution of cell types
Arendt, D., Musser, J. M., Baker, C. V. H., Bergman, A., Cepko, C., Erwin, D. H., Pavlicev, M., Schlosser, G., Widder, S., Laubichler, M. D., et al. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.127 · Cited by 764
Self-citation
Tissue biology perspective on macrophages
Okabe, Y., & Medzhitov, R. M. (2015) · Nature Immunology · doi:10.1038/ni.3320 · Cited by 651

See all 527

Authors: Arendt, D.
Affiliations: European Molecular Biology Laboratory (DE)
Corresponding author: Arendt, Detlev
ORCID: Arendt, Detlev
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-11
Volume: 9
Issue: 11
Pages: 868-882
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2416
OpenAlex: W2072977772
Cited by: 525
References: 126
Citations by year: 2026: 25 · 2025: 33 · 2024: 44 · 2023: 50 · 2022: 30 · 2021: 33 · 2020: 37 · 2019: 27 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 45 · 2014: 31 · 2013: 19 · 2012: 17
FWCI: 1.44
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: cell type evolution, animal evolution, multicellularity
MeSH terms: Animals, Cell Differentiation, Endocrine System, Biological Evolution, Immune System, Nervous System, Phylogeny, DNA Fingerprinting, Cell Lineage

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The evolution of cell types in animals: emerging principles from molecular studies

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