Understanding type 1 diabetes through genetics: advances and prospects

Finding the missing heritability of complex diseases

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

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Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

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Genome structural variation discovery and genotyping

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419

Type 1 diabetes

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Five Years of GWAS Discovery

Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425

Type 1 diabetes mellitus

Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, Å. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.16 · Cited by 1,475

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Eizirik, D. L., Pasquali, L., & Cnop, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0355-7 · Cited by 854

Pitfalls of predicting complex traits from SNPs

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Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Gheorghe, I., Curuțiu, C., Holban, A. M., Picu, A. A., Petcu, L. M., & Chifiriuc, M. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01830 · Cited by 552

Genetic architecture: the shape of the genetic contribution to human traits and disease

Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

Prasad, R., & Groop, L. (2015) · Genes · doi:10.3390/genes6010087 · Cited by 458

Generation of stem cell-derived β-cells from patients with type 1 diabetes

Millman, J. R., Xie, C., Dervort, A. V., Gürtler, M., Pagliuca, F. W., & Melton, D. A. (2016) · Nature Communications · doi:10.1038/ncomms11463 · Cited by 390

Bringing genome-wide association findings into clinical use

Manolio, T. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3523 · Cited by 363

Genetics and Pathogenesis of Inflammatory Bowel Disease

Liu, T.-C., & Stappenbeck, T. S. (2016) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044152 · Cited by 289

Metabolomics of type 1 and type 2 diabetes

Arneth, B., Arneth, R., & Shams, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102467 · Cited by 262

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

Valle, A., Giamporcaro, G. M., Scavini, M., Stabilini, A., Grogan, P., Bianconi, E., Sebastiani, G., Masini, M., Maugeri, N., Porretti, L., et al. (2013) · Diabetes · doi:10.2337/db12-1345 · Cited by 203

Cytokines in type 1 diabetes: mechanisms of action and immunotherapeutic targets

Lü, J., Liu, J., Li, L., Lan, Y., & Liang, Y. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1122 · Cited by 180

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

Tai, N., Peng, J., Liu, F., Gülden, E., Hu, Y., Zhang, X., Chen, L., Wong, F. S., & Li, W. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160526 · Cited by 167

New Insights Into Gestational Glucose Metabolism: Lessons Learned From 21st Century Approaches

Angueira, A. R., Ludvik, A. E., Reddy, T. E., Wicksteed, B. L., Lowe, W. L., & Layden, B. T. (2015) · Diabetes · doi:10.2337/db14-0877 · Cited by 165

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology

Stefan, M., Zhang, W., Concepcion, E., Yi, Z., & Tomer, Y. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.10.001 · Cited by 150

Genetic and Epigenetic Factors in Etiology of Diabetes Mellitus Type 1

Stankov, K., Benc, D., & Drašković, D. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1652 · Cited by 135

Metabolomics in diabetes research

Friedrich, N. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0120 · Cited by 138

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

Bergholdt, R., Brorsson, C., Palleja, A., Berchtold, L. A., Fløyel, T., Bang-Berthelsen, C. H., Frederiksen, K. S., Jensen, L. J., Størling, J., & Pociot, F. (2012) · Diabetes · doi:10.2337/db11-1263 · Cited by 125

Type 1 diabetes: A predictable disease

Simmons, K. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.380 · Cited by 129

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

Marroquí, L., Santín, I., dos Santos, R. S., Marselli, L., Marchetti, P., & Eizirik, D. L. (2014) · Diabetes · doi:10.2337/db13-1443 · Cited by 113

Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review

Xie, X., Wu, C., Hao, Y., Wang, T., Yang, Y., Cai, P., Zhang, Y., Huang, J., Deng, K., Yan, D., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1301093 · Cited by 129

MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes

Salas‐Pérez, F., Ethel Codner, D., Valencia, E., Pizarro, C., Carrasco, E., & Pérez‐Bravo, F. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.08.276 · Cited by 104

Type 1 diabetes genome‐wide association studies: not to be lost in translation

Pociot, F. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.51 · Cited by 101

Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review

Watkins, R. A., Evans‐Molina, C., Blum, J. S., & DiMeglio, L. A. (2014) · Translational research · doi:10.1016/j.trsl.2014.02.004 · Cited by 87

Interleukin-15 in autoimmunity

Allard‐Chamard, H., Mishra, H. K., Nandi, M., Mayhue, M., Menéndez, A., Ilangumaran, S., & Ramanathan, S. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155258 · Cited by 84

Stem-cell based organ-on-a-chip models for diabetes research

Rogal, J., Zbinden, A., Schenke‐Layland, K., & Loskill, P. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.010 · Cited by 89

Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes

Tomer, Y., Dolan, L. M., Kahaly, G. J., Divers, J., D'Agostino, R. B., Imperatore, G., Dabelea, D., Marcovina, S. M., Black, M. H., Pihoker, C., et al. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.03.006 · Cited by 80

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

Santín, I., Moore, F., Grieco, F. A., Marchetti, P., Brancolini, C., & Eizirik, D. L. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.158 · Cited by 80

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children

Achenbach, P., Hummel, M., Thümer, L., Boerschmann, H., Höfelmann, D., & Ziegler, A. G. (2013) · Diabetologia · doi:10.1007/s00125-013-2896-y · Cited by 76

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review

Tizaoui, K., Terrazzino, S., Cargnin, S., Lee, K. H., Gauckler, P., Li, H. J., Shin, J. I., & Kronbichler, A. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2021.03.004 · Cited by 76

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions

Zilbauer, M., Rayner, T. F., Clark, C., Coffey, A. J., Joyce, C. J., Palta, P., Palotie, A. V., Lyons, P., & Smith, K. G. C. (2013) · Blood · doi:10.1182/blood-2013-05-503201 · Cited by 71

Integrative omics analysis elucidates the genetic basis underlying seed weight and oil content in soybean

Yuan, X.-B., Jiang, X., Zhang, M., Wang, L., Wu, J., Chen, H., Mao, J., Ye, W., & Song, Q. (2024) · The Plant Cell · doi:10.1093/plcell/koae062 · Cited by 70

12q24 locus association with type 1 diabetes:SH2B3orATXN2?

Auburger, G. W. J. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i3.316 · Cited by 64

Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease

Carbonetto, P. S., & Stephens, M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003770 · Cited by 68

Functional profiling of the gut microbiome in disease-associated inflammation

Börnigen, D., Morgan, X. C., Franzosa, E. A., Ren, B., Xavier, R. J., Garrett, W. S., & Huttenhower, C. (2013) · Genome Medicine · doi:10.1186/gm469 · Cited by 72

Genetic heterogeneity: Challenges, impacts, and methods through an associative lens

Woodward, A., Urbanowicz, R. J., Naj, A. C., & Moore, J. H. (2022) · Genetic Epidemiology · doi:10.1002/gepi.22497 · Cited by 71

Antigen Presentation in the Autoimmune Diabetes of the NOD Mouse

Unanue, E. R. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095941 · Cited by 63

Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus

Wang, Q., Xi, B., Reilly, K. H., Liu, M., & Fu, M. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1805-7 · Cited by 63

MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

Juan‐Mateu, J., Villate, O., & Eizirik, D. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0916 · Cited by 59

Anti-Inflammatory Therapy in Type 1 Diabetes

Baumann, B., Salem, H. H., & Boehm, B. O. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0299-y · Cited by 59

Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries

Zayed, H. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0736-4 · Cited by 56

NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count

Qin, J., Fu, S., Speake, C., Greenbaum, C. J., & Odegard, J. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12783 · Cited by 55

Identification of new key genes for type 1 diabetes through construction and analysis of protein–protein interaction networks based on blood and pancreatic islet transcriptomes

Safari‐Alighiarloo, N., Taghizadeh, M. T., Tabatabaei, S. M., Shahsavari, S., Namaki, S., Khodakarim, S., & Rezaei–Tavirani, M. (2016) · Journal of Diabetes · doi:10.1111/1753-0407.12483 · Cited by 54

Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset

Gioia, L., Holt, M., Costanzo, A. E., Sharma, S. M., Abe, B. T., Kain, L., Nakayama, M., Wan, X., Su, A. I., Mathews, C. E., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw6329 · Cited by 54

Autoimmunity's next top models

Wekerle, H., Flügel, A., Fugger, L. H., Schett, G. A., & SERREZE, D. V. (2012) · Nature Medicine · doi:10.1038/nm.2635 · Cited by 53

On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes

Busch, R., Riva, A. D., Hadjinicolaou, A. V., Jiang, W., Hou, T., & Mellins, E. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2012.9 · Cited by 53

Development of T‐cell tolerance utilizes both cell‐autonomous and cooperative presentation of self‐antigen

Perry, J. S. A., & Hsieh, C. (2016) · Immunological Reviews · doi:10.1111/imr.12403 · Cited by 56

PD‐L1 gene polymorphisms and low serum level of PD‐L1 protein are associated to type 1 diabetes in Chile

Pizarro, C., García‐Díaz, D. F., Ethel Codner, D., Salas‐Pérez, F., Carrasco, E., & Pérez‐Bravo, F. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2552 · Cited by 51

Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?

O’Kell, A. L., Wasserfall, C. H., Catchpole, B., Davison, L. J., Hess, R. S., Kushner, J. A., & Atkinson, M. A. (2017) · Diabetes · doi:10.2337/db16-1551 · Cited by 54

Dietary Cows’ Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice

Chia, J. S., McRae, J. L., Enjapoori, A. K., Lefèvre, C. M., Kukuljan, S., & Dwyer, K. M. (2018) · Nutrients · doi:10.3390/nu10091291 · Cited by 52

New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

Teo, A. K. K., Wagers, A. J., & Kulkarni, R. N. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.010 · Cited by 49

Monogenic autoimmune diseases of the endocrine system

Johnson, M. B., Hattersley, A. T., & Flanagan, S. E. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30095-x · Cited by 48

The Critical Role of Bach2 in Shaping the Balance between CD4 + T Cell Subsets in Immune-Mediated Diseases

Yang, L., Chen, S., Zhao, Q., Sun, Y., & Nie, H. (2019) · Mediators of Inflammation · doi:10.1155/2019/2609737 · Cited by 47

The NOD Mouse Beyond Autoimmune Diabetes

Aubin, A., Lombard‐Vadnais, F., Collin, R., Aliesky, H. A., McLachlan, S. M., & Lesage, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.874769 · Cited by 51

The multi-faceted functioning portrait of LRF/ZBTB7A

Constantinou, C., Σπέλλα, Μ., Chondrou, V., Patrinos, G. P., Papachatzopoulou, A., & Sgourou, A. (2019) · Human Genomics · doi:10.1186/s40246-019-0252-0 · Cited by 48

Genetic Aspects of type 1 diabetes

Lee, H. S., & Hwang, J. S. (2019) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2019.24.3.143 · Cited by 57

Pancreatic islet autoimmunity

Boîtard, C. (2012) · La Presse Médicale · doi:10.1016/j.lpm.2012.10.003 · Cited by 48

Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5

Loh, N. Y., Bentley, L., Dimke, H., Verkaart, S., Tammaro, P., Gorvin, C. M., Stechman, M., Ahmad, B. N., Hannan, F. M., Piret, S. E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055412 · Cited by 43

Advances in immunotherapy of type I diabetes

Ni, Q., Pham, N. B., Meng, W. S., Zhu, G., & Chen, X. S. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.003 · Cited by 42

Natural Killer Cells as Key Mediators in Type I Diabetes Immunopathology

Gardner, G., & Fraker, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.722979 · Cited by 44

Frequent delay of coeliac disease diagnosis in symptomatic patients with type 1 diabetes mellitus: Clinical and genetic characteristics

Bakker, S. F., Tushuizen, M. E., Stokvis‐Brantsma, W. H., Aanstoot, H., Winterdijk, P., van Setten, P. A., Flier, B., Mulder, C. J. J., & Şimşek, S. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.01.016 · Cited by 41

Genome-Wide Scan Reveals LEMD3 and WIF1 on SSC5 as the Candidates for Porcine Ear Size

Zhang, L., Liang, J., Luo, W., Liu, X., Yan, H., Zhao, K., Shi, H., Zhang, Y., Wang, L., & Wang, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102085 · Cited by 40

Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose

O’Brien, R. M. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0422-8 · Cited by 40

Modeling different types of diabetes using human pluripotent stem cells

Abdelalim, E. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03710-9 · Cited by 38

Helminth Infection and Type 1 Diabetes

Zaccone, P., & Hall, S. W. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.272 · Cited by 43

The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors

Cangoz, S., Chang, Y.-Y., Chempakaseril, S. J., Guduru, R. C., Huynh, L. M., John, J. S., John, S. T., Joseph, M. E., Judge, R., Kimmey, R., et al. (2013) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12077 · Cited by 35

Association of 32 type 1 diabetes risk loci in Pakistani patients

Kiani, A. K., John, P. C. L., Bhatti, A., Zia, A., Shahid, G., Akhtar, P., Wang, X., Demirci, F. Y., & Kamboh, M. I. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.01.022 · Cited by 35

Type 1 diabetes: genes associated with disease development

Klak, M., Gomółka, M., Kowalska, P. D., Cichoń-Woźniak, J., Ambrożkiewicz, F., Serwańska-Świętek, M., Berman, A., & Wszola, M. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2020.103386 · Cited by 39

Polymorphism in the Innate Immune Receptor SIRPα Controls CD47 Binding and Autoimmunity in the Nonobese Diabetic Mouse

Wong, A. S. L., Mortin-Toth, S. M., Sung, M., Canty, A. J., Gulban, O., Greaves, D. R., & Danska, J. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401984 · Cited by 34

AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination

Tsukumo, S., Subramani, P. G., Seija, N., Tabata, M., Maekawa, Y., Mori, Y., Ishifune, C., Itoh, Y., Ota, M., Fujio, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq0008 · Cited by 36

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

Ye, Y., Richardson, T. G., McArdle, W. L., Relton, C. L., Gillespie, K. M., Suderman, M. J., & Hemani, G. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.06.005 · Cited by 33

Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis

Leung, S. S., Forbes, J. M., & Borg, D. J. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0782-y · Cited by 31

A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats

Qaisar, N., Lin, S., Ryan, G., Yang, C., Oikemus, S., Brodsky, M. H., Bortell, R., Mordes, J. P., & Wang, J. P. (2016) · Diabetes · doi:10.2337/db16-0462 · Cited by 31

Regulatory T cell-based therapy in type 1 diabetes: Latest breakthroughs and evidence

Huang, Q., & Zhu, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112724 · Cited by 33

Unravelling the Roles of Susceptibility Loci for Autoimmune Diseases in the Post-GWAS Era

Ye, Y., Gillespie, K. M., & Rodrı́guez, S. (2018) · Genes · doi:10.3390/genes9080377 · Cited by 31

Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula

Alnaqbi, H., Mawart, A., Alshamsi, J., AlSafar, H. S., & Tay, G. K. (2021) · Immunogenetics · doi:10.1007/s00251-021-01204-x · Cited by 31

Environmental factors in the etiology of type 1 diabetes, celiac disease, and narcolepsy

Lernmark, Å. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12390 · Cited by 29

Older Age Results in Differential Gene Expression after Mild Traumatic Brain Injury and Is Linked to Imaging Differences at Acute Follow-up

Cho, Y., Latour, L. L., Kim, H., Turtzo, L. C., Olivera, A., Livingston, W. S., Wang, D., Martin, C. G., Lai, C., Cashion, A. K., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00168 · Cited by 27

Increased expression of microRNAs, miR-20a and miR-326 in PBMCs of patients with type 1 diabetes

Azhir, Z., Dehghanian, F., & Hojati, Z. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4352-z · Cited by 27

Progress in Understanding Type 1 Diabetes Through Its Genetic Overlap with Other Autoimmune Diseases

Roizen, J. D., Bradfield, J. P., & Hakonarson, H. H. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0668-4 · Cited by 27

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools

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Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes

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