MicroRNAs in placental health and disease
Open accessAbstract
MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded by the genomes of most organisms. They regulate gene expression through posttranscriptional mechanisms to attenuate protein output in various genetic networks. The discovery of miRNAs has transformed our understanding of gene regulation and sparked intense efforts intended to harness their potential as diagnostic markers and therapeutic tools. Over the last decade, a flurry of studies has shed light on placental miRNAs but has also raised many questions regarding the scope of their biologic action. Moreover, the recognition that miRNAs of placental origin are released continually in the maternal circulation throughout pregnancy suggested that circulating miRNAs might serve as biomarkers for placental function during pregnancy. Although this generated much enthusiasm, recently recognized challenges have delayed the application of miRNA-based biomarkers and therapeutics in clinical practice. In this review, we summarize key findings in the field and discuss current knowledge related to miRNAs in the context of placental biology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The human placenta expresses a wide variety of non-coding RNAs, but few data are available regarding their responsiveness to hypoxia.
“The human placenta expresses a wide variety of non-coding RNAs (398), but few data are available regarding their responsiveness to hypoxia.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [398]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,896 · see citing works
miRBase: annotating high confidence microRNAs using deep sequencing data
Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 4,629 · see citing works
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603 · see citing works
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560 · see citing works
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,355 · see citing works
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 4,333 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592 · see citing works
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 3,181 · see citing works
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873 · see citing works
Processing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784 · see citing works
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y. C., Huang, K., Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,754 · see citing works
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741 · see citing works
Functional siRNAs and miRNAs exhibit strand bias
Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645 · see citing works
MicroRNA maturation: stepwise processing and subcellular localization
Lee, Y., Jeon, K., Lee, J., Kim, S., & Kim, V. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf476 · Cited by 2,468 · see citing works
Griffiths-Jones, S. (2004) · Nucleic Acids Res. · doi:10.1093/nar/gkh023 · Cited by 2,446 · see citing works
Argonaute2 is the catalytic engine of mammalian RNAi
Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,353 · see citing works
Asymmetry in the Assembly of the RNAi Enzyme Complex
Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,323 · see citing works
Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,287 · see citing works
Dicer is essential for mouse development
Bernstein, E., Kim, S. Y., Carmell, M., Murchison, E., Alcorn, H. L., Li, M. Z., Mills, A., Elledge, S., Anderson, K., & Hannon, G. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 2,100 · see citing works
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941 · see citing works
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899 · see citing works
A uniform system for microRNA annotation
Ambros, V., Bartel, B., Bartel, D. P., Burge, C. B., Carrington, J. C., Chen, X., Dreyfuss, G., Eddy, S. R., Griffiths‐Jones, S., Marshall, M. S., et al. (2003) · RNA · doi:10.1261/rna.2183803 · Cited by 1,885 · see citing works
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791 · see citing works
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765 · see citing works
Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B., Liggins, A. P., Pulford, K. A. F., Banham, A. H., Pezzella, F., Boultwood, J., Wainscoat, J. S., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07077.x · Cited by 1,739 · see citing works
Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00431-7 · Cited by 1,600 · see citing works
Ventura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A., Erkeland, S. J., Newman, J. J., Bronson, R. T., Crowley, D. G., Stone, J. R., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.019 · Cited by 1,592 · see citing works
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,558 · see citing works
Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,527 · see citing works
Intronic microRNA precursors that bypass Drosha processing
Ruby, J. G., Jan, C. H., & Bartel, D. P. (2007) · Nature · doi:10.1038/nature05983 · Cited by 1,445 · see citing works
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
Raiborg, C., & Stenmark, H. (2009) · Nature · doi:10.1038/nature07961 · Cited by 1,408 · see citing works
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
Helwak, A., Kudla, G., Dudnakova, T., & Tollervey, D. (2013) · Cell · doi:10.1016/j.cell.2013.03.043 · Cited by 1,269 · see citing works
Wang, G., Zhu, J., Zhang, J., Li, Q., Li, Y., He, J., Qin, Y., & Jing, Q. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq013 · Cited by 1,168 · see citing works
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L. E., & Galas, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813371106 · Cited by 1,149 · see citing works
Quantitative and stoichiometric analysis of the microRNA content of exosomes
Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,105 · see citing works
microRNA target predictions in animals
Rajewsky, N. (2006) · Nature Genetics · doi:10.1038/ng1798 · Cited by 1,086 · see citing works
Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084 · see citing works
Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080 · see citing works
The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila
Okamura, K., Hagen, J. W., Duan, H., Tyler, D. M., & Lai, E. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.028 · Cited by 1,028 · see citing works
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,026 · see citing works
Export of microRNAs and microRNA-protective protein by mammalian cells
Wang, K., Zhang, S., Weber, J., Baxter, D., & Galas, D. J. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq601 · Cited by 1,002 · see citing works
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
Huang, Q., Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S., Egan, D. A., Li, A., Huang, G., Klein–Szanto, A. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1681 · Cited by 973 · see citing works
Perspective: machines for RNAiPreprint
Tomari, Y., & Zamore, P. D. (2005) · Genes & Development · doi:10.1101/gad.1284105 · Cited by 950 · see citing works
Babiarz, J., Ruby, J. G., Wang, Y., Bartel, D. P., & Blelloch, R. H. (2008) · Genes & Development · doi:10.1101/gad.1705308 · Cited by 905 · see citing works
Detection and Characterization of Placental MicroRNAs in Maternal Plasma
Chim, S. S. C., Shing, T. K. F., Hung, E. C. W., Leung, T.-Y., Lau, T. K., Chiu, R. W. K., & Lo, Y. M. D. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.097972 · Cited by 844 · see citing works
A Human snoRNA with MicroRNA-Like Functions
Ender, C., Krek, A., Friedländer, M. R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N., & Meister, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.017 · Cited by 837 · see citing works
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works
Mogilyansky, E., & Rigoutsos, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.125 · Cited by 810 · see citing works
The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r
Keniry, A., Oxley, D., Monnier, P., Kyba, M., Dandolo, L., Smits, G., & Reik, W. (2012) · Nature Cell Biology · doi:10.1038/ncb2521 · Cited by 806 · see citing works
Berezikov, E., Chung, W., Willis, J., Cuppen, E. P. J. G., & Lai, E. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.028 · Cited by 795 · see citing works
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes & Development · doi:10.1101/gad.1884710 · Cited by 732 · see citing works
Nabhan, J. F., Hu, R., Oh, R. S., Cohen, S. N., & Lu, Q. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200448109 · Cited by 722 · see citing works
Evolution of microRNA diversity and regulation in animals
Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712 · see citing works
An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 697 · see citing works
miR-122 – A key factor and therapeutic target in liver disease
Bandiera, S., Pfeffer, S., Baumert, T. F., & Zeisel, M. B. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.004 · Cited by 633 · see citing works
Szabó, G., & Bala, S. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.87 · Cited by 596 · see citing works
Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
Zeng, Y., Yi, R., & Cullen, B. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600491 · Cited by 566 · see citing works
Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants
Yang, J.-S., & Lai, E. C. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.024 · Cited by 498 · see citing works
Human placental trophoblasts confer viral resistance to recipient cells
Delorme‐Axford, E., Donker, R. B., Mouillet, J., Chu, T., Bayer, A., Ouyang, Y., Wang, T., Stolz, D. B., Sarkar, S. N., Morelli, A. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304718110 · Cited by 494 · see citing works
Self-citationLuo, S.-S., Ishibashi, O., Ishikawa, G., Ishikawa, T., Katayama, A., Mishima, T., Takizawa, T., Shigihara, T., Goto, T., Izumi, A., et al. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.075481 · Cited by 489 · see citing works
MicroRNA Regulatory Networks in Cardiovascular Development
Liu, N., & Olson, E. N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.010 · Cited by 488 · see citing works
RNAi: The Nuts and Bolts of the RISC Machine
Filipowicz, W. (2005) · Cell · doi:10.1016/j.cell.2005.06.023 · Cited by 485 · see citing works
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · see citing works
Yang, J.-S., Maurin, T., Robine, N., Rasmussen, K. D., Jeffrey, K. L., Chandwani, R., Papapetrou, E. P., Sadelain, M., O’Carroll, D., & Lai, E. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006432107 · Cited by 481 · see citing works
MicroRNAs in cardiovascular disease: an introduction for clinicians
Romaine, S. P. R., Tomaszewski, M., Condorelli, G., & Samani, N. J. (2015) · Heart · doi:10.1136/heartjnl-2013-305402 · Cited by 479 · see citing works
Plasma miR-208 as a Biomarker of Myocardial Injury
Ji, X., Takahashi, R., Hiura, Y., Hirokawa, G., Fukushima, Y., & Iwai, N. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.125310 · Cited by 471 · see citing works
A Large Imprinted microRNA Gene Cluster at the Mouse Dlk1-Gtl2 Domain
Seitz, H., Royo, H., Bortolin, M.-L., Lin, S.-P., Ferguson-Smith, A. C., & Cavaillé, J. (2004) · Genome Research · doi:10.1101/gr.2743304 · Cited by 450 · see citing works
Pineles, B. L., Romero, R., Montenegro, D., Tarca, A. L., Han, Y. M., Kim, Y. M., Draghici, S., Espinoza, J., Kusanovic, J. P., Mittal, P., et al. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.01.008 · Cited by 450 · see citing works
Circulating MicroRNA biomarker studies: pitfalls and potential solutions
Witwer, K. W. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.221341 · Cited by 447 · see citing works
Leukemia cell to endothelial cell communication via exosomal miRNAs
Umezu, T., Ohyashiki, K., Kuroda, M., & Ohyashiki, J. H. (2012) · Oncogene · doi:10.1038/onc.2012.295 · Cited by 446 · see citing works
Methodological challenges in utilizing mi<scp>RNA</scp>s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436 · see citing works
Assembly and function of RNA silencing complexes
Sontheimer, E. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1568 · Cited by 424 · see citing works
Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1
Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., Rothstein, J., & Yang, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410944 · Cited by 390 · see citing works
Ruvkun, G. (2001) · Science · doi:10.1126/science.1066315 · Cited by 357 · see citing works
MicroRNA-210: A unique and pleiotropic hypoxamir
Chan, S. Y., & Loscalzo, J. (2010) · Cell Cycle · doi:10.4161/cc.9.6.11006 · Cited by 357 · see citing works
MicroRNAs in kidney physiology and disease
Trionfini, P., Benigni, A., & Remuzzi, G. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.202 · Cited by 352 · see citing works
Zhu, X.-M., Han, T., Sargent, I. L., Yin, G.-W., & Yao, Y.-Q. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.12.045 · Cited by 345 · see citing works
Williams, Z., Ben‐Dov, I. Z., Elias, R. T., Mihailovic, A., Brown, M., Rosenwaks, Z., & Tuschl, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214046110 · Cited by 339 · see citing works
The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes
Donker, R. B., Mouillet, J., Chu, T., Hubel, C. A., Stolz, D. B., Morelli, A. E., & Sadovsky, Y. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas013 · Cited by 337 · see citing works
Self-citationMicroRNAs and cardiac pathology
Latronico, M. V. G., & Condorelli, G. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.56 · Cited by 318 · see citing works
Determining the role of microRNAs in psychiatric disorders
Issler, O., & Chen, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3879 · Cited by 309 · see citing works
The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition
Cloonan, N., Brown, M. K., Steptoe, A. L., Wani, S., Chan, W. L., Forrest, A. R., Kolle, G., Gabrielli, B., & Grimmond, S. M. (2008) · Genome Biology · doi:10.1186/gb-2008-9-8-r127 · Cited by 304 · see citing works
Bar, M., Wyman, S. K., Fritz, B. R., Qi, J., Garg, K. S., Parkin, R. K., Kroh, E. M., Bendoraite, A., Mitchell, P. S., Nelson, A. M., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0356 · Cited by 300 · see citing works
Many Families of C. elegans MicroRNAs Are Not Essential for Development or Viability
Alvarez-Saavedra, E., & Horvitz, H. R. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.051 · Cited by 295 · see citing works
miR‐210: More than a silent player in hypoxia
Devlin, C. M., Greco, S., Martelli, F., & Ivan, M. (2011) · IUBMB Life · doi:10.1002/iub.427 · Cited by 289 · see citing works
MicroRNA expression profiles of trophoblastic cells
Prieto, D. M. M., Chaiwangyen, W., Ospina‐Prieto, S., Schneider, U., Herrmann, J., Gruhn, B., & Markert, U. R. (2012) · Placenta · doi:10.1016/j.placenta.2012.05.009 · Cited by 252 · see citing works
Zhao, J., Yang, J., Lin, J., Yao, N., Zhu, Y., Zheng, J., Xu, J., Cheng, J. Q., Lin, J.-Y., & Ma, X. (2008) · Child s Nervous System · doi:10.1007/s00381-008-0701-x · Cited by 246 · see citing works
Placental microRNA expression in pregnancies complicated by preeclampsia
Enquobahrie, D. A., Abetew, D. F., Sorensen, T. K., Willoughby, D., Chidambaram, K., & Williams, M. A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.09.004 · Cited by 239 · see citing works
MIR-210 modulates mitochondrial respiration in placenta with preeclampsia
Muralimanoharan, S., Maloyan, A., Mele, J., Guo, C., Myatt, L. G., & Myatt, L. (2012) · Placenta · doi:10.1016/j.placenta.2012.07.002 · Cited by 237 · see citing works
Zhang, Y., Fei, M., Xue, G., Zhou, Q., Jia, Y., Li, L., Xin, H., & Sun, S. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01291.x · Cited by 236 · see citing works
Li, M., Lee, K. F., Lu, Y., Clarke, I. D., Shih, D. J. H., Eberhart, C. G., Collins, V. P., Meter, T. E. V., Picard, D. J., Zhou, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.025 · Cited by 235 · see citing works
Chiba, M., KIMURA, M., & ASARI, S. (2012) · Oncology Reports · doi:10.3892/or.2012.1967 · Cited by 232 · see citing works
C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts
Bortolin‐Cavaillé, M., Dance, M., Weber, M., & Cavaillé, J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp205 · Cited by 231 · see citing works
Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy
Xu, P., Zhao, Y., Liu, M., Wang, Y., Wang, H., Li, Y., Zhu, X., Yao, Y., Wang, H., Qiao, J., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02647 · Cited by 219 · see citing works
iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2011) · Journal of Visualized Experiments · doi:10.3791/2638 · Cited by 206 · see citing works
Kleinman, C. L., Gerges, N., Papillon‐Cavanagh, S., Sin‐Chan, P., Pramatarova, A., Khuong-Quang, D.-A., Adoue, V., Busche, S., Caron, M., Djambazian, H. H. V., et al. (2013) · Nature Genetics · doi:10.1038/ng.2849 · Cited by 197 · see citing works
Fornari, F., Milazzo, M., Chieco, P., Negrini, M., Marasco, E., Capranico, G., Mantovani, V., Marinello, J., Sabbioni, S., Callegari, E., et al. (2012) · The Journal of Pathology · doi:10.1002/path.3995 · Cited by 189 · see citing works
Review: Placenta-specific microRNAs in exosomes – Good things come in nano-packages
Ouyang, Y., Mouillet, J., Coyne, C. B., & Sadovsky, Y. (2013) · Placenta · doi:10.1016/j.placenta.2013.11.002 · Cited by 188 · see citing works
Self-citationMicroRNA Biogenesis via Splicing and Exosome-Mediated Trimming in Drosophila
Flynt, A. S., Greimann, J. C., Chung, W., Lima, C. D., & Lai, E. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.014 · Cited by 183 · see citing works
MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells
Ren, J., Jin, P., Wang, E., Marincola, F. M., & Stroncek, D. F. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-20 · Cited by 181 · see citing works
A Resource for the Conditional Ablation of microRNAs in the Mouse
Park, C. Y., Jeker, L. T., Carver-Moore, K., Oh, A., Liu, H. J., Cameron, R., Richards, H. W., Li, Z., Adler, D., Yoshinaga, Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.008 · Cited by 174 · see citing works
Ishibashi, O., Ohkuchi, A., Ali, M. M., Kurashina, R., Luo, S.-S., Ishikawa, T., Takizawa, T., Hirashima, C., Takahashi, K., Migita, M., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.180232 · Cited by 173 · see citing works
Noncoding RNAs and myocardial fibrosis
Thum, T. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.125 · Cited by 170 · see citing works
Fu, G., Ye, G., Nadeem, L., Ji, L., Manchanda, T., Wang, Y., Zhao, Y., Qiao, J., Wang, Y., Lye, S. J., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.203489 · Cited by 170 · see citing works
MicroRNA-155 contributes to preeclampsia by down-regulating CYR61
Zhang, Y., Diao, Z., Su, L., Sun, H., Li, R., Cui, H., & Hu, Y. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.057 · Cited by 167 · see citing works
Kumar, P., Luo, Y., Tudela, C. M., Alexander, J. M., & Mendelson, C. R. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01228-12 · Cited by 161 · see citing works
miR-210 Inhibits Trophoblast Invasion and Is a Serum Biomarker for Preeclampsia
Anton, L., Olarerin-George, A. O., Schwartz, N., Srinivas, S. K., Bastek, J. A., Hogenesch, J. B., & Elovitz, M. A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.07.021 · Cited by 159 · see citing works
MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal
Luo, L., Ye, G., Nadeem, L., Fu, G., Yang, B. B., Dunk, C., Lye, S. J., & Peng, C. (2012) · Journal of Cell Science · doi:10.1242/jcs.096412 · Cited by 155 · see citing works
Morita, S., Horii, T., Kimura, M., Goto, Y., Ochiya, T., & Hatada, I. (2007) · Genomics · doi:10.1016/j.ygeno.2007.01.004 · Cited by 152 · see citing works
Characterization of placenta‐specific microRNAs in fetal growth restriction pregnancy
東島, 愛., Miura, K., Mishima, H., Kinoshita, A., Jo, O., Abe, S., Hasegawa, Y., Miura, S., Yamasaki, K., Yoshida, A., et al. (2013) · Prenatal Diagnosis · doi:10.1002/pd.4045 · Cited by 140 · see citing works
miR-210: Fine-Tuning the Hypoxic Response
Ivan, M., & Huang, X. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_10 · Cited by 135 · see citing works
miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines
Lee, D.-C., Romero, R., Kim, J.-S., Tarca, A. L., Montenegro, D., Pineles, B. L., Kim, E., Lee, J., Kim, S. Y., Draghici, S., et al. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.04.035 · Cited by 135 · see citing works
The miR‐379/miR‐410 cluster at the imprinted Dlk1‐Dio3 domain controls neonatal metabolic adaptation
Labialle, S., Marty, V., Bortolin‐Cavaillé, M., Hoareau-Osman, M., Pradère, J., Valet, P., Martin, P. G. P., & Cavaillé, J. (2014) · The EMBO Journal · doi:10.15252/embj.201387038 · Cited by 134 · see citing works
Colleoni, F., Padmanabhan, N., Yung, H.-W., Watson, E. D., Cetin, I., Tissot van Patot, M. C., Burton, G. J., & Murray, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055194 · Cited by 128 · see citing works
C19MC MicroRNAs Regulate the Migration of Human Trophoblasts
Xie, L., Mouillet, J., Chu, T., Parks, W. T., Sadovsky, E., Knöfler, M., & Sadovsky, Y. (2014) · Endocrinology · doi:10.1210/en.2014-1501 · Cited by 124 · see citing works
Self-citationA Primate Herpesvirus Uses the Integrator Complex to Generate Viral MicroRNAs
Cazalla, D., Xie, M., & STEITZ, J. A. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.025 · Cited by 118 · see citing works
Dai, Y., Qiu, Z., Diao, Z., Shen, L., Xue, P., Sun, H., & Hu, Y. (2012) · Placenta · doi:10.1016/j.placenta.2012.07.012 · Cited by 115 · see citing works
MicroRNA-210 Contributes to Preeclampsia by Downregulating Potassium Channel Modulatory Factor 1
Luo, R., Shao, X., Xu, P., Liu, Y., Wang, Y., Zhao, Y., Liu, M., Ji, L., Li, Y., Chang, C. K., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03530 · Cited by 114 · see citing works
Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases
Zhao, Z., Moley, K. H., & Gronowski, A. M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.01.026 · Cited by 113 · see citing works
Dampening Enthusiasm for Circulating MicroRNA in Breast Cancer
Leidner, R. S., Li, L., & Thompson, C. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057841 · Cited by 113 · see citing works
Human trophoblasts confer resistance to viruses implicated in perinatal infection
Bayer, A., Delorme‐Axford, E., Sleigher, C., Frey, T. K., Trobaugh, D. W., Klimstra, W. B., Emert‐Sedlak, L. A., Smithgall, T. E., Kinchington, P. R., Vadia, S., et al. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.07.060 · Cited by 112 · see citing works
Self-citationRippe, V., Dittberner, L., Lorenz, V., Drieschner, N., Nimzyk, R., Sendt, W., Junker, K., Belge, G., & Bullerdiek, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009485 · Cited by 110 · see citing works
Circulating C19MC MicroRNAs in Preeclampsia, Gestational Hypertension, and Fetal Growth Restriction
Hromadníková, I., Kotlabová, K., Ondráčková, M., Kestlerová, A., Novotna, V., Hympanova, L. H., Doucha, J., & Krofta, L. (2013) · Mediators of Inflammation · doi:10.1155/2013/186041 · Cited by 104 · see citing works
Deregulated microRNA species in the plasma and placenta of patients with preeclampsia
Yang, S., Li, H., Ge, Q., Guo, L., & Chen, F. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3414 · Cited by 95 · see citing works
Elsevier Trophoblast Research Award Lecture: Origin, evolution and future of placenta miRNAs
Prieto, D. M. M., Ospina‐Prieto, S., Schmidt, A., Chaiwangyen, W., & Markert, U. R. (2013) · Placenta · doi:10.1016/j.placenta.2013.11.017 · Cited by 92 · see citing works
Kambe, S., Yoshitake, H., Yuge, K., Ishida, Y., Ali, M. M., Takizawa, T., Kuwata, T., Ohkuchi, A., Matsubara, S., Suzuki, M., et al. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.121616 · Cited by 90 · see citing works
Understanding functional miRNA–target interactions in vivo by site-specific genome engineering
Bassett, A. R., Azzam, G., Wheatley, L., Tibbit, C., Rajakumar, T., McGowan, S. J., Stanger, N., Ewels, P., Taylor, S., Ponting, C. P., et al. (2014) · Nature Communications · doi:10.1038/ncomms5640 · Cited by 88 · see citing works
Tumour‐derived exosomes: Tiny envelopes for big stories
Miller, I. V., & Grunewald, T. (2015) · Biology of the Cell · doi:10.1111/boc.201400095 · Cited by 87 · see citing works
Differentially Expressed Genes in the Pre-Eclamptic Placenta: A Systematic Review and Meta-Analysis
Kleinrouweler, C. E., van Uitert, M., Moerland, P. D., Ris‐Stalpers, C., van der Post, J., & Afink, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068991 · Cited by 82 · see citing works
Guo, L., Tsai, S. Q., Hardison, N. E., James, A., Motsinger‐Reif, A. A., Thames, B., Stone, E. A., Deng, C., & Piedrahita, J. A. (2013) · Placenta · doi:10.1016/j.placenta.2013.04.007 · Cited by 77 · see citing works
MicroRNAs in embryonic stem cells and early embryonic development
Laurent, L. C. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00513.x · Cited by 75 · see citing works
Anton, L., Olarerin-George, A. O., Hogenesch, J. B., & Elovitz, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122707 · Cited by 74 · see citing works
The Function of TrophomiRs and Other MicroRNAs in the Human PlacentaPreprint
Sadovsky, Y., Mouillet, J., Ouyang, Y., Bayer, A., & Coyne, C. B. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023036 · Cited by 71 · see citing works
Self-citationCell-free microRNAs: potential biomarkers in need of standardized reporting
Kirschner, M. B., van Zandwijk, N., & Reid, G. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00056 · Cited by 69 · see citing works
Myatt, L., Muralimanoharan, S., & Maloyan, A. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1031-1_12 · Cited by 62 · see citing works
Li, Q., Pan, Z., Wang, X., Gao, Z., Ren, C., & Yang, W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.059 · Cited by 59 · see citing works
TLR3-Induced Placental miR-210 Down-Regulates the STAT6/Interleukin-4 Pathway
Kopriva, S. E., Chiasson, V. L., Mitchell, B. M., & Chatterjee, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067760 · Cited by 57 · see citing works
Tan, S. M., Kirchner, R. D., Jin, J., Hofmann, O., McReynolds, L. A., Hide, W. A., & Lieberman, J. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.023 · Cited by 56 · see citing works
Biogenesis and the regulation of the maturation of miRNAs
Tran, N., & Hutvágner, G. (2013) · Essays in Biochemistry · doi:10.1042/bse0540017 · Cited by 52 · see citing works
Oulas, A., Karathanasis, N., Louloupi, A., Pavlopoulos, G. A., Poirazi, P., Kalantidis, K., & Iliopoulos, I. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-2291-8_13 · Cited by 39 · see citing works
Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes
Liu, H., Chen, Y., Lv, J., Liu, H., Zhu, R., Su, J., Liu, X., Zhang, Y., & Wu, Q. (2013) · Scientific Reports · doi:10.1038/srep02576 · Cited by 25 · see citing works
Wang, D., Chen, X., Song, Y., Lv, Q., Lai, L., & Li, Z. (2014) · Gene · doi:10.1016/j.gene.2014.06.059 · Cited by 18 · see citing works
Do Platform-Specific Factors Explain MicroRNA Profiling Disparities?
Watson, A. K., & Witwer, K. W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.175281 · Cited by 17 · see citing works
Guillermo, M., & Tajudeen, D. (2014) · Journal of Fertilization In Vitro - IVF-Worldwide Reproductive Medicine Genetics & Stem Cell Biology · doi:10.4172/jfiv.1000118 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia
Tannetta, D., Masliukaitė, I., Vatish, M., Redman, C. W. G., & Sargent, I. L. (2016) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2016.08.008 · Cited by 209 · see citing works
“008 lipids and miRNAs (recently reviewed by (Tannetta and Sargent, 2013; Tannetta et al., 2014; Mouillet et al., 2015), whilst in PE both qualitative and quantitative differences in shed STBEV have been found, such as changes in the size of EV released and the molecular”
BackgroundInfluentialLapehn, S., & Paquette, A. G. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00354-8 · Cited by 166 · see citing works
“Identification of placenta-specific microRNAs secreted into the maternal blood from exosomes is an area of growing interest as a noninvasive biomarker for pregnancy health [17].”
BackgroundMicroRNAs: crucial regulators of placental development
Hayder, H., O’Brien, J. A., Nadeem, U., & Peng, C. (2018) · Reproduction · doi:10.1530/rep-17-0603 · Cited by 157 · see citing works
Yang, L., Semmes, E. C., Ovies, C., Megli, C., Permar, S. R., Gilner, J. B., & Coyne, C. B. (2022) · eLife · doi:10.7554/elife.79794 · Cited by 132 · see citing works
“To further confirm that TOs and DOs recapitulated their tissues of origin, we profiled the expression of three members of the chromosome 19 microRNA family (C19MC), which are specifically expressed in the human placenta (Mouillet et al., 2015).”
BackgroundSelf-citationPrimary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication
Aagaard, K. M., Lahon, A., Suter, M., Arya, R. P., Seferovic, M. D., Vogt, M. B., Hu, M., Stossi, F., Mancini, M. A., Harris, R. A., et al. (2017) · Scientific Reports · doi:10.1038/srep41389 · Cited by 127 · see citing works
“Since C19MC miRNAs and miR-21 may modulate viral replication and inflammatory responses 29–33 , we sought to characterize the expression of the miRNAs in primary human tropho-blasts following ZIKV infection using qPCR.”
Ghafourian, M., Mahdavi, R., Jonoush, Z. A., Sadeghi, M., Ghadiri, N., Farzaneh, M., & Salehi, A. M. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00853-z · Cited by 128 · see citing works
“More than one thousand miRNAs are identified, which are expressed by different layers of the human placenta [106].”
BackgroundSyncytiotrophoblast extracellular vesicles – Circulating biopsies reflecting placental health
Tannetta, D., Collett, G. P., Vatish, M., Redman, C. W. G., & Sargent, I. L. (2016) · Placenta · doi:10.1016/j.placenta.2016.11.008 · Cited by 117 · see citing works
Defense and infection of the human placenta
Heerema‐McKenney, A. (2018) · Apmis · doi:10.1111/apm.12847 · Cited by 120 · see citing works
“to maternal cells distant from the placenta (1, 2, 45).”
BackgroundPlacental programming of neuropsychiatric disease
Kratimenos, P., & Penn, A. A. (2019) · Pediatric Research · doi:10.1038/s41390-019-0405-9 · Cited by 112 · see citing works
Ouyang, Y., Bayer, A., Chu, T., Tyurin, V. A., Kagan, V. E., Morelli, A. E., Coyne, C. B., & Sadovsky, Y. (2016) · Placenta · doi:10.1016/j.placenta.2016.09.008 · Cited by 105 · see citing works
Self-citationNiu, Z., Han, T., Sun, X.-L., Luan, L., Gou, W., & Zhu, X. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.568 · Cited by 102 · see citing works
A Dormant Microbial Component in the Development of Preeclampsia
Kell, D. B., & Kenny, L. C. (2016) · Frontiers in Medicine · doi:10.3389/fmed.2016.00060 · Cited by 99 · see citing works
MicroRNAs: New Players in the Pathobiology of Preeclampsia
Bounds, K. R., Chiasson, V. L., Pan, L. J., Gupta, S., & Chatterjee, P. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00060 · Cited by 100 · see citing works
Imprinted MicroRNA Gene Clusters in the Evolution, Development, and Functions of Mammalian Placenta
Malnou, C. E., Umlauf, D., Mouysset, M., & Cavaillé, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00706 · Cited by 100 · see citing works
Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations
Gormley, M. J., Ona, K. R., Kapidzic, M., Garrido‐Gómez, T., Zdravkovic, T., & Fisher, S. J. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.03.017 · Cited by 95 · see citing works
Sex at the interface: the origin and impact of sex differences in the developing human placenta
Braun, A. E., Mitchel, O. R., Gonzalez, T. L., Sun, T., Flowers, A. E., Pisarska, M. D., & Winn, V. D. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00459-7 · Cited by 94 · see citing works
“Sex differences in microRNA in human placenta Consisting of single-stranded non-coding RNA molecules approximately 22 nucleotides in length [94], microRNAs (miRNAs) regulate mRNA transcription and translation [95].”
BackgroundImpacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta
Strakovsky, R. S., & Schantz, S. L. (2018) · Current Zoology · doi:10.1093/eep/dvy022 · Cited by 90 · see citing works
“miRs are small non-coding RNAs that post-transcriptionally regulate gene expression, and several miR clusters within the placenta have been shown to regulate placental development and function (reviewed in [42]).”
BackgroundBiró, O., Alasztics, B., Molvarec, A., Joó, J. G., Nagy, B., & Rigó, J. J. (2017) · Pregnancy Hypertension · doi:10.1016/j.preghy.2017.09.002 · Cited by 87 · see citing works
“More than one thousand miRNAs are expressed by different layers of the human placenta, some of which are primate-specific and only present in placental and stem cells [19].”
BackgroundPregnancy immune tolerance at the maternal-fetal interface
Li, X., Zhou, J., Fang, M., & Yu, B. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1777292 · Cited by 85 · see citing works
Second trimester extracellular microRNAs in maternal blood and fetal growth: An exploratory study
Rodosthenous, R. S., Burris, H. H., Sanders, A. P., Just, A. C., Dereix, A. E., Svensson, K., Solano, M., Téllez‐Rojo, M. M., Wright, R. O., & Baccarelli, A. (2017) · Epigenetics · doi:10.1080/15592294.2017.1358345 · Cited by 85 · see citing works
“mal and abnormal placentas, and were detected in maternal blood EVs as well.(6) In addition, a few studies have identified microRNAs that were differentially expressed in placentas from pregnancies complicated by fetal growth restriction.”
BackgroundPlacental outcomes of phthalate exposure
Warner, G. R., Dettogni, R. S., Bagchi, I. C., Flaws, J. A., & Graceli, J. B. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.05.001 · Cited by 82 · see citing works
Poirier, C., Desgagné, V., Guérin, R., & Bouchard, L. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0856-5 · Cited by 76 · see citing works
Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer
Hiura, H., Hattori, H., Kobayashi, N., Okae, H., Chiba, H., Miyauchi, N., Kitamura, A., Kikuchi, H., Yoshida, H., & Arima, T. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0379-6 · Cited by 75 · see citing works
“Abnormal expression of miRNAs has been observed in pregnancy-associated diseases and recurrent pregnancy loss [13, 14].”
BackgroundFallen, S., Baxter, D. H., Wu, X., Kim, T., Shynlova, O. P., Lee, M. Y., Scherler, K., Lye, S. J., Hood, L., & Wang, K. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13570 · Cited by 73 · see citing works
“The miRNAs in these clusters have been implicated in placenta development.(20) The chromosome 14 microRNA cluster (C14MC) is located at the imprinted, maternally expressed DLK-DIO3 region on the human chromosome 14q32 and is the largest known miRNA cluster with 52 miRNA precursors (miRBase, www.”
BackgroundMicroRNAs: Small molecules with a large impact on pre‐eclampsia
Hemmatzadeh, M., Shomali, N., Yousefzadeh, Y., Mohammadi, H., Ghasemzadeh, A., & Yousefi, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29286 · Cited by 67 · see citing works
Pillay, P., Vatish, M., Duarte, R. A. B., Moodley, J., & Mackraj, I. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s208865 · Cited by 71 · see citing works
Circulating MicroRNAs as Biomarkers of Gestational Diabetes Mellitus: Updates and Perspectives
Guarino, E., Poggi, C. D., Grieco, G. E., Cenci, V., Ceccarelli, E., Crisci, I., Sebastiani, G., & Dotta, F. (2018) · International Journal of Endocrinology · doi:10.1155/2018/6380463 · Cited by 65 · see citing works
Placenta-Derived MicroRNAs in the Pathophysiology of Human Pregnancy
Xu, P., Ma, Y., Wu, H., & Wang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646326 · Cited by 64 · see citing works
Progress in the understanding of the etiology and predictability of fetal growth restriction
Tang, L. P., He, G., Liu, X., & Xu, W. (2017) · Reproduction · doi:10.1530/rep-16-0287 · Cited by 62 · see citing works
“Although C14MC produces many groups of miRNAs in the placenta, most of them are considered nonfunctional and the function of others remain unknown (Mouillet et al. 2015).”
BackgroundMiRNA‐548c‐5p downregulates inflammatory response in preeclampsia via targeting PTPRO
Wang, Z., Wang, P., Wang, Z., Qin, Z., Xiu, X., Xu, D., Zhang, X., & Wang, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27758 · Cited by 61 · see citing works
Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study
Licini, C., Avellini, C., Picchiassi, E., Mensa’, E., Fantone, S., Ramini, D., Tersigni, C., Tossetta, G., Castellucci, C., Tarquini, F., et al. (2020) · Translational research · doi:10.1016/j.trsl.2020.07.011 · Cited by 61 · see citing works
FLT1 and transcriptome-wide polyadenylation site (PAS) analysis in preeclampsia
Ashar-Patel, A., Kaymaz, Y., Rajakumar, A., Bailey, J. A., Karumanchi, S. A., & Moore, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-11639-6 · Cited by 60 · see citing works
Addo, K., Palakodety, N., Hartwell, H. J., Tingare, A., & Fry, R. C. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.08.002 · Cited by 58 · see citing works
Identification of microRNAs in skeletal muscle associated with lung cancer cachexia
van de Worp, W. R. P. H., Schols, A. M. W. J., Dingemans, A. C., den Kamp, C. M. O., Degens, J. H. R. J., KELDERS, M. C. J. M., Coort, S. L., Woodruff, H. C., Kratassiouk, G., Harel‐Bellan, A., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12512 · Cited by 55 · see citing works
“C19MC is one of the largest miRNA clusters in human genome.(52,53) The miRNAs of the C19MC are expressed from the paternal chromosome and promote pluripotent stem cell phenotype,(52) and their activity towards promoting stem cell survival has been implicated in muscle mass maintenance.”
BackgroundEndogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion
Takahashi, H., Ohkuchi, A., Kuwata, T., Usui, R., Baba, Y., Suzuki, H., Kyi, T. T. C., Matsubara, S., Saito, S., & Takizawa, T. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.016 · Cited by 54 · see citing works
MiRNAs in the Peri-Implantation Period: Contribution to Embryo–Maternal Communication in Pigs
Kaczmarek, M. M., Szuszkiewicz, J., Guzewska, M. M., & Przygrodzka, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062229 · Cited by 53 · see citing works
“To date, miRNAs have been shown to change significantly throughout the course of many diseases and physiological conditions, including pregnancy disorders [89].”
BackgroundMicroRNA-Mediated Gene Regulatory Mechanisms in Mammalian Female Reproductive Health
Gebremedhn, S., Ali, A., Hossain, M. M., Hoelker, M., Salilew‐Wondim, D., Anthony, R. V., & Tesfaye, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020938 · Cited by 52 · see citing works
“Chromosome 14 miRNA cluster (C14MC) produces 63 mature miRNAs in humans, which are highly expressed in the placenta [107].”
BackgroundProsthetic joint infections in the elderly.
Powers, K., Terpenning, M. S., Voice, R. A., & Kauffman, C. A. (1990) · PubMed · Cited by 52 · see citing works
miR-142-3p as a biomarker of blastocyst implantation failure - A pilot study
Borges, E., Setti, A. S., Braga, D. P. A. F., Geraldo, M. V., Figueira, R. D. C. S., & Iaconelli, A. (2016) · JBRA · doi:10.5935/1518-0557.20160039 · Cited by 49 · see citing works
“They were first described in the nematode Caenorhabditis elegans (Lee et al. 1993; Wightman et al. 1993) and later found in the genomes of protists, plants, animals, and viruses (Mouillet et al., 2015).”
BackgroundHayder, H., Shan, Y., Chen, Y., O’Brien, J. A., & Peng, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.995462 · Cited by 49 · see citing works
“They are also reported to be dysregulated in many pregnancy-related diseases including PE (Fu et al., 2013a; Bidarimath et al., 2014; Mouillet et al., 2015; Munaut et al., 2016; Cai et al., 2017; Carreras-Badosa et al., 2017; Lykoudi et al., 2018; Ali et al., 2021).”
BackgroundMicroRNA-Mediated Control of Inflammation and Tolerance in Pregnancy
Kamity, R., Sharma, S., & Hanna, N. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00718 · Cited by 48 · see citing works
“A previous study reported the deletion of the miR379/410 cluster (from C14MC) without consequence (84).”
BackgroundLi, L., Huang, X., He, Z., Xiong, Y., & Fang, Q. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14335 · Cited by 48 · see citing works
Fitzgerald, W., Gomez‐Lopez, N., Erez, O., Romero, R. J., & Margolis, L. B. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12860 · Cited by 47 · see citing works
Vrachnis, N., Loukas, N., Vrachnis, D. N., Antonakopoulos, N., Zygouris, D., Kοlialexi, A., Pergialiotis, V., Iavazzo, C. R., Mastorakos, G. P., & Iliodromiti, Z. (2021) · Nutrients · doi:10.3390/nu13072426 · Cited by 47 · see citing works
“In addition, altered placental micro-RNA expression has the potential to affect fetal growth by affecting placental development and function [11,12].”
BackgroundPlacental miR-340 mediates vulnerability to activity based anorexia in mice
Schroeder, M., Jakovcevski, M., Polacheck, T., Drori, Y., Luoni, A., Röh, S., Zaugg, J., Ben‐Dor, S., Albrecht, C., & Chen, A. (2018) · Nature Communications · doi:10.1038/s41467-018-03836-2 · Cited by 44 · see citing works
“d−f Fetus weight was similar in control and PNS offspring (d), but placental weight was reduced by PNS only in females (twoway ANOVA Fint(1,18)= 4.”
BackgroundInfluentialGu, H., Chen, L., Xue, J., Huang, T., Wei, X., Liu, D., Ma, W., Cao, S., & Yuan, Z. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.110 · Cited by 46 · see citing works
Balaguer, N., Moreno, I., Herrero, M., Gonzáléz-Monfort, M., Vilella, F., & Simón, C. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.02.047 · Cited by 44 · see citing works
The expression level of C19MC miRNAs in early pregnancy and in response to viral infection
Dumont, T., Mouillet, J., Bayer, A., Gardner, C. L., Klimstra, W. B., Wolf, D. G., Yagel, S., Balmir, F., Binstock, A., Sanfilippo, J. S., et al. (2017) · Placenta · doi:10.1016/j.placenta.2017.03.011 · Cited by 42 · see citing works
Self-citationKowalczyk, A., Gajda, A., Ruzycka-Ayoush, M., Targońska, A., Mosieniak, G., Głogowski, M., Szumera‐Ciećkiewicz, A., Prochorec‐Sobieszek, M., Bamburowicz‐Klimkowska, M., Nowicka, A. M., et al. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00772 · Cited by 41 · see citing works
MicroRNAs in Uteroplacental Vascular Dysfunction
Hu, X., & Zhang, L. (2019) · Cells · doi:10.3390/cells8111344 · Cited by 41 · see citing works
“Not surprisingly, dysregulated expression of uteroplacental miRNAs has been demonstrated in both preeclampsia and IUGR, implicating their potential roles in the pathogenesis of these complications [15,18,19].”
BackgroundDiabetes in Pregnancy and MicroRNAs: Promises and Limitations in Their Clinical Application
Ibarra, A., Guedes, B. V., Brito‐Casillas, Y., & Wägner, A. M. (2018) · Non-Coding RNA · doi:10.3390/ncrna4040032 · Cited by 38 · see citing works
“The human placenta also expresses numerous types of miRNA species (reviewed in Reference [33]), which are encoded at all but chromosome Y [34].”
BackgroundLégaré, C., Clément, A., Desgagné, V., Thibeault, K., White, F., Guay, S., Arsenault, B. J., Scott, M. S., Jacques, P., Perron, P., et al. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-021-00883-1 · Cited by 38 · see citing works
“Studies support that microRNAs (miRNAs) regulate embryonic and fetal growth and development as well as maternal metabolic adaptations and maintenance of pregnancy [1, 2].”
BackgroundLin, X., Yang, P., Reece, E. A., & Yang, P. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.008 · Cited by 36 · see citing works
Cirkovic, A. M., Stanisavljevic, D. M., Milin-Lazovic, J. S., Rajović, N., Pavlovic, V. R., Milicevic, O. S., Savic, M. D., Kostic, J., Aleksic, N., Milic, N., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.782845 · Cited by 37 · see citing works
“This results in pathologic remodeling of the placental arterioles, which become narrow, with reduced flow and sclerotic changes in the arteriolar walls (Mouillet et al., 2015).”
BackgroundInfluentialPrecise Personalized Medicine in Gynecology Cancer and Infertility
Zhang, P.-Y., & Yu, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00382 · Cited by 34 · see citing works
Diagnostic Potential of MicroRNAs as Biomarkers in the Detection of Preeclampsia
Horňáková, A., Kolková, Z., Holubeková, V., Loderer, D., Lasabová, Z., Biringer, K., & Halášová, E. (2020) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2019.0264 · Cited by 34 · see citing works
“Several studies have explored the importance of miRNA-regulated gene expression in the physiological process of placental development, as well as in the pathogenesis of PE (Fu et al. , 2013; Mouillet et al. , 2015; Wang et al. , 2016b; Gormley et al. , 2017).”
Identifying miRNA regulatory mechanisms in preeclampsia by systems biology approaches
Biró, O., Nagy, B., & Rigó, J. J. (2016) · Hypertension in Pregnancy · doi:10.1080/10641955.2016.1239736 · Cited by 33 · see citing works
“the regulation of placental development and are essential for normal physiology (10).”
BackgroundJoshi, A. S., Azuma, R., Akumuo, R. C., Goetzl, L. M., & Pinney, S. E. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0485-y · Cited by 33 · see citing works
Smith, M., Pillman, K. A., Jankovic‐Karasoulos, T., McAninch, D., Wan, Q., Bogias, K. J., McCullough, D., Bianco‐Miotto, T., Breen, J., & Roberts, C. T. (2021) · RNA Biology · doi:10.1080/15476286.2021.1963105 · Cited by 33 · see citing works
Associations of maternal and placental extracellular vesicle miRNA with preeclampsia
Aharon, A., Rebibo-Sabbah, A., Ahmad, R. S., Dangot, A., Bar-Lev, T. H., Brenner, B., Halberthal-Cohen, A., David, C. B., Weiner, Z., & Solt, I. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1080419 · Cited by 33 · see citing works
“…2013; Mitchell et al., 2015) suggests that the relevant mechanism is apparently a non-random process (Diehl et al., 2012; Boon and Vickers, 2013; Niu et al., 2018) related to EVs as a source of miRNAs that promote GVCs. Previously, we demonstrated that EVs from women with GVCs contain higher…”
BackgroundPaquette, A. G., Chu, T., Wu, X., Wang, K., Price, N. D., & Sadovsky, Y. (2018) · Placenta · doi:10.1016/j.placenta.2018.10.004 · Cited by 31 · see citing works
“Selected C19MC miRNA species also hinder trophoblast differentiation [20], and regulate the migration of extravillous trophoblasts by targeting specific transcripts related to cellular movement [5,21].”
BackgroundSelf-citationMeng, M., Cheng, Y. K. Y., Wu, L., Chaemsaithong, P., Leung, B. W., Chim, S. S. C., Sahota, D. S., Li, W., Poon, L. C., Wang, C. C., et al. (2020) · Placenta · doi:10.1016/j.placenta.2020.02.002 · Cited by 31 · see citing works
Medina, L., Castillo, C., Liempi, A. I., Guerrero-Muñoz, J., Rojas-Pirela, M., Maya, J. D., Humberto Prieto, E., & Kemmerling, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.595250 · Cited by 31 · see citing works
“Moreover, epigenetic and genetic defects in miRNAs and their processing machinery are a common hallmark of infection and diseases that include pregnancy-specific pathologies such as preeclampsia (17, 38).”
BackgroundHan, S., Chen, Y., Gao, Y. L., Sun, B., & Kong, Y. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.09.010 · Cited by 30 · see citing works
Serum miRNA biomarker discovery for placenta accreta spectrum
Chen, S., Pang, D., Li, Y., Zhou, J., Liu, Y., Yang, S., Liang, K., & Yu, B. (2020) · Placenta · doi:10.1016/j.placenta.2020.09.068 · Cited by 30 · see citing works
Data-Driven Medicine in the Diagnosis and Treatment of Infertility
de Santiago, I., & Polański, Ł. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216426 · Cited by 29 · see citing works
“…as non-coding RNAs, where some authors propose the use of non-coding RNAs and microRNAs as being predictive of male infertility [45,46], placental function during pregnancy [47], and of circulating small non-coding RNAs in the first trimester [48] as a non-invasive diagnostic tool for preeclampsia.”
BackgroundOgoyama, M., Ohkuchi, A., Takahashi, H., Zhao, D., Matsubara, S., & Takizawa, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031237 · Cited by 29 · see citing works
“, placenta-associated miRNAs), there are two other placenta-associated miRNA clusters in chromosome 19: the chromosome-19 miRNA cluster (designated as C19MC; 46 miRNA precursors) and the miR-371-3 cluster (three miRNA precursors in the vicinity of C19MC) [84,85].”
BackgroundInfluentialA blood-based miRNA signature for early non-invasive diagnosis of preeclampsia
Bao, S., Zhou, T., Yan, C., Bao, J., Yang, F., Chao, S., Zhou, M., & Xu, Z. (2022) · BMC Medicine · doi:10.1186/s12916-022-02495-x · Cited by 29 · see citing works
Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2
Guo, M., Zhao, X., Yuan, X., & Li, P. (2017) · Journal of Human Hypertension · doi:10.1038/jhh.2017.65 · Cited by 29 · see citing works
Distinct microRNA profiles for complete hydatidiform moles at risk of malignant progression
Lin, L. H., Maestá, I., Laurent, J. D. S., Hasselblatt, K. T., Horowitz, N. S., GOLDSTEIN, D. P., Quade, B. J., Sun, S. Y., Braga, A., Fisher, R. A., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.09.048 · Cited by 29 · see citing works
Tang, M., Bai, L., Wan, Z., Wan, S., Xiang, Y., Qian, Y., Cui, L., You, J., Hu, X., Qu, F., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.06.012 · Cited by 27 · see citing works
“In the placenta, at least 500 different miRNAs have been identified.(14) These miRNAs are involved in placental”
BackgroundMiura, K., 東島, 愛., Murakami, Y., Fuchi, N., Tsukamoto, O., Abe, S., Hasegawa, Y., Miura, S., & Masuzaki, H. (2016) · Reproductive Sciences · doi:10.1177/1933719116653837 · Cited by 25 · see citing works
“plasma may reflect the condition of placental abruption.(18-21) If prenatal prediction of placental abruption can be provided by monitoring the circulating pattern of cell-free C19MC miRNAs in maternal plasma, it will enable a reduction in both fetal and maternal mortalities from this condition.”
BackgroundmicroRNA signatures associated with fetal growth restriction: a systematic review
Kochhar, P., Vukku, M., Rajashekhar, R., & Mukhopadhyay, A. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-01041-x · Cited by 26 · see citing works
Peiris, H. N., Vaswani, K., Almughlliq, F. B., Koh, Y. Q., & Mitchell, M. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.013 · Cited by 24 · see citing works
Saha, S., Chakraborty, S., Bhattacharya, A., Biswas, A., & Ain, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-16566-0 · Cited by 24 · see citing works
Awamleh, Z., & Han, V. K. M. (2020) · Pregnancy Hypertension · doi:10.1016/j.preghy.2020.01.002 · Cited by 24 · see citing works
Sundrani, D. P., Karkhanis, A. R., & Joshi, S. (2021) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2020.1858994 · Cited by 23 · see citing works
“These placental extracellular miRNAs are derived primarily from the trophoblast layer, which lines the human placental villi (Mouillet et al. 2015).”
BackgroundZolfaghari, M. A., Motavalli, R., Soltani‐Zangbar, M. S., Parhizkar, F., Danaii, S., Maleki, L. A., Noori, M., Dolati, S., Ahmadi, M., Kafil, H. S., et al. (2021) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2021.103317 · Cited by 23 · see citing works
Whigham, C., MacDonald, T. M., Walker, S. P., Hiscock, R. J., Hannan, N. J., Pritchard, N., Cannon, P., Nguyen, T. V., Miranda, M., Tong, S. Y. C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73783-w · Cited by 21 · see citing works
Yao, P., Hu, G., & Niu, H. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10095-2 · Cited by 22 · see citing works
The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure
Lawless, L., Xie, L., & Zhang, K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1148906 · Cited by 22 · see citing works
“Within the placenta, miRNAs are involved in regulating trophoblast differentiation, migration, invasion, and vasculogenesis (Mouillet et al., 2015; Hayder et al., 2018).”
BackgroundTimofeeva, A. V., Fedorov, I. S., Вячеславовна, С. Ю., Ivanets, T. Y., & Sukhikh, G. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098006 · Cited by 21 · see citing works
Cell-free nucleic acids in prenatal diagnosis and pregnancy-associated diseases.
Nagy, B. (2019) · PubMed Central · Cited by 19 · see citing works
Xu, N., Zhou, X., Shi, W., Ye, M., Cao, X., Chen, S., & Xu, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.893744 · Cited by 19 · see citing works
“Approximately 600 miRNAs are expressed in the human placenta and play key roles in placental development and function by regulating the expressions of genes involved in trophoblast proliferation, differentiation, invasion, migration, apoptosis, and angiogenesis (Mouillet et al., 2015; Chen et al., 2021).”
BackgroundPisarska, M. D., Akhlaghpour, M., Lee, B., Barlow, G. M., Xu, N., Wang, E. T., Mackey, A. J., Farber, C. R., Rich, S. S., Rotter, J. I., et al. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4936 · Cited by 19 · see citing works
Non‐coding RNAs and their cross‐talks impacting reproductive health of women
Jain, N., Gupta, P., Sahoo, S., & Mallick, B. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1695 · Cited by 19 · see citing works
“Not surprisingly, the human placenta expresses a large number of miRNAs, particularly in trophoblasts, indicating their importance in fetal development (Mouillet et al., 2015).”
BackgroundPrats‐Puig, A., Xargay‐Torrent, S., Carreras‐Badosa, G., Mas‐Parés, B., Bassols, J., Petry, C. J., Girardot, M., de Zegher, F., Ibáñez, L., Dunger, D. B., et al. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0450-9 · Cited by 18 · see citing works
HMGA2 is regulated by LIN28 and BRCA1 in human placental cells†
West, R. C., McWhorter, E. S., Ali, A., Goetzmann, L. N., Russ, J. E., Gonzalez-Berrios, C. L., Anthony, R. V., Bouma, G. J., & Winger, Q. A. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy183 · Cited by 17 · see citing works
Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development
Jeyarajah, M. J., Patterson, V. S., Bhattad, G. J., Zhao, L., Whitehead, S. N., & Renaud, S. J. (2024) · Communications Biology · doi:10.1038/s42003-024-06938-4 · Cited by 17 · see citing works
Fetal microchimerism by mode of delivery: a prospective cohort study
Shree, R. S., Harrington, W., Kanaan, S. B., Forsyth, A. M., Cousin, E. M., López, A. M. A., Nelson, J. L., & Gammill, H. S. (2018) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15432 · Cited by 17 · see citing works
Liu, B., Liu, L., Cui, S., Qi, Y. A., & Wang, T. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14732 · Cited by 17 · see citing works
“At present, at least 500 different miRNAs are known to be expressed in placental trophoblast cells, but the biological significance of most miRNAs is still unclear.(6) Recent studies have shown that the disorder of miRNA in placental tissues is related to the pathogenesis of PE.”
BackgroundSex differences in microRNA expression in first and third trimester human placenta
Flowers, A. E., Gonzalez, T. L., Joshi, N. V., Eisman, L. E., Clark, E. L., Buttle, R. A., Sauro, E., DiPentino, R., Lin, Y., Wu, D., et al. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab221 · Cited by 18 · see citing works
“miRNAs generally cause target messenger RNA to be degraded, or prevent translation to protein [13]; small changes in miRNA expression can result in multi-fold changes in gene expression [14].”
BackgroundMaternal paraben exposure and intra-pair thyroid-stimulating hormone difference in twin neonates
Hu, L., Mei, H., Cai, X., Hu, X.-J., Duan, Z., Liu, J., Tan, Y., Yang, P., Xiao, H., & Zhou, A. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114502 · Cited by 16 · see citing works
Maternal plasma mRNA species in fetal heart defects: a potential for molecular screening
Curti, A., Lapucci, C., Berto, S., Prandstraller, D., Perolo, A., Rizzo, N., & Farina, A. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4853 · Cited by 16 · see citing works
“miRNAs are released into the extracellular systemic circulation via exosomes(7) and have also been isolated in maternal plasma as has recently been reported.(8) It is worth noting that both circulating mRNA and miRNA species have recently been evaluated for their possible association with CHDs.”
BackgroundEvaluation of circulating miRNAs during late pregnancy in the mare
Loux, S. C., Scoggin, K. E. S., Bruemmer, J. E., Canisso, I. F., Troedsson, M. H. T., Squires, E. L., & Ball, B. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175045 · Cited by 16 · see citing works
Increased fetal microchimerism in immune and stem cell subsets in preeclampsia
McCartney, S. A., Kolarova, T. R., Kanaan, S. B., Chae, A., Laughney, C. I., Nelson, J. L., Gammill, H. S., & Shree, R. S. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13666 · Cited by 15 · see citing works
Physiopathology of late-onset fetal growth restriction
Júnior, E. A., Zamarian, A. C. P., Caetano, A. C. R., Peixoto, A. B., & Nardozza, L. M. M. (2021) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.21.04771-7 · Cited by 15 · see citing works
kshv-mir-k12-1-5p promotes cell growth and metastasis by targeting SOCS6 in Kaposi’s sarcoma cells
Zhang, J., Pu, X., & Xiong, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s198411 · Cited by 15 · see citing works
“They can also serve as cancer diagnostic markers and potential therapeutic targets.(15) One study showed that miR-143/145 was an upregulated miRNA biomarker, while miR-221/222, miR-155, and the let-7 family were downregulated in KS.”
BackgroundAwamleh, Z., & Han, V. K. M. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05705-y · Cited by 15 · see citing works
- Authors
- Mouillet, J.-F., Ouyang, Y., Coyne, C. B., & Sadovsky, Y.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Sadovsky, Yoel
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 213
- Issue
- 4
- Pages
- S163-S172
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC4592520
- OpenAlex
- W2128949071
- Cited by
- 195
- References
- 157
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 13 · 2023: 20 · 2022: 25 · 2021: 25 · 2020: 23 · 2019: 18 · 2018: 19 · 2017: 19 · 2016: 15
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pennsylvania Department of Health
- National Institutes of Health (0863906)
- National Institute of Allergy and Infectious Diseases (R01AI081759)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071707, R01HD065893, R01HD075665)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- microRNA, placenta, placental function, placental disease, circulating microRNAs, pregnancy, biomarkers, post-transcriptional regulation, non-coding RNA, miRNA-based therapy
- MeSH terms
- Extracellular Space, Female, Humans, Placenta Diseases, Pregnancy, Biomarkers, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review