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Polygenic adaptation: a unifying framework to understand positive selection

Barghi, Neda, Hermisson, Joachim, Schlötterer, Christian·2020·Nature Reviews Genetics
DOI 10.1038/s41576-020-0250-z
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Abstract

Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential and population genetic principles. Because adaptation can be typically achieved by many different combinations of adaptive alleles (redundancy), we describe how two characteristics - heterogeneity among loci and non-parallelism between replicated populations - are hallmarks for the characterization of polygenic adaptation in evolving populations. We discuss how this unified framework can be applied to natural and experimental populations.

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  • It is likely that allelic variation within populations that have undergone replicated phenotypic evolution will show corresponding signs of adaptation in the genetic elements controlling the trait.

    “It is also likely that allelic variation within populations that have undergone replicated phenotypic evolution will show corresponding signs of adaptation in the genetic elements controlling the trait (Barghi et al. 2020).”

    From From Trees to Traits: A Review of Advances in PhyloG2P Methods and Future Directions (2025) · cites this paper as Barghi et al. 2020

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Metadata

Authors
Barghi, N., Hermisson, J., & Schlötterer, C.
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2020-06-29
Volume
21
Issue
12
Pages
769-781
ISSN
  • 1471-0056
  • 1471-0064
DOI
10.1038/s41576-020-0250-z
Cited by
425
References
11
Language
en
Update notices
correction (2020-08-06)
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