Diet promotes dysbiosis and colitis in susceptible hosts
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In the IL10 knockout model, colitis exacerbation may involve Bilophila wadsworthia directly promoting a T helper 1 cell-mediated immune response and/or producing hydrogen sulfide, which disrupts the intestinal epithelial barrier.
“In this model system, the exacerbation of colitis may involve a direct effect of Bilophila wadsworthia, which promote a T helper 1 cell-mediated immune response and/or the production of hydrogen sulfide, a toxic small molecule that disrupts intestinal epithelial barrier function70.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [70]
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- Authors
- Sartor, R. B.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Sartor, R. Balfour
- ORCID
- Sartor, R. Balfour
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2012-08-14
- Volume
- 9
- Issue
- 10
- Pages
- 561-562
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2144673429
- Cited by
- 43
- References
- 10
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 9
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- diet, gut dysbiosis, inflammatory bowel disease, colitis, genetic susceptibility, immune response, milk fat, sulfate-reducing bacteria, host-microbe interactions
- MeSH terms
- Animals, Colitis, Diet, Disease Susceptibility, Humans, Lactose Intolerance, Gastrointestinal Tract, Mice, Metagenome
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