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Adaptation–not by sweeps alone
Open accessAbstract
There has been recent progress in identifying selective sweeps underlying a range of adaptations. Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection.
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“Selective sweep scans are limited in their ability to detect polygenic adaptation of complex traits that may be due to small shifts in allele frequency at many loci (Pritchard and Di Rienzo 2010).”
From The neural crest cell hypothesis: no unified explanation for domestication (2021) · cites this paper as Pritchard and Di Rienzo 2010
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Detecting Natural Selection in Genomic Data
Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133526 · Cited by 694
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Metadata
- Authors
- Pritchard, J. K., & Di Rienzo, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature Reviews Genetics
- Published
- 2010-09-14
- Volume
- 11
- Issue
- 10
- Pages
- 665-667
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC4652788
- OpenAlex
- W1525285200
- Cited by
- 445
- References
- 24
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 20 · 2023: 16 · 2022: 19 · 2021: 37 · 2020: 43 · 2019: 27 · 2018: 41 · 2017: 36 · 2016: 32 · 2015: 35 · 2014: 30 · 2013: 23 · 2012: 29
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (R01MH084703, MH84703)
- National Institute of General Medical Sciences (GM79558, R01GM079558)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 56670, R01DK056670)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- polygenic adaptation, selective sweeps, natural selection, adaptation, quantitative traits
- MeSH terms
- Adaptation, Physiological, Animals, Genetics, Population, Humans, Selection, Genetic, Evolution, Molecular, Multifactorial Inheritance
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